US Pat. No. 9,228,459

ACTUATOR FOR AXIAL DISPLACEMENT OF A GAS EXCHANGE VALVE IN A COMBUSTION ENGINE

FREEVALVE AB, Angelholm ...

1. An actuator for axial displacement of a gas exchange valve in a combustion engine, the actuator comprises
an actuator piston disc (4),

an actuator piston rod (7), which is fixedly connected to and axially projecting from the actuator piston disc (4), and which, together with the actuator piston disc, forms an actuator piston,

a cylinder volume, the actuator piston disc (4) dividing said cylinder volume into a first part (5) and a second part (6) and being, in the axial direction, reciprocally displaceable in said cylinder volume between an inactive position and an
active position,

a pressure fluid circuit (10) arranged for controllable fluid communication with the first part (5) of the cylinder volume, and

a first hydraulic circuit (21) comprising a liquid-filled space (22), the actuator piston rod (7) being disposed to be axially displaced in relation to said liquid-filled space (22) in connection with axial displacement of the actuator piston disc (4) in the cylinder volume, characterized in that the actuator piston comprises a second hydraulic circuit (24), the liquid-filled space (22) of the first hydraulic circuit (21) being in fluid communication with an inner cavity (25) in the second hydraulic circuit (24) when the actuator piston disc (4) is in said inactive position, said inner cavity (25) partly being delimited by a positioning piston (29), which, in the axial direction, is reciprocally displaceable in relation to the actuator piston and which is arranged to
press on said gas exchange valve in the second part (6) of the cylinder volume, the second hydraulic circuit (24) comprising a valve (27) that is disposed to prevent fluid flow from the inner cavity (25), the actuator piston rod (7) having a free end (30), which is disposed to at least partly abut against a stop surface (31) in the liquid-filled space (22), when the actuator piston disc (4) is in the inactive position, a pressurized area of the positioning piston (29), which faces the inner cavity (25), being as large as or smaller than a pressurized area of the free end (30) of the actuator piston rod (7).

US Pat. No. 9,060,857

HEART VALVE PROSTHESIS AND METHODS OF MANUFACTURE AND USE

Medtronic CoreValve LLC, ...

1. A valve prosthesis comprising:
a valve body comprising three leaflets, each leaflet including:
a body,
a free edge, and
enlarged lateral ends at either end of the free edge,
wherein adjacent enlarged lateral ends of adjoining leaflets are sewn together to form commissures; and
a self-expanding frame, the frame having an inflow section having a first row of cells in a circumferentially repeating pattern,
an outflow section having a second row of cells in a circumferentially repeating pattern and including an eyelet, and a middle
region between the inflow section and the outflow section, wherein the middle region is configured to avoid blocking blood
flow to the coronary arteries when the frame is implanted in a body, wherein the area of individual cells in the first row
of cells is less than the area of individual cells in the second row of cells,

wherein the frame supports the valve body, wherein the frame has a longitudinal axis, wherein the frame has a contracted delivery
configuration and an expanded deployed configuration,

wherein, when the frame is in the expanded deployed configuration, the outflow section diameter is larger than the inflow
section diameter,

wherein each commissure spans a cell of the frame,
wherein a plurality of cells of the frame are positioned between the cells spanned by commissures,
wherein each free edge is suspended from the leaflet's commissures to define coaptation edges and a center of coaptation,
and

wherein the length of each free edge forms a substantially continuous curve extending downwardly between the respective commissures
so that the free edges of the leaflets generally define the shape of catenaries to substantially uniformly distribute loads
over the leaflets.

US Pat. No. 9,060,858

METHODS, SYSTEMS AND DEVICES FOR CARDIAC VALVE REPAIR

Evalve, Inc., Menlo Park...

1. A method for treating regurgitation through a valve in a heart, the heart having an atrium fluidically coupled to a ventricle
by the valve, the valve including at least two leaflets which coapt along a line of coaptation, the method comprising:
introducing percutaneously a medical device system into a patient's heart to a vicinity of a gap within the line of coaptation
of the valve, the medical device system comprising:

a steerable guide catheter configured for delivery through the patient's vasculature to the vicinity of the gap;
a retractable sheath moveably disposed over a device comprising a frame sized to fit within a heart chamber and a pair of
arms moveably coupled to the frame, the arms are structurally configured to move from a fluid flow-blocking position during
a systole to a fluid flow-allowing position during a diastole in response to pressure changes occurring between the systole
and the dystole, the device being compressed to a reduced size by the retractable sheath when the retractable sheath is disposed
over the device;

using the guide catheter to position the device within the gap along the line of coaptation;
retracting the sheath to release the blocker from compressive forces maintaining the device in the delivery configuration,
the device expanding to a size larger than the reduce size in response to the sheath being retracted; and

retracting the catheter and the sheath from the heart.

US Pat. No. 10,058,630

METHODS FOR INHIBITING STENOSIS, OBSTRUCTION, OR CALCIFICATION OF A STENTED HEART VALVE OR BIOPROSTHESIS

CONCIEVALVE, LLC, Minnea...

1. A method for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall, said method comprising:providing a bioprosthetic heart valve comprising tissue having one or more cusps, said bioprosthetic heart valve mounted on an elastical stent for replacement of a natural diseased valve;
treating said bioprosthetic heart valve with a tissue fixative prior to applying a coating composition comprising one or more therapeutic agents;
coating said stent, one or more cusps, or both with the coating composition after treating the bioprosthetic heart valve with the tissue fixative, said coating composition including (i) a nitric oxide activator; (ii) an anti-proliferative agent; and (ii) an inhibitor of extracellular protein matrix production;
implanting said bioprosthetic valve into said vessel in a diseased natural valve site;
eluting said coating composition from said elastical stent, one or more cusps, or both;
inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, said stem cells circulating external and proximate to the bioprosthetic heart valve, elastical stent or both by (a) activating nitric oxide production, (b) inhibiting cell proliferation, and (c) inhibiting extracellular protein matrix production, (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.

US Pat. No. 9,964,006

ACTUATOR FOR AXIAL DISPLACEMENT OF AN OBJECT

FREEVALVE AB, Angelholm ...

1. An actuator for axial displacement of an object, the actuator (1) comprises:an actuator piston (4) comprising an actuator piston rod (7) having a first end (8) and a second end (9), wherein the actuator piston (4) is displaceable in the axial direction in a reciprocating manner between a first position and a second position, and
a hydraulic circuit (20) comprising a liquid filled chamber (21), the first end (8) of the actuator piston rod (7) being arranged to be displaced in the axial direction within said liquid filled chamber (21) in conjunction with axial displacement of the actuator piston (4),
wherein an axially extending recess (22) mouth in said liquid filled chamber (21) and is arranged to receive the first end (8) of the actuator piston rod (7) when the actuator piston (4) is in said first position,
characterized in that the actuator piston rod (7) in the area of the first end (8) presents a cylindrical envelope surface (24), and in that the recess (22) presents a cylindrical inner surface (25), the cylindrical envelope surface (24) and the cylindrical inner surface (25) presenting matching shapes,
wherein the actuator comprises a passage extending between the recess (22) and the liquid filled chamber (21) when the cylindrical envelope surface (24) and the cylindrical inner surface (25) are located in overlapping configuration, wherein a section of a predetermined maximum overlap is constituted by a braking overlap (35), the passage presenting at said braking overlap section (35) a cross section area (A1) that decrease as a function of increasing overlap between the cylindrical envelope surface (24) and the cylindrical inner surface (25), wherein said cross section area (A1) of the passage at a beginning of said braking overlap section (35) decrease with decreasing derivative and at an end of said braking overlap section (35) decrease with increasing derivative, as a function of increasing overlap.

US Pat. No. 9,232,942

MATERIAL FOR TREATMENT OF A HEART VALVE, IN PARTICULAR A MITRAL VALVE

Medtronic Corevalve LLC, ...

1. Material for treating a heart valve comprising:
a first guide member deployable from a distal end of a catheter, the guide member having a distal portion of a length that
is configured to extend from the distal end of the catheter such that when the guide member is deployed for treating the heart
valve the distal portion of the guide member extends from a proximal side to a distal side of a valve annulus to engage the
distal side of the valve annulus;

a second deployable guide member slidably movable relative to the first guide member, the second guide member having a distal
portion of a length that is configured to extend from the distal end of the catheter such that when the second guide member
is deployed for treating the heart valve the distal portion of the second guide member extends from the distal end of the
catheter to engage a proximal side of the valve annulus; and

an implant having a helical shape engaged around the first and second guide members and rotatable relative thereto, the implant
being detachably connected to an actuator that is configured to cause the implant to advance distally along the first and
second guide members while being rotated around the first and second guide members,

wherein the implant is configured to be deployed from the distal end of the catheter and to penetrate the tissue of the valve
annulus while advancing along and rotating relative to the deployed distal portions of the first and second guide members,
and

wherein the implant remains engaged with and rotates around both of the deployed distal portions of the first and second guide
members during advancement of the implant from the distal end of the catheter.

US Pat. No. 10,119,435

COMBUSTION ENGINE AND MANTLE ASSEMBLY THEREFORE

Freevalve AB, Angelholm ...

1. A combustion engine, comprising:a cylinder head (6) that comprises a controllable first engine valve (8) arranged to selectively open/close a combustion chamber (7) included in the combustion engine (1), and a controllable second engine valve (9) arranged to selectively open/close the combustion chamber (7);
a first valve actuator (10) operatively connected to said first engine valve (8), said first valve actuator (10) comprising at least one inlet opening (11) for pressure fluid and at least one outlet opening (12) for pressure fluid;
a second valve actuator (13) operatively connected to said second engine valve (9), said second valve actuator (13) comprising at least one inlet opening (14) for pressure fluid and at least one outlet opening (15) for pressure fluid;
a closed pressure fluid circuit, said first valve actuator (10) and said second valve actuator (13) being arranged in parallel with each other in said closed pressure fluid circuit; and
a cylinder head chamber (16) that forms part of said closed pressure fluid circuit, said cylinder head chamber (16) delimited by said cylinder head (6) and at least a first cylinder head mantle (17),
wherein both said at least one outlet opening (12) of the first valve actuator (10) and said at least one outlet opening (15) of the second valve actuator (13) are in fluid communication with said cylinder head chamber (16).

US Pat. No. 10,548,614

TRICUSPID VALVE REPAIR SYSTEM

Evalve, Inc., Santa Clar...

1. An interventional tissue clip device configured for repair of a cardiac valve, the clip device comprising:a pair of distal elements rotatably joined to a coupling member; and
a pair of proximal elements resiliently biased toward the pair of distal elements, the pair of distal elements being configured to receive the pair of proximal elements so as to enable the grasping of tissue therebetween, the pair of proximal elements including a plurality of adjustable tines moveable between a retracted configuration and an open configuration, the open configuration positioning the tines more perpendicular to respective longitudinal axes of the pair of proximal elements so as to enable enhanced grasping of tissue by the pair of proximal elements;
wherein the tines are coupled to one or more control lines, wherein adjusting tension of the one or more control lines controls movement of the tines between the open and retracted configurations.

US Pat. No. 9,885,261

ACTUATOR FOR AXIAL DISPLACEMENT OF AN OBJECT

FREEVALVE AB, Angelholm ...

1. Actuator for axial displacement of an object, the actuator comprises:
an actuator piston disc (5),

a cylinder volume, wherein the actuator piston disc (5) separates said cylinder volume in a first portion (6) and a second portion (7) and is in axial direction displaceable back and forth in said cylinder volume between an inactive position and an active
position,

an inlet channel (11) extending between a pressure fluid inlet (12) and the first portion (6) of the cylinder volume, a first inlet valve body (15) and a second inlet valve body (9, 9?, 9?) arranged in said inlet channel (11),

an outlet channel (13) extending between the first portion (6) of the cylinder volume and a pressure fluid outlet (14),

an outlet valve body (17) arranged in said outlet channel (13), wherein the actuator comprises an electrically controlled pilot valve (19) configured to communicate a first control pressure to the first inlet valve body (15) via a first control pressure channel (21) and configured to communicate a second control pressure to the outlet valve body (17) via a second control pressure channel (22), wherein the pilot valve (19) is configured to place itself in a resting state, in which the first control pressure channel (21) is in fluid communication with a control fluid inlet (25) of the pilot valve (19) and the second control pressure channel (22) is in fluid communication with a control fluid outlet (26) of the pilot valve (19), and in an active state, in which the first control pressure channel (21) is in fluid communication with the control fluid outlet (26) and the second control pressure channel (22) is in fluid communication with the control fluid inlet (25), respectively, and that the inlet channel (11) is kept closed by the second inlet valve body (9, 9?, 9?) when the actuator piston disc (5) is located at least a predetermined distance from the actuator piston disc's inactive position.

US Pat. No. 9,347,466

ACTUATOR

FREEVALVE AB, Angelholm ...

1. An actuator, comprising:
a cylinder (1);

an actuator piston (2) displacably arranged in the cylinder (1);

a pressure fluid circuit having a channel (3) mouthing in said cylinder (1), the pressure fluid being a gas;

an indirectly electrically controlled first valve body (4), arranged in said channel (3) for controlling a flow of a pressure fluid in said channel (3), wherein, in a first position the first valve body (4) keeps the channel (3) of the pressure fluid circuit closed, and in a second position the first valve body (4) keeps the channel (3) of the pressure fluid circuit channel open;

a second valve body (5), arranged in or at said channel (3) to open and close the channel (3), the second valve body (5) being a member fixedly connected to the actuator piston (2), and the first valve body (4) and the second valve body (5) being arranged in series with each other in said channel (3);

an electrically controlled three-way valve (18) that is arranged to alternately open for pressure fluid communication i) between an activation channel (19) and a high pressure source (HP), and ii) between the activation channel (19) and a low pressure source (LP), wherein chosen pressure fluid pressure in the activation channel (19) is arranged to act against and admit displacement of the first valve body (4);

a hydraulic lock (11) comprising a non-return valve (13) located within a further channel (12) extending from said channel (3), wherein the hydraulic lock (11) acts against the second valve body (5) via the further channel (12); and

a hydraulic valve located in the further channel (12) and connected to the first valve body (4), wherein the hydraulic valve is open when the first valve body (4) is in the first position keeping the channel (3) of the pressure fluid circuit closed, and the hydraulic valve is closed when the first valve body (4) is in the second position keeping the channel (3) of the pressure fluid circuit open.

US Pat. No. 9,988,952

COMBUSTION ENGINE

FREEVALVE AB, Angelholm ...

1. A combustion engine comprisinga cylinder head (6) that comprises a controllable engine valve (8) configured to open/close a combustion chamber (7) included in the combustion engine (1),
a valve actuator (10) that is operatively connected to and configured to displace said engine valve (8), and
a closed pressure fluid circuit, wherein said valve actuator (10) is arranged in said closed pressure fluid circuit, said combustion engine (1) further comprising a cylinder head chamber (13) that is included in said closed pressure fluid circuit and that is delimited by said cylinder head (6) and a cylinder head mantle (14), by the valve actuator (10) comprising a pneumatic pressure fluid circuit configured to operate the valve actuator (10) to displace the controllable engine valve (8) and comprising an outlet opening (12) for pressure fluid, which outlet opening (12) is in fluid communication with said cylinder head chamber (13), and by the cylinder head chamber (13) comprising a hydraulic liquid drainage valve (36), wherein a drainage conduit (37) stretches from the hydraulic liquid drainage valve (36) to a hydraulic liquid vessel (38) of the combustion engine (1) for draining away hydraulic liquid accumulated in the cylinder head chamber (13).

US Pat. No. 9,504,564

HEART VALVE PROSTHESIS AND METHODS OF MANUFACTURE AND USE

Medtronic Corevalve LLC, ...

1. A valve prosthesis comprising:
a self-expanding multi-level frame having a contracted delivery configuration and an expanded deployed configuration, and
a cell pattern that defines contours, wherein the cell pattern includes a plurality of cells having sizes that vary along
the length of the prosthesis, the cell pattern defined by struts; and

a valve body affixed to the multi-level frame, the valve body comprising a plurality of leaflets affixed to a skirt at joints,
wherein the valve body has a center of coaptation, wherein adjoining leaflets form commissures, wherein the commissures are
affixed to the multi-level frame at a location distal of the center of coaptation, and wherein the commissures include flaps
that span an entire area of at least one cell of the cell pattern;

wherein the joints include curved portions between a curved base of each leaflet and a scalloped upper edge of the skirt,
wherein the curved portions curve longitudinally towards and away from a proximal end of the multi-level frame, wherein the
curved portions are aligned with and directly affixed to a curved contour of the multi-level frame defined by the struts of
the cells of the multi-level frame so that most of the length of the joints is directly supported by the frame to evenly distribute
forces through the valve body to the multi-level frame.

US Pat. No. 9,060,856

TRANSCATHETER HEART VALVES

Medtronic CoreValve LLC, ...

1. A prosthetic heart valve comprising:
a biological tissue valve; and
a collapsible and expandable support frame having a longitudinal axis, the frame comprising:
an outflow circumferential structure defining an outflow end of the frame and consisting essentially of a single row of diamond-shaped
expandable cells;

three V-shaped structures spaced apart from the outflow circumferential structure;
three struts longitudinally aligned with the longitudinal axis of the frame, configured to facilitate mounting the biological
tissue valve to the frame, and interconnecting the outflow circumferential structure to the three V-shaped structures, each
strut of the three struts having:

a first end terminating at a respective junction between two adjacent diamond-shaped expandable cells of the outflow circumferential
structure; and

a second end terminating at a respective apex of one V-shaped structure of the three V-shaped structures,
wherein the three struts are axially continuous with the outflow circumferential structure and the three V-shaped structures;
and

three undulating structures, each of the three undulating structures interconnecting respective adjacent V-shaped structures
of the three V-shaped structures,

wherein the prosthetic heart valve is configured to be collapsed for introduction into a patient using a catheter and to be
expanded for deployment at an implantation site.

US Pat. No. 9,778,014

METHOD AND POSITION SENSOR ASSEMBLY FOR DETERMINING A MUTUAL POSITION BETWEEN A FIRST OBJECT AND A SECOND OBJECT

FREEVALVE AB, Angelholm ...

1. A method for determining a mutual position between a first body (10) and a coil (11) by means of a position sensor assembly, which comprises said first body (10), said coil (11), a control unit, and a sensor circuit (12), said first body (10) being reciprocally displaceable in the axial direction in relation to said coil (11), the sensor circuit (12) comprising a comparator (15) connected to a first branch comprising said coil (11), a power switch (16), and a measuring resistance (18) coupled in series with each other, the comparator (15) being arranged to obtain and compare an instantaneous measuring voltage across the measuring resistance (18) and an instantaneous reference voltage, and being arranged to, based on the mutual relationship between the measuring voltage
and reference voltage, generate a state change of a digital output signal, the method comprising the steps of:
sending a rising edge of a digital input signal pulse from the control unit to the power switch (16) to produce a state change of the power switch (16) from open to closed,

in the control unit, detecting a first state change of the output signal from the comparator (15), and

determining a mutual position between said first body (10) and said coil (11) based on the time delay between the rising edge of the input signal pulse and the first state change of the output signal,

or comprising the steps of:
sending a rising edge of a digital input signal pulse from the control unit to the power switch (16) to produce a state change of the power switch (16) from open to closed,

in the control unit, detecting a first state change of the output signal from the comparator (15),

in the control unit, detecting a second state change of said output signal, and
determining a mutual position between said first body (10) and said coil (11) based on the time delay between the first state change of the output signal and the second state change of the output signal.

US Pat. No. 10,344,683

COMBUSTION ENGINE AS WELL AS METHOD FOR ENGINE BRAKING USING SUCH A COMBUSTION ENGINE

FREEVALVE AB, Angelholm ...

10. A combustion engine, comprising:at least one cylinder (2) having a cylinder volume (6) and a piston (3) displaceable in said cylinder (2);
an intake air channel (9) having a first pressure (P1);
a first inlet valve (7) arranged between the intake air channel (9) and the cylinder volume (6);
an exhaust air channel (10) having a second pressure (P2);
a first outlet valve (8) arranged between the cylinder volume (6) and the exhaust air channel (10); and
a storage reservoir (11) having a third pressure (P3) that is higher than said first pressure (P1) and said second pressure (P2),
the storage reservoir (11) being arranged in controllable fluid communication with the cylinder volume (6), the combustion engine (1) being configured to be driven in two-stroke cycle during engine braking,
the first inlet valve (7) being configured to be open during at least a part of the time the piston (3) is displaced from the upper dead centre to the lower dead centre,
the combustion engine being configured to open the fluid communication between the storage reservoir (11) and the cylinder volume (6) in connection with the piston (3) being located at the lower dead centre and when the first inlet valve (7) is closed, and
the storage reservoir (11) being configured to be in fluid communication with the cylinder volume (6) during at least a part of the time the piston (3) is displaced from the lower dead centre to the upper dead centre.

US Pat. No. 9,510,829

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

Evalve, Inc., Menlo Park...

1. A fixation device for engaging tissue comprising:
a coupling member having a first branch and a second branch, the first branch and the second branch being attached at a first
end of the coupling member and being bifurcated at a second end of the coupling member, opposite the first end of the coupling
member, such that the first and the second branch are configured to move independently,

a pair of proximal gripping elements operably coupled with the coupling member, each of the gripping elements having a first
end attached to the first end of the coupling member, a free end opposite the first end, and a gripping surface therebetween
for gripping the tissue, the first ends being movably coupled together such that the gripping elements are moveable between
a first position wherein the free ends are spaced apart with the gripping surfaces generally facing away from each other,
and a second position wherein the free ends are separated even further apart; and

a pair of distal fixation elements operably coupled with the coupling member, each of the fixation elements having a first
end attached to the first end of the coupling member, a free end opposite the first end, and an engagement surface therebetween
for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between
an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with
the engagement surfaces generally facing each other.

US Pat. No. 9,066,799

PROSTHETIC VALVE FOR TRANSLUMINAL DELIVERY

MEDTRONIC COREVALVE LLC, ...

1. A prosthetic valve assembly for use in replacing a deficient native valve, the valve assembly comprising:
a valve having a plurality of leaflets, a base, and a plurality of commissure points; and
a valve support comprising a generally cylindrical band of expandable cells, the valve support configured to be collapsible
for transluminal delivery and expandable to contact the anatomical annulus of a native valve when the assembly is positioned
in situ,

wherein the base and the commissure points of the valve are secured to the generally cylindrical band of the valve support,
wherein the valve support has a longitudinal axis,
wherein the commissure points of the valve are located on a first plane perpendicular to the longitudinal axis of the valve
support, and

wherein a portion of one or more of the expandable cells of the valve support is positioned between the commissure points
on the first plane.

US Pat. No. 10,238,494

SELF-ALIGNING RADIOPAQUE RING

EVALVE, INC., Santa Clar...

1. A device for aligning components of an intravascular system, the device comprising:a head having a face at a distal end of the device, the face having a face radius;
a body connected to the head and positioned proximally of the head, the body having a body radius wherein a ratio of the face radius to the body radius is in a range of 1.20 to 1.75;
a base connected to the body and positioned proximally of the body;
a guide surface positioned on the head and longitudinally between the face and the body, the guide surface extending distally radially outward and forming an angle with an outer surface of the body in a range of 100° to 160°; and
a major channel and a plurality of minor channels extending longitudinally from the distal end to the base, the plurality of minor channels communicating with the major channel in the head and being separated from the major channel in the base.

US Pat. No. 10,624,618

METHODS AND DEVICES FOR CAPTURING AND FIXING LEAFLETS IN VALVE REPAIR

EVALVE, INC., Santa Clar...

1. A method for repairing a cardiac valve having valve leaflets, the method comprising:advancing a catheter having a capture device through an atrium of the heart to a location near the cardiac valve, wherein the capture device comprises at least one proximal element and at least one distal element adapted to protrude radially outward from a center of the capture device;
holding the at least one proximal element proximally upward by a suture;
extending the at least one distal element radially outward from the center of the capture device after advancing the capture device to the location near the cardiac valve of the heart;
atraumatically positioning the at least one distal element against at least one leaflet of the cardiac valve;
releasing the at least one proximal element by slacking the suture from a tensioned condition toward a slacked condition to allow the at least one proximal element to extend radially outward from the center of the capture device to capture the at least one leaflet between the at least one proximal element and the at least one distal element; and
detaching the capture device from the catheter.

US Pat. No. 10,426,616

CARDIAC IMPLANT DELIVERY SYSTEM

Evalve, Inc., Santa Clar...

1. A delivery system configured for delivering an interventional device to a targeted treatment area within a body, the delivery system comprising:a steerable catheter having a proximal end and a distal end; and
an interventional device delivery system positioned within the steerable catheter and configured to be translatable within the steerable catheter so as to selectively deploy the interventional device beyond the distal end of the steerable catheter, the interventional device delivery system comprising:
a shaft; and
a sheath operatively coupled to the shaft, the sheath having a first portion, a second portion, and a space defined by the first portion and the second portion, the first portion of the sheath enclosing a first portion of the interventional device, the second portion of the sheath enclosing a second portion of the interventional device, and the first and second portions of the sheath being selectively moveable relative to one another and relative to the interventional device so as to:
selectively deploy the first portion of the interventional device from the sheath while maintaining the second portion of the interventional device within the sheath, or
alternatively, selectively deploy the second portion of the interventional device from the sheath while maintaining the first portion of the interventional device within the sheath, and
once one portion of the interventional device is deployed and positioned at the targeted treatment area, move the other portion of the sheath to selectively deploy the other portion of the interventional device,
wherein a portion of the sheath is translatable upon subjection to a hydraulic force, from a fluid ejected into the space enclosing the interventional device prior to the sheath separating to deploy the interventional device, to deploy one of the first portion or the second portion of the interventional device.

US Pat. No. 9,572,666

MITRAL VALVE FIXATION DEVICE REMOVAL DEVICES AND METHODS

Evalve, Inc., Santa Clar...

1. A method of disabling a fixation device that holds anterior and posterior leaflets of the mitral valve together, the fixation
device comprising a clip and being deployable during a first procedure, the method comprising:
during a second procedure, cutting the previously deployed fixation device so that an anterior distal element and an anterior
gripping element of the fixation device, which hold the anterior leaflet therebetween, remain attached to the anterior leaflet,
and a posterior distal element and a posterior gripping element of the fixation device, which hold the posterior leaflet therebetween,
remain attached to the posterior leaflet, cutting the previously deployed fixation device separates the anterior and posterior
leaflets.

US Pat. No. 10,238,495

DELIVERY CATHETER HANDLE AND METHODS OF USE

EVALVE, INC., Santa Clar...

1. A medical delivery system, comprising:a housing;
a delivery device disposed at least partially within the housing;
a lock configured to releasably secure the delivery device relative to the housing when in a locked configuration, and to allow translation of the delivery device within the housing when in an unlocked configuration, the lock disposed on a portion of the delivery device and selectively contacts an outer surface of the portion of the delivery device to selectively lock both translation and rotation of the portion, the lock is configured as a spring clamp, the spring clamp having a diameter when in a relaxed configuration that is smaller than a diameter when in a stressed configuration;
a lock actuator configured to engage with the lock to move the lock from the locked configuration toward the unlocked configuration; and
a handle coupled to the lock actuator, the handle being configured to move the lock actuator to engage with the lock upon the handle being moved from a default position toward a depressed position;
a sleeve having a proximal end coupled to the housing; and
a catheter having a proximal end coupled to the delivery device, the catheter extending distally from the delivery device through a lumen of the sleeve;
wherein depression of the handle allows the delivery device to be translated within the housing so as to translate the catheter within the sleeve.

US Pat. No. 10,653,427

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

EVALVE, INC., Santa Clar...

1. A system for fixation of leaflets of a heart valve comprising:an implantable fixation device comprising:
a first distal element and a second distal element,
a first proximal element moveable relative to the first distal element between a first position and a second position, and
a second proximal element moveable relative to the second distal element between a first position and a second position; and
a delivery device comprising:
a catheter having a proximal end portion and a distal end portion, the implantable fixation device releasably coupled to the distal end portion of the catheter, the catheter defining at least one lumen extending between the proximal end portion and the distal end portion,
a first proximal element line extending through the at least one lumen, the first proximal element line coupled to the first proximal element and actuatable to move the first proximal element between the first position and second position, and
a second proximal element line extending through the at least one lumen, the second proximal element line coupled to the second proximal element and actuatable to move the second proximal element between the first position and second position,
wherein the first proximal element line and the second proximal element line are independently actuatable.

US Pat. No. 10,624,664

APPARATUSES AND METHODS FOR CUTTING A TISSUE BRIDGE AND/OR REMOVING A HEART VALVE CLIP OR SUTURE

EVALVE, INC., Santa Clar...

1. An apparatus for excising and removing a clip or suture joining leaflets of a native heart valve, the apparatus comprising:an elongate shaft configured for remote access to a native heart valve, the elongate shaft having a proximal end, a distal end, and a lumen defined therein;
opposing clamp members disposed within the lumen and extendable from the distal end of the elongate shaft and moveable between an open position and a closed position, the opposing clamp members in the closed position defining a passageway therebetween sized to receive a leaflet-fixation clip or suture therein, wherein the opposing clamp members are configured to be positioned on opposite sides of the leaflet-fixation clip or suture in the open position, and to encapsulate the leaflet-fixation clip or suture in the closed position; and
a cutter moveable within the passageway to encompass the leaflet-fixation clip or suture and cut native heart valve leaflet tissue.

US Pat. No. 10,226,309

DEVICES, SYSTEMS, AND METHODS TO SUPPORT, STABILIZE, AND POSITION A MEDICAL DEVICE

EVALVE, INC., Santa Clar...

1. A stabilizer system for supporting a medical device, the stabilizer comprising:a platform;
a translation actuator coupled to a block member supported by the platform; and
a stabilizer body positioned on the platform and being translatable about the platform, the stabilizer body including a receiving member configured to engage with the block member coupled to the translation actuator and a window configured to receive an upwardly extending raised portion of the platform, the combination of the upwardly extending raised portion and the window limiting translation of the stabilizer body along the platform;
wherein actuation of the translation actuator passes a force to the receiving member allowing the stabilizer body to translate relative to the platform.

US Pat. No. 10,184,361

COMBUSTION ENGINE WITH PNEUMATIC VALVE RETURN SPRING

FREEVALVE AB, Angelholm ...

1. A combustion engine, comprising:a cylinder head (6) adjacent to a combustion chamber (7);
a controllable engine valve (8) including a valve stem (38), the cylinder head (6) arranged to guide the valve stem (38) of the engine valve (8), the engine valve (8) being axially displaceable in relation to said cylinder head (6) between a closed position that closes the combustion chamber (7) and a fully open position that opens the combustion chamber (7); and
a valve spring retainer (39) that is connected to said valve stem (38),
wherein the valve spring retainer (39) partly delimits a gas spring volume (48), the gas spring volume (48) being in fluid communication with an adjacent gas volume (49) via a port (50) when the engine valve (8) is in the closed position, and the gas spring volume (48) being separated from the adjacent gas volume (49) when the engine valve (8) is in the fully open position,
said port (50) being open during at least forty-five percent of a maximal stroke of the engine valve (8).

US Pat. No. 10,398,553

OPPOSING DISK DEVICE FOR GRASPING CARDIAC VALVE TISSUE

Evalve, Inc., Santa Clar...

1. A method for repairing a targeted cardiac valve, the method comprising:positioning a repair device at a targeted cardiac valve, the repair device being moveable between a collapsed configuration and an expanded configuration, the repair device including:
a proximal disk element;
a distal disk element spaced apart from the proximal disk element so as to define a grasping space therebetween for grasping cardiac valve tissue; and
a neck section joining the proximal disk element and the distal disk element, the neck section having a diameter that is smaller than a diameter of the proximal disk element and the distal disk element;
wherein the proximal disk element, the distal disk element, and the neck section are integrally formed as a self-expanding structure
deploying the distal disk element on a first side of targeted cardiac valve tissue to move the distal disk element from the collapsed configuration to the expanded configuration; and
deploying the proximal disk element on a second side of the targeted cardiac valve tissue to move the proximal disk element from the collapsed configuration to the expanded configuration so as to grasp the cardiac valve tissue between the deployed distal disk element and the deployed proximal disk element.

US Pat. No. 9,510,837

SURGICAL DEVICE FOR CONNECTING SOFT TISSUE

Evalve, Inc., Menlo Park...

1. A system for repairing a cardiac valve, said system comprising:
a tube suitable for introduction through a patient's vasculature and into a chamber of a heart;
a clipping system comprising a first element adapted to be brought up beneath a pair of valve leaflets from the ventricular
side and a second element adapted to be brought down over the pair of valve leaflets from the atrial side, wherein the first
element engages the ventricular side of both leaflets and the second element engages the atrial side of both the leaflets
to capture both leaflets therebetween; and

a pair of elongate elements, wherein the pair of elongate elements are extensible from a distal end of the tube, wherein each
elongate element of the pair of elongate elements is adapted to grasp a valve leaflet of the pair of valve leaflets when vacuum
is applied thereto, wherein the pair of elongate elements are configured to draw the grasped pair of valve leaflets together.

US Pat. No. 10,631,871

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

EVALVE, INC., Santa Clar...

1. A system for fixation of native leaflets of a heart valve comprising:a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, the delivery catheter further comprising an actuator rod; and
a fixation device releasably coupled to the delivery catheter, the fixation device comprising:
a first arm moveable between a closed position and an open position by the actuator rod, wherein the first arm is configured to engage a ventricular side of a first native leaflet of the native leaflets;
a second arm moveable between a closed position and an open position by the actuator rod, wherein the second arm is configured to engage a ventricular side of a second native leaflet of the native leaflets;
a first gripping element movable relative to the first arm in the open position, the first gripping element biased toward the first arm on an atrial side of the first native leaflet to capture the first native leaflet of the heart valve therebetween;
a second gripping element movable relative to the second arm in the open position, the second gripping element biased toward the second arm on an atrial side of the first native leaflet to capture the second native leaflet of the heart valve therebetween,
wherein the first gripping element and the second gripping element each comprises a plurality of barbs extending therefrom, the plurality of barbs aligned in at least one row transversely with the respective first and second gripping element; and
a covering disposed on each of the first gripping element and the second gripping element, wherein the plurality of barbs of the first gripping element and the second gripping element, respectively, protrude through the covering.

US Pat. No. 10,577,988

ACTUATOR FOR AXIAL DISPLACEMENT OF AN OBJECT

FREEVALVE AB, Angelholm ...

1. An actuator for axial displacement of an object, the actuator comprising:an actuator piston disc (5);
a cylinder volume, wherein the actuator piston disc (5) separates said cylinder volume in a first portion (6) and a second portion (7) and is displaceable in an axial direction back and forth inside in said cylinder volume between an actuator piston inactive position and an actuator piston active position;
an inlet channel (11) extending between a pressure fluid inlet (12) and the first portion (6) of the cylinder volume;
a first inlet valve body (15) arranged in said inlet channel (11), the first inlet valve body (15) being constituted by a seat valve body having a valve body inactive position at which the inlet channel (11) is closed;
an outlet channel (13) extending between the first portion (6) of the cylinder volume and a pressure fluid outlet (14);
an outlet valve body (27) arranged in said outlet channel (13); and
a slave piston (17) that is displaceable back and forth in a bore (18) between a slave piston inactive position and a slave piston active position,
wherein the slave piston (17) is configured to, during movement from the slave piston inactive position to the slave piston active position, ram said first inlet valve body (15) and displace said first inlet valve body (15) to a valve body active position at which the inlet channel (11) is open,
wherein the outlet valve body (27) is connected to and jointly displaceable with the slave piston (17), and
wherein a first side of the seat valve body is biased by a spring (16) that biases said seat valve body in a closing direction toward the valve body inactive position.

US Pat. No. 10,690,022

PNEUMATIC ACTUATOR FOR AN ENGINE VALVE

FREEVALVE AB, Angelholm ...

1. An actuator for axial displacement of an object, the actuator comprising:an actuator piston disc (5);
a cylinder volume, wherein the actuator piston disc (5) separates said cylinder volume into a first portion (6) and a second portion (7), and the actuator piston disc (5) is displaced back and forth in an axial direction in said cylinder volume between a first inactive position and a first active position;
an inlet channel (11) extending between a pressure fluid inlet (12) and the first portion (6) of the cylinder volume;
a first inlet valve body (15) arranged in said inlet channel (11);
an outlet channel (13) extending between the first portion (6) of the cylinder volume and a pressure fluid outlet (14);
an outlet valve body (37) arranged in said outlet channel (13); and
a slave piston (17) that is displaced back and forth in a bore (18) between a second inactive position and a second active position,
the slave piston (17) being configured to, during a displacement of the slave piston (17) from the second inactive position to the second active position, displace said first inlet valve body (15) to a third active position at which the inlet channel (11) is open, and
the slave piston (17) comprising a piston driver (20) that is located in a piston driver volume (21) of said bore (18) and having at least one projection configured to interact with an opening (28) that connects the piston driver volume (21) of the bore (18) and a control pressure channel (29) configured to be connected to an electrically controlled pilot valve (31),
the projection (30) being located in the opening (28) and the opening (28) having a first flow area (A1) through which a flow is permitted to pass through the opening (28) when the slave piston (17) is located in the second inactive position,
and said projection (30) being located at a distance from the opening (28) and the opening (28) having a second flow area (A2) through which the flow is permitted to pass through the opening (28) when the slave piston (17) is located in the second active position,
said second flow area (A2) being greater than said first flow area (A1) so that a movement of the slave piston (17) is pneumatically damped just before the slave piston (17) takes the second inactive position.

US Pat. No. 10,327,743

DEVICE AND METHODS FOR ENDOSCOPIC ANNULOPLASTY

EVALVE, INC., Santa Clar...

1. A method of modifying a heart valve of a patient, comprising:advancing an access catheter through the patient's vasculature into the heart from a vascular access point remote from the heart, the access catheter having a central lumen and a distal end;
extending a delivery catheter through the central lumen of the access catheter through the distal end of the access catheter, the delivery catheter comprising an actuatable grasping element and a lumen extending through the actuatable grasping element;
deploying a structure from the delivery catheter through the lumen extending through the actuatable grasping element into a gutter on the ventricular side of the annulus of the heart valve, the structure adapted to modify the annulus so as to reduce regurgitation in the heart valve;
holding leaflets of the heart valve together using the actuatable grasping element of the delivery catheter so as to reduce regurgitation in the heart valve during the deployment of the structure from the delivery catheter; and
withdrawing the actuatable grasping element of the delivery catheter after the structure is deployed in the gutter of the ventricular side of the annulus of the heart valve, such that the structure remains deployed in the gutter of the annulus once the actuatable grasping element is withdrawn.

US Pat. No. 11,109,972

DELIVERY CATHETER HANDLE AND METHODS OF USE

Evalve, Inc., Santa Clar...


1. A delivery system for staged deployment of an implantable device at a target area, the delivery system comprising:a delivery catheter having a proximal end and a distal end;
an adjustable implantable device coupled to the distal end of the delivery catheter; and
a delivery device coupled to the proximal end of the delivery catheter, the delivery device including a deployment handle and one or more lock lines extending from the deployment handle through the catheter to the implantable device, the one or more lock lines being configured to engage with the implantable device to allow locking of the implantable device, the deployment handle including:
a lock cap removably attached to a housing lid;
a lock line assembly coupled to the one or more lock lines and configured to lock the implantable device by moving from an unlocked position toward a locked position, the lock line assembly including a lock tab configured to lodge within a lock slot disposed on the housing lid so as to hold the lock line assembly in the unlocked position; and
an actuator handle at least partially enclosed by the lock cap, the actuator handle being configured to provide decoupling of the implantable device from the delivery device upon actuation of the actuator handle;
wherein the lock cap is configured to prevent access to the actuator handle prior to removal, and is configured to engage with the lock tab upon removal of the lock cap so as to dislodge the lock tab to allow the lock line assembly to move toward the locked position to lock the implantable device; and
further wherein the lock cap includes a tab configured to pass over the lock slot upon rotation of the lock cap.

US Pat. No. 10,390,943

DOUBLE ORIFICE DEVICE FOR TRANSCATHETER MITRAL VALVE REPLACEMENT

EVALVE, INC., Santa Clar...

1. An orifice valve device for attachment to a mitral valve defining at least two orifices, the device comprising:an anchoring and manifold assembly coupleable to a delivery catheter;
a peripheral ring anchoring system fluidly communicating with and secured to the anchoring and manifold assembly, the peripheral ring anchoring system including:
two expandable anchoring rings, wherein each expandable anchoring ring can be expanded within a respective orifice of the mitral valve so as to surround a perimeter of the respective orifice and form a corresponding opening, the two expandable anchoring rings being in fluid communication and disposed on opposite sides of the anchoring and manifold assembly whereby the anchoring and manifold assembly forms a portion of a perimeter of each of the corresponding openings;
two helical sutures, each of the two helical sutures being helically disposeable about a respective one of the two expandable anchoring rings to secure the respective one of the two expandable anchoring rings to leaflet tissue around the perimeter of the respective orifice of the mitral valve; and
two trap door valves, each trap door valve hingedly secured within a respective opening formed by the peripheral ring anchoring system, each trap door valve comprising:
a trap door body that selectively seals against a respective one of the two expandable anchoring rings extending around the perimeter of a respective orifice of the mitral valve during a systole portion of a cardiac cycle, the trap door body selectively unsealing relative to the one of the two expandable anchoring rings so as to open the corresponding opening and thus the respective orifice of the mitral valve, during a diastole portion of the cardiac cycle.

US Pat. No. 10,363,138

DEVICES FOR ADJUSTING THE CURVATURE OF CARDIAC VALVE STRUCTURES

EVALVE, INC., Santa Clar...

1. An interventional system for temporarily adjusting the structure of a heart, the system comprising:a curvature device moveable between a collapsed configuration having a profile suitable for delivery of the device to a coronary sinus and great cardiac vein of a patient and an expanded configuration having a profile suitable for lodging of the device at the coronary sinus and great cardiac vein, the curvature device including:
a distal end section, at least a portion of the distal end section being configured to anchor within the great cardiac vein when deployed to the expanded position at the great cardiac vein;
a proximal end section, at least a portion of the proximal end section being configured to anchor within the coronary sinus when deployed to the expanded position at the coronary sinus; and
a tether disposed at the distal end section and extending through and past the proximal end section, the tether being tensionable such that an increase in tension increases the curvature of the device, and a release of tension lessens the curvature of the device,
a delivery catheter having a proximal end and a distal end, the delivery catheter including a sheath at the distal end configured to house the curvature device to maintain the curvature device in the collapsed configuration while housed within the sheath; and
a handle coupled to the proximal end of the delivery catheter, the tether extending to the handle, the handle including a tether control operatively coupled to the tether to enable adjusting of tension in the tether through actuation of the control and including a deployment control operatively coupled to the sheath or curvature device to enable proximal retraction of the sheath or distal pushing of the curvature device.

US Pat. No. 10,989,149

INTERNAL COMBUSTION ENGINE AND METHOD FOR CONTROLLING SUCH AN INTERNAL COMBUSTION ENGINE

1. An internal combustion engine (1) comprising a set of combustion chambers, each combustion chamber (2) being provided with:a controllable intake valve (7) configured for opening and closing an intake port (8),
a controllable exhaust valve (9) configured for opening and closing an exhaust port (10),
a piston (5) displaceable back and forth in said combustion chamber (2) between a top dead center (TDC) and a bottom dead center (BDC), and
a fuel injector (14),the internal combustion engine (1) further comprising an intake manifold (12) connected to the intake port (8) of each combustion chamber of said set of combustion chambers, wherein the internal combustion engine (1) is configured to be operated in a low load mode (LL), wherein each combustion chamber (2) is configured to be driven in four-stroke operation comprising a 720 crank angle degrees cycle, wherein the internal combustion engine (1) is configured to perform the following activities:open the intake port (8) during the exhaust stroke, the intake port (8) starting to open in the range 610 to 690 CAD, and close the exhaust port (10) during the exhaust stroke, the exhaust port (10) becomes fully closed in the range 630 to 710 CAD, wherein the exhaust gas is forced into the intake manifold (12) by means of the piston (5), and
mix fuel and exhaust gas in the intake manifold (12).

US Pat. No. 10,667,804

MITRAL VALVE FIXATION DEVICE REMOVAL DEVICES AND METHODS

Evalve, Inc., Santa Clar...

1. A system for disabling or removing a mitral valve fixation device that coapts leaflets, the system comprising:a first catheter with a cutting assembly disposed at a distal end of the first catheter, a portion of the cutting assembly being configured to move longitudinally along the first catheter to cut the leaflet tissue, the cutting assembly comprising a cutting blade and a cutting board, and
a second catheter with a capturing mechanism disposed at a distal end thereof and movable relative to the distal end, the capturing mechanism configured to selectively capture the mitral valve fixation device.

US Pat. No. 10,667,823

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

EVALVE, INC., Santa Clar...

1. A system for fixation of native leaflets of a heart valve comprising:a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, the delivery catheter further comprising a rotatable actuator rod having a threaded fastener at a distal end thereof; and
a fixation device releasably coupled by a threaded connection to the threaded fastener of the actuator rod, the fixation device comprising:
a first arm moveable between a closed position and an open position by the actuator rod, wherein the first arm is configured to engage a ventricular side of a first native leaflet of the native leaflets;
a second arm moveable between a closed position and an open position by the actuator rod, wherein the second arm is configured to engage a ventricular side of a second native leaflet of the native leaflets;
a first gripping element movable relative to the first arm in the open position, the first gripping element biased toward the first arm on an atrial side of the first native leaflet to capture the first native leaflet of the heart valve therebetween;
a second gripping element movable relative to the second arm in the open position, the second gripping element biased toward the second arm on an atrial side of the second native leaflet to capture the second native leaflet of the heart valve therebetween,
wherein the first gripping element and the second gripping element each comprises a plurality of barbs extending therefrom, the plurality of barbs aligned in at least one row transversely with the respective first and second gripping element; and
a covering disposed on each of the first gripping element and the second gripping element, wherein the plurality of barbs of the first gripping element and the second gripping element, respectively, protrude through the covering.

US Pat. No. 10,514,105

MULTI-WAY VALVE AS WELL AS ACTUATOR COMPRISING SUCH A MULTI-WAY VALVE

FREEVALVE AB, Angelholm ...

1. A multi-way valve for serving an actuator for axial displacement of an object, the multi-way valve comprises a control pressure channel (5) and is configured to communicate an adjustable control pressure via said control pressure channel (5), the multi-way valve (1) comprising:a first control fluid channel (11) extending between a first opening (12) and said control pressure channel (5),
a second control fluid channel (13) extending between a second opening (14) and said control pressure channel (5),
a valve body arrangement (15) arranged in said first control fluid channel (11) and in said second control fluid channel (13), and
an electrically controlled device (6) having a drive member (7) and a displaceable armature (8),
an entirety of the displaceable armature (8) being displaceable back and forth under the effect of said drive member (7) between an inactive position and an active position, wherein the multi-way valve (1) is configured by means of the movement of the displaceable armature (8) from the inactive position to the active position to displace the valve body arrangement (15) to an active position where the first control fluid channel (11) is closed and the second control fluid channel (13) is open, and the electrically controlled device (6) further comprising a drive body (17) connected to said displaceable armature (8) and a spring member (18) arranged between the displaceable armature (8) and said drive body (17),
wherein the drive body (17) is arranged in said first control fluid channel (11), the drive body (17) being configured to abut the valve body arrangement (15) and the spring member (18) being in a compressed state when the displaceable armature (8) is located in the active position.

US Pat. No. 10,376,673

CATHETER GUIDING SYSTEM AND METHODS

Evalve, Inc., Santa Clar...

1. A guidance system for accessing a target area within a body, the guidance system comprising: a guidable catheter having a proximal end and a distal end; a tip ring attached to the distal end of the guidable catheter, the tip ring having a distal surface with a first indentation in the distal surface, a first saddle formed within the first indentation and having an inclined surface extending distally to an apex of the saddle that is equal or proximal to the distal surface having the first indentation, a first pullwire channel extends proximally from an opening formed in the inclined surface; and a first pullwire extending to the first saddle, through the opening, over the apex of the saddle, and then extending proximally through a second pullwire channel and from the first saddle, the first pullwire being configured to engage with the first saddle of the tip ring upon application of tension to the first pullwire, the first pullwire thereby subjecting the guidable catheter to a first curving force upon application of tension to the first pullwire; further comprising a second pullwire and a third pullwire extending to the tip ring and configured to engage with a second saddle and a third saddle formed in the tip ring, respectively, the second saddle and the third saddle being formed as raised surfaces within second and third indentations in the distal surface.

US Pat. No. 10,746,064

MULTI-WAY VALVE AS WELL AS ACTUATOR COMPRISING SUCH A MULTI-WAY VALVE

1. A multi-way valve for serving an actuator for axial displacement of an object, the multi-way valve comprises a control pressure channel (5) and is configured to communicate an adjustable control pressure via said control pressure channel (5), the multi-way valve (1) comprising:a first control fluid channel (12) extending between a first opening (13) and said control pressure channel (5),
a second control fluid channel (14) extending between a second opening (15) and said control pressure channel (5),
a valve body arrangement (16) arranged in said first control fluid channel (12) and in said second control fluid channel (14), in order to alternately open and close the first control fluid channel (12) and the second control fluid channel (14), respectively and
an electrically controlled device (6) having a drive member (7) and an armature (8), the armature (8) being displaceable back and forth under the effect of said drive member (7) between an inactive position and an active position,
wherein the multi-way valve (1) is configured by means of the movement of the armature (8) from the inactive position to the active position to displace the valve body arrangement (16) from an inactive position where the first control fluid channel (12) is open and the second control fluid channel (14) is closed to an active position where the first control fluid channel (12) is closed and the second control fluid channel (14) is open, and the electrically controlled device (6) further comprising a drive body (18) connected to said armature (8) and a first spring member (19) arranged between the armature (8) and said drive body (18), wherein the valve body arrangement (16) is biased in the direction towards the inactive position by means of a second spring member (17), and wherein the armature (8) when located in the inactive position is biased in the direction towards the active position by means of a third spring member (20), the first spring member (19) exerting a greater spring force than the third spring member (20), wherein the second opening (15) is configured to be connected to a control fluid source (HP), wherein the second control fluid channel (14) is constituted by a control fluid inlet channel and the second opening (15) is constituted by a control fluid inlet, and wherein the first opening (13) is configured to be connected to a control fluid sink (LP), wherein the first control fluid channel (12) is constituted by a control fluid outlet channel and the first opening (13) is constituted by a control fluid outlet.

US Pat. No. 10,646,229

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

EVALVE, INC., Santa Clar...

1. A system for fixation of native leaflets of a heart valve comprising:a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, the delivery catheter further comprising a rotatable actuator rod having a threaded fastener at a distal end thereof; and
a fixation device releasably coupled by a threaded connection to the threaded fastener of the actuator rod, the fixation device comprising:
a first arm moveable between a closed position and an open position by the actuator rod, wherein the first arm is configured to engage a ventricular side of a first native leaflet of the native leaflets;
a second arm moveable between a closed position and an open position by the actuator rod, wherein the second arm is configured to engage a ventricular side of a second native leaflet of the native leaflets;
a first gripping element movable relative to the first arm in the open position, the first gripping element biased toward the first arm on an atrial side of the first native leaflet to capture the first native leaflet of the heart valve therebetween;
a second gripping element movable relative to the second arm in the open position, the second gripping element biased toward the second arm on an atrial side of the second native leaflet to capture the second native leaflet of the heart valve therebetween; and
a covering disposed on each of the first gripping element and the second gripping element.

US Pat. No. 10,458,292

GAS EXCHANGE VALVE ACTUATOR FOR AXIAL DISPLACEMENT OF A GAS EXCHANGE VALVE OF A COMBUSTION ENGINE

FREEVALVE AB, Angelholm ...

1. A gas exchange valve actuator for axial displacement of a gas exchange valve of a combustion engine, the actuator being configured to be connected to a pressure fluid source and a pressure fluid sink, respectively, and being configured to be driven by a gaseous pressure fluid, the actuator comprising:an actuator piston comprising an actuator piston disc and an actuator piston rod projecting from the actuator piston disc in an axial direction;
a cylinder volume, the actuator piston disc separating said cylinder volume in a first part and a second part and being displaceable back and forth in the axial direction in said cylinder volume between an inactive position and an active position, the first part of the cylinder volume being configured for controllable fluid communication with said pressure fluid source and said pressure fluid sink, respectively, the actuator piston being biased in a direction from the second part of the cylinder volume towards the first part of the cylinder volume; and
a hydraulic circuit comprising a chamber, a free end of the actuator piston rod being disposed in said chamber,
wherein the actuator piston rod is displaceable back and forth in the axial direction in a channel in connection with axial displacement of the actuator piston disc in the cylinder volume, said channel extending between the first part of the cylinder volume and the chamber of the hydraulic circuit, and
wherein said channel comprises at least one circumferential ventilation groove that is configured to be constantly connected to said pressure fluid sink.

US Pat. No. 10,413,408

DELIVERY CATHETER SYSTEMS, METHODS, AND DEVICES

Evalve, Inc., Santa Clar...

1. An intravascular device for delivering a device to a target location within a patient's anatomy, the intravascular device comprising:a monolithic elongated body having a proximal end and a distal end, at least part of the elongated body being made of a body material and having a length therebetween;
a major lumen defined by the elongated body and extending from the proximal end to the distal end;
a plurality of minor lumen defined by the elongated body and extending from the proximal end through at least a portion of the length of the elongated body, the minor lumen being fixed relative to the major lumen in transverse cross-section, a wall ratio of a thickness of a lumen wall between the major lumen and one of the plurality of minor lumens relative to a radius of the elongated body being within a range of 0.100 and 0.150; and
a reinforcement layer connected to the elongated body and forming an outer surface of the intravascular device when the intravascular device is used to deliver the device to the target location within the patient's anatomy, the reinforcement layer including a reinforcement material having a greater elastic modulus than the body material.

US Pat. No. 11,071,564

CARDIAC VALVE CUTTING DEVICE

EVALVE, INC., Santa Clar...


1. An interventional device for cutting tissue at a targeted cardiac valve, the interventional device comprising:a catheter having a proximal end and a distal end, the distal end of the catheter being positionable at the targeted cardiac valve, the distal end comprising a bifurcated distal end opening formed by a first catheter lumen and a second catheter lumen, each of the first catheter lumen and the second catheter lumen having a non-circular cross-section, a combination of the first catheter lumen and the second catheter lumen forming an entirety of the bifurcated distal end opening;
a cutting mechanism positionable at the distal end of the catheter and being configured to be deployed from within the first catheter lumen, the cutting mechanism including one or more cutting elements configured to cut leaflet tissue of the targeted cardiac valve when engaged against the leaflet tissue, wherein each of the one or more cutting elements is configured as a blade structure;
a stabilizing cup extendable distally past the distal end of the catheter and being configured to be deployed from within the second catheter lumen, the stabilizing cup being configured to engage against the targeted cardiac valve to stabilize the distal end of the catheter relative to the targeted valve, the stabilizing cup comprising an opening aligned with a longitudinal axis of the catheter;
a handle coupled to an electrical source configured to power a motor configured to drive at least rotative motion of the one or more cutting elements; and
wherein the cutting mechanism is translatable within the catheter such that it is routable through the catheter to be passed beyond the distal end of the catheter and/or to be retracted proximally into the catheter.

US Pat. No. 10,736,632

METHODS AND DEVICES FOR VALVE CLIP EXCISION

Evalve, Inc., Santa Clar...

1. A method for excising a clip approximating an opposed pair of valve leaflets in a heart valve, said method comprising:introducing a capture catheter into a heart chamber adjacent to the valve leaflets on one side of the clip;
introducing a transfer catheter into the heart chamber adjacent to the valve leaflets on another side of the clip;
deploying a cutting element from the transfer catheter to the capture catheter to place the cutting element against tissue of at least one of the valve leaflets;
engaging the cutting element against the valve leaflet tissue; and
excising the clip from at least one valve leaflet using the cutting member.

US Pat. No. 10,667,815

TISSUE GRASPING DEVICES AND RELATED METHODS

EVALVE, INC., Santa Clar...

1. A tissue fixation system configured for intravascular delivery and for use in joining mitral valve tissue during treatment of the mitral valve, comprising:a body;
a first and second distal elements, each including:
a first end pivotally coupled to the body and extending to a second end; and
a tissue engagement surface between the first and second end, the tissue engagement surface being configured to approximate and engage a portion of leaflets of the mitral valve; and
a tissue gripping device formed of a shape-memory material, including:
a base section; and
a first arm and a second arm, each arm having a distal end coupled to the base section by an arm bend feature, a proximal end extending laterally from the base section, and a furcated section having an opening with a radiused-terminal distal end formed with a first radius in the arm bend feature, a tapered-terminal proximal end formed with a second radius in the first arm, wherein the second radius is smaller than the first radius, and an intermediate portion having a cross-section larger than both the terminal distal end and the tapered-terminal proximal end, the first and second arms being disposed opposite one another and each arm being configured to cooperate with one of the first or second distal elements to form a space for receiving and holding a portion of mitral valve tissue therebetween.

US Pat. No. 11,078,855

INTERNAL COMBUSTION ENGINE AND METHOD FOR CONTROLLING SUCH AN INTERNAL COMBUSTION ENGINE


1. An internal combustion engine (1), comprising:a set of combustion chambers (2), each combustion chamber (2) being provided with:a controllable intake valve (7) configured for opening and closing an intake port (8),
a controllable exhaust valve (9) configured for opening and closing an exhaust port (10),
a piston (5) displaceable back and forth in said combustion chamber (2) between a top dead center (TDC) and a bottom dead center (BDC), and
a fuel injector (16); and

an intake manifold (12) connected to the intake port (8) of each combustion chamber of said set of combustion chambers (2),
wherein the internal combustion engine (1) is configured to be operated in a catalytic converter warm-up mode,
wherein each combustion chamber (2) is configured to be driven in four-stroke operation comprising a 720 crank angle degrees cycle, and
wherein the internal combustion engine (1) is configured to:open the intake port (8), the intake port (8) starting to open in a range 90 to 180 CAD, and close the intake port (8), the intake port (8) becomes fully closed in a range 180 to 270 CAD,
open the exhaust port (10) during the power stroke, the exhaust port (10) starting to open in a range 405 to 495 CAD,
open the intake port (8) during the exhaust stroke, the intake port (8) starting to open in a range 610 to 690 CAD, and close the exhaust port (10) during the exhaust stroke, the exhaust port (10) becomes fully closed in a range 630 to 710 CAD, wherein the exhaust gas is forced into the intake manifold (12) by means of the piston (5),
mix fuel and exhaust gas in the intake manifold (12), and
close the intake port (8), the intake port (8) becomes fully closed in a range 700 to 720+20 CAD.


US Pat. No. 10,729,811

METHODS FOR INHIBITING STENOSIS, OBSTRUCTION, OR CALCIFICATION OF A STENTED HEART VALVE OR BIOPROSTHESIS

CONCIEVALVE, LLC, Minnea...

1. An apparatus for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall comprising:a fixative-pretreated bioprosthetic heart valve having one or more cusps, said fixative-pretreated bioprosthetic heart valve mounted on an elastical stent for replacement of a natural diseased valve;
a coating composition coated on said one or more cusps of the bioprosthetic heart valve after fixation thereof, on said stent or both, wherein said coating composition includes an eNOS activator; an anti-proliferative agent for inhibiting cell proliferation; an extracellular matrix production inhibitor; and an inhibitor of osteoblastogenesis,
wherein said coating composition when eluted inhibits stenosis, obstruction and/or calcification of the bioprosthetic heart valve when implanted by preventing the attachment of cKit positive stem cells, SCA1 cells, COP cells, and/or mesenchymal stem cells to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.

US Pat. No. 10,667,911

METHODS, SYSTEMS AND DEVICES FOR CARDIAC VALVE REPAIR

EVALVE, INC., Santa Clar...

1. A method of attaching a chordal replacement device, the method comprising:advancing a proximal anchor into a heart;
attaching a flexible patch of the proximal anchor to the heart;
attaching a leaflet attachment device of the proximal anchor to an upper surface of a portion of a leaflet;
advancing a distal anchor of the chordal replacement device into a ventricle of the heart, the distal anchor including a balloon;
positioning the balloon at least partially into a sidewall of the ventricle; and
filling the balloon with fluid to increase tension on a flexible tether, which is coupled to and tensioned between the proximal and distal anchors,
wherein the filled balloon of the distal anchor remains at least partially within the sidewall of the ventricle.

US Pat. No. 10,517,598

TISSUE TENSIONING DEVICE FOR CARDIAC VALVE REPAIR

EVALVE, INC., Santa Clar...

1. An interventional system for tensioning cardiac valve tissue at a targeted gap of a cardiac valve, the system comprising:an interventional tissue tensioning device, the tensioning device comprising:
a distal section;
a proximal section;
an intermediate section disposed between and joining the distal section and the proximal section; and
an elastomer film cover,
wherein the intermediate section has a default width, the intermediate section being laterally compressible from the default width to a compressed width sized for fitting within the targeted gap, and
wherein the intermediate section is configured to be biased toward the default width when compressed, the intermediate section thereby providing a tensioning force upon edges of the targeted gap; and
a self-centering delivery catheter, the delivery catheter including a pair of laterally extending fins extending from a distal section of the delivery catheter, the fins enabling alignment of the delivery catheter with a line of coaptation at the targeted gap,
wherein the fins are configured to be intra-procedurally adjustable in width, and
wherein the distal section of the delivery catheter includes a pair of skives and a corresponding pair of wires laterally extendable through the skives to form the fins.

US Pat. No. 11,116,633

OPPOSING DISK DEVICE FOR GRASPING CARDIAC VALVE TISSUE

EVALVE, INC., Santa Clar...


1. A method for repairing a targeted cardiac valve, the method comprising:positioning a repair device at a targeted cardiac valve, the repair device being moveable between a collapsed configuration and an expanded configuration, the repair device comprising:a proximal grasping assembly movable between a first position and a second position;
a distal grasping assembly movable between a third position and a fourth position, the distal grasping assembly being spaced apart from the proximal grasping assembly so as to define a grasping space therebetween for grasping tricuspid valve leaflets when the proximal grasping assembly and the distal grasping assembly are in second position and fourth position, respectively, and are deployed at a tricuspid valve; and
an actuator rod mounted operatively connected to each of the proximal grasping assembly and the distal grasping assembly so that distal movement of the actuator rod simultaneously moves the proximal grasping assembly proximally and the distal grasping assembly distally;

deploying the distal grasping assembly and the proximal grasping assembly to capture targeted cardiac valve tissue between the distal grasping assembly and the proximal grasping assembly.

US Pat. No. 11,096,691

TISSUE GRASPING DEVICES AND RELATED METHODS

EVALVE, INC., Santa Clar...


1. A tissue fixation system configured for intravascular delivery and for heart valve tissue treatment, comprising:a center portion defining a longitudinal axis;
a distal element pivotally moveable relative the longitudinal axis; and
a gripper formed of a shape-memory material, wherein at least a portion of the gripper is configured to move relative to the distal element to capture native valve leaflet tissue therebetween, wherein the gripper includes:a bend configured to flex to allow the gripper to move relative to the distal element,
a furcated section having an opening defined therein, the opening including:a first end portion having a first maximum cross-dimension defined at a widest location within the first end portion, and
a second end portion having a second maximum cross-dimension defined at a widest location within the second end portion,
wherein the first maximum cross-dimension is different than the second maximum cross dimension, and

a barb section comprising at least one barb,wherein the furcated section is separate from the barb section.



US Pat. No. 11,065,119

LONG ARM VALVE REPAIR CLIP

Evalve, Inc., Santa Clar...


1. A fixation device for engaging tissue comprising:a pair of fixation elements, each fixation element having a first end and a second end opposite the first end, the first ends being moveable between a closed position and an open position;
a pair of gripping elements, each gripping element moveable with a respective fixation element and disposed in opposition to at least a portion of the respective fixation element to capture tissue therebetween; and
a central portion operatively connected to each gripping element at a respective central portion-gripping element interface, the central portion having a distal end, the central portion having a width “W1” proximate the distal end, each gripping element having a free end opposite its respective central portion-gripping element interface and a length “L1” defined between the respective central portion-gripping element interface and the free end, wherein the length L1 is at least about three times the width W1,
wherein each gripping element includes at least one gripper line attachment location disposed along the length L1 of the gripping element with each attachment location spaced from the free end of the gripping element.

US Pat. No. 10,945,842

ANNULAR AUGMENTATION DEVICE FOR CARDIAC VALVE REPAIR

Evalve, Inc., Santa Clar...

1. A repair device configured for repairing tissue at a targeted anatomical location, the repair device comprising:a body having a perimeter that defines an upper side and a lower side, the perimeter having a posterior section and an anterior section, the body being shaped so as to define an annular groove disposed along at least a portion of the posterior section, the annular groove being configured to receive tissue of the targeted anatomical location when the repair device is deployed at the targeted anatomical location;
a first anchor extending from the body in an anterior direction, the first anchor comprising an atraumatic end; and
a second anchor extending from the body in the anterior direction, the second anchor comprising an atraumatic end,
wherein the first and second anchors are configured to engage with tissue to prevent movement of the repair device from the targeted anatomical location when the repair device is deployed at the targeted anatomical location, and
wherein each of the first anchor and second anchor includes a flexible upper section and a flexible lower section configured to grip tissue therebetween.

US Pat. No. 10,925,604

FLEXIBLE ACTUATOR MANDREL FOR TISSUE APPOSITION SYSTEMS

Evalve, Inc., Menlo Park...

1. A delivery system for delivering an implantable fixation device to a plurality of leaflets of a heart valve, the fixation device including a first arm and a second arm, wherein the first arm and the second arm are moveable between an open position and a closed position, a first gripping element moveable relative to the first arm between a first position and a second position, and a second gripping element moveable relative to the second arm between a first position and a second position, the delivery system comprising:a catheter having a proximal end portion and a distal end portion, the catheter defining at least one lumen extending between the proximal end portion and the distal end portion; and
an actuation element to actuate the implantable fixation device, the actuation element releasably coupled to the implantable fixation device and comprising a flexible cable disposed within the at least one lumen, the flexible cable having a plurality of layers of wires;
wherein the flexible cable is resiliently biased to return to a substantially linear configuration after being deflected 90° or more;
wherein the flexible cable comprises an inner most layer of wires and an outermost layer of wires; and
wherein the flexible cable is drawn such that wires of the outermost layer of wires are formed of wires abutting along a substantially flat surface of the wires when viewed from a cross-section perpendicular to the length of the flexible cable and wires of an innermost layer of wires are formed of wires having a circular cross section when viewed from a cross-section perpendicular to the length of the flexible cable.

US Pat. No. 10,856,988

SELF-ALIGNING RADIOPAQUE RING

EVALVE, INC., Santa Clar...

1. An intravascular system, the system comprising:a delivery catheter having a distal end and a proximal end, the delivery catheter having an inner surface defining a lumen and an outer surface; and
a ring affixed to the distal end of the delivery catheter and at least a part of the ring being positioned within the lumen, the ring including:
a head having a face at a distal end of the ring, the face having a face radius,
a body connected to the head and positioned proximally of the head, the body having a body radius wherein a ratio of the face radius to the body radius is in a range of 1.20 to 1.75,
a longitudinal axis extending through the head and body, and
a guide surface positioned longitudinally between the face and the body, the guide surface extending distally radially outward and forming an angle with the longitudinal axis in a range of 100° to 160°.

US Pat. No. 10,828,042

FIXATION DEVICES, SYSTEMS AND METHODS FOR ENGAGING TISSUE

EVALVE, INC., Santa Clar...

1. A system for fixation of leaflets of a heart valve comprising:an implantable fixation device comprising:
a first distal element and a second distal element,
a first proximal element moveable relative to the first distal element between a first position and a second position, and
a second proximal element moveable relative to the second distal element between a first position and a second position; and
a delivery device comprising:
a catheter having a proximal end portion, a distal end portion, and a rotatable actuator rod configured to be moved axially between an extended position and a retracted position, the actuator rod having a threaded fastener at a distal end thereof to fasten with the implantable fixation device when in the extended position,
an axial release mechanism having a mating portion engaged with the implantable fixation device and surrounding the actuator rod in the extended position, the axial release mechanism configured to disengage from the implantable fixation device by axial movement of the actuator rod to the retracted position,
a first proximal element line coupled to the first proximal element and actuatable to move the first proximal element between the first position and second position, and
a second proximal element line coupled to the second proximal element and actuatable to move the second proximal element between the first position and second position.

US Pat. No. 10,779,829

TISSUE COMPRESSION DEVICE FOR CARDIAC VALVE REPAIR

EVALVE, INC., Santa Clar...

1. An interventional device for compressing cardiac valve tissue at a targeted gap, the device comprising:a distal member having a width defined between opposing side edges;
a pair of opposing arms each flexibly joined to the distal member along the width, each arm extending proximally from the distal member to a free end, the arms defining an interior space therebetween for holding cardiac valve tissue,
wherein the arms have a default position, the arms being flexibly moveable apart from one another away from the default position to increase the interior space and to enable receiving cardiac valve tissue within the interior space, further wherein the arms are configured to be biased toward the default position when moved apart from one another, the arms thereby providing a compressive force upon cardiac valve tissue held within the interior space; and
an anchor coupled to the distal member and extending proximally from the distal member, wherein the anchor extends through the interior space and has a width greater than the width of the distal member,
wherein the device is detachable from a delivery device for implant to cardiac valve tissue.

US Pat. No. 10,779,837

ADJUSTABLE ARM DEVICE FOR GRASPING TISSUES

EVALVE, INC., Santa Clar...

1. A repair device configured for repairing tissues at a targeted anatomical site, the repair device comprising:a shaft;
a first distal gripping element having a medial end pivotally coupled to the shaft and extending to a lateral end;
a first proximal gripping element having a medial end pivotally coupled to the shaft and extending to a lateral end, wherein the proximal gripping element is configured to cooperate with the distal gripping element to grasp targeted tissue therebetween;
at least one adjustable arm coupled to an associated one of the distal gripping element or proximal gripping element, the adjustable arm selectively slidable relative the associated gripping element between a retracted position and an extended position so that, upon actuation, the adjustable arm extends outward to increase a lateral reach of the associated gripping element; and
a spring configured to bias the adjustable arm outward; and
a control line attached to the adjustable arm and coupled with a proximal handle, the control line routed such that applying a tension to the control line moves the adjustable arm toward the retracted position and releasing tension on the control line moves the adjustable arm toward the extended position.

US Pat. No. 10,314,586

ROTATABLE DEVICE AND METHOD FOR FIXING TRICUSPID VALVE TISSUE

EVALVE, INC., Santa Clar...

1. A method of repairing tissue at a targeted heart valve, the method comprising:delivering a repair device to the targeted heart valve and passing a distal portion of the repair device from a proximal side through the heart valve to a distal side, the repair device including:
a pair of distal arms; and
a pair of corresponding proximal arms disposed opposite the pair of distal arms, a first distal arm of the distal arms and a first corresponding proximal arm of the proximal arms, opposite the first distal arm, forming a first arm pair, and a second distal arm of the distal arms and a second corresponding proximal arm of the proximal arms, opposite the second distal arm, forming a second arm pair;
actuating the repair device to grasp leaflet tissue between the proximal arms disposed on the proximal side of the heart valve and the distal arms disposed on the distal side of the heart valve, the first arm pair grasping leaflet tissue at a first engagement point, and the second arm pair grasping leaflet tissue at a second engagement point;
deploying one or more suture lines in the leaflet tissue at the second engagement point;
pivoting the second arm pair so that the first arm pair remains engaged at the first engagement point and the second arm pair moves from the second engagement point to a third engagement point; and
adjusting tension in the one or more suture lines to tie together leaflet tissue between the second and third engagement points.