US Pat. No. 9,464,057

ANTI-MALARIAL AGENTS

MMV MEDICINES FOR MALARIA...

1. A pyrazole derivative according to Formula (I),

wherein X1 is selected from F and H; X2 is selected from Cl and F; R1 is selected from methyl and trifluoromethyl; R2 is selected from the following groups:

as well as any pharmaceutically acceptable salt, hydrate, solvate, polymorph, tautomers, geometrical isomers, or optically
active isomers thereof.

US Pat. No. 9,538,672

FERROELECTRIC NANOSHELL DEVICES

Drexel University, Phila...

1. A nanoscale device, comprising: a nanoshell comprising a ferroelectric material, the nanoshell comprising: an inner nanoshell
surface; and an outer nanoshell surface having a radius of curvature in the range of from 5 nm to 500 nm, and the thickness
between said inner nanoshell surface and said outer nanoshell surface in the range of from greater than 1 nm to less than
100 nm; and wherein the ferroelectric nanoshell is characterized as being ferroelectric, ferromagnetic, or both; a first amount
of conductive material that surmounts at least a portion of the outer nanoshell surface; and a second amount of conductive
material that surmounts at least a portion of the inner nanoshell surface.
US Pat. No. 9,102,807

TOUGHENING CROSS-LINKED THERMOSETS

The United States of Amer...

1. A grafted triglyceride comprising an acrylated triglyceride grafted with an average of more than zero fatty acid residues
per triglyceride, wherein the grafted triglyceride has a molecular weight of at least about 900 g/mole, the fatty acid residue
contains from 4 to 28 carbon atoms and the ratio of vinyl groups to grafted fatty acid residues is from about 0.2 to about
5.0.

US Pat. No. 9,099,384

CHARGE ORDERED VERTICAL TRANSISTORS

Drexel University, Phila...

1. A vertical charge ordered transistor comprising:
a charge ordered layer;
a source layer located adjacent the charge ordered layer;
a drain layer located adjacent the charge ordered layer;
a gate located adjacent to at least one of the layers; and
a source electrode located on the source layer and a drain electrode located on the drain layer.

US Pat. No. 9,511,240

APPARATUS FOR ATMOSPHERIC PRESSURE PIN-TO-HOLE SPARK DISCHARGE AND USES THEREOF

Drexel University, Phila...

1. An atmospheric pressure pin-to-hole pulsed spark discharge device, comprising:
a conduit for fluidically communicating as gas, a plasma, or both, therethrough, the conduit comprising first and second ends,
the first end being capable of connecting to a gas supply, and a second end being capable of emitting a plasma;

a positive electrode comprising a sharp tip, located within the conduit, the positive electrode further capable of receiving
a high voltage from a positive terminal of a capacitive circuit;

the second end of the conduit comprising a ground plate electrode comprising an opening passing through the ground plate electrode,
the opening characterized as having a dimension, d,

the ground plate electrode capable of being in electrical communication with ground and a negative electrode of the capacitive
circuit, the sharp tip of the positive electrode being axially displaced from the opening of the ground plate electrode by
distance h, the distance h defining a spark zone between the sharp tip of the positive electrode and the opening of the ground
plate electrode;

wherein the sharp tip of the positive electrode and the spark zone are located within the conduit;
the capacitive circuit comprising positive and negative leads in electrical communication with the positive and negative electrodes,
respectively, the positive lead of the capacitive circuit being disposed between the sharp tip of the positive electrode and
a positive terminal of a high voltage power supply, and the negative lead of the capacitive circuit being disposed between
the opening of the ground plate electrode and a negative terminal of the high voltage power supply,

wherein the high voltage power supply is capable of charging the capacitive circuit to provide a voltage of between 500 V
and 5000 V across the positive and negative electrodes, and the capacitive circuit is adapted to create a pulsed spark discharge
at a rate of between 1 Hz and 30 Hz in the spark zone, and;

wherein a dielectric material covers the positive electrode except for the sharp tip portion of the positive electrode.

US Pat. No. 9,107,739

SMALL DIAMETER VASCULAR GRAFT PRODUCED BY A HYBRID METHOD

Drexel University, Phila...

1. A hybrid graft comprising an exterior surface and a luminal surface, wherein the luminal surface comprises a first polymer
with a micropattern of grooves to which cells adhere and orient along, and wherein the exterior surface comprises a second
polymer electrospun on the first polymer, wherein the second polymer provides mechanical properties to the first polymer,
wherein each groove has a depth of about 1 ?m, a width of about 5 ?m and is positioned 5 ?m apart from each other.
US Pat. No. 9,394,427

TOUGHENING CROSS-LINKED THERMOSETS

The United States of Amer...

1. A cured resin comprising a cured product obtained by curing a material selected from the group consisting of vinyl esters
and unsaturated polyesters and mixtures thereof and a grafted triglyceride comprising an acrylated triglyceride grafted with
an average of more than zero fatty acid residues per triglyceride, wherein the grafted triglyceride has a molecular weight
of at least about 900 g/mole, the fatty acid residue contains from 4 to 28 carbon atoms and the ratio of vinyl groups to grafted
fatty acid residues is from about 0.2 to about 5.0.
US Pat. No. 9,365,688

POLYMERIZED IONIC LIQUID BLOCK COPOLYMERS AS BATTERY MEMBRANES

Drexel University, Phila...

1. A block copolymer comprising at least a first and second block, said second block copolymer comprising a polymerized ionic
liquid;
said polymerized ionic liquid comprising a tethered ionic liquid cation and a mobile anion, wherein the cation of the polymerized
ionic liquid is tethered to the polymer backbone by a carboalkoxy linking group,

said polymerized ionic liquid being stable in the presence of aqueous hydroxide, and wherein said block copolymer exhibits
at least one region of nanophase separation.

US Pat. No. 9,236,955

RECONFIGURABLE ANTENNAS FOR PERFORMANCE ENHANCEMENT OF INTERFERENCE NETWORKS EMPLOYING INTERFERENCE ALIGNMENT

Drexel University, Phila...

1. A system with increased sum capacity for k users, k>1, of an interference network employing interference alignment as the
interference management scheme, said system comprising a plurality of reconfigurable antennas that offer pattern diversity,
said plurality of reconfigurable antennas implementing said interference alignment scheme, wherein an interference channel
between a first reconfigurable antenna and a second reconfigurable antenna is optimized to maximize a distance between interference
and desired signal space.

US Pat. No. 9,484,475

SEMICONDUCTOR FERROELECTRIC COMPOSITIONS AND THEIR USE IN PHOTOVOLTAIC DEVICES

The Trustees Of The Unive...

1. A ferroelectric perovskite characterized as having a band gap, Egap, of less than 2.5 eV and comprising a solid solution of KNbO3 and BaNi1/2Nb1/2O3-?, wherein ? is in the range of from 0 to about 1.

US Pat. No. 9,444,134

TRANSPARENT CONFORMAL POLYMER ANTENNAS FOR RFID AND OTHER WIRELESS COMMUNICATIONS APPLICATIONS

Drexel University, Phila...

1. An optically transparent conductive polymer antenna comprising:
a flexible substrate; and
an antenna printed on said flexible substrate, said antenna comprising an optically transparent conductive polymer material
not having any electrically conductive particles added to the conductive polymer material, said material having a conductivity
that is at least 5×105 S/m and a surface tension between 0.028-0.060 N/m so as to enable said material to pass through a print head for printing
on said flexible substrate.

US Pat. No. 9,531,497

REAL-TIME AND PROTOCOL-AWARE REACTIVE JAMMING IN WIRELESS NETWORKS

Drexel University, Phila...

1. A real-time reactive jamming device for jamming signal transmissions in a wireless network, comprising:
a real-time signal detector that detects an event in received packets in said wireless network;
a reactive jamming device that sends a triggering signal when said event is detected; and
a jamming generator responsive to said triggering signal to generate a jamming signal that has a user-defined delay so as
to enable jamming of specific portions of received packets in the wireless network.

US Pat. No. 9,289,400

D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE

Drexel University, Phila...

1. A method of treating or ameliorating levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, said
method comprising administering to said patient a therapeutically effective amount of at least one compound of formula (I):
wherein in formula (I):
R1, R2 and R3 are independently selected from the group consisting of H, cyano, halo, hydroxyl, alkoxy, nitro, C1-6 alkyl, and carboxy;

R4 and R5 are independently selected from the group consisting of H, C1-6 alkyl, and substituted C1-6 alkyl; and,

n is 2,mixtures thereof, or a pharmaceutically acceptable salt thereof.

US Pat. No. 9,388,126

SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME

Drexel University, Phila...

1. A compound selected from the group consisting of:
1-(3-(4-fluorophenoxy)propyl)-3-(4-iodophenyl)guanidine (Compound A);
1-(3-(4-fluorophenoxy)propyl)-3-(4-methoxyphenyl)guanidine (Compound B);
1-(3-(4-fluorophenoxy)propyl)-3-(4-trifluoromethylphenyl)guanidine (Compound F);
1-(3-(4-fluorophenoxy)propyl)-3-(4-chlorophenyl)guanidine (Compound G); or
a salt, solvate or N-oxide thereof, and any combinations thereof.

US Pat. No. 9,324,310

MULTI-TOUCH PIANO KEYBOARD

Drexel University, Phila...

1. A musical keyboard touch sensor pad comprising:
(a) a plurality of integrated touch sensors disposed in an array, the plurality of integrated touch sensors representing a
keyboard key, wherein each of a first group of the plurality of sensors are generally saw-tooth shaped and are longitudinally
arranged adjacent to each other; and

(b) a processor electronically coupled to the plurality of integrated touch sensors, the processor being programmed to receive
input from several of the plurality of integrated touch sensors and to generate a sound signal based on the input from the
several of the plurality of integrated touch sensors, the sound signal being variable based on the number in the plurality
and the location of the plurality in the array, wherein the processor is adapted to process a touch moving longitudinally
along the array to generate a pitch change signal based on the length and speed of the longitudinal movement.

US Pat. No. 9,488,622

ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS

Drexel University, Phila...

1. A piezoelectric sensor system comprising:
a piezoelectric sensor including a piezoelectric layer, at least one conducting element operatively associated with the piezoelectric
layer and at least one receptor capable of binding a species of interest; and

a DC bias electric field generator associated with said piezoelectric sensor for applying a DC bias electric field to said
piezoelectric layer sufficient to enhance both:

(a) a change to a Young's modulus of said piezoelectric layer due to binding of the species of interest to said at least one
receptor, and

(b) non-180° polarization domain switching in said piezoelectric layer due to binding of the species of interest to said at
least one receptor.

US Pat. No. 9,533,990

INHIBITORS OF SECRETION OF HEPATITIS B VIRUS ANTIGENS

Drexel University, Phila...

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and the R-enantiomer of at least one selected
from the group consisting of:
7-(2-Chloro-6-fluorophenyl)-5-(4-chlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
5-(4-Chlorophenyl)-7-(2,6-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine;
5-(4-Chlorophenyl)-7-(2,6-difluorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine;
7-(2-Chloro-4-fluorophenyl)-5-(4-chlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(2-chlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(3-chlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(4-fluorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
5-(4-Bromophenyl)-7-(2-chloro-6-fluorophenyl)-4,7-dihydro[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(4-ethylphenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(4-methoxyphenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
5-([1,1?-Biphenyl]-4-yl)-7-(2-chloro-6-fluorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(naphthalen-2-yl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(3,4-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(2,4-dichlorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(2,4-difluorophenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine;
7-(2-Chloro-6-fluorophenyl)-5-(3,4-dimethylphenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]-pyrimidine; and
7-(2-Chloro-6-fluorophenyl)-5-(4-chlorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine.

US Pat. No. 9,371,244

DESALINATION SYSTEM AND PROCESS

Drexel University, Phila...

1. A desalination system for treating a liquid, comprising:
at least one pair of electrodes positions for direct contact with the liquid;
a power source connected to said electrodes configured to provide an alternating voltage to said electrodes that generates
at least one oscillating electric field having a field strength sufficient to cause bulk precipitation of mineral particles
in the liquid and said electrodes and said power source are configured to provide said oscillating electric field at a frequency
of 13.56 to 27.12 MHz in at least a portion of the liquid; and

a desalination device that is configured to substantially reduce the presence of contaminants in the liquid that has been
treated with said oscillating electric field, said contaminants being selected from the group consisting of: ions, minerals,
salts, particulates or a combination thereof.

US Pat. No. 9,168,328

LAYERED MANUFACTURING UTILIZING FOAM AS A SUPPORT AND MULTIFUNCTIONAL MATERIAL FOR THE CREATION OF PARTS AND FOR TISSUE ENGINEERING

Drexel University, Phila...

1. A solid freeform fabrication method of creating a three-dimensional article built at least in part from scaffolding layers,
the method comprising:
providing a scaffolding material;
providing a supporting material in a shape of a foamy layer; and
contacting the scaffolding material with the foamy layer to form at least one scaffolding layer and thereby creating the three
dimensional article.

US Pat. No. 9,431,598

SOL-GEL PRECURSORS AND METHODS FOR MAKING LEAD-BASED PEROVSKITE FILMS

Drexel University, Phila...

1. A method for producing a lead-containing perovskite film comprising the steps of:
(a) dissolving lead acetate and other film components in a suitable solvent to provide a precursor solution,
(b) depositing the precursor on a substrate;
(c) pyrolyzing the deposited precursor;
(d) annealing the pyrolyzed precursor; and
(e) repeating steps (b)-(d) to obtain a desired film thickness, wherein sufficient lead is employed in step (a) to provide
a 25-75 mole percent stoichiometric excess of lead, relative to a stoichiometric amount of lead required to react with said
other film components for form said perovskite film, wherein the lead acetate comprises lead acetate anhydrous, and

wherein the lead acetate anhydrous is aged in air for 19 to 24 days.
US Pat. No. 9,359,603

MODULATION OF PRE-MRNA USING SPLICE MODULATING OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS IN THE TREATMENT OF DISEASE

Drexel University, Phila...

1. A method of treating amyotrophic lateral sclerosis (ALS) in a subject in need thereof, comprising administering a composition
comprising a splice modulating oligonucleotide (SMO) that specifically binds a complementary sequence of a pre-mRNA that undergoes
splicing to form a mRNA encoding a glutamate activated ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor
subunit (GluR), wherein said SMO decreases expression of the flip isoform of said GluR.

US Pat. No. 9,193,595

COMPOSITIONS COMPRISING FREE-STANDING TWO-DIMENSIONAL NANOCRYSTALS

Drexel University, Phila...

1. A composition comprising at least one layer having first and second surfaces, each layer comprising:
a substantially two-dimensional array of crystal cells,
each crystal cell having an empirical formula of Mn+1Xn, such that each X is positioned within an octahedral array of M,

wherein M is at least one Group IIIB, IVB, VB, or VIB metal,
wherein each X is C, N, or a combination thereof;
n=1, 2 or 3; and
wherein at least one of said surfaces of each layer has surface terminations comprising alkoxide, carboxylate, halide, hydroxide,
hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof.

US Pat. No. 9,086,380

SURFACE-ENHANCED RAMAN SCATTERING SUBSTRATES

Drexel University, Phila...

1. A surface-enhanced Raman scattering substrate comprising:
a substrate; and
a fractal aggregate of nanoparticles formed from a nanoparticle ink comprising a material which enhances Raman scattering
located on a surface of said substrate and wherein the nanoparticles provide an amplification of the Raman scattering signal
of from about 1×103 to about 2.5×1010.

US Pat. No. 9,417,240

CAPPED AND CONJUGATED QUANTUM DOTS

Drexel University, Phila...

1. A quantum dot having a core selected from the group consisting of CdSe, CdTe, CdPbS, and ZnSnS and which are capped with
a mercaptocarboxylic acid capping agent and at least part of said mercaptocarboxylic acid capping agent is replaced with mercaptosilane
capping agent to provide a molar ratio of mercaptosilane capping agent to the moles of quantum dots is from about 0.5 to about
4, and wherein the ratio of capping agent:metal:Se, Te or S is from about 2:1:1 to about 16:8:1.

US Pat. No. 9,415,570

COMPOSITIONS COMPRISING FREE-STANDING TWO-DIMENSIONAL NANOCRYSTALS

Drexel University, Phila...

1. A polymer composite comprising an organic polymer and a MXene composition comprising at least one layer having first and
second surfaces, each layer comprising:
a substantially two-dimensional array of crystal cells,
each crystal cell having an empirical formula of Mn+1Xn, such that each X is positioned within an octahedral array of M,

wherein M is at least one Group IIIB, IVB, VB, or VIB metal, or Mn
wherein each X is C, N, or a combination thereof;
n=1, 2, or 3; and
wherein at least one of said surfaces of each layer has surface terminations comprising alkoxide, carboxylate, halide, hydroxide,
hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof.

US Pat. No. 9,456,918

ORTHOSIS AND METHOD OF USE FOR TREATMENT AND REHABILITATION OF DROPFOOT

Drexel University, Phila...

1. A method of providing assistance and rehabilitation to peroneal muscles of an intended wearer of an orthosis comprising
the steps of:
detecting a position of said intended wearer's foot using at least four sensors located at different locations relative to
the position of the intended wearer's foot to provide signals responsive to different elements of the intended wearer's gait;
and

transmitting activation signals to electrodes positioned for stimulation of said peroneal muscles based upon said detected
position of said intended wearer's foot.

US Pat. No. 9,216,177

SMALL MOLECULAR INHIBITORS OF RAD51 RECOMBINASE AND METHODS THEREOF

Drexel University, Phila...

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of Formula (1):
wherein:
R1 is pyridinyl;

R2 is selected from the group consisting of C1-C6 alkyl, —(C1-C6)alkylene-phenyl, and —(C1-C6)alkylene-phenyl wherein the phenyl is substituted with a C1-C6 alkyl;

R3 is H or a salt thereof.

US Pat. No. 9,151,486

HEAT PUMP WATER HEATER

Drexel University, Phila...

1. A heat pump system comprising:
an evaporator, wherein said evaporator comprises an evaporator;
a heater associated with said evaporator for heating an environmental medium prior to said environmental medium contacting
said evaporator coil;

a compressor;
a condenser;
a refrigerant flow circuit connecting said evaporator, compressor and condenser;
an energy transfer device for transferring energy between said refrigerant and a fluid;
a reservoir for containing the fluid, wherein said reservoir is operatively associated with said condenser for energy transfer
from said refrigerant to said fluid via said condenser; and

an electrode positioned on a surface of said heat pump system within the reservoir at a location that said electrode is immersed
within said fluid when said fluid is present in the heat pump system and said electrode is configured for discharging a plasma
pulse spark in said fluid for preventing fouling.

US Pat. No. 9,492,306

CERVICAL SPINE PROTECTION APPARATUS AND METHODS OF USE

Drexel University, Phila...

1. A protection apparatus for wearing by a person for reducing risk of cervical spine injuries, comprising
(a) an upper attachment structure for wearing on a person's head;
(b) a lower attachment structure for wearing on a person's body below the head; and
(c) a plurality of composite bands connected between the upper attachment structure and the lower attachment structure for
dynamically limiting motion of the cervical spine to functional and non-injurious motion;

(d) wherein each composite band provides non-linear variable flexibility that is dependent upon variations in loading rates;
and

(e) wherein each composite band comprises,
(i) an elastic component comprising an elastic or spring-like material for providing elasticity of the composite band,
(ii) a substantially non-extendable component attached to the elastic component, the substantially non-extendable component
comprising a substantially non-extendable material, and

(iii) a viscous material contained in an area between the elastic component and the substantially non-extendable component.

US Pat. No. 9,480,409

SENSING PROBE COMPRISING MULTIPLE, SPATIALLY SEPARATE, SENSING SITES

Drexel University, Phila...

1. A method comprising:
detecting signals via a sensing probe comprising a plurality of electrical conductors, wherein each conductor of the plurality
of electrical conductors comprises a plurality of sensing sites, spatially separate combined sensing sites are formed from
the plurality of sensing sites by proximate portions of multiple electrical conductors of the plurality of electrical conductors,
and no two combined sensing sites are formed by a same combination of electrical conductors, and wherein the detected signals
are indicative of neural activity; and

combinatorially unmixing the detected signals to determine a source of the neural activity, wherein a configuration of the
plurality of electrical conductors of the sensing probe is application configurable.

US Pat. No. 9,452,195

USE OF CHEC PEPTIDES TO TREAT NEUROLOGICAL AND CARDIOVASCULAR DISEASES AND DISORDERS

Drexel University, Phila...

1. A method of treating a mammal afflicted with epilepsy associated with elevated levels of secreted phospholipase A2 (sPLA2)
activity, said method comprising administering a pharmaceutical composition comprising an effective amount of a sPLA2 inhibitor
to said mammal, wherein said sPLA2 inhibitor comprises at least one selected from the group consisting of a CHEC-9 peptide
and a CHEC-7 peptide, thereby treating said epilepsy in said mammal.

US Pat. No. 9,352,984

FLUID TREATMENT USING PLASMA TECHNOLOGY

Drexel University, Phila...

1. A water treatment apparatus comprising:
(a) a vessel capable of containing water, said vessel comprising a water flow inlet and water flow outlet configured to allow
the water to pass through the vessel; and

(b) at least three electrode modules for generating an elongated spark discharge in said fluid within the vessel, wherein
each electrode module comprises an electrode and an associated capacitor configured in electrical series with one another,
and each electrode module is in parallel arrangement with one another.

US Pat. No. 9,274,087

PIEZOELECTRIC MICROCANTILEVER SENSORS FOR BIOSENSING

Drexel University, Phila...

1. A method for using a piezoelectric microcantilever sensor comprising the steps of:
actuating a microcantilever sensor having a Q value greater than 20, comprising a piezoelectric layer, a non-piezoelectric
layer, and a receptor, wherein said piezoelectric layer has a thickness of about 1 ?m to about 127 ?m, a dielectric constant
of at least 1600, and a piezoelectric coefficient ?d31 of at least about 250 pm/V;

binding a molecule or compound to said receptor,
detecting a force exerted on said piezoelectric layer by said bound molecule or compound, and
determining one or more of a presence of said molecule or compound and a concentration of said molecule or compound from said
detected force.

US Pat. No. 9,186,190

FUNCTIONALIZED NANODIAMOND REINFORCED BIOPOLYMERS

Drexel University, Phila...

1. A nanocomposite material comprising poly-L-lactic acid (PLLA) and 1-10% by weight of octadecylamine-surface-functionalized
nanodiamonds (ND-ODA), wherein ND-ODA has the formula of
and wherein the Young's modulus of the nanocomposite material is between 5.1 and 8.0 GPa.

US Pat. No. 9,054,423

MIMO ANTENNA ARRAYS BUILT ON METAMATERIAL SUBSTRATES

Drexel University, Phila...

1. A wireless transmission apparatus comprising a rectangular patch antenna array including multiple antenna elements mounted
on a substrate comprising a plurality of unit cells having rectangular inductive spiral loops embedded uniformly and uni-directionally
within a host dielectric substrate so as to form a magnetic permeability enhanced metamaterial, said unit cells being uniformly
stacked on each other to form a three-dimensional resonance structure that is oriented orthogonally to a magnetic field of
said antenna array, where dimensions of said rectangular inductive spiral loops are selected whereby said metamaterial has
a resonance frequency that matches a resonance frequency of said multiple antenna elements of said antenna array.

US Pat. No. 9,427,496

METHOD FOR CREATING AN INTERNAL TRANSPORT SYSTEM WITHIN TISSUE SCAFFOLDS USING COMPUTER-AIDED TISSUE ENGINEERING

Drexel University, Phila...

1. An artificial tissue comprising an internal mass transport network having a plurality of channels, wherein the internal
mass transport network comprises a biodegradable transporting material that is substantially free of suspended cells, and
which is simultaneously deposited in a pattern with a scaffold material to form a plurality of layers of the artificial tissue,
and wherein the channels are designed to substantially mimic a naturally occurring vascular network, such that the internal
mass transport network creates a basic circulatory system within the scaffold, and wherein the internal mass transport network
having a plurality of channels comprises the void space remaining after the biodegradable transporting material has biodegraded.

US Pat. No. 9,059,264

TUNABLE HOT-ELECTRON TRANSFER WITHIN A NANOSTRUCTURE

Drexel University, Phila...

1. An electronic device, comprising:
a semiconductor structure supported by a substrate,
the semiconductor structure comprising a first material and a second material contacting one another, the first and second
materials being arranged in a non-planar configuration,

the second material comprising a binary or ternary inorganic or organic semiconductor material,
the second material having a valence bandgap, conduction bandgap, or both that are broader than the corresponding band of
the first material,

wherein when the second material is a binary inorganic or organic semiconductor material, the first material is an elemental
inorganic or organic semiconductor material, and when the second material is a ternary inorganic or organic semiconductor
material, the first material is an elemental or binary in organic or organic semiconductor material,

and
the structure being in electronic communication with a source electrode and a drain electrode;
and,
a source of illumination in optical communication with the structure, the source of illumination having a controllable intensity,
wavelength, or both,

wherein said device produces tunable negative differential resistance modulation, phase modulation, or both in response to
varying the intensity or wavelength received from the source of illumination.

US Pat. No. 9,300,048

BI-DIRECTIONAL MAGNETIC PERMEABILITY ENHANCED METAMATERIAL (MPEM) SUBSTRATE FOR ANTENNA MINIATURIZATION

Drexel University, Phila...

1. A bi-directional antenna comprising a plurality of unit cells stacked in two perpendicular planes to form a unit cell,
each unit cell comprising a magnetic permeability enhanced metamaterial formed into an inductive loop in a substrate and each
unit cell forming a face of the three-dimensional unit cell whereby inductive loops of respective unit cells are situated
on four perpendicular faces of said three-dimensional unit cell formed by said two perpendicular planes.

US Pat. No. 9,196,970

METAMATERIAL RECONFIGURABLE ANTENNAS

Adant Technologies, Inc.,...

1. A pattern and/or polarization reconfigurable antenna comprising:
at least one Composite Right Left Handed (CRLH) unit cell including a standard transmission line with added series capacitance
and shunt inductance and adapted to radiate an electrical field; and

at least a variable capacitance and/or inductance in series with the shunt inductance and at least a variable capacitance
and/or inductance in parallel with the series capacitance, whereby said at least a variable capacitance and/or inductance
in series with the shunt inductance and said at least a variable capacitance and/or inductance in parallel with the series
capacitance are responsive to at least two DC biases used to independently control the variable capacitance and/or inductance
in parallel with the series capacitance and the variable capacitance and/or inductance in series with the shunt inductance
to thereby control the group delay of the transmission line and/or a polarization of the radiated electrical field.

US Pat. No. 9,168,260

BENZODIAZEPINE COMPOUNDS WITH ANTI-FLAVIVIRUS ACTIVITY

Baruch S. Blumberg Instit...

1. A method for treating a flavivirus infection, said method comprising administering to an infected subject an effective
amount of at least one compound of the formula (I) or a pharmaceutically acceptable salt;

wherein the flavivirus infection is dengue virus or yellow fever virus.

US Pat. No. 9,082,918

METHODS FOR MAKING WATER SOLUBLE QUANTUM DOTS

Drexel University, Phila...

1. A quantum dot comprising:
an inner region comprising a first metal sulfide selenide, and
an outer region having a different composition than the inner region, said outer region comprising a second metal sulfide
selenide,

wherein a molar ratio of (M1+M2):(S+Se) is from 1 to 8; wherein M1 and M2 are different metal elements; and

a cap,
said quantum dot having at least one narrow bandwidth emission in the wavelength range from of about 600 nm to about 1100
nm.

US Pat. No. 9,469,507

MODULAR ESCALATING WHEELCHAIR LIFT

Drexel University, Phila...

1. A modular wheelchair lift comprising:
a first rail adapted to be fixedly mounted on a flight of stairs, the first rail having a first top end and a first bottom
end;

a second rail extending parallel to the first rail, the second rail being adjustably mounted on the flight of stairs, the
second rail having a second top end and a second bottom end;

a first fork movable along the first rail between the first top end and the first bottom end;
a second fork movable along the second rail between the second top end and the second bottom end; and
a screw assembly coupled to the second rail, the screw assembly being adapted to slide the second rail alternatively toward
and away from the first rail;

such that, as the first fork moves along the first rail between the first top end and the first bottom end, the second fork
moves along the second rail between the second top end and the second bottom end.

US Pat. No. 9,171,679

ELECTROCHEMICAL FLOW CAPACITORS

Drexel University, Phila...

1. An energy storage device comprising
(a) a positive electrode current collector, a negative electrode current collector, and an ion-permeable separator separating
the positive and negative electrode current collectors;

(b) a positive electrode disposed between the positive electrode current collector and the ion-permeable separator;
(c) a negative electrode disposed between the negative electrode current collector and the ion-permeable separator;
(d) wherein at least one of the positive and negative electrodes comprises a non-stationary solid or semi-solid composition
comprising supercapacitive particles and an electrolytic solvent; and

(e) wherein the electrolytic solvent is substantially free of electrochemically oxidizable or reducible species.
US Pat. No. 9,074,247

P53 ASSAY FOR A URINE TEST FOR HCC SCREENING

Drexel University, Phila...

1. A method for detecting hepatocellular carcinoma in a subject comprising:
amplifying a low molecular weight p53 249T mutation in a urine sample from said subject, wherein the amplification comprises:
suppressing the amplification of wildtype p53 nucleic acid sequences using a Locked Nucleic Acid clamp formed of GGAGGCC,
wherein the Locked Nucleic Acid clamp binds wildtype p53 but not p53 249T nucleic acid sequences, and

amplifying the sample with primers consisting of SEQ ID NO: 1 and SEQ ID NO: 3; and
detecting the presence of p53 249T mutant using an oligonucleotide probe, wherein the presence of p53 249T mutant nucleic
acid sequences is indicative of hepatocellular carcinoma.

US Pat. No. 9,484,896

RESONANT FREQUENCY DIVIDER DESIGN METHODOLOGY FOR DYNAMIC FREQUENCY SCALING

Drexel University, Phila...

1. A dynamic rotary traveling wave oscillator circuit comprising:
a plurality of multi-output spot-advancing blocks (MOSABs) forming a main-loop;
a plurality of multi-input spot-advancing blocks (MISABs) forming a sub-loop;
wherein depending on a desired division ratio, a connection connects blocks on the MOSABs and MISABs to create the desired
division ratio;

wherein the MOSABs and the MISABs comprise a 4-to-1 multiplexer.

US Pat. No. 9,476,648

SYSTEMS AND METHODS OF USING PHASE CHANGE MATERIAL IN POWER PLANTS

Drexel University, Phila...

1. A cooling system for cooling a fluid comprising: a heat exchanger comprising a recirculating mesh including a plurality
of encapsulated phase change material meshes each including a plurality of encapsulated phase change material particles, and
a cable driven by a device for moving the recirculating mesh between the fluid and an airflow chamber in a manner whereby
some of said modules are positioned for heat exchange with said fluid and some of said modules are positioned for heat exchange
with an air flow in said cooling system, wherein heat is transferred from the fluid to the encapsulated phase change material
particles to melt at least some of the encapsulated phase change material particles to provide encapsulated liquid phase change
material.

US Pat. No. 9,415,398

MAGNETIC FLUID MANIPULATORS AND METHODS FOR THEIR USE

Drexel University, Phila...

1. A device for sorting non-magnetic particles, the device comprising:
(a) a fluid holding chamber comprising an inner and outer surface;
(b) a fluid in contact with the inner surface of the fluid holding chamber, said fluid containing a dispersion of magnetic
particles and at least two sets of non-magnetic particles; and

(c) at least two sources of magnetic fields positioned in close proximity to, or inside of, the fluid holding chamber which
produce a changeable pattern of magnetic field minima and maxima regions thereby causing said non-magnetic particles in the
fluid to be transported towards the magnetic field minima regions by magnetic force, wherein at least one of said sources
of magnetic fields comprises an array of magnetizable features on a micrometer or nanometer length scale, and further wherein
at least one of said sources of magnetic fields comprises a time-varying magnetic field supplied by a source held external
to said fluid holding chamber.

US Pat. No. 9,410,636

FLOW CONTROL/SHUT-OFF VALVE ASSEMBLY

Drexel University, Phila...

1. A flow valve assembly comprising:
a piston operable between an open position and a closed position;
a controller mechanically coupled to the piston to operate the piston between the open position and the closed position when
the rate of fluid flow exceeds a predetermined value, the controller comprising;

a first linkage member operable between a first position in which the piston is in the open position, and a second position
in which the piston is in the closed position;

a second linkage member having a first end pivotally coupled to the first linkage member to move the first linkage between
the first position and the second position and a second end;

a first biasing member having a first end coupled to the second linkage member between the first end and the second end a
second end connected to a support such that, when the first linkage member is in the second positon, the first biasing member
biases the first linkage member toward the first position.

US Pat. No. 9,416,011

COMPOSITIONS COMPRISING FREE-STANDING TWO-DIMENSIONAL NANOCRYSTALS

Drexel University, Phila...

1. A polymer composite comprising:
(a) an organic polymer; and
(b) a planar MXene composition comprising at least one layer having first and second surfaces, each layer comprising:
a substantially two-dimensional array of crystal cells,
each crystal cell having an empirical formula of Mn+1Xn, such that each X is positioned within an octahedral array of M,

wherein M is at least one Group IIIB, IVB, VB, or VIB metal,
wherein each X is C, N, or a combination thereof and
n=1, 2, or 3;
wherein at least one of said surfaces of each layer has surface terminations comprising alkoxide, carboxylate, halide, hydroxide,
hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof;

wherein the planar MXene composition is distributed within the polymer.

US Pat. No. 9,472,717

METHODS FOR MAKING WATER SOLUBLE QUANTUM DOTS

Drexel University, Phila...

1. A quantum dot comprising:
an inner region comprising a first metal sulfide, selenide or sulfide selenide, and
an outer region having a different composition than the inner region, said outer region comprising a second metal sulfide,
selenide or sulfide selenide,

wherein a molar ratio of (M1+M2):(S+Se) is from 1 to 8 and M1 and M2 are different metal elements and the metal of the second
metal sulfide, selenide or sulfide selenide is selected from the group consisting of zinc, tin, nickel, cobalt, iron, copper
and manganese; and

a cap,
said quantum dot having at least one narrow bandwidth emission in the wavelength range from of about 600 nm to about 1100
nm.

US Pat. No. 9,375,474

COMPOUNDS USEFUL FOR INHIBITING METASTASIS FROM CANCER AND METHODS USING SAME

Drexel University, Phila...

1. A method of treating bone metastasis in a subject diagnosed with a solid cancer selected from the group consisting of breast
cancer and prostate cancer,
the method comprising administering to the subject in need thereof a therapeutically effective amount of at least one CX3CR1 or fractalkine antagonist,

wherein the at least one antagonist is a compound of Formula (I), or a pharmaceutically acceptable salt thereof:
wherein in (I):
A1 is CH2;

n is 0, 1, 2, 3, 4 or 5;
A2 and A3 are both H, or A2 and A3 combine to form a divalent radical selected from the group consisting of methanediyl, ethane-1,2-diyl, or propane-1,3-diyl;

A4 is CH2;

R1 and R2 are both H, and R3 is

wherein ring A is selected from the group consisting of phenyl, substituted phenyl, pyridinyl, and substituted pyridinyl;
R4 is nil;

R5 is phenyl, substituted phenyl, triazolyl, substituted triazolyl, 1,2-benzisoxazolyl or substituted 1,2-benzisoxazolyl;

R7 is H or OH;
wherein administration of the at least one antagonist to the subject treats bone metastasis in the subject.

US Pat. No. 9,216,400

HIGH POWER NON-THERMAL PLASMA SYSTEM FOR INDUSTRIAL APPLICATIONS

Drexel University, Phila...

1. A non-thermal plasma reactor assembly comprising:
(a) an electrically grounded central reaction chamber having at least one inlet for feedstock and at least one outlet for
product;

(b) at least two non-thermal plasma reactors, each reactor being electrically insulated from the central reaction chamber
and comprising at least one inlet circumferential gas flow inlet apparatus, an electrode, and a flow restricted exit portal,
the flow restricted exit portal of each reactor being connected in fluidic communication with the central reaction chamber,
and each reactor configured to eject a jet of non-thermal plasma external to said reactor and into the central reaction chamber;

the at least one inlet circumferential flow apparatus and flow restricted exit portal of a first of the at least two reactors
configured to mix a first gas within the first reactor upon introduction of said first gas through the at least one circumferential
inlet gas flow apparatus into said first reactor; and

the at least one inlet circumferential flow apparatus and flow restricted exit portal of a second of the at least two reactors
configured to be provide mixing of a second gas within the second reactor upon introduction of said second gas through the
at least one circumferential inlet gas flow apparatus into said second reactor;

the at least two non-thermal plasma reactors configured to work in tandem with one another such that the electrode of at least
the first of the at least two reactors can be maintained at a high voltage electric potential relative to the electrode of
the second of the at least two reactors, said first and second reactor electrodes forming an electrode pair capable of maintaining
a non-thermal plasma discharge between the first and second reactor electrodes when energized.

US Pat. No. 9,095,610

UNIFORM FIELD MAGNETIZATION AND TARGETING OF THERAPEUTIC FORMULATIONS

DREXEL UNIVERSITY, Phila...

1. A method for magnetically targeting a therapeutic particle to an intracorporeal device in a subject, comprising the steps
of:
(a) administering to the subject at least one therapeutic particle comprising at least one therapeutic agent and a first magnetic
or magnetizable material, wherein the at least one therapeutic particle is a microparticle or nanoparticle; and

(b) generating across the intracorporeal device a uniform magnetic field capable of magnetizing magnetizable materials, wherein
the uniform magnetic field is provided by a magnetic field generator comprising first and second magnets and wherein the uniform
magnetic field generates a magnetic field gradient proximal to the intracorporeal device, said intracorporeal device comprising
a second magnetic or magnetizable material, wherein the gradient targets the at least one therapeutic particle to the intracorporeal
device; and

(c) targeting the at least one therapeutic particle to the intracorporeal device via the magnetic field gradient;
wherein the step of generating the magnetic field comprises selectively placing the first and second magnets around the subject
to direct the uniform magnetic field through the intracorporeal device.

US Pat. No. 9,178,131

FERROELECTRIC NANOSHELL DEVICES

Drexel University, Phila...

1. A method for controlling spontaneous ferroelectric polarization in a nanoshell device comprising:
applying a voltage via one or more electrodes to switch the spontaneous ferroelectric polarization of a nanoshell device,
the nanoshell device comprising an inner nanoshell surface having a radius of curvature in the range of from about 3 nm to
about 300 nm,

an outer nanoshell surface having a radius of curvature in the range of from about 5 nm to about 500 nm,
a thickness between said inner nanoshell surface and said outer nanoshell surface in the range of from greater than about
1 nm to less than about 100 nm, and

wherein the ferroelectric nanoshell is characterized as being ferroelectric, ferromagnetic, or both.

US Pat. No. 9,535,058

FLOW CHAMBER ANALYTE DETECTION METHOD

Drexel University, Phila...

11. A method for detecting an analyte using a flow chamber comprising:
positioning a plurality of cells within the flow chamber on a first surface of a permeable membrane within a first compartment,
said first compartment having a fluid inlet and a fluid outlet;

cycling a flow rate of a flow of fluid flowing between the fluid inlet and the fluid outlet in a direction substantially parallel
to the first surface of the permeable membrane between a control flow rate and a plurality of different flow rates, wherein
each of the different flow rates exerts a different shear stress on the first surface of the permeable membrane in the first
compartment; and

detecting one or more analytes produced by said plurality of cells.

US Pat. No. 9,476,009

ACIDIC METHANOL STRIPPING PROCESS THAT REDUCES SULFUR CONTENT OF BIODIESEL FROM WASTE GREASES

Drexel University, Phila...

1. A method of producing fatty acid alkyl esters from a lipid, comprising steps of:
introducing a gas comprising vapor containing an alcohol into the lipid in a bubble column reactor in a form of bubbles to
enable the bubbles to pass through the lipid and be discharged from the lipid; and

adding an alcohol solution of an acid catalyst to the lipid in the bubble column reactor.

US Pat. No. 9,233,138

COMPOSITIONS FOR PROMOTING HIV-1 VIROLYSIS AND METHODS USING SAME

Drexel University, Phila...

1. A compound of formula (I), or a salt or solvate thereof:
BINDER-LINKER-SEQ ID NO:3  (I),
wherein in (I) the BINDER binds to gp120, and the LINKER covalently connects the C-terminus of BINDER and the N-terminus of
SEQ ID NO:3,

wherein the BINDER comprises at least one selected from the group consisting of:
SEQ ID NO:1;
SEQ ID NO:12;
SEQ ID NO:22 (X1X2X3NIXWX4) (III), wherein in (III)

X1 is absent or E,

X2 is selected from the group consisting of F,K,E,R, and Cit,

X3 is N or I,

X4 is S or T;

SEQ ID NO:23 (RINNIXW);
SEQ ID NO:24 (INNIXW);
SEQ ID NO:25 (NNIXWS);
SEQ ID NO:26 (INIXWS);
SEQ ID NO:27 (NNIXW);
wherein X is the modified proline of formula (IV)

 wherein in (IV) R is selected from the group consisting of naphthyl,p-methyl phenyl, p-ethyl phenyl,2-phenylethyl and metallocene;
and

wherein the LINKER is a peptide of formula (II):
LINKER1-(LINKER2)n  (II),

wherein in (II) the LINKER1 comprises 1 to 60 amino acid residues; the LINKER2 comprises (His)6 (SEQ ID NO:5) or AspTyrLysAspAspAspAspLys (SEQ ID NO:9), and ‘n’ is 0 or 1.

US Pat. No. 9,163,338

FIBROUS MATS CONTAINING CHITOSAN NANOFIBERS

Drexel University, Phila...

1. A fibrous mat comprising chitosan nanofibers having an average diameter of about 50 to about 120 nanometers, wherein said
fibrous mat is substantially free of fibers of polyethylene oxide or fibers of poly(vinyl alchohol), and wherein said chitosan
nanofibers are electrospun from chitosan.

US Pat. No. 9,540,257

PLASMA SPARK DISCHARGE REACTOR AND DURABLE ELECTRODE

Drexel University, Phila...

1. A plasma spark discharge reactor comprising:
a HV electrode having a head;
a ground electrode surrounding at least a portion of the HV electrode; and
a gas passage extending longitudinally through the HV electrode to an outlet at a location proximate to the head of the HV
electrode.

US Pat. No. 9,205,175

THERMOSENSITIVE AND CROSSLINKABLE POLYMER COMPOSITE FOR THREE-DIMENSIONAL SOFT TISSUE SCAFFOLD PRINTING

Drexel University, Phila...

1. A hydrogel material comprising:
a first triblock polymer having a formula ABA; and
a second triblock polymer having a formula AmaBAma, wherein:
A is polyethylene glycol;
B is poly(DL-lactic acid-co-glycolic acid); and
Ama is a methacrylate of the first polymer, wherein the material is thermosensitive and photocrosslinkable.

US Pat. No. 9,192,092

RECIPROCATING METERING DEVICE

Drexel University, Phila...

1. A reciprocating metering device comprising:
(a) an elongated tube having an outer perimeter and a receptacle therein for storing a material to be discharged;
(b) a slide pipe disposed around the outer perimeter of the tube, and arranged to slide along the tube between a first position
and a second position, the slide pipe having a longitudinal slot formed therethrough;

(c) a biasing member extending outwardly of and longitudinally along the slide pipe, the biasing member having a first end
fixedly coupled to the slide pipe and a second end fixedly coupled to the tube by a retainer extending through the longitudinal
slot, the biasing member biasing the slide pipe downward relative to the tube toward the first position;

(d) a chute extending outwardly of and longitudinally along the slide pipe, wherein the chute is configured to receive the
material from the receptacle and to discharge a metered portion of the material;

(e) a diverter disposed within the handle, the diverter being configured to form a metering passage with the chute when the
slide pipe is between the first position and the second position; and

(f) a member disposed within the tube such that, when the slide pipe is in the first position, the member is enclosed within
the device and the material is able to be discharged from a discharge end of the device and, when the slide pipe is in the
second position, the member is extended from the device and the material is retained within the device.

US Pat. No. 9,110,078

DIAGNOSIS OF LIVER PATHOLOGY THROUGH ASSESSMENT OF ANTI-GAL IGG GLYCOSYLATION

Drexel University, Phila...

1. A method for detecting a liver disease in a subject suspected of having the liver pathology comprising:
obtaining biological fluid from the subject;
separating anti-gal IgG from said biological fluid using a separation agent;
contacting said separated anti-gal IgG from said biological fluid with a fucose-binding lectin, IgG, and allowing said lectin
to bind to said anti-gal IgG; quantifiably detecting lectin bound to said anti-gal IgG to obtain a detected bound lectin value;

comparing the detected bound lectin value with a reference value for lectin binding on said anti-gal IgG from a comparable
biological fluid of subjects without said liver disease, said detected bound lectin value relative to the reference value
being indicative of the presence or absence of said liver disease, wherein a detected bound lectin value that deviates from
said reference value to a statistically significant degree is indicative of the presence of said liver disease, or,

comparing the detected bound lectin value with a reference value for lectin binding on said anti-gal IgG from a comparable
biological fluid of subjects in which said liver disease is known to be present, said detected bound lectin value relative
to the reference value being indicative of the presence or absence of said liver disease, wherein a detected bound lectin
value that deviates from said reference value to a statistically significant degree is indicative of the absence of said liver
disease.

US Pat. No. 9,565,717

RECONFIGURABLE ANTENNAS AND CONFIGURATION SELECTION METHODS FOR AD-HOC NETWORKS

Drexel University, Phila...

1. An ad-hoc network system, comprising:
at least one multi-element reconfigurable transmitter and/or at least one multi-element reconfigurable receiver where each
said multi-element reconfigurable transmitter and receiver comprises multiple antennas where each antenna is capable of changing
a radiation pattern and/or a polarization of a radiated field; and

a processor that processes software implementing a configuration selection method for selecting an antenna configuration for
said at least one multi-element reconfigurable transmitter and/or receiver, where the antenna configuration is selected based
on changes in interference in a transmission over a transmission link including the antenna being configured, a transmission
rate of at least one transmitter, a received signal strength of at least one receiver, an error vector magnitude of at least
one receiver, a channel matrix of at least one receiver, and/or a packet error rate of at least one of the receivers or transmitters
of the transmission link,

wherein the software processed by the processor implements a centralized configuration selection process that has knowledge
of part or all communication and interference channels in the ad-hoc network and selects the antenna configuration that optimizes
the sum capacity of the ad-hoc network, the sum throughput of the ad-hoc network, and/or the error rate of the ad-hoc network,
and wherein optimizing the sum capacity of the ad-hoc network, the sum throughput of the ad-hoc network, and/or the error
rate of the ad-hoc network comprises solving the following optimization problem:

where c is an 1×2L vector that contains a configuration for all links l in the ad-hoc network, I denotes channel interference,
?2 is noise power, PT/NT represents diagonal elements of a diagonal matrix, Hlrc,ltc is a channel between a receiver of link l and a transmitter of link l for a receive configuration (rc) of link l and a transmit
configuration (tc) of link l, HHlrc,ltc is a conjugate transpose of Hlrc,ltc and R1 is an interference plus noise covariance matrix for link l.

US Pat. No. 9,399,619

SULFAMOYLBENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION

Baruch S. Blumberg Instit...

1. A method for treating Hepatitis B virus (HBV) infection and related conditions, said method comprising administering to
a subject in need of such treatment a therapeutically effective amount of at least one compound having formula (I):

wherein
R1 is hydrogen;

R2 is selected from a group consisting of hydrogen, methyl, trifluoromethyl, fluorine, and chlorine;

R3 is selected from a group consisting of hydrogen, methyl, fluorine, and chlorine;

R4 is selected from a group consisting of hydrogen, fluorine, chlorine, and methyl;

R5 is selected from a group consisting of hydrogen and chlorine;

R7 is selected from a group consisting of hydrogen, chlorine, fluorine, and bromine;

R9 is selected from a group consisting of hydrogen, methyl, fluorine, and chlorine;

Rx is selected from the group consisting of: NH2,


or a pharmaceutically acceptable salt form thereof.

US Pat. No. 9,339,783

TUBULAR FLOATING ELECTRODE DIELECTRIC BARRIER DISCHARGE FOR APPLICATIONS IN STERILIZATION AND TISSUE BONDING

Drexel University, Phila...

1. A method for contacting a biological substrate with non-thermal plasma, comprising:
fluidicly communicating a gas through a dielectric conduit characterized as comprising an upstream end and a downstream end,
the upstream end having an opening capable of receiving gas from a gas source, and the downstream end having an opening capable
of transmitting non-thermal plasma therethrough;

energizing an RF electrode disposed circumferentially adjacent to an exterior wall of the dielectric conduit that in the presence
of a floating igniter electrode disposed within an upstream portion of the dielectric conduit ionizes at least a portion of
the gas to form a non-thermal plasma; and

placing the biological substrate in a position no further than a first distance from the downstream opening of the dielectric
conduit, wherein the first distance is a distance where discharge of the non-thermal plasma is characterized as being in a
transferring mode, in which the non-thermal plasma first impinges on a surface of the biological substrate in a cloud shape,
such that the substrate acts as ground.

US Pat. No. 9,114,107

COMPOSITIONS FOR INHIBITING VIRUS ENTRY AND PROMOTING VIROLYSIS, AND METHODS THEREOF

Drexel University, Phila...


wherein: X is (2,4)-4-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylic acid, and ?A is beta-alanine.

US Pat. No. 9,278,855

FLEXIBLE SERS SUBSTRATES WITH FILTERING CAPABILITIES

Drexel University, Phila...

1. A method for fabricating a flexible surface-enhanced Raman spectroscopy substrate comprising the steps of:
applying a nanoparticle ink to a flexible substrate having filtering capability for trapping an analyte of interest on said
substrate during filtration of a media containing said analyte and comprising a material selected from glass fibers, cellulose
fibers and polyimide fibers, and wherein the flexible substrate provides a three dimensional surface having multiple anchoring
sites for an analyte molecule, and the nanoparticle ink comprises a liquid vehicle, a plurality of nanoparticles, and a stabilizer;

heating the nanoparticle ink and the substrate to a suitable temperature for a period of time to remove the liquid vehicle
and at least some of said stabilizer and form fractal aggregates of nanoparticles on the substrate, wherein said heating step
is terminated when an amplification of Raman scattering signal of from about 1×103 to about 2.5×1010 is achieved relative to a Raman scattering signal of said flexible substrate in the absence of said nanoparticles.

US Pat. No. 9,140,923

POLYMER DISPERSED LIQUID CRYSTAL PHOTOVOLTAIC DEVICE AND METHOD FOR MAKING

Drexel University, Phila...

1. A method for fabricating a photovoltaic device comprising the steps of:
synthesizing a polymer dispersed liquid crystal material comprising:
a conductive polymer;
light absorbing liquid crystals dispersed in said conductive polymer; and
conductive elements dispersed on a surface of said conductive polymer by dispersing said light absorbing liquid crystals and
said conductive elements in said conductive polymer and curing the conductive polymer, wherein said conductive elements have
a density which causes said conductive elements to migrate to said surface of said conductive polymer prior to completion
of said curing step thereby forming at least a central region of said polymer dispersed liquid crystal material which does
not contain said conductive elements; and

operatively associating at least one electric lead with at least one said conductive element of said polymer dispersed liquid
crystal material.

US Pat. No. 9,301,678

APPARATUS AND METHOD FOR ASSESSING EFFECTS OF DRUGS BY RECORDING OCULAR PARAMETERS

Drexel University, Phila...

1. An apparatus for recording ocular parameters comprising:
a digital camera for capturing a sequence of images of a portion of an eye and converting said images to a recordable digital
format;

a source of illumination in the visible range of wavelengths, said illumination source being arranged in relation to said
camera to illuminate a patient's eye when the camera is positioned to record images of the patient's eye;

a control operatively connected to said source of illumination for varying the intensity of illumination emitted by said source;
means for measuring in said images at least one parameter from among pupil area, pupillary hippus, angular displacement of
the eye, and the rate of said angular displacement; and

recording means responsive to said control and to said digital camera for generating a record in which said at least one parameter
is correlated with the intensity of said illumination.

US Pat. No. 9,134,308

ANTIBODY IMMOBILIZATION USING POLY(ETHYLENE GLYCOL) CROSSLINKING

Drexel University, Phila...

1. A method of immobilizing an antibody to a solid support at a surface density of 1.14-1.15 ng/cm2, the method comprising:
i) contacting the solid support with a linear or branched poly(ethylene glycol) (PEG) molecule, wherein the solid support
has a surface having a first functional group and, wherein the PEG molecule comprises at least a second and a third functional
group and wherein the second functional group reacts with the first functional group to form a covalent bond;

ii) contacting the PEG molecule with a crosslinker, wherein the crosslinker comprises glutaraldehyde, and wherein the crosslinker
has a fourth and a fifth functional group, wherein the fourth functional group reacts with the third functional group to form
a covalent bond; and

iii) contacting the crosslinker with the antibody comprising a sixth functional group, wherein the fifth functional group
reacts with the sixth functional group to form a covalent bond, thereby immobilizing the antibody to the solid support, thereby
immobilizing the antibody to a solid support at a surface density of 1.14-1.15 ng/cm2.

US Pat. No. 9,220,709

DRUG LOADED CONTRAST AGENTS: COMBINING DIAGNOSIS AND THERAPY

Drexel University, Phila...

1. A hardening stage adsorption method for producing echogenic doxorubicin-loaded polymer microcapsules, nanocapsules, or
mixtures thereof, the method comprising:
(a) forming a first mixture comprising a solution of poly (D,L-lactic acid) (PLA) in at least one volatile non-polar solvent
and optionally at least one non-water soluble sublimable substance;

(b) forming a second mixture comprising a solution of at least one water soluble sublimable substance in at least one polar
solvent;

(c) adding said first mixture to said second mixture to form a third mixture;
(d) emulsifying the third mixture to produce a first population of polymer microcapsules, nanocapsules, or mixtures thereof
comprising PLA, said at least one water-soluble sublimable substance, and optionally, said at least one non-water sublimable
soluble substance;

(e) mixing said first population of polymer microcapsules, nanocapsules, or mixtures thereof with a surfactant solution and
homogenizing to break apart said first population of microcapsules or nanocapsules to form a second population of polymer
microcapsules, nanocapsules, or mixtures thereof that are smaller in size than said first population;

(f) hardening said second population of polymer microcapsules, nanocapsules, or mixtures thereof by contacting with at least
one hardening solvent comprising doxorubicin dissolved or dispersed in said at least one hardening solvent to form a first
population of doxorubicin-loaded polymer microcapsules, nanocapsules, or mixtures thereof in which at least 95% of the non-polar
solvent is removed;

(g) optionally removing traces of said at least one hardening solvent and thereby further hardening said first population
of doxorubicin-loaded polymer microcapsules, nanocapsules, or mixtures thereof; and

(h) removing said water soluble sublimable substance and said non-water soluble sublimable substance if present from doxorubicin-loaded
population of polymer microcapsules, nanocapsules, or mixtures thereof to form echogenic doxorubicin-loaded polymer microcapsules,
nanocapsules, or mixtures thereof which comprise at least 119% more of doxorubicin as compared to (1) echogenic doxorubicin-loaded
polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding doxorubicin prior to said emulsifying or (2) echogenic
doxorubicin-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding doxorubicin to lyophilized
polymer microcapsules, nanocapsules, or mixtures thereof.

US Pat. No. 9,657,013

INHIBITORS OF HEPATITIS B VIRUS COVALENTLY CLOSED CIRCULAR DNA FORMATION AND THEIR METHOD OF USE

Baruch S. Blumberg Instit...

1. A compound having formula (Ia):

or hydrates, solvates and pharmaceutically acceptable salts thereof, wherein:
(a) R1 is 2-halo-5-trifluoromethyl phenyl;

R2 is selected from the group consisting of substituted phenyl, and optionally substituted heteroaryl; and

R3 is selected from the group consisting of optionally substituted phenyl, optionally substituted C1-C6 linear alkyl, optionally substituted C1-C6 branched alkyl, optionally substituted C3-C7 cycloalkyl,


or
(b) R1 is 2,5-substituted phenyl, wherein the substituents at the 2-position and 5-position of the phenyl are independently selected
from the group consisting of halo and trifluoromethyl;

R2 is phenyl; and

R3 is selected from the group consisting of


n is 1;
L1 is, independently, —[C(R4aR4b)]m—;

m is 1 or 2;
at each occurrence R4a and R4b are each independently selected from a group consisting of hydrogen and methyl; or R4a and R4b are taken together with the carbon atom to which they are bound to form a cyclopropyl ring; and

x is 1.
US Pat. No. 9,579,419

THERMOSENSITIVE AND CROSSLINKABLE POLYMER COMPOSITE FOR THREE-DIMENSIONAL SOFT TISSUE SCAFFOLD PRINTING

Drexel University, Phila...

1. A hydrogel material comprising:
a first triblock polymer having a formula ABA; and
a second triblock polymer having a formula AmaBAma, wherein:
A is a first polymer;
B is a second polymer; and
Ama is a methacrylate of the first polymer,
wherein the material is thermosensitive and photocrosslinkable, and
wherein the material has a viscosity of less than about 230 centipoise at 20 degrees Celsius and a viscosity of greater than
122,000 centipoise at 33 degrees Celsius.

US Pat. No. 9,126,937

ALKYLATED IMINO SUGARS EXHIBITING GLUCOSIDASE INHIBITION AND THEIR METHOD OF USE

Baruch S. Blumberg Instit...

1. The compound having formula (III):

Including hydrates, solvates, pharmaceutically acceptable salts, and complexes thereof, wherein:
R1 at each occurrence is independently selected from the group consisting of hydrogen and COR4;

R5 is selected from a group consisting of optionally substituted C1-6 alkyl, optionally substituted branched C1-6 alkyl, optionally substituted cyclic C3-8 alkyl, optionally substituted C5-C10 bicycloalkyl, optionally substituted aryl which may be substituted by 0-5 moieties, OR5? and NHR6;

R3 is selected from a group consisting of optionally substituted C1-6 alkyl, optionally substituted branched C1-6 alkyl, optionally substituted cyclic C3-8 alkyl, 1-adamantyl, 2-adamantyl, optionally substituted C5-C10 bicycloalkyl, and optionally substituted aryl which may be substituted by 0-5 moieties;

R3 and R5 are taken together with the atom to which they are bound to form an optionally substituted ring having 5 ring atoms;

R3 and R5 are taken together with the atom to which they are bound to form an optionally substituted ring having 5 ring atoms;

R3 and R5 are taken together with the atom to which they are bound to form


R3 and R5 are taken together with the atom to which they are bound to form


R4 at each occurrence is independently selected from the group consisting of optionally substituted C1-6 alkyl and optionally substituted branched C1-6 alkyl;

R5 is selected from a group consisting of an optionally substituted C1-6 alkyl, optionally substituted branched C1-6 alkyl, optionally substituted cyclic C3-8 alkyl, optionally substituted C5-C10 bicycloalkyl, and optionally substituted aryl which may be substituted by 0-5 moieties;

R6 is selected from a group consisting of hydrogen, an optionally substituted C1-6 alkyl, optionally substituted branched C1-6 alkyl, optionally substituted cyclic C3-8 alkyl, optionally substituted C5-C10 bicycloalkyl, and optionally substituted aryl which may be substituted by 0-5 moieties;

R7a, R7b, R7c, and R7d are each selected from a group consisting of hydrogen, optionally substituted C1-6 alkyl, and optionally substituted aryl which may be substituted by 0-5 moieties;

R8a, R8b, R8c, and R8d are each selected from a group consisting of hydrogen, halogen, optionally substituted C1-6 alkyl, optionally substituted branched C1-6 alkyl, and optionally substituted C1-6 alkoxy.

US Pat. No. 9,623,071

MODULATION OF HEPATITIS B VIRUS CCCDNA TRANSCRIPTION

Drexel University, Phila...

1. A method of inhibiting covalently closed circular DNA (cccDNA) transcription of hepatitis B virus in a subject, the method
comprising administering to the subject a therapeutically effective amount of an inhibitor of class I histone deacetylase
activity, wherein the inhibitor of class I histone deacetylase activity is selected from the group consisting of Trichostatin
A, suberoyl bis hydroxamic acid, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl] benzamide, and Apicidin or an analog thereof,
or a stereoisomer or pharmaceutically acceptable salt thereof.

US Pat. No. 9,644,059

RENEWABLE BIO-BASED (METH)ACRYLATED MONOMERS AS VINYL ESTER CROSS-LINKERS

Drexel University, Phila...

1. A polymerizable monomer selected from the group consisting of:

US Pat. No. 9,576,694

APPLICATIONS FOR ALLIFORM CARBON

Drexel University, Phila...

1. An energy storage device comprising:
a. A first and a second electrode, each electrode comprising a body in electrical communication with a current collector;
and

b. an electrolyte;
wherein at least one body comprises a three-dimensionally porous matrix of alliform carbon particles, the alliform carbon
particles comprising at least one concentric graphitic shell having at least 25% of the shell comprising sp2 carbon, the alliform
carbon particles being substantially spherical in shape, without carbon nanotube appendages, and substantially physically
connected;

said alliform carbon particles having a substantially unimodal size distribution with a mean particle diameter as measured
by TEM photomicrograph image analysis of in a range of from 2 to 30 nanometers and

said alliform carbon particles having a mean specific surface area in the range of 250 to 750 m2g-1;
wherein the electrolyte physically contacts and is in electrical communication with said three-dimensionally porous matrix
of alliform carbon particles; and

wherein the energy storage device exhibits capacitance when a voltage polarity is applied across the first and second electrodes.

US Pat. No. 9,618,497

ALL ELECTRIC PIEZOELECTRIC FINGER SENSOR (PEFS) FOR SOFT MATERIAL STIFFNESS MEASUREMENT

Drexel University, Phila...

1. A method for determining stiffness of a substrate at a plurality of locations, said method comprising steps of;
(a) applying a compressive force to a first location of the substrate via a sensor having a cantilever when said cantilever
is in contact with the substrate;

(b) detecting a displacement of the cantilever due to said compressive force of step (a);
(c) applying a compressive force to a different location of the substrate via a sensor having a cantilever when said cantilever
is in contact with the substrate;

(d) detecting a displacement of the cantilever due to said compressive force of step (c);
(e) determining stiffness of the substrate using the displacements detected in steps (b) and (d).

US Pat. No. 9,585,390

MATERIALS FOR DISINFECTION PRODUCED BY NON-THERMAL PLASMA

Drexel University, Phila...

1. A method comprising:
contacting an aqueous composition, the aqueous composition being an aqueous gel or water containing an organic material comprising
an amino acid, with a plasma to form a disinfection composition, wherein the plasma is a dielectric barrier discharge, a corona
or pulsed corona discharge, arc, spark, gliding arc, radio frequency discharge, or microwave discharge plasma.

US Pat. No. 9,179,470

METHOD FOR SELECTING STATE OF A RECONFIGURABLE ANTENNA IN A COMMUNICATION SYSTEM VIA MACHINE LEARNING

Drexel University, Phila...

1. A method of selecting an antenna array state for a multi-element reconfigurable transmitter and/or receiver antenna, comprising
the steps of:
a processor executing a learning algorithm that optimizes a wireless link between at least one reconfigurable transmitter
antenna and at least one reconfigurable receiver antenna over time over different antenna array states of said at least one
reconfigurable transmitter antenna and said at least one reconfigurable receiver antenna; and

the processor setting the antenna array configuration for the transmitter and/or a receiver antenna based at least in part
on the antenna array states determined by said learning algorithm to lead to an optimized wireless link between said at least
one reconfigurable transmitter antenna and said at least one reconfigurable receiver antenna over time,

wherein executing the learning algorithm includes formulating selection of an antenna array state as a multi-armed bandit
problem for learning unknown wireless channel conditions of said wireless link so as to maximize the wireless link between
said at least one reconfigurable transmitter antenna and said at least one reconfigurable receiver antenna over time.

US Pat. No. 9,663,372

DISAGGREGATION OF AGGREGATED NANODIAMOND CLUSTERS

Drexel University, Phila...

1. A method of disaggregating nanodiamond clusters comprising:
milling aggregated nanodiamond clusters with a plurality of milling bodies and a solid disaggregating agent having a Mohs
hardness less than 6 Mohs hardness units, the aggregated nanodiamond clusters comprising nanodiamonds and having an initial
mean effective diameter, the milling being done for a time sufficient to produce a nanodiamond particulate form having a mean
effective diameter less than the initial mean effective diameter of the aggregated nanodiamond clusters.

US Pat. No. 9,560,073

RECONFIGURABLE ANTENNA BASED SOLUTIONS FOR DEVICE AUTHENTICATION AND INTRUSION DETECTION IN WIRELESS NETWORKS

Drexel University, Phila...

1. A method of authenticating a transmitting device in a communication system using at least one multi-mode reconfigurable
antenna, comprising the steps of:
collecting wireless channel information for different antenna modes of said at least one reconfigurable antenna for a legitimate
transmitter;

combining the collected wireless channel information for different modes of said at least One reconfigurable antenna into
a characteristic transmission fingerprint;

forming a detection threshold based on the characteristic transmission fingerprint for the legitimate transmitter at the outset
of a communication connection;

comparing wireless channel information from a later transmission with said fingerprint based on a test metric to determine
if the wireless channel information from the later transmission corresponds to said fingerprint within a designated threshold;
and

identifying the transmitter of said later transmission as an intruder if said wireless channel transmission does not correspond
to said fingerprint within said designated threshold,

wherein said designated threshold for a given false alarm rate is computed during a connection initialization phase of said
communication connection by transmitting multiple training packets from the legitimate transmitter to a receiver and the test
metric is computed between fingerprints corresponding to all of the training packets.

US Pat. No. 9,599,612

FLOW-BASED ENHANCEMENT OF SPECIFICITY FOR LABEL-FREE BIOCHEMICAL ASSAYS

Drexel University, Phila...

1. A method of analyzing an analyte, the method comprising:
(A) exposing a target-receptor layer that comprises a plurality of target receptors adapted to bind a target substance selected
from bacteria and spores in a fluid that comprises the analyte including the target substance; and

(B) performing label-free interrogation of the target-receptor layer for a presence of the target substance bound thereto
while subjecting the target-receptor layer to a laminar flow of the fluid flowing at a flow speed in a range of from 2.7 mm/s
to 4.05 mm/s that is controlled based on calibration data for the selectivity of binding of the target substance relative
to binding of at least one non-target substance that can interfere with detection of the target substance by binding to the
target receptors thereby providing a higher specificity of detection of the target substance in the analyte compared to a
corresponding specificity of detection with the fluid being stationary, and

wherein the target substance is a spore of Bacillus anthraces.

US Pat. No. 10,031,137

DEVICES, METHODS, AND KITS FOR DETECTING AN ANALYTE IN A SAMPLE

Drexel University, Phila...

1. A method for detecting at least one analyte in a fluid sample, the method comprising:adding a labeled moiety that specifically binds to an analyte to a fluid sample;
suspending solid support substrates conjugated to an unlabeled moiety that specifically binds to the analyte in the fluid sample;
providing a device comprising:
an absorbent pad;
a funnel comprising:
a wide end; and
a narrow end above and adjacent to the absorbent pad; and
a sample-loading region in communication with the wide end of the funnel via a non-absorbent lateral channel in between the sample-loading region and the wide end of the funnel;
introducing the fluid sample into the sample loading region of the device;
capturing the solid support substrates in a reduced sample volume in the funnel; and
detecting the labeled moiety bound to the analyte that is, in turn, bound to the unlabeled moiety in the region of the captured solid support substrates when an analyte is present in the sample,
wherein the presence of the labeled moiety in the region of the captured solid support substrates is indicative of both the labeled and unlabeled moieties binding to the analyte.

US Pat. No. 9,945,785

FLEXIBLE SERS SUBSTRATES WITH FILTERING CAPABILITIES

Drexel University, Phila...

1. A surface-enhanced Raman spectroscopy substrate comprising:a flexible substrate having filtering capability for trapping an analyte of interest on said substrate during filtration of a media containing said analyte and including a material selected from glass fibers, cellulose fibers and polyimide fibers, said flexible substrate having a distribution of nanoparticle cluster sizes and interparticle distances and said flexible substrate providing a three dimensional surface having multiple anchoring sites for an analyte molecule; and
fractal aggregates of nanoparticles comprising a material which enhances Raman scattering located on a surface of said substrate, wherein said nanoparticles provide an amplification of a Raman scattering signal of from about 1×103 to about 2.5×1010 relative to a Raman scattering signal of said flexible substrate in the absence of said nanoparticles.

US Pat. No. 9,924,522

METHOD FOR SELECTING STATE OF A RECONFIGURABLE ANTENNA IN A COMMUNICATION SYSTEM VIA MACHINE LEARNING

Drexel University, Phila...

1. A method of selecting an antenna array state for a multi-element reconfigurable transmitter and/or receiver antenna, comprising
the steps of:
a processor executing a learning algorithm that optimizes a wireless link between at least one reconfigurable transmitter
antenna and at least one reconfigurable receiver antenna over time over different antenna array states of said at least one
reconfigurable transmitter antenna and said at least one reconfigurable receiver antenna; and

the processor setting the antenna array configuration for the transmitter and/or a receiver antenna based at least in part
on the antenna array states determined by said learning algorithm to lead to an optimized wireless link between said at least
one reconfigurable transmitter antenna and said at least one reconfigurable receiver antenna over time,

wherein executing the learning algorithm includes formulating selection of an antenna array state using an online learning
framework for learning at least one unknown wireless channel condition of said wireless link and selecting the antenna array
state that maximizes the at least one wireless channel condition between said at least one reconfigurable transmitter antenna
and said at least one reconfigurable receiver antenna over time.

US Pat. No. 9,861,594

TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER

Drexel University, Phila...

1. A method of treating attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) in a subject in
need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of formula
(I):
wherein:
R1, R2 and R3 are independently selected from the group consisting of H, cyano, hydroxyl, halo, alkoxy, nitro, C1-6 alkyl, and carboxy;

R4 is selected from the group consisting of H and C1-6 alkyl;

R5 is selected from the group consisting of H, C1-6 alkyl, and substituted C1-6 alkyl; and,

n is 2;a pharmaceutically acceptable salt or solvate thereof, and any mixtures thereof.

US Pat. No. 9,871,284

SYSTEMS AND METHODS FOR SELECTING RECONFIGURABLE ANTENNAS IN MIMO SYSTEMS

Drexel University, Phila...

1. A method of selecting an antenna array configuration for a multi-element reconfigurable transmitter antenna and/or a multi-element
reconfigurable receiver antenna in a transmission system, comprising the steps of:
providing receiver look-up tables for at least 1 of N antenna array configurations between said transmitter antenna and said
receiver antenna, said receiver look up tables including values for antenna related parameters of discrimination between different
wireless channel scenarios;

a receiver processor associated with said receiver antenna estimating from received signals from a transmitter antenna communicating
with said receiver antenna values for said antenna related parameters for at least one but less than N antenna array configurations;
and

said receiver processor selecting a receiver look-up table based on a current antenna array configuration including the receiver
antenna and/or the transmitter antenna and setting an updated antenna array configuration based at least in part on using
said estimated values to select the updated antenna array configuration from the selected receiver look-up table, said updated
antenna array configuration for the receiver antenna and/or the transmitter antenna being set independent of a transmission
scheme or configuration adopted by another antenna in said communication system.

US Pat. No. 9,805,705

MULTI-TOUCH PIANO KEYBOARD

Drexel University, Phila...

1. A plurality of keys on a musical keyboard comprising:
(a) each key of the plurality of keyboard keys arranged adjacent at least one other key of the plurality, each of the plurality
of keyboard keys having a plurality of integrated touch sensors adjacent to each other and disposed in an array; and

(b) a processor electronically coupled to the plurality of integrated touch sensors, the processor being programmed to receive
input from several of the plurality of integrated touch sensors and to generate a sound signal based on the input from the
several of the plurality of integrated touch sensors, such that a touch on the keyboard keys can be tracked across more than
one of the plurality of keyboard keys,

wherein the processor is adapted to calculate a size and a position of a centroid based on a plurality of touches on the array
and to generate a logical signal based on the size and the position of the centroid.

US Pat. No. 9,810,972

ROBOT SPECIMEN PHOTOGRAPHY MOUNT

Drexel University, Phila...

1. A robot specimen photography mount comprising:
a base;
a cradle support assembly extending upwardly from the base;
a cradle rotatably supported by the cradle support assembly;
a rotation motor mounted on the cradle;
a specimen mount rotatably mounted on the rotation motor, the specimen mount having a vacuum opening formed therein; and
a vacuum conduit in fluid communication with the vacuum opening.

US Pat. No. 9,856,260

COMPOUNDS USEFUL FOR INHIBITING METASTASIS FROM CANCER AND METHODS USING SAME

Drexel University, Phila...

1. A compound of Formula (I):
wherein:
A1 is CH2;

n is 0, 1, 2, 3, 4 or 5;
A2 and A3 are both H, or A2 and A3 combine to form a divalent radical selected from the group consisting of methanediyl, ethane-1,2-diyl, or propane-1,3-diyl;

A4 is CH2;

R1 and R2 are both H, and R3 is


R4 is nil;

R7 is H or OH;

wherein:
(a) ring A is selected from the group consisting of phenyl and substituted phenyl, and R5 is triazolyl, substituted triazolyl, 1,2-benzisoxazolyl or substituted 1,2-benzisoxazolyl; or

(b) ring A is selected from the group consisting of

 and R5 is phenyl, substituted phenyl, triazolyl, substituted triazolyl, 1,2-benzisoxazolyl, or substituted 1,2-benzisoxazolyl;

a pharmaceutically acceptable salt or solvate thereof, or any combinations thereof.

US Pat. No. 9,972,894

WEARABLE POWER HARVESTING SYSTEM

Drexel University, Phila...

1. A wearable power harvesting system comprising:a knitted fabric rectenna including an antenna adapted to receive radio-frequency energy within a desired frequency band;
a rectifier circuit that converts received radio-frequency energy into a DC current and voltage;
a knitted fabric load/storage unit that stores DC power from said rectifier circuit and
wherein the antenna of the rectenna comprises a compact wideband folded dipole antenna, and wherein the antenna comprises a single layer and includes a non-conductive fabric surrounded by a conductive fabric.
US Pat. No. 10,072,047

TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES

Drexel University, Phila...

1. A method for assessing the capacity of a candidate molecule to inhibit covalently closed circular (ccc) DNA of a hepadnavirus comprising the steps of(a) contacting a cell comprising a nucleic acid molecule comprising a nucleic acid sequence encoding a tagged hepadnavirus e antigen with said candidate molecule; wherein the nucleic acid molecule comprises a sequence encoding one or more tags, wherein the sequence is inserted into the epsilon structure as encoded by a hepadnavirus genome,wherein said nucleic acid molecule comprising a sequence encoding the one or more tag is inserted between nucleotides corresponding to position C1902 and position A1903 of the HBV genome,wherein said nucleic acid molecule comprises 5? of the sequence encoding the one or more tag a sequence that is capable of forming base pairs with the lower stem of the epsilon structure as encoded by a hepadnavirus genome and wherein the sequence that is capable of forming base pairs with said lower stem of the epsilon structure as encoded by a hepadnavirus genome is capable of forming base pairs with nucleotides corresponding to positions T1849 to A1854 of the HBV genome;(b) assessing the level of the tagged hepadnavirus e antigen; and
(c) selecting a candidate molecule when the level of tagged hepadnavirus e antigen is decreased compared to a control.

US Pat. No. 9,857,808

DYNAMIC LOAD MODELING OF A BUILDING'S ENERGY CONSUMPTION FOR DEMAND RESPONSE APPLICATIONS

Drexel University, Phila...

1. A method for using a dynamic electrical load model to model an energy consumption characteristic in a building with respect
to changes in temperature for use in demand response applications, the method comprising:
determining changes in a building temperature control;
using a dynamic electrical load model to accurately model electrical energy consumption of an HVAC chiller in response to
the changes in the building temperature control, wherein the dynamic electrical load model is automatically updated to account
for a difference between a modeled electrical energy consumption of the HVAC chiller and an actual electrical energy consumption
of the HVAC chiller, and wherein the dynamic electrical load model operates in accordance with the equation Pd(t)=Ps(?)+(Pt(?)?Ps(?))e?(t?tc)/Tr, wherein Pd is a dynamic electrical load as a function of time t, ? is an outlet water temperature, Ps is a steady state electric power level as a function of ?, Pt is a transient power level as a function of ?, tc is a time delay between an outlet water temperature setpoint change of the HVAC chiller and a corresponding response in ?,
and Tr is a load power recovery time;

planning a real-time schedule for dispatching of energy and a day-ahead schedule for dispatching of energy for demand side
response based on said use of said dynamic electrical load model; and

dispatching energy for demand side response in accordance with the real-time schedule and the day-ahead schedule.

US Pat. No. 9,938,236

ANTIVIRAL AGENTS AGAINST HBV INFECTION

Drexel University, Phila...

1. A compound of Formula (I), or an enantiomer, diastereomer, pharmaceutically accepted salt, or solvate thereof:wherein in (I):A is selected from the group consisting of SO2 and CO;
R1 is selected from the group consisting of optionally substituted C1-6 linear alkyl, optionally substituted C1-6 branched alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted benzyl, optionally substituted 3-7 membered cycloheteroalkyl, optionally substituted C2-8 alkenyl, optionally substituted C2-8 alkynyl, and optionally substituted heterocyclic;
R2 is selected from the group consisting of hydrogen, optionally substituted C1-6 linear alkyl, optionally substituted C3-7 cycloalkyl, and optionally substituted heterocyclic;
R3 is selected from the group consisting of optionally substituted aryl and optionally substituted heteroaryl;
R4 is selected from the group consisting of hydrogen and optionally substituted C1-6 linear alkyl;
R5 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-6 linear alkyl, optionally substituted C1-6 branched alkyl, optionally substituted C1-6 haloalkyl, OR9, cyano, and N(R9)2;
R6 and R8 are selected independently at each occurrence from the group consisting of fluoro, C1-3 alkyl, and C1-3 alkoxy;
R7 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-6 linear alkyl, optionally substituted C1-6 branched alkyl, OR9, cyano, and N(R9)2;
R9 is independently at each occurrence selected from the group consisting of hydrogen, optionally substituted C1-6 linear alkyl, optionally substituted C1-6 branched alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted benzyl, and optionally substituted heterocyclyl;
wherein a substituted group is substituted with at least one selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, C2-8 alkenyl, C2-8 alkynyl, C3-6 cycloalkyl, —F, —Cl, —Br, —I, —CN —NO2, —OR41 , —SR14, —N(R14)2, —NR14C(O)R14,—SO2 R14 ,—SO2 OR14 —SO2N(R14)2, —C(O)R14, —C(O)OR14 —C(O)N(R14)2, aryl, heterocyclyl, or heteroaryl, wherein each occurrence of R14 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C2-8 alkenyl, C2-8 alkynyl, and C3-6 cycloalkyl, or two R14 units taken together with the atom(s) to which they are bound form an optionally substituted carbocyclyl or heterocyclyl group, wherein the carbocyclyl or heterocyclyl group has 3 to 7 ring atoms,
wherein the heteroaryl is selected from the group consisting of diazolyl, imidazolyl, imidazolyl, triazinyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolinyl, furanyl, thiophenyl, pyrimidinyl, pyridinyl, tetrazolyl, benzofuranyl, benzothiophenyl, benzoxazolyl, benzthiazolyl, benztriazolyl, cinnolinyl, naphthyridinyl, phenanthridinyl, 7H-purinyl, 9H-purinyl, 6-amino-9H -purinyl, 5H-pyrrolo[3,2-d]pyrimidinyl, 7H-pyrrolo[2,3-d]pyrimidinyl, pyrido[2,3-(ijpyrimidinyl, 2-phenylbenzo[d]thiazolyl, 1H-indolyl, 4,5,6,7-tetrahydro-1-H-indolyl, quinoxalinyl, quinazolinyl, quinolinyl, and isoquinolinyl;
provided that, when A is SO2, then the compound is not selected from any of groups (a) through (c):
(a) R3 is optionally substituted phenyl and R1or R2, either individually or when taken together, contain a hydroxyl group; or
(b) R3 is optionally substituted phenyl, and N(R1)(R2) is selected from the group consisting of

 or
(c) R3 is optionally substituted phenyl and N(R1)(R2) is selected from the group consisting of:

US Pat. No. 9,856,343

RENEWABLE BIO-BASED (METH)ACRYLATED MONOMERS AS VINYL ESTER CROSS-LINKERS

Drexel University, Phila...

1. A polymerizable monomer selected from the group consisting of:

US Pat. No. 9,596,125

EFFICIENT DISTRIBUTED ALGORITHM FOR THE LOCATION DESIGN AND ROUTING PROBLEM

Drexel University, Phila...

1. A computer-implemented method of identifying nodes or distribution centers for decentralized distribution of information
or materials throughout a network or throughout a geographic area, comprising:
(a) starting with an empty forest of potential nodes or distribution centers of said network or said geographic area, a computer
assigning each potential node or distribution center of the forest to be a member of its own connected component;

(b) for each potential node or distribution center that has not yet been assigned to be a node or distribution center, the
computer adding a cut edge of a connected component to the forest and merging the cut edge with a potential node or distribution
center on the other end of the cut edge;

(c) when a potential node or distribution center is merged with another potential node or distribution center that has been
assigned to a node or distribution center, the computer assigning the same node or distribution center to the potential node
or distribution center and stopping a resulting merged node from actively growing;

(d) the computer repeating steps (a)-(c) until all potential nodes or distribution centers have been assigned to a node or
distribution center and each connected component has at least one distribution center for distribution of said information
or materials to other nodes in said each connected component;

wherein each potential node or distribution center has a unique identifier with a globally agreed ordering, the processor
further implementing the step of using the unique identifiers of potential nodes or distribution centers to construct a total
ordering over the cut edges of the connected components by combining unique identifiers of incident potential nodes or distribution
center.

US Pat. No. 10,071,098

COMPOSITIONS USEFUL FOR TREATING HERPES SIMPLEX LABIALIS AND/OR HERPES ESOPHAGITIS, AND METHODS USING SAME

Drexel University, Phila...

1. A composition comprising acyclovir and KU-55933, or a salt, solvate or N-oxide thereof,wherein the acyclovir and the KU-55933 are present in the composition in a therapeutically effective amount that treats a HSV-1 infection in a subject in need thereof, and
wherein the HSV-1 infection comprises at least one selected from the group consisting of herpes simplex labialis and herpes esophagitis.
US Pat. No. 10,041,075

MODULATION OF PRE-MRNA USING SPLICE MODULATING OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS IN THE TREATMENT OF DISEASE

Drexel University, Phila...

1. A method of treating a subject afflicted with epilepsy or seizure disorder, said method comprising administering to said subject a composition comprising a splice modulating oligonucleotide (SMO) that specifically binds a complementary sequence of a pre-mRNA that undergoes splicing to form a mRNA encoding a glutamate activated ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit (GluR), wherein said SMO decreases expression of the flip isoform of said GluR.

US Pat. No. 9,995,665

DYNAMIC IMPACT FATIGUE DEVICE

Drexel University, Phila...

1. An impact fatigue device comprising:(a) a striker rod assembly configured to reciprocally move between an upstream position and a downstream position, the striker rod assembly comprising:
i. a striker rod slidingly mounted on a support member; and
ii. a trigger located upstream of the striker rod and adapted to move downstream to engage the striker rod and propel the striker rod downstream;
(b) an actuator assembly located upstream of the striker rod assembly, the actuator assembly configured to releasably engage the trigger and to translate the trigger upstream; and
(c) a reset mechanism configured to releasably engage the striker rod and to move the striker rod from the downstream position to the upstream position,
wherein the striker rod assembly and the actuator assembly are operable along a first longitudinal axis and wherein the reset mechanism is operable along a second longitudinal axis, perpendicular to the first longitudinal axis,
wherein the reset mechanism comprises:
(a) a reset rod movable along the second longitudinal axis, the reset rod having an engagement end; and
(b) a retractor wheel mounted on the engagement end of the reset rod and engageable with the striker rod to move the striker rod from the downstream position to the upstream position, wherein the reset rod moves the retractor wheel linearly.

US Pat. No. 9,910,414

SEMI-AUTONOMOUS RESCUE APPARATUS

Drexel University, Phila...

1. A cutting device configured to attach to a boom arm, the cutting device comprising:
a saw assembly including a cutting portion configured to cut into a target surface, the saw assembly comprising a saw blade
extending in a blade plane and mounted on a support arm;

a motor assembly coupled to the saw assembly, the motor assembly including a first motor configured to rotate the saw assembly
about a first axis, a second motor configured to rotate the saw assembly about a second axis, and a third motor configured
to rotate the saw assembly about a third axis; and a control system operatively connected to the motor assembly, wherein the
control system is configured to actuate the first, second, and third motors to thereby rotate the saw assembly about the first,
second, and third axes; and

four distance measuring sensors mounted on the support arm such that the four distance measuring sensor pivot with the saw
assembly, with two of the four sensors mounted on a first side of the blade plane in a first sensor plane parallel to the
blade plane, and a remaining two of the four sensors mounted on a second side of the blade plane in a second sensor plane
parallel to the blade plane, the four distance measuring sensors all configured to, in conjunction with the control assembly,
determine a distance between the saw assembly and the target surface.

US Pat. No. 9,662,012

APPARATUS AND METHOD FOR ASSESSING EFFECTS OF DRUGS BY RECORDING OCULAR PARAMETERS

Drexel University, Phila...

1. A method for assessing the impact of a drug or dosage thereof on a subject, comprising:
measuring in said subject at least one parameter from among pupillary hippus and the rate of angular displacement of the eye,
wherein the measurement of said at least one parameter is obtained while said subject's gaze is fixed on a single object in
the absence of other visual stimuli; and

comparing the measurement of said at least one parameter to a control.

US Pat. No. 9,925,054

PROSTHETIC ANKLE WITH CONIC SADDLE SHAPED JOINT

Drexel University, Phila...

1. A prosthetic ankle comprising:a tibial component having a top surface for location adjacent to a tibia and a bottom surface; and
a talar component having a bottom surface for location adjacent to a talus, and a top surface having:
(a) a convex curvature relative to a location above the top surface, in an anterior to posterior direction as viewed in a sagittal plane cross-section,
(b) a concave curvature relative to a location above the top surface, in a medial to lateral direction as viewed in a frontal plane cross-section, and
(c) an average radius of curvature of at least a major portion of a medial side of the top surface of the talar component is larger than an average radius of curvature of at least a major portion of a lateral side of the top surface of the talar component as viewed in sagittal plane cross-sections; and
wherein a concave curvature of the top surface of the talar component varies from an anterior end towards a posterior end of the talar component, as viewed in frontal plane cross-sections.

US Pat. No. 9,837,182

COMPOSITIONS COMPRISING FREE-STANDING TWO-DIMENSIONAL NANOCRYSTALS

Drexel University, Phila...

1. A method of transferring urea from an aqueous solution to a MXene composition, the method comprising contacting an aqueous
solution comprising urea with the MXene composition for a time sufficient to form an intercalated MXene composition comprising
urea; wherein
the MXene composition comprises a stacked assembly of at least two layers, each layer having first and second surfaces, each
layer comprising:

a substantially two-dimensional array of crystal cells,
each crystal cell having the empirical formula of Mn+1Xn, such that each X is positioned within an octahedral array of M;

wherein M is at least one Group IIIB, IVB, VB, or VIB metal;
each X is C, N, or a combination thereof; and
n=1, 2, or 3; and wherein
the layers are characterized as having an average surface area; and
at least one of said surfaces of each layer has bound thereto surface terminations comprising alkoxide, carboxylate, halide,
hydroxide, hydride, oxide, sub-oxide, nitride, sub-nitride, sulfide, thiol, or a combination thereof.

US Pat. No. 9,814,339

DEVICE TO MEASURE AND MONITOR DRINKING AND EATING HAVING A CUP HOLDER WITH A DIGITAL CAMERA

Drexel University, Phila...

1. A cup assembly comprising:
a cup holder comprising:
a base having a microcontroller incorporated therein;
a handle extending upwardly from the base; and
a camera support extending upwardly from the base, the camera support supporting a digital camera, the digital camera being
electronically coupled to the microcontroller; and

a cup removably insertable into the cup holder.
US Pat. No. 10,087,173

SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION

Baruch S. Blumberg Instit...

1. A compound selected from:(4-(pyridin-2-yl)-2-(pyrimidin-2-ylamino)thiazol-5-yl)methyl acetate;
(4-(pyridin-2-yl)-2-(pyrimidin-2-ylamino)thiazol-5-yl)methyl butyrate;
Ethyl 4-(pyridin-2-yl)-2-(pyrimidin-2-ylamino)thiazole-5-carboxylate;
Tert-butyl 2-(tert-butyl(pyrimidin-2-yl)amino)-4-(pyridine-2-yl)thiazole-5-carboxylate;
Ethyl 2-((4-methylpyrimidin-2-yl)amino)-4-(pyridin-2-yl)thiazole-5-carboxylate;
4-(pyridin-2-yl)-2-(pyrimidin-2-ylamino)thiazole-5-carboxylic acid;
Methyl 4-(pyridin-2-yl)-2-(pyrimidin-2-ylamino)thiazole-5-carboxylate;and pharmaceutically acceptable salts thereof.

US Pat. No. 9,946,344

FUNCTIONAL NEAR INFRARED SPECTROSCOPY BASED BRAIN COMPUTER INTERFACE

Drexel University, Phila...

1. A system, comprising:one or more near infrared sources configured to emit infrared radiation onto a portion of a cortical region of a person;
one or more detectors configured to receive infrared radiation indicative of a level of oxygenated hemoglobin and a level of deoxygenated hemoglobin in the portion of the cortical region;
the system further comprising a feedback source configured to provide feedback to the person based on one or more of the level of oxygenated hemoglobin and the level of deoxygenated hemoglobin in the cortical region; and
the system comprising a processor configured to correlate a change in the one or more of the level of oxygenated hemoglobin and the level of deoxygenated hemoglobin with a change in the feedback,
the feedback being changed when a change in the one or more of the level of oxygenated hemoglobin and the level of deoxygenated hemoglobin is above a threshold value.

US Pat. No. 9,773,079

METHODS AND COMPUTER-READABLE MEDIA FOR SYNTHESIZING A MULTI-CORNER MESH-BASED CLOCK DISTRIBUTION NETWORK FOR MULTI-VOLTAGE DOMAIN AND CLOCK MESHES AND INTEGRATED CIRCUITS

Drexel University, Phila...

1. An integrated circuit including a multi-corner mesh-based clock distribution network synthesized according to a method
comprising:
(a) for each of a plurality of voltage domains, placing N×N max size buffers at an (n?1)st level of one of the voltage domains
i until a maximum slew slewmax within the voltage domain i exceeds a defined slew threshold;

(b) calculating maximum insertion delay values for all cases for each of the voltage domains;
(c) if the maximum insertion delay values for all cases are associated with a single voltage domain j:
(i) adding a max size buffer to all voltage domains except voltage domain j; and
(ii) repeating steps (b) and (c);
(d) reducing buffer sizes for each of the voltage domains, in order of decreasing skew, by:
(i) downsizing all buffers in a k-th level of the voltage domain;
(ii) if the downsizing step (i) does not improve a calculated skew across the plurality of voltage domains, (1) undoing the
downsizing step (d)(i) and (2) performing substep (i) for the k+1th level of the voltage domain; and

(iii) otherwise, repeating substep (d)(i);
(e) recalculating maximum insertion delay values for all cases for each of the voltage domains; and
(f) adding parallel buffers to a first level of the voltage domain having a highest maximum insertion delay until the calculated
skew across the plurality of voltage domains no longer improves.

US Pat. No. 9,750,742

SMALL MOLECULAR INHIBITORS OF RAD51 RECOMBINASE AND METHODS THEREOF

Drexel University, Phila...

1. A method of treating a RAD51-overexpressing cancer in a subject in need thereof, the method comprising administering to
the subject a pharmaceutical composition comprising a pharmaceutically effective amount of at least one compound selected
from the group consisting of Formula (1), Formula (2), Formula (3), a salt thereof, and any combinations thereof:
wherein in (1):
R1 is pyridinyl,

R2 is selected from the group consisting of C1-C6 alkyl, —(C1-C6)alkylene-phenyl, and —(C1-C6)alkylene-phenyl wherein the phenyl is substituted with a C1-C6 alkyl; and

R3 is H;

the method further comprising administering to the subject a treatment selected from the group consisting of (i) radiation
therapy, and (ii) a pharmaceutically effective amount of a chemotherapeutic agent.

US Pat. No. 9,695,068

PRE-TREATING WATER WITH NON-THERMAL PLASMA

Drexel University, Phila...

1. A method of treating adulterated water, said adulterated water having an initial level of bicarbonate ion of at least about
250 ppm and an initial level of calcium ion of at least 500 ppm, said method comprising:
(a) contacting the adulterated water with a non-thermal plasma to produce plasma treated water having a level of bicarbonate
ion of less than about 100 ppm, wherein the non-thermal plasma is formed with the coincident injection of air, oxygen, or
a combination thereof; and

(b) optionally distilling the plasma treated water.

US Pat. No. 10,143,720

MODULATION OF HEPATITIS B VIRUS CCCDNA TRANSCRIPTION

Drexel University, Phila...

1. A compound of formula II:
wherein
R1 is (CH2)n— or —C(?O)—;
R2 is —C(?O)— or —C(Z)N(R4)—;
R4 is hydrogen, alkyl, aryl, aralkyl, dialkylaminoalkyl, or carboxyalkyl;
R3 is —CH(R5)—;
R5 is hydrogen, —CH3, or an alpha amino acid R group;
R6 is —(CH2)mC(X)Y, —(CH2)2CH3, or —(CH2)q-phenyl-(CH2)mC(?O)NHOH;
X is ?O, H2, ?N—NH2, or ?N—NH—C(?O)NH2;
Y is NHOH or —CH2CH3;
Z is H2 or O;
R7 is hydrogen or alkoxy;
R8 is alkyl or carboxyalkyl;
n is 0-2;
m is 0-6; and,
q is 0-3;
or a stereoisomer or pharmaceutically acceptable salt thereof.

US Pat. No. 9,919,085

DUAL-PUMP CONTINUOUS-FLOW TOTAL ARTIFICIAL HEART

Drexel University, Phila...

1. A total artificial heart for a mammalian cardiovascular system, comprising:
a casing including an outer housing and an integral hollow support shaft extending therethrough, said casing defining a first
flow path within the outer housing about an exterior of said hollow support shaft and a separate second flow path extending
within said hollow support shaft;

an annular impeller housed within said outer housing of said casing for rotation about said hollow support shaft to provide
a centrifugal flow pump in said first flow path; and

an axial flow impeller housed within said hollow support shaft of said casing for forming an axial flow pump in said second
flow path.

US Pat. No. 9,866,174

RESONANT FREQUENCY DIVIDER DESIGN METHODOLOGY FOR DYNAMIC FREQUENCY SCALING

Drexel University, Phila...

1. A dynamic rotary traveling wave oscillator circuit comprising:
a plurality of multi-output spot-advancing blocks (MOSABs) forming a main-loop;
a plurality of multi-input spot-advancing blocks (MISABs) forming a sub-loop;
wherein depending on a desired division ratio, a connection connects blocks on the MOSABs and MISABs to create the desired
division ratio;

wherein the MOSABs and the MISABs comprise components that perform multiplexing of signals.

US Pat. No. 9,853,997

MULTI-CHANNEL CHANGE-POINT MALWARE DETECTION

Drexel University, Phila...

1. A malware detection system comprising:
sensors that monitor the status of a host computer being monitored for malware, including malware that do not propagate through
a network;

a feature extractor including a processor and a memory that stores instructions that when executed by the processor causes
the processor to compute streams of feature data from raw sensor data from the sensors corresponding to predetermined features;

local detectors that perform malware detection on each stream of feature data from the feature extractor independently; and
a data fusion center that applies a k out of N fusion rule, where k is a threshold of a number of positive detections and
N is a total number of decisions reported by the local detectors, where N=2M and M is the number of local detectors, to the
malware detection decisions from the local detectors to infer whether the host computer is infected by malware.

US Pat. No. 9,945,835

ALL ELECTRIC PIEZOELECTRIC FINGER SENSOR (PEFS) FOR SOFT MATERIAL STIFFNESS MEASUREMENT

Drexel University, Phila...

1. A sensor comprising:two or more cantilevers, wherein each of the cantilevers, includes:
a first piezoelectric layer, wherein a portion of said piezoelectric layer forms an exposed contact surface for contacting a sample and a second piezoelectric layer electrically separated from the first piezoelectric layer;
an apparatus for generating a force in at least one of said two or more cantilevers; and
a means for measuring a value indicative of a displacement of one of said first and second piezoelectric layers resultant from said generated force and wherein said sensor is capable of simultaneously inducing a force in said two or more cantilevers and measuring the value indicative of displacement of one of said first and second piezoelectric layers, and wherein the two or more cantilevers are used in combination.

US Pat. No. 9,912,325

POWER SUPPLY VOLTAGE DETECTION AND POWER DELIVERY CIRCUIT

Drexel University, Phila...

1. A power supply detection and power delivery unit comprising:
a device plane comprising a voltage domain served by a power plane with a power module that delivers power to the device plane,
wherein each power module includes a voltage-controlled voltage source (VCVS) controlled by voltage generated from a frequency
to voltage converter (FVC), wherein a ring oscillator in each voltage domain provides a controlling frequency to the FVC.

US Pat. No. 9,823,113

FIBER OPTIC HYDROPHONE SENSORS AND USES THEREOF

Drexel University, Phila...

10. A system for detecting changes in pressure in an immersion medium or solid, the system comprising:
an optical fiber having a layer of material deposited on an immersion surface contact region of the fiber, wherein the layer
of material on the immersion surface contact region is of a thickness of from about 3.5 nm to 6 nm, wherein using the thickness
of the thin layer of the material within the range from about 3.5 nm to 6 nm improves sensitivity of the detection over a
fiber optic with no layer of material surmounting an immersion surface of the contact region by over 35 dB, wherein the optical
fiber has a core diameter at the immersion surface contact region of the fiber of less than about 30 um.

US Pat. No. 9,806,314

POLYMERIZED IONIC LIQUID BLOCK COPOLYMERS AS BATTERY MEMBRANES

Drexel University, Phila...

1. A block copolymer comprising a first and second block, said first block comprising an acrylate or methacrylate derivative;
said second block comprising (a) polymerized ionic liquid, said polymerized ionic liquid comprising a tethered ionic liquid
cation and a mobile anion, and (b) a lithium ion salt of said mobile anion, wherein said block copolymer exhibits at least
one region of nanophase separation.
US Pat. No. 9,700,640

STABILIZED ULTRASOUND CONTRAST AGENT

Drexel University, Phila...

1. A freeze-dried ultrasound contrast agent (UCA) comprising:
at least a first surfactant, wherein the first surfactant is a sorbitan monostearate;
a second surfactant, wherein the second surfactant is a polyoxyethylene sorbitan monooleate; and
a saccharide, wherein the saccharide is selected from the group consisting of glucose and trehalose.
US Pat. No. 9,642,830

USE OF STING AGONISTS TO TREAT HEPATITIS B VIRUS INFECTION

Drexel University, Phila...

1. A method of treating a hepatitis B viral (HBV) infection in a subject, the method comprising administering a pharmaceutically
effective amount of a STING agonist to the subject, wherein the STING agonist comprises at least one selected from the group
consisting of 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), methoxyvone, 6,4?-dimethoxyflavone, 4?-methoxyflavone, 3?,6?-dihydroxyflavone,
7,2?-dihydroxyflavone, daidzein, formononetin, retusin 7-methyl ether, and any combinations thereof.

US Pat. No. 9,568,442

STRAIN MAPPING IN TEM USING PRECESSION ELECTRON DIFFRACTION

Drexel University, Phila...

1. A method for strain mapping a material comprising the steps of:
scanning a sample of a material with a transmission electron microscope (TEM), wherein the scanning of the material occurs
over multiple steps having a step size and at a beam precession angle;

comparing each scan at each step and beam precession angle to a template to produce data, wherein the template is generated
from parameters of the material and information from the scanning step;

analyzing the data using local mis-orientation mapping analysis or Nye tensor analysis; and
producing a local strain map of the sample.
US Pat. No. 9,551,710

SIGNALING MOLECULE INVOLVED IN ULTRAVIOLET DAMAGE TO SKIN

Drexel University, Phila...

1. A method of detecting and treating or protecting against ultraviolet radiation (UVR)-induced skin damage in a mammal, said
method comprising the steps of:
measuring a level of Syk kinase in a skin sample obtained from said mammal by performing an immunoassay for assessing the
level of said Syk kinase in said sample, said immunoassay selected from the group consisting of: a western blot, ELISA, immunoprecipitation,
immunohistochemistry, immunofluorescence, radioimmunoassay, dot blotting, and fluorescence-activated cell sorting (FACS) or
a nucleic acid assay for assessing the level of a nucleic acid encoding said Syk kinase in said sample, said nucleic acid
assay selected from the group consisting of: a northern blot, a Southern blot, in situ hybridization, PCR assay, RT-PCR assay,
a probe-array-based assay, a gene-chip-based assay, and a microarray-based assay,

comparing the level of said Syk kinase in said sample to a control level of Syk kinase in a control sample, wherein when the
level of said Syk kinase in said sample is elevated compared to the level of Syk kinase in the control sample, Syk kinase
is activated and said mammal is afflicted with UVR-induced skin damage, and

administering to said mammal a therapeutically effective amount of a pharmaceutical composition comprising piceatannol or
a salt thereof when the level of said Syk kinase in said sample is elevated compared to the level of Syk kinase in a control
sample, thereby treating or protecting said mammal afflicted with UVR-induced skin damage.

US Pat. No. 9,846,161

WATER SOLUBLE NANOCRYSTALLINE QUANTUM DOTS CAPABLE OF NEAR INFRARED EMISSIONS

DREXEL UNIVERSITY, Phila...

1. A method for using a quantum dot comprising the steps of: providing a quantum dot having the formula DxM(1-x)SeyS(1-y); wherein M is a metal selected from the group consisting of cadmium and zinc and mixtures thereof;
wherein D is selected from the group consisting of: lead, iron, manganese and mixtures thereof;
wherein S represents sulfide;
wherein Se represents selenide;
wherein y is within the range of 0-1; and
wherein x is from 0.25 to 0.85 and is selected to provide a quantum dot having an emission having a wavelength of from about
750 nm to about 1100 nm;

binding a receptor to said quantum dot;
binding said receptor to a target moiety; and
exciting said quantum dot such that it produces near infrared emissions.
US Pat. No. 9,744,262

ALIMENTARY PROTEIN-BASED SCAFFOLDS (APS) FOR WOUND HEALING, REGENERATIVE MEDICINE AND DRUG DISCOVERY

DREXEL UNIVERSITY, Phila...

1. A method of treating a wound in a subject, the method comprising contacting an electroprocessed composition comprising
fibers of a soy protein isolate-derived biomaterial and a synthetic polymer to the wound of a subject in need thereof.

US Pat. No. 9,758,477

SULFAMOYLBENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION

Drexel University, Phila...

1. A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier, at least one compound of formula
(III):
wherein:
R10 is selected from the group consisting of H, CH3, Cl and Br;

Ry is selected from the group consisting of


or a pharmaceutically acceptable salt thereof,and at least one additional agent that treats Hepatitis B virus (HBV) infection.

US Pat. No. 9,758,780

WHOLE GENOME MAPPING BY DNA SEQUENCING WITH LINKED-PAIRED-END LIBRARY

Drexel University, Phila...

10. A method of generating a linked-paired-end nucleic acid fragment from a DNA sample, the method comprising:
a. contacting a double-stranded DNA template having a first and a second DNA strand with a first nicking endonuclease to form
a nick at a sequence-specific nicking location on the first DNA strand;

b. conducting a base extension reaction on the first DNA strand along a corresponding region of the second DNA strand thereby
forming a single-stranded flap on the double-stranded DNA template adjacent to the sequence-specific nicking location;

c. contacting the double-stranded DNA template of b) with a second nicking endonuclease being a T7 endonuclease to generate
a cut of the second DNA strand across the nicking sites thereby generating two cut DNA fragments: a first fragment with a
blunt end and a second fragment with an overhang corresponding to the single stranded flap of b); and,

d. conducting a base extension reaction on the second fragment with the flap overhang from c) wherein the based extension
being along the corresponding region of the single stranded flap, and the reaction starting at the nick site of the T7 endonuclease
and progressing toward the end of the stranded flap thereby generating a blunt end double-stranded DNA fragment that shares
common linker sequences with the first double-stranded DNA fragment of c).

US Pat. No. 9,644,850

HEAT PUMP WATER HEATER

Drexel University, Phila...

12. A method for operating a heat pump system at low ambient temperatures of about 5° C. or less comprising the steps of:
operating the heat pump system to transfer energy from an environmental medium to a refrigerant and subsequently transfer
energy from said refrigerant to a fluid;

activating a heater to heat said environmental medium when a dew point and temperature of the environmental medium is at or
below about 0° C. prior to said environmental medium contacting an evaporator coil of said heat pump system containing said
refrigerant; and

inducing a plasma discharge in said fluid sufficient for producing shock waves that cause precipitation of mineral ions from
said fluid and generating an electric field in said fluid.

US Pat. No. 9,668,846

TEXTILE-TEMPLATED ELECTROSPUN ANISOTROPIC SCAFFOLDS FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Drexel University, Phila...

1. A method of preparing an anisotropic scaffold, comprising the steps of:
electrospinning a solution of matrix material in a solvent upon an anisotropic textile template to form said anisotropic scaffold;
and

peeling said anisotropic scaffold from said anisotropic textile template.
US Pat. No. 10,045,961

USE OF STING AGONISTS TO TREAT CHRONIC HEPATITIS B VIRUS INFECTION

Drexel University, Phila...

1. A method of treating a hepatitis B virus (HBV) infection in a subject infected with HBV, the method comprising administering a pharmaceutically effective amount of a STING agonist to the subject,wherein the STING agonist comprises at least one selected from the group consisting of 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), methoxyvone, 6,4?-dimethoxyflavone, 4?-methoxyflavone, 3?,6?-dihydroxyflavone, 7,2?-dihydroxyflavone, daidzein, formononetin, retusin 7-methyl ether, and any combinations thereof, and
wherein the STING agonist is administered orally or by injection to the subject.

US Pat. No. 9,955,901

FUNCTIONAL NEAR-INFRARED SPECTROSCOPY AS A MONITOR FOR DEPTH OF ANESTHESIA

Drexel University, Phila...

1. A method of removing the effect of an artifact on a functional near-infrared signal of a cortical anesthesia monitoring system to improve the system accuracy, the method comprising:capturing a functional near-infrared signal of a patient, the functional near-infrared signal including a non-cortical signal, wherein the non-cortical signal is indicative of a signal-causing artifact;
processing the functional near-infrared signal with a principal component analysis (PCA) noise removal algorithm and an independent component analysis (ICA) noise removal algorithm,
analyzing outputs from the principal component analysis and the independent component analysis algorithms to select an artifact signal; and
removing the effect of the artifact from the functional near-infrared signal by subtracting a portion of the non-cortical signal from the functional near-infrared signal based on the selected artifact signal.

US Pat. No. 9,941,058

FLEXIBLE AND CONDUCTIVE WASTE TIRE-DERIVED CARBON/POLYMER COMPOSITE PAPER AS PSEUDOCAPACITIVE ELECTRODE

UT-BATTELLE, LLC, Oak Ri...

1. A method of making a supercapacitor from waste tires, comprising the steps of:providing rubber pieces;
contacting the rubber pieces with a sulfonation bath to produce sulfonated rubber;
pyrolyzing the sulfonated rubber to produce tire-derived carbon composite comprising carbon black embedded in sulfonated rubber-based carbon matrix with graphitized interface portions, wherein the pyrolizing comprises heating to at least 200° C.-2400° C., and comprises at least two stage heating at heating rates between 1 and 20° C./min;
activating the tire-derived carbon composite by contacting the tire-derived carbon composite with a specific surface area-increasing composition to increase the specific surface area of the carbon composite to provide activated tire-derived carbon composite;
mixing the activated tire-derived carbon composite with a monomer and polymerizing the monomer to produce a redox-active polymer coated, activated tire-derived carbon composite; and,
forming the redox-active polymer coated, activated tire-derived carbon composite into a film.

US Pat. No. 9,884,944

REMENDABLE INTERFACES FOR POLYMER COMPOSITES

Drexel University, Phila...

1. A composite material comprising:
a Diels-Alder reaction product of:
a polymer matrix material including at least a first reactive group that is capable of a thermoreversible Diels-Alder reaction;
and

a reinforcing material including at least a second reactive group that is capable of a thermoreversible Diels-Alder reaction
with the first reactive group of the polymer matrix material to produce a remendable composite material, wherein the second
reactive group of the reinforcing material comprises a reactive group selected from the group consisting of a furan group,
a fulvene group, and a maleimide group, and when said second reactive group comprises a maleimide group, said composite material
is made by the steps of:

(i) silanating the reinforcing material with an amino group-containing silane,
(ii) functionalizing the silanated reinforcing material by reacting the amino group with a maleimide having two or more maleimide
groups, and

(iii) reacting the reaction product of step (ii) with the polymer matrix material by a Diels-Alder reaction.
US Pat. No. 9,878,059

TIN SULFIDE QUANTUM DOTS FOR IN VIVO NEAR INFRARED IMAGING

DREXEL UNIVERSITY, Phila...

1. A method for the preparation of tin sulfide quantum dots that exhibit a near infrared emission for use in in vivo imaging
comprising steps of:
(a) reacting Sn2+ cations with S2? anions in water, a water-miscible solvent or a combination thereof and a capping molecule to form capped SnS quantum dots
by

(i) providing a solution of capping molecule at a pH of from about 1 to about 7 and a temperature of from about 50-90° C.;
(ii) adding a precursor solution containing Sn2+ cations while maintaining the temperature at from about 50-90° C. and maintaining the pH at from about 1 to about 7 to provide
a mixture; and

(iii) adding an aqueous precursor solution containing S2? anions to the mixture while maintaining the temperature at from about 50-90° C. and maintaining the pH at from about 1 to
about 7;

(b) optionally extending at least some of the capping moieties of the SnS quantum dots by peptide bond formation to provide
extended capped SnS quantum dots; and

(c) if necessary, neutralizing the extended capped SnS quantum dots, and
(d) heat treating the extended capped SnS quantum dots to increase a photoluminescence intensity of the quantum dots; andwherein the molar ratio of capping molecule:S in the quantum dots is from about 8.1 to about 32:1 and the molar ratio of Sn:S
in the quantum dots is from about 3:1 to about 12:1.

US Pat. No. 9,834,442

GLIDING ARC PLASMATRON REACTOR WITH REVERSE VORTEX FOR THE CONVERSION OF HYDROCARBON FUEL INTO SYNTHESIS GAS

Drexel University, Phila...

1. A process for reforming a hydrocarbon fuel, comprising:
inputting the hydrocarbon fuel and a first oxidizing gas into a first stage reactor, wherein the relative amounts of the hydrocarbon
fuel and the first oxidizing gas provide a first oxygen to carbon (O/C) ratio;

partially reforming using non-thermal plasma the hydrocarbon fuel into partially reformed hydrocarbon fuel;
inputting the partially reformed hydrocarbon fuel and a second oxidizing gas into a second stage reactor having a reverse
vortex flow, wherein the relative amounts of the partially reformed hydrocarbon fuel and the second oxidizing gas provide
a second oxygen to carbon (O/C) ratio, the first O/C ratio being less than 1 and the second O/C ratio being greater than 1,
such that the overall ratio of carbon in the hydrocarbon fuel and oxygen in the oxidizing gas is maintained near 1; and

completing the reforming process of at least a portion of the partially reformed hydrocarbon fuel in the second stage reactor
to produce an outlet stream.

US Pat. No. 9,625,878

DYNAMIC TIME MULTIPLEXING FABRICATION OF HOLOGRAPHIC POLYMER DISPERSED LIQUID CRYSTALS FOR INCREASED WAVELENGTH SENSITIVITY

Drexel University, Phila...

1. A holographic polymer dispersed liquid crystal film that reflects a hyperspectral continuum of optical energy within a
spectrum of wavelengths, the holographic polymer dispersed liquid crystal film comprising:
a continuous polymer phase comprising an acrylate-containing polymer; and
an overlapping liquid crystal layer structure within the continuous polymer phase, the holographic polymer dispersed liquid
crystal film exhibiting:

a hyperspectral continuum of peak reflective wavelengths produced by a continuous exposure process exhibiting a uniform reflectance
and ranging from a first peak reflective wavelength indicative of a first end of the spectrum to a second peak reflective
wavelength greater than the first peak reflective wavelength, the second peak reflective wavelength indicative of a second
end of the spectrum, inclusively, wherein:

each and every point of the hyperspectral continuum of peak reflective wavelengths is indicative of a peak reflectance of
a respective wavelength of a respective Bragg reflection grating;

the hyperspectral continuum of peak reflective wavelengths between the first and second peak reflective wavelengths having
a full width at half maximum (FWHM) in a range of from 15 nm to 100 nm or 100 nm or greater;

the holographic polymer dispersed liquid crystal film exhibits a scattering intensity less than 1×10?7 dB outside the hyperspectral continuum of peak reflective wavelengths; and

the hyperspectral continuum of peak reflective wavelengths is electrically controllable by switching fields of about 15 to
20 Volts per micrometer at switching times of less than 2 milliseconds;
wherein the holographic polymer dispersed liquid crystal film comprises a plurality of reflective gratings within the holographic
polymer dispersed liquid crystal film, and at least one of the plurality of reflective gratings is curved.

US Pat. No. 9,616,065

COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME

Drexel University, Phila...

1. A compound of Formula (III):
wherein in Formula (III),
ring A is triazinoindolyl optionally substituted with 1-4 R1 groups;

each occurrence of R1 is independently selected from the group consisting of —C1-C6 alkyl, —C1-C6 fluoroalkyl, —C1-C6 heteroalkyl, F, Cl, Br, and I;

R2 is selected from the group consisting of H and C1-C6 alkyl;

R3 is selected from the group consisting of —S(?O)2R4 and —C(?O)R4;

phenyl which is optionally substituted with one or two substituents selected from the group consisting of C1-C6 alkyl, OH, C1-C6 alkoxy, halo, amino, acetamido and nitro; and

x is an integer from 0-4;a salt or solvate thereof, and any combinations thereof.
US Pat. No. 10,180,436

DIAGNOSIS OF LIVER PATHOLOGY THROUGH ASSESSMENT OF ANTI-GAL IGG GLYCOSYLATION

Drexel University, Phila...

1. A method for assessing the severity of fibrosis in a subject suspected of having fibrosis comprising:separating anti-gal IgG from a biological fluid of said subject using a separation agent;
contacting said separated anti-gal IgG from said biological fluid with a fucose-binding reagent, and allowing said reagent to bind to said anti-gal IgG;
quantifiably detecting fucose-binding reagent bound to said anti-gal IgG to obtain a detected bound reagent value;
comparing the detected bound reagent value with a reference value for reagent binding on said anti-gal IgG from a comparable biological fluid of one or more subjects without fibrosis; and,
staging the severity of fibrosis in said subject as one of no fibrosis, limited fibrosis, or severe fibrosis, based on the results of said comparison.

US Pat. No. 10,030,254

MAXIMIZING PRODUCTION OF HYDROGEN FROM WASTE MATERIALS BY ACTIVE REMOVAL OF HYDROGEN

Drexel University, Phila...

1. A method of producing hydrogen from a waste material, comprising steps of:a) fermenting a fermentation mixture comprising the waste material in a reactor with a headspace under anaerobic conditions;
b) removing hydrogen from a gas generated in the headspace during fermentation to provide hydrogen and a remainder gas; and
c) recirculating at least a portion of the remainder gas to the reactor.

US Pat. No. 9,920,073

COMPOSITIONS USEFUL FOR INHIBITING HIV-1 INFECTION AND METHODS USING SAME

Drexel University, Phila...

1. A compound of formula (I), or a salt or solvate thereof:

wherein:
R1 is


ring A is

wherein the atom labeled with A is linked to ring R1;

linker L is selected from the group consisting of:

wherein the atom labeled with B is linked to ring B;
ring B is selected from the group consisting of:

each occurrence of R2 is independently selected from the group consisting of —(C1-C6)alkyl, —(C1-C6)fluoroalkyl, —F, —Cl, —Br, —I, and —OR7;

R4 is 1,2,4-triazolyl optionally substituted with (C1-C6)alkyl;

R5 is selected from the group consisting of H, —(C1-C6)alkyl, —(C1-C6)fluoroalkyl, and —OR7;

R6 is H or F;

each occurrence of R7 is independently selected from the group consisting of H and —(C1-C6)alkyl;

X is CH or N;
x is an integer from 0-5; and
each occurrence of n is independently 0 or 1.

US Pat. No. 9,799,007

METHOD OF COLLABORATIVE SOFTWARE DEVELOPMENT

Drexel University, Phila...

1. A method of collaboratively developing software, comprising:
(a) recording a plurality of developers' tasks as the tasks occur via software executing on a computer, wherein the tasks
comprise viewing and editing files;

(b) determining an actual score between two tasks via software executing on a computer, wherein the actual score is determined
by a weight comprising: a high amount of weight comprising 1 when a common file is edited in both tasks, a low amount of weight
comprising 0.59 when the common file is viewed in both tasks, and a middle amount of weight comprising 0.79 when the common
file is viewed in one task and edited in the other task;

(c) calculating a score between the two tasks via software executing on a computer by dividing the actual score by a maximum
potential score to produce a ratio, wherein the maximum potential score is a union of files between the two tasks that have
been edited and/or viewed; and

(d) determining the developers of the two tasks need to coordinate if the score exceeds a threshold score.

US Pat. No. 9,729,765

MOBILE VIRTUAL CINEMATOGRAPHY SYSTEM

Drexel University, Phila...

1. A virtual cinematography system (SmartVCS) comprising:
a first mobile tablet device including a touch-sensor screen, a first hand control, a second hand control, and a motion sensor;
a motion tracking camera configured to track and record movements of the motion sensor and generate motion tracking information
to navigate a virtual camera; and

a computer operatively coupled to the motion tracking camera that is configured to receive from the motion tracking camera
data of the motion tracking information and transmit the data to the first mobile tablet device; and

wherein the first mobile tablet device is configured to generate and overlay virtual camera images based on the motion tracking
information data onto a virtual landscape and produce a virtual motion capture.

US Pat. No. 9,725,693

THREE-DIMENSIONAL SCAFFOLDS FOR TISSUE ENGINEERING MADE BY PROCESSING COMPLEX EXTRACTS OF NATURAL EXTRACELLULAR MATRICES

Drexel University, Phila...

1. A method of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of
a cell, the method comprising:
providing an unfractionated extracellular matrix extract from a mammalian tissue in a form selected from the group consisting
of a powder, a solution, a hydrogel and a suspension;

placing the unfractionated extracellular matrix extract in a mold;
freezing the unfractionated extra cellular matrix extract at 0° C. or below at a controlled freezing rate of less than about
1° C./min;

freeze-drying the unfractionated extra cellular matrix extract by subjecting the unfractionated extracellular matrix extract
to a temperature between about ?130° C. and about ?80° C. for a time sufficient to remove at least 90% of a liquid from the
unfractionated extracellular matrix extract and thereby obtaining a lyophilized unfractionated extracellular matrix extract;
and

optionally crosslinking the lyophilized unfractionated extracellular matrix extract by contacting with a crosslinker and thereby
providing the biologically active three-dimensional scaffold having porous morphology.

US Pat. No. 9,752,932

TUNABLE ELECTRO-OPTIC FILTER STACK

Drexel University, Phila...

1. A hyperspectral imaging system comprising:
a hyperspectral imager that includes a holographic polymer dispersed liquid crystal (HPDLC) tunable optical filter through
which light passes, the hyperspectral imager configured to acquire and spectrally multiplex hyperspectral imaging data, wherein:

the HPDLC tunable optical filter comprises a stacked assembly of two or more HPDLC thin film elements, each HPDLC thin film
element being switchable between a light reflecting state and a transparent or semitransparent state with a switching time
of no more than twenty microseconds; and

each HPDLC thin film element, when in its light reflecting state, reflects a different Bragg wavelength than the other HPDLC
thin film elements such that when exposed to incident light and in its respective reflecting state, each HPDLC thin film element
allows a different spectrum of incident light to be transmitted through the stack,

the collective sets of spectra of incident light from the plurality of HPDLC thin film elements being the hyperspectral imaging
data.

US Pat. No. 10,307,406

METHODS AND COMPOSITIONS FOR RE-ACTIVATING EPSTEIN-BARR VIRUS AND SCREENING COMPOUNDS THEREFOR

The Wistar Institute of A...

1. A method for reactivating latent Epstein-Barr virus (EBV) in a cell, said method comprising administering a compound of the formula to a subject in need thereof:wherein:R1 is H, C1 to C6 alkyl, C1 to C6 alkoxy, or halogen;
R2 is H, C1 to C6 alkyl, or C1 to C6 alkoxy;
R3 is a phenyl group substituted on the C in its second position with —C(O)OCH3;
R4 is H or optionally substituted C1 to C6 alkyl;
R5 to R11 are, independently, selected from the group consisting of H and C1 to C6 alkyl; and
R13 is H, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable acid salt or base salt or prodrug thereof.

US Pat. No. 10,073,020

MODULAR LIGHT GAS ACCELERATOR

Drexel University, Phila...

1. A modular light gas accelerator comprising:a first stage including:
a chamber having a rear portion and a discharge portion;
a barrel located inside the chamber, the barrel having a rear port at the rear portion of the chamber and a discharge port extending outwardly from the discharge portion of the chamber; and
a piston slidingly located inside the barrel proximate to the rear port and adapted to be propelled through the barrel and out of the discharge port;
and
a second stage removably attached to the discharge end of the first stage, the second stage including:
a receiver adapted to receive the piston from the discharge port, the receiver having a receiver passage having a first upstream diameter and a second downstream diameter, smaller than the first upstream diameter;
a frangible member extending across the second downstream diameter;
a projectile located downstream of the frangible member, the projectile being adapted to travel along the receiver passage; and
a target chamber located at a downstream end of the receiver passage, such that a target is able to be mounted in the target chamber and be struck by the projectile after the projectile exits the receiver passage.

US Pat. No. 10,053,529

RENEWABLE BIO-BASED (METH)ACRYLATED MONOMERS AS VINYL ESTER CROSS-LINKERS

Drexel University, Phila...

1. A method of making a polymer comprising the step of curing a composition comprising at least one polymerizable monomer selected from the group consisting of:

US Pat. No. 10,038,240

WIDE BAND RECONFIGURABLE PLANAR ANTENNA WITH OMNIDIRECTIONAL AND DIRECTIONAL RADIATION PATTERNS

Drexel University, Phila...

1. A planar reconfigurable antenna capable of generating omnidirectional and directional radiation patterns over a wide frequency band or over multiple frequency bands, comprising:a substrate;
a plurality of conductive elements on respective sides of said substrate, wherein each of said conductive elements is a wideband or multiband radiating element;
a common RF feed point; and
respective switches between said conductive elements and said RF feed point that selectively connect all of said conductive elements on said respective sides of said substrate to said common RF feed point for generation of an omnidirectional radiation pattern and that selectively connect pairs of less than all of said conductive elements on said respective sides of said substrate to said common RF feed point for generation of a directional radiation pattern,
wherein conductive elements are configured such that conductive elements that are not connected to said common RF feed point act as a reflector for other conductive elements that are connected to said common RF feed point, and
wherein said conductive elements are arranged on said substrate such that the contributions of radiation from each of said conductive elements when all of said conductive elements are directly connected to the common RF feed point form a radiation structure resembling an Alford loop antenna and sum up to generate said omnidirectional radiation pattern in an azimuth plane.

US Pat. No. 9,996,644

SOLVER FOR HARDWARE BASED COMPUTING

DREXEL UNIVERSITY, Phila...

13. A system for emulating power flow in a power transmission system, which comprises:a power supply;
a variable resistor including at least one reconfigurable operational transconductance amplifier operably connected to said power supply;
a device for measuring a current or voltage output of said system; and
a DC network emulation of a power system bus k of the power transmission system, said power system bus k having complex voltage values and being represented by four networks with four buses KI, KII, KIII and KIV as equivalents and for feasible bus voltages the following conditions of equation (16) are satisfied:

US Pat. No. 9,965,656

METHODS AND APPARATUS FOR COMPUTER-AIDED TISSUE ENGINEERING FOR MODELING, DESIGN AND FREEFORM FABRICATION OF TISSUE SCAFFOLDS, CONSTRUCTS, AND DEVICES

Drexel University, Phila...

1. A method for multi-nozzle biopolymer deposition of heterogeneous materials to create or modify a composite biopolymer multi-part three-dimensional assembly having at least one biomimetic and at least one non-biomimetic feature, the method comprising:(a) utilizing a CAD environment to design and/or modify a composite multi-part assembly, thereby producing a CAD design;
(b) converting the CAD design into a three-dimensional heterogeneous material and multi-part assembly model in a format suitable for three-dimensional, multi-nozzle printing, wherein the design comprises at least one biomimetic feature and at least one non-biomimetic feature; and
(c) printing the composite assembly by simultaneously depositing the heterogeneous materials using multiple, different, specialized nozzles, wherein the simultaneous depositing includes direct deposition of cells and biological factors.

US Pat. No. 9,899,516

ENGINEERED FERROELECTRIC GATE DEVICES

DREXEL UNIVERSITY, Phila...

1. A ferroelectric gate device for a field effect transistor comprising a compositionally graded ferroelectric film including
a ferroelectric material having a formula of:
A(1-y)A?yB(1-x)B?xO3,
wherein A and A? each represent an element independently selected from lanthanides, alkaline earth metals, and alkali metals,
B and B? each represent an independently selected transition metal, x is in the range of from 0 to 1, and y is in the range
of from 0 to 1, and
the ferroelectric material has a composition gradient along a thickness of the ferroelectric film with x decreasing from one
side to another side of the ferroelectric film.

US Pat. No. 9,885,049

MODULATION OF PRE-MRNA USING SPLICE MODULATING OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS IN THE TREATMENT OF DISEASE

Drexel University, Phila...

1. A composition comprising a splice modulating oligonucleotide (SMO) that specifically binds a complementary sequence of
a pre-mRNA that undergoes exon 3 or exon 11 splicing to form a mRNA encoding HER3, wherein said SMO is selected from at least
one of SEQ ID NOs: 729 through 813, or a sequence having at least 90% identity over the full sequence of any of SEQ ID NOs:
729 through 813,wherein at least one nucleotide in said SMO contains a non-naturally occurring modification.

US Pat. No. 9,889,102

SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME

Drexel University, Phila...

1. A compound of Formula (II):
RA—RB  (II),
wherein:
RA is selected from the group consisting of


X4 is selected from the group consisting of —OCH3, F, Cl, Br, and I; and

RB is selected from the group consisting of:

or a salt, solvate, or N-oxide thereof; and any combinations thereof.
US Pat. No. 10,122,001

POLYMERIZED IONIC LIQUID BLOCK COPOLYMERS AS BATTERY MEMBRANES

Drexel University, Phila...

1. A lithium ion transport medium comprising a block copolymer comprising a first and second block, wherein(a) the first block comprises a polymerized styrene or vinylpyridine derivative; and
(b) the second block comprises:
(i) a polymerized ionic liquid comprising a tethered ionic liquid cation and a mobile anion; and
(ii) a lithium ion salt of said mobile anion;
wherein the cation of the polymerized ionic liquid is tethered to the polymer backbone by a carboalkoxy, carboxylato, carboxyamino, or ether linkage; and wherein said block copolymer exhibits at least one region of nanophase separation.

US Pat. No. 10,014,585

MINIATURIZED RECONFIGURABLE CRLH METAMATERIAL LEAKY-WAVE ANTENNA USING COMPLEMENTARY SPLIT-RING RESONATORS

Drexel University, Phila...

1. A device comprising:a reconfigurable leaky-wave antenna comprising a plurality of cascaded metamaterial unit cells where each unit cell has a complementary resonator in its ground plane, and adjustable varactor diodes that are biased to change a propagation constant through the plurality of cascaded metamaterial unit cells so that a directive beam from the reconfigurable leaky-wave antenna can be steered around an azimuth plane,
wherein each of the plurality of cascaded metamaterial unit cells comprises a shunt component, wherein the shunt component comprises a first varactor diode in series with a shunt stub.

US Pat. No. 10,694,526

ADAPTIVE PURSUIT LEARNING METHOD TO MITIGATE SMALL-CELL INTERFERENCE THROUGH DIRECTIONALITY

Drexel University, Phila...

1. A method for avoiding interference for a communication link, comprising:synchronizing a common time base between a transmitting node and a receiving node, wherein the transmitting node and the receiving node receive and transmit using directional antennas;
based on the synchronizing of the common time base, sending a link schedule to a client of the transmitting node, wherein the link schedule is for scheduling concurrent directional channel access;
responsive to the sending of the link schedule to the client, receiving an acknowledgment message from the client, wherein the acknowledgment message comprises pursuit statistics of the client, wherein the pursuit statistics comprise a reward metric or selection count; and
coordinating directional transmissions between the transmitting node and the receiving node based on the acknowledgement message.

US Pat. No. 10,433,970

PROSTHETIC ANKLE

DREXEL UNIVERSITY, Phila...

1. A prosthetic ankle comprising:a tibial component having a top surface for location adjacent to a tibia and a bottom surface; and
a talar component having a bottom surface for location adjacent to a talus, and a top surface having:
(a) a convex curvature relative to a location above the top surface, in an anterior to posterior direction as viewed in a sagittal plane cross-section, and
(b) a concave curvature relative to a location above the top surface, in a medial to lateral direction as viewed in a frontal plane cross-section, and
wherein an axis of a cone projected with the cone's apex pointing in a substantially lateral direction based on medial and lateral circles located in medial and lateral sagittal plane cross-sections of the talar component which approximate the average radius of curvature of the top surface of the talar component as viewed in medial and lateral sagittal plane cross-sections, has a total offset angle from the lateral direction in the range of 0° to 45°.
US Pat. No. 10,253,135

TOUGHENING OF ANHYDRIDE CURED THERMOSETTING EPOXY POLYMERS USING GRAFTED TRIGLYCERIDES

DREXEL UNIVERSITY, Phila...

1. An epoxy thermoset prepared by reaction of:(a) a grafted triglyceride prepared by grafting at least one acid anhydride moiety onto an epoxidized triglyceride, wherein the acid anhydride contains from about 4 to about 40 carbon atoms per molecule;
(b) an epoxy resin; and
(c) an anhydride curing agent, wherein the weight ratio of the grafted triglyceride to the epoxy resin is in the range of about 1:99 to about 99:1, and wherein phase separation of the grafted triglycerides from the epoxy resin occurs during curing.

US Pat. No. 10,121,712

ACCELERATED FAILURE TEST OF COUPLED DEVICE STRUCTURES UNDER DIRECT CURRENT BIAS

DREXEL UNIVERSITY, Phila...

1. A method of conducting a reliability test on a device having a layered structure and at least two electrodes the method comprising the steps of:locating an electron transparent cross-sectional portion of the device in a holder to form an electrical circuit including the cross-sectional portion of the device via portions of at least two electrodes in the cross-sectional portion of the device;
transmitting a direct current bias voltage from the holder to the cross-sectional portion of the device via the at least two electrodes of the device; and
observing and quantifying the microstructural changes of the cross-sectional portion of the device located in the holder
depositing a protection layer on a surface on the device where the electrodes are located;
drilling holes through the protection layer to access each of the electrodes;
depositing a conductive material in the drilled holes to form protruding outreach electrodes for the device; and
removing an electron transparent cross-sectional portion of an area of interest in the device including at least a portion of two of said electrodes and corresponding protruding outreach electrodes.
US Pat. No. 10,082,512

DIAGNOSIS OF LIVER PATHOLOGY THROUGH ASSESSMENT OF PROTEIN GLYCOSYLATION

Drexel University, Phila...

1. A kit for assessing the pathological status of a liver in a subject suspected of having a liver pathology comprising:a deglycosylated capture reagent for isolating from a biological fluid a protein selected from GP73, HBsAg, hepatitis B viral particle, alpha-1-antichymotrypsin, alpha-1-antichymotrypsin His-Pro-less, Ceruloplasmin, alpha-2-macroglobulin, Haptoglobin, Fibrinogen gamma chain precursor, APO-D, Kininogen, Histidine rich glycoprotein, Complement factor 1 precursor, complement factor I heavy chain, complement factor I light chain, Complement C1s, Complement factor B precursor, complement factor B Ba fragment, Complement factor B Bb fragment, Complement C3 precursor, Complement C3 beta chain, Complement C3 alpha chain, C3a anaphylatoxin, Complement, C3b alpha? chain, Complement C3c fragment, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C5, Complement C5 beta chain, Complement C5 alpha chain, C5a anaphylatoxin, Complement C5 alpha? chain, Complement C7, alpha-1 B glycoprotein, Vitamin D-binding protein, Inter-alpha-trypsin inhibitor heavy chain H2, Alpha-1B-glycoprotein, Angiotensinogen precursor, Angiotensin-1, Angiotensin-2, Angiotensin-3, GARP protein, beta-2-glycoprotein, Clusterin (Apo J), Integrin alpha-8 precursor glycoprotein, Integrin alpha-8 heavy chain, Integrin alpha-8 light chain, hepatitis C viral particle, elf-5, HSP33-homolog, lysyl endopeptidase or Leucine-rich repeat-containing protein 32 precursor, wherein said capture reagent for isolating said protein is specific to said protein;
a reagent that binds to core fucosyl moieties on said isolated protein, wherein the binding of said reagent is determinative as to the presence of a core fucosyl moiety on said protein;
a detection reagent for detecting the reagent bound to the fucosyl moieties to provide a detected core fucosylation value, and instructions for using the kit in a method for assessing the pathological status of the liver by comparing the detected core fucosylation value with a reference value for core fucosylation on said protein in a comparable biological fluid of subjects without said liver pathology, said detected core fucosylation value relative to the reference value being indicative of the presence or absence of said liver pathology, wherein a detected core fucosylation value that deviates from said reference value to a statistically significant degree is indicative of the presence of said liver pathology,
or
comparing the detected core fucosylation value with a reference value for core fucosylation on said protein in a comparable biological fluid of subjects in which said liver pathology is known to be present, said detected core fucosylation value relative to the reference value being indicative of the presence or absence of said liver pathology, wherein a detected core fucosylation value that deviates from said reference value to a statistically significant degree is indicative of the absence of said liver pathology.

US Pat. No. 10,543,180

D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE

Drexel University, Phila...

1. A pharmaceutical composition comprising at least one pharmaceutically acceptable carrier and at least one compound of formula (I):wherein:R1 is selected from the group consisting of H, F, Cl, Br, and I, wherein R1 is ortho to the

 substituent;
R2 is selected from the group consisting of H and F, wherein R2 is para to the

 substituent;
with the proviso that R1 and R2 are not simultaneously H;
R3 is selected from the group consisting of H, cyano, F, Cl, Br, I, C1-6 alkyl, heteroalkyl, carboxy, alkylcarboxy, formyl, and alkyl-carbonyl;
R4 is selected from the group consisting of H and C1-3 alkyl;
R5 is selected from the group consisting of C1-3 alkyl, C1-3 alkyl substituted with at least one selected from the group consisting of —OH and C1-C3 alkoxy, and heteroalkyl; and,
n is 2;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,197,565

PIEZOELECTRIC PLATE SENSOR AND USES THEREOF

DREXEL UNIVERSITY, Phila...

8. An insulated piezoelectric plate sensor comprising a piezoelectric layer and an insulating layer, wherein said insulated piezoelectric plate sensor is made by a method comprising:contacting the piezoelectric plate sensor with a mercaptopropyltrimethoxysilane solution having a concentration of from about 0.01 v/v % to about 0.5 v/v % and an amount of water of from about 0.1 v/v % to about 1 v/v % at pH from about 8 to about 10 for a time period of from about 8 to about 150 hours to produce a piezoelectric plate sensor having an insulation layer thereon, and
wherein the piezoelectric layer comprises a piezoelectric material with a ?d31 coefficient of from about 20 pm/V to about 5000 pm/V.

US Pat. No. 10,178,124

RECONFIGURABLE ANTENNA BASED SOLUTIONS FOR DEVICE AUTHENTICATION AND INTRUSION DETECTION IN WIRELESS NETWORKS

Drexel University, Phila...

1. A method of detecting intrusion into a wireless transmission between a transmitter and a receiver in a communication system using at least one multi-mode reconfigurable antenna, comprising:at a physical layer of the multi-mode reconfigurable antenna, determining wireless channel information between said transmitter and receiver for different antenna modes of said at least one multi-mode reconfigurable antenna;
determining, based on the wireless channel information for the different antenna modes, a likelihood ratio function associated with the wireless channel information, wherein the likelihood ratio function comprises an estimate of cumulative wireless channel information between the transmitter and receiver;
determining a threshold for the likelihood ratio function based at least on a maximum value generated by applying a generalized likelihood ratio test to a sequence of channel estimate values generated during an initial training period of the transmitter;
determining, via use of the generalized likelihood ratio test, if the likelihood ratio function exceeds the predetermined threshold during the wireless transmission; and
generating an alarm when the predetermined threshold is exceeded, said exceeding being representative of an intrusion.

US Pat. No. 10,499,838

NON-INVASIVE BRAIN WATER MONITORING DEVICE FOR CEREBRAL EDEMA AND CEREBRAL AUTOREGULATION MONITORING SYSTEM AND METHOD

Drexel University, Phila...

1. A portable, point-of-care, near-infrared-based imaging device for quantitatively monitoring and evaluating changes in water and hemoglobin content in a patient's brain, comprising:a pair of separate and identical probes, one of said probes being adapted for non-invasive placement against a left side of a forehead of a patient and the other one of said probes being adapted for separate non-invasive placement against a right side of the forehead of the patient, each of said probes having a light emitting diode (LED) light source mounted thereon for separately and sequentially irradiating light at three different pre-determined wavelengths between 600 and 1100 nm, each of said probes having a pair of photo detectors mounted thereon at different predetermined distances from said light source for measuring an amount of light reflected during irradiation of light at each wavelength, and each of said probes having a temperature sensor mounted thereon; and
at least one electronic processing unit for receiving measurements from said probes of light reflected for each of the wavelengths and temperature and for using the measurements to determine a change in water content, a change in oxygenated hemoglobin, and a change of deoxygenated hemoglobin separately for each of the right and left hemispheres of the patient's brain;
wherein each of said probes includes a flexible circuit board able to flex to match a contour of a patient's forehead, a cushioning material covering the flexible circuit board, and an adhesive for securing the probe in a non-invasive manner on the patient's forehead;
wherein the three different predetermined wavelengths include a wavelength of 730 nm for use in determining changes in deoxygenated hemoglobin content, a wavelength of 850 nm for use in determining changes in oxygenated hemoglobin content, and a wavelength of 940 or 960 nm for use in determining changes in water content;
wherein said at least one electronic processing unit is configured to control operation of the light sources such that light is emitted at only one wavelength at a time and such that light is emitted at each of the three wavelenghts in a sequential manner;
wherein said at least one electronic processing unit is configured to apply a modified Beer-Lambert law (MBLL) algorithm to determine relative changes in water, deoxygenated hemoglobin, and oxygenated hemoglobin over time based on changes of optical density detected for each of the three wavelengths;
wherein information of temperature, wavelength of light, light source to photo detector spacing, left and right hemisphere measurements and oxygen saturation is utilized by said algorithm to adjust the determination of relative changes in water, deoxygenated hemoglobin, and oxygenated hemoglobin; and
wherein said at least one electronic processing unit is configured to automatically identify re-positioning movements of the patient's head based on changes in water content, changes in oxygenated hemoglobin content, and changes in deoxygenated hemoglobin content that exceed a pre-determined threshold within a pre-determined amount of time.

US Pat. No. 10,466,784

FINGER-WORN DEVICE WITH COMPLIANT TEXTILE REGIONS

Drexel University, Phila...

1. A wearable device comprising:at least one compliant textile region adapted and configured to be placed over a joint of a subject; and
at least two flexible but less compliant textile regions coupled to opposite ends of the compliant region located on either side of the joint and encircling the joint;
wherein the joint is a finger joint.

US Pat. No. 10,466,096

FIBER OPTIC HYDROPHONE SENSORS AND USES THEREOF

Drexel University, Phila...

1. A system for detecting changes in pressure in an immersion medium or solid, the system comprising:an optical fiber, wherein the optical fiber has a diameter at an immersion surface contact of the optical fiber of less than 10 um; and
a layer of material deposited on a tip of the fiber, wherein the layer of material is of a thickness of from about 2 nm to about 10 nm;
wherein detecting the pressure in the immersion medium or solid is based on the interaction between evanescent electromagnetic fields that exist outside the optical fiber surface and ultrasound waves propagating in the immersion medium or solid.

US Pat. No. 10,466,194

PIEZOELECTRIC BIOCHIPS HAVING FLUIDIC CHANNELS

Drexel University, Phila...

1. A piezoelectric biochip for detecting one or more analytes in a liquid, said piezoelectric biochip comprising a substrate and a plurality of biosensors in fluidic channels, wherein,the substrate comprises:
i) a piezoelectric material,
ii) a substrate top surface and
iii) a substrate bottom surface,
each of said fluidic channels comprises:
i) a top fluidic inlet,
ii a top fluidic outlet,
iii) a top fluidic channel formed in the substrate top surface and having one of the plurality of biosensors therein, and said top fluidic channel is configured to permit said liquid to traverse from the top fluidic inlet to the top fluidic outlet,
iv) a bottom fluidic inlet,
v) a bottom fluidic outlet, and
vi) a bottom well formed in the substrate bottom surface and having one of the plurality of biosensors therein, or a bottom fluidic channel formed in the substrate bottom surface and having one of the plurality of biosensors therein, and said bottom fluidic channel is configured to permit said liquid to traverse from the bottom fluidic inlet to the bottom fluidic outlet, and said bottom fluidic channel, or said bottom well is located below the top fluidic channel between the bottom fluidic inlet and the bottom fluidic outlet; and
the biosensor in the top fluidic channel comprises:
i) a top electrode formed within the top fluidic channel on the substrate top surface and located above the bottom fluidic channel or the bottom well;
ii) a top electrical trace formed on the substrate top surface and traversing from a top-electrode tap to the top electrode; and the biosensor in the bottom well or bottom fluidic channel comprises:
i) a bottom electrode formed within the bottom well or bottom fluidic channel on the substrate bottom surface and located below the top electrode; and
ii) a bottom electrical trace formed on the substrate bottom surface and traversing from a bottom-electrode tap to the bottom electrode, and
wherein the plurality of biosensors have a resonant frequency of at least 50 MHz, and
the top fluidic channel is fluidically isolated from the bottom fluidic channel or the bottom well.

US Pat. No. 10,338,633

SLEW-DRIVEN CLOCK TREE SYNTHESIS

Drexel University, Phila...

1. A system for performing slew-driven clock tree synthesis for selecting a merging point location for a set of existing nodes comprising the steps:pair selection and cost metric definition considering physical distance between nodes for efficient sink clustering;
slew and skew-aware merging point computation for routing; and
slew and insertion slew-aware net splitting;
wherein pair selection, slew and skew-aware merging point computation, and slew and insertion slew-aware net splitting merge pairs of nodes into a new node and the steps are repeated for pairs from the set of nodes and a set of new nodes until the number of nodes from the set of nodes and new nodes equals one node, wherein the one is the merging point location, wherein the repeating of the steps is an iteration.

US Pat. No. 10,251,931

CYCLIC PEPTIDES AND METHODS USING SAME

Drexel University, Phila...

1. A cyclic compound of formula (I), or a salt, solvate, enantiomer, or diastereoisomer thereof:Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-P1  (I),
wherein in (I):
Xaa1 is selected from the group consisting of absent, Glu, and Arg;
Xaa2 is selected from the group consisting of absent, Phe, Asp, Glu, and Ile;
Xaa3 is selected from the group consisting of absent, Asn, Asp, and Glu;
Xaa4 is selected from the group consisting of Asn and Asp;
Xaa5 is a modified glycine of formula (III)
wherein in (III) R is selected from the group consisting of C1-C6 alkyl and C3-C6 cycloalkyl;Xaa6 is the modified proline of formula (IV)
wherein in (IV) R is selected from the group consisting of naphthyl, p-methyl phenyl, p-ethyl phenyl, 2-phenylethyl, 1-adamantyl, 2-adamantyl, and metallocene;Xaa7 is selected from the group consisting of Trp and 3-(3-benzothienyl)-L-alanine;
Xaa8 is selected from the group consisting of 2,4-diaminobutanoic acid, Orn, and Lys;
Xaa9 is selected from the group consisting of absent, 2,4-diaminobutanoic acid, Orn, Lys, Glu, and 2-(2-(2-aminoethoxy)ethoxy)acetic acid;
P1 is absent, or is a group that comprises at least one thiol group and is covalently linked through an amide bond to (i) the C-terminus of Xaa9 if Xaa9 is not absent, or (ii) the C-terminus of Xaa8 if Xaa9 is absent;
the side chain amino group of one residue selected from the group consisting of 2,4-diaminobutanoic acid at Xaa8, Orn at Xaa8, Lys at Xaa8, 2,4-diaminobutanoic acid at Xaa9, Orn at Xaa9, and Lys at Xaa9 forms an amide bond with the side chain carboxylic acid group of one residue selected from the group consisting of Glu at Xaa2, Asp at Xaa2, Glu at Xaa3, Asp at Xaa3 and Asp at Xaa4; and
the C-terminus of Xaa8 is optionally amidated if Xaa9 and P1 are absent, or the C-terminus of Xaa9 is optionally amidated if P1 is absent.

US Pat. No. 10,280,951

ARTICULATING DEVICES

Drexel University, Phila...

1. An articulating device comprising:an inflatable elastic layer; and
a textile shell surrounding or impregnated within at least a portion of the inflatable elastic layer, the textile shell including at least two regions having different material properties or knit patterns, wherein the at least two regions include:
a region of relatively lower elasticity; and
a region of relatively higher elasticity;
wherein the region of higher elasticity includes thinner fibers than the region of lower elasticity;
wherein the textile shell selectively constrains expansion of the inflatable elastic layer to produce controlled bending or torsion.
US Pat. No. 10,214,567

TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES

Drexel University, Phila...

1. A nucleic acid molecule comprising a nucleic acid sequence encoding a tagged hepadnavirus e antigen, wherein the nucleic acid molecule comprises a sequence encoding one or more tags, wherein the sequence is inserted into an epsilon structure as encoded by a hepadnavirus genome, wherein said nucleic acid molecule comprising a sequence encoding the one or more tag is inserted between nucleotides corresponding to position C1902 and position A1903 of the HBV genome, wherein said nucleic acid molecule comprises 5? of the sequence encoding the one or more tag a sequence that is capable of forming base pairs with the lower stem of the epsilon structure as encoded by a hepadnavirus genome and wherein the sequence that is capable of forming base pairs with said lower stem of the epsilon structure as encoded by a hepadnavirus genome is capable of forming base pairs with nucleotides corresponding to positions T1849 to A1854 of the HBV genome.
US Pat. No. 10,202,522

SUPERAMPHIPHOBIC SURFACES AND COMPOSITIONS AND METHODS OF FORMING THE SAME

Drexel University, Phila...

1. A fluid composition comprising:at least one silane having one or more hydrophilic groups;
at least one silane having one or more fluorinated moieties; and
stringed silica nanoparticles.

US Pat. No. 10,172,567

SYSTEM AND METHOD OF DETECTING AND PREDICTING SEIZURES

Drexel University, Phila...

1. A method for preventing a seizure in a subject, comprising:recording single interneuron activity for a plurality of interneurons;
recording local field potential (LFP);
measuring interneuron synchrony;
detecting a specific pattern of interneuron activity and interneuron synchrony comprising:
increased synchrony between interneuron action potentials and theta-wave LFP oscillations, followed by
increased synchrony between interneuron action potentials and gamma-wave LFP oscillations;
wherein detection of the specific pattern of interneuron activity and interneuron synchrony signifies an increased likelihood of a seizure;
wherein detecting the specific pattern of interneuron activity and interneuron synchrony is performed by a system comprising an algorithm; and
wherein the parameters of the algorithm are automatically generated without a human observer; and
administering a therapeutically effective intervention to the subject to prevent the onset of a seizure in response to the detection of the specific pattern.

US Pat. No. 10,544,265

THERMOSET POLYMERS HAVING A TRIAZINE NETWORK OBTAINED BY REACTION OF CYANATE ESTERS WITH DICYANAMIDE ROOM TEMPERATURE IONIC LIQUIDS

DREXEL UNIVERSITY, Phila...

1. A curable composition for preparing a thermoset polymer having a triazine network, said curable composition comprising:(a) a cyanate ester monomer; and
(b) at least one ionic liquid comprising a dicyanamide anion.

US Pat. No. 10,500,407

APPARATUS FOR ATMOSPHERIC PRESSURE PIN-TO-HOLE SPARK DISCHARGE AND USES THEREOF

Drexel University, Phila...

1. A method of treating a biological tissue using non-thermal plasma, comprising:flowing a gas through a cold spark discharge zone simultaneously with the creation of a pulsed spark discharge to give rise to a non-thermal plasma emitted from a conduit, the nonthermal plasma comprising a predetermined concentration of nitric oxide (NO); and
contacting a wound on the biological tissue with said non-thermal plasma for sufficient time and intensity to give rise to healing of the wound;
wherein the cold spark discharge voltage is in the range of 500 V to 5 kV;
wherein the diameter of the non-thermal plasma is in the range of 3 mm to 5 mm;
wherein the duration of the pulsed spark discharge is in the range of from 5 microseconds to 50 microseconds and is pulsed at a frequency in the range of 1 Hz to 30 Hz.

US Pat. No. 10,488,368

INTEGRATION OF DIGITAL IMAGE CORRELATION WITH ACOUSTIC EMISSION

Drexel University, Phila...

1. A nondestructive method of determining the structural integrity and making life fraction predictions of a -specimen as a load is applied to the specimen, the method comprising the steps of:attaching at least one acoustic emission sensor to the specimen;
applying a contrasting pattern on the surface of the specimen;
calibrating a pair of stereoscopic cameras at the contrasting pattern;
passively recording acoustic stress waves propagating in the specimen in an Acoustic Emission (AE) system electronically coupled to the at least one acoustic sensor and generating AE data;
time synchronizing cumulative energy calculated from the AE data with information about the load:
triggering operation of the cameras by the AE system based on changes of the AE data;
adaptively recording data generated by operation of the cameras;
measuring deformation in the specimen based on load-induced movement of the contrasting pattern in a Digital Image Correlation (DIC) system, the DIC system being electronically coupled to the cameras; and
correlating stress waves traveling through the specimen and strain data measured on a surface of the specimen to determine the structural health of the specimen and making a life fraction prediction of the specimen.