US Pat. No. 9,237,864

ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME

DexCom, Inc., San Diego,...

1. A continuous analyte sensor configured for in vivo use, the continuous analyte sensor comprising:
an elongated conductive body comprising a first electrode comprising an electroactive surface, wherein the elongated conductive
body further comprises a second electrode; and

a membrane covering at least a portion of the first electrode;
wherein the continuous analyte sensor has a yield strength at least 60 ksi, wherein the continuous analyte sensor has a fatigue
life of at least 20 cycles of flexing from about 45° to about ?45° at a bend radius of about 0.031-inches.

US Pat. No. 9,386,522

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for transmitting data between a first communication device associated with an analyte sensor and a primary communication
device and a secondary communication device configured to provide user access to analyte values and/or information derived
from analyte values, comprising:
establishing a communication channel between a secondary communication device and a first communication device during a transmission
time window of a sensor session;

determining whether a primary communication device has previously been in communication with the first communication device
during the sensor session; and

rejecting requests for data or commands sent by the secondary communication device to the first communication device if the
primary communication device has not been in communication with the first device during the sensor session; wherein the first
communication device comprises a sensor electronics module, the sensor electronics module configured to electronically couple
to an analyte sensor and to generate an analyte data stream using the analyte sensor, and wherein the sensor session is defined
as a period of time the analyte sensor is in use.

US Pat. No. 9,439,589

DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS

DexCom, Inc., San Diego,...

1. An implantable optical-based continuous glucose sensing system, the system comprising:
an optical sensor configured to measure in vivo a signal indicative of glucose concentration, wherein the optical sensor is
configured to be implanted;

sensor electronics operably connected to the sensor; and
a membrane configured to interface with tissue or a biological fluid; wherein the membrane comprises an outer surface and
an inner surface, wherein the outer surface of the membrane is more distal to the sensor than the inner surface of the membrane,
wherein at least a portion of the outer surface of the membrane comprises metallization.

US Pat. No. 9,060,742

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A system for measuring an analyte in a host, comprising:
an on-skin assembly configured to releasably attach with a sensor electronics housing; and
a flexible sensor comprising at least one electrode, the flexible sensor comprising:
a flexible in vivo portion adapted for insertion through an exit port of the sensor housing and through an exit site of the
host's skin; and

a flexible ex vivo portion adapted to remain above the host's skin after sensor insertion and to operably connect to the sensor
electronics housing,

wherein attachment of the sensor electronics housing to the on-skin assembly causes the ex vivo portion to bend relative to
the in vivo portion at an angle of about 90 degrees to maintain a low profile during use.

US Pat. No. 9,439,602

ALERT SYSTEM FOR HYPO AND HYPERGLYCEMIA PREVENTION BASED ON CLINICAL RISK

DexCom, Inc., San Diego,...

1. A system for communicating glycemic risk to a patient, comprising:
a continuous glucose monitoring device that generates a series of data points indicative of a glucose level in the patient;
and

processing circuitry configured to iteratively:
calculate a glucose level and a rate of change of the glucose level based on the series of data points;
determine a dynamic risk score based a nonlinear transformation that converts the current glucose level and the rate of change
of the current glucose level to a dynamic risk score; and

select a color from a color scale based on the dynamic risk score, the color scale comprising a plurality of colors, each
color indicative of one of a plurality of risk levels of the patient; and

display, on a user interface, the current glucose level, the rate of change, and the color indicative of one of a plurality
of risk levels of the patient so that glycemic risk is communicated.

US Pat. No. 9,439,029

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for wirelessly exchanging glucose information between a first communication device associated with a continuous
glucose sensor and a second communication device associated with a glucose information display device, the method comprising:
exchanging information related to authentication between the first communication device and the second communication device;
wherein the exchange of the authentication information includes determining by the second communication device whether a first
device ID that is transmitted by the first communication device matches a second device ID that is stored at the second communication
device;

opening a time window periodically for communication between the first communication device and the second communication device
at a first rate; detecting an error at the first communication device;

upon the detection of the error, transmitting a request for reference information from the first communication device to the
second communication device and opening the time window between the first communication device and the second communication
device at a second rate, wherein the second rate is faster than the first rate;

receiving by the first communication device the reference information responsive to the request from the second communication
device; and

resuming the opening of the time window at the first rate subsequent to the receipt of the reference information by the first
communication device from the second communication device.

US Pat. No. 9,247,878

CONTINUOUS ANALYTE MONITOR DATA RECORDING DEVICE OPERABLE IN A BLINDED MODE

DexCom, Inc., San Diego,...

1. A method for monitoring a glucose concentration of a host using a continuous glucose sensor, comprising:
generating, using a continuous glucose sensor, a data stream indicative of a host's glucose concentration during a first time
period and a second time period;

processing the data stream to determine a real-time glucose concentration value of the host;
recording, using a mobile computing device, the data stream and/or information derived from or associated with the data stream;
triggering, using the mobile computing device, a real-time hypoglycemia event alarm, wherein the determining of when to trigger
the alarm is based at least in part on comparing the determined real-time glucose concentration to a predetermined hypoglycemia
threshold;

initiating, using the mobile computing device, a first mode wherein display of the real-time glucose concentration values
based on the data stream is disabled by the computing device but triggering the hypoglycemia event alarm is enabled by the
mobile computing device;

initiating a second mode, using the mobile computing device, wherein both display of glucose concentration values based on
the data stream and triggering the hypoglycemia event alarm are enabled by the mobile computing device; and

generating and displaying on a computer display a performance report that user-perceptively distinguishes glucose concentration
values associated with the data stream generated during the first time period from glucose concentration values associated
with the data stream generated during the second time period, wherein the first time period is when the mobile computing device
is in the first mode and wherein the second time period when the mobile computing device is in the second mode.

US Pat. No. 9,446,194

METHODS AND SYSTEMS FOR PROMOTING GLUCOSE MANAGEMENT

DexCom, Inc., San Diego,...

1. A method of rewarding a patient using a continuous glucose monitoring system to encourage taking corrective action, the
method comprising:
automatically generating sensor data using a continuous glucose sensor of the continuous glucose monitoring system while the
continuous glucose sensor is continuously worn by a patient, the sensor data indicative of glucose concentration values of
the patient over time;

processing, using processor circuitry, the sensor data, wherein the processor circuitry is operably connected to the continuous
glucose sensor;

triggering, using the processor circuity, an alarm responsive to the processing;
initiating a timer responsive to the triggered alarm;
modifying, using the processor circuitry, an animated character displayed on a user interface when the processor circuitry
determines that one or more glucose concentration values as indicated by the sensor data satisfies a threshold level and the
timer indicates a time less than a predetermined amount of time has expired from the alarm being triggered, thereby rewarding
the patient based on corrective action taken by the patient.

US Pat. No. 9,339,222

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A system for continuous in vivo measurement of an analyte in a host, the system comprising:
a continuous analyte sensor configured for implantation in a host and configured to generate a signal indicative of an analyte
concentration; and

a layer disposed over at least a portion of the sensor, wherein the layer comprises a particle-containing domain comprising
a metal, wherein the particle-containing domain is configured to react with at least one interfering species.

US Pat. No. 9,247,901

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A method for processing sensor data from a continuous glucose sensor, the method comprising:
receiving continuous glucose sensor data, the continuous glucose sensor data comprising a plurality of sensor data points;
measuring, using a signal reliability module, a reliability of the continuous glucose sensor data, whereby a level of reliability
is obtained;

outputting to a medicament administration device, using an output module, the continuous glucose sensor data and an indication
of the level of reliability of the continuous glucose sensor data, wherein the indication comprises is one or more of a numerical
value and a rating in terms of a percentage; and

administering, using the medicament administration device, medicament to a patient based on the indication of reliability.

US Pat. No. 9,220,449

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

DexCom, Inc., San Diego,...

1. A system for calibrating a continuous analyte sensor, comprising:
a continuous analyte sensor configured to provide sensor data indicative of an analyte concentration in a host; and
electronic circuitry configured to receive sensor data from a continuous analyte sensor comprising at least one sensor data
point indicative of a glucose concentration in a host's interstitial fluid, to receive reference data from a reference analyte
monitor comprising at least one reference data point indicative of a glucose concentration in the host's blood, and to determine
a conversion function for converting the sensor data into estimated blood glucose values based on a most probable set of parameters
based on one or more probability distributions.

US Pat. No. 9,131,885

ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME

DexCom, Inc., San Diego,...

1. A continuous analyte sensor configured for in vivo use, the continuous analyte sensor comprising:
an elongated conductive body comprising a working electrode, wherein the elongated conductive body has a Young's modulus of
from about 170 GPa to about 220 GPa and a yield strength from about 800 MPa to about 3,000 MPa; and

a membrane covering at least a portion of the working electrode, wherein the membrane comprises an enzyme layer.

US Pat. No. 9,345,425

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for processing continuous analyte sensor data, the method comprising:
placing a continuous analyte sensor in a host, wherein a sensor system comprises the sensor and sensor electronics, wherein
the sensor is configured to generate a signal associated with an in vivo analyte concentration when the sensor is implanted
in the host;

exposing the sensor to a biological fluid;
providing a fail-safe module comprising a processor for executing computer program code stored in memory to cause the processor
to:

perform a steady state analysis and a transient analysis of the signal;
evaluate a relationship between the steady state analysis and the transient analysis; and
detect a malfunction of the system based on the relationship.

US Pat. No. 9,339,238

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

DexCom, Inc., San Diego,...

1. A computer-implemented method for classifying a level of noise in a signal obtained from a continuous glucose sensor based
on a signal strength, the method comprising executing on a computing system the steps of:
receiving a signal from a continuous glucose sensor during a sensor session;
determining a level of noise in the signal;
classifying the determined level of noise in the signal into one of a plurality of different predetermined noise classifications
during the sensor session based a plurality of noise ranges; and

controlling an output of information during the sensor session responsive to the noise classification, wherein the information
is selected from the group consisting of rate of change information, alarm information, and medicament delivery information,

wherein the controlling comprises executing instructions to request user interaction, using a user interface of the computing
system, with an insulin delivery system based on the noise classification.

US Pat. No. 9,078,608

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

DexCom, Inc., San Diego,...

1. A system for calibrating an analyte sensor, comprising:
a sensor data receiving module configured to receive sensor data from a first continuous analyte sensor and a second continuous
analyte sensor; and

a processor module in data communication with the sensor data receiving module, the processor module configured to calibrate
the sensor data from the second continuous analyte sensor using the sensor data from the first continuous analyte sensor,

wherein the first continuous analyte sensor and the second continuous analyte sensor are identical transcutaneous sensors.

US Pat. No. 9,247,900

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. An applicator system configured to insert a transcutaneous analyte sensor into a host, the applicator system comprising:
a housing configured for placement against a skin of the host;
a sensor configured for transcutaneous placement through the skin of a host; and
an applicator comprising applicator components, a trigger, a needle and a spring-loaded mechanism configured to insert the
needle and the sensor into the host and subsequently retract the needle from the host, wherein the applicator components rotatingly
engage one another with a continuous torque to insert the sensor into the host and subsequently retract the needle from the
host, wherein the sensor is inserted automatically into the host to a predetermined depth responsive to actuation of the trigger.

US Pat. No. 9,241,631

CONTINUOUS ANALYTE MONITOR DATA RECORDING DEVICE OPERABLE IN A BLINDED MODE

DexCom, Inc., San Diego,...

1. A system for monitoring glucose concentration, the system comprising:
a continuous glucose sensor, the continuous glucose sensor configured to continuously measure glucose a concentration of a
host and output a data stream associated with the glucose concentration; and

a device configured to operatively connect with the continuous glucose sensor, the device comprising at least one processor
configured to process the data stream from the continuous glucose sensor to generate real-time measured glucose concentration
values and store the measure glucose concentration values in memory, and a user interface configured to display the measured
glucose concentration values,

wherein the device is configured for toggling between an unblinded mode allowing for display of real-time glucose concentration
values associated with the continuous glucose sensor on the user interface and a blinded mode preventing display of real-time
glucose concentration values associated with the continuous glucose sensor on the user interface and

a network server configured to generate a computer-displayable performance report that includes a graphical representation
of measured glucose concentration values over time, wherein the report graphically distinguishes glucose values measured during
the unblinded mode from glucose values measured during the blinded mode identifies changes in sensor data over at least two
different time periods, wherein a first time period of the at least two time periods is a time period when the device is in
the blinded mode and wherein a second time period of the at least two time periods is a time period when the device is in
the unblinded mode.

US Pat. No. 9,173,606

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A system for measurement of an analyte concentration, the system comprising:
an implantable sensor comprising a sensing region configured to continuously produce in vivo sensor data indicative of an
analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing region, wherein
the membrane comprises a layer configured to reduce a flux of the analyte therethrough, wherein the layer comprises a material
that is a polymer produced by a reaction of an isocyanate;

a processor configured to process sensor data; and
a user interface configured to display information corresponding to continuous sensor data;
wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy
corresponding to a mean absolute relative difference of less than 10% over a sensor session length of from 3 to 7 days, wherein
one or more reference measurements used to calculate the mean absolute relative difference are determined by analysis of blood.

US Pat. No. 9,149,234

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for calibration of a continuous glucose sensor, the method comprising:
receiving a signal from a continuous glucose sensor;
determining a sensor performance during a sensor session based on determining an amount of drift on the signal over a period
of time, wherein determining the amount of drift comprises monitoring a change in calibration information;

determining a time in the future when to request reference data responsive to the sensor performance determined, wherein the
time is selected from a plurality of predetermined time periods based on sensor performance; and

displaying an indication on a display device representative of a request to obtain the reference data, wherein the displaying
is responsive to the determined time; and

controlling delivery and/or insulin therapy instructions based on the sensor performance.

US Pat. No. 9,050,413

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. An integrated diabetes management system for selectively switching between fully-automated and semi-automated modes, the
system comprising:
a glucose sensor, wherein the glucose sensor is configured to substantially continuously measure glucose concentration in
a host for a period exceeding one hour, and is configured to output a data stream, including one or more sensor data points;
and

a processor module operably connected to the glucose sensor, wherein the processor module that receives the data stream calculates
a therapy comprising instructions for administration of a medicament and sends the instructions to a medicament delivery device,
wherein the processor module operates the integrated system in a fully-automated mode unless a semi-automated mode is triggered,
wherein the fully automated mode does not require user interaction to send instructions to the medicament delivery device,
wherein the semi-automated mode requires user interaction before sending instructions to the medicament delivery device, and
wherein the semi-automated mode is automatically triggered responsive the processor module detecting a clinical risk.

US Pat. No. 9,320,466

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A sensor system for continuous measurement of a glucose concentration in a host, the sensor system comprising:
a first sensor configured to measure a glucose concentration and generate a first signal, wherein the first sensor has a first
sensitivity to an interferent;

a second sensor configured to measure the glucose concentration and generate a second signal, wherein the second sensor has
a second sensitivity to the interferent, wherein the first sensitivity and the second sensitivity are different; and

sensor electronics configured to determine a glucose concentration value based on at least one of the first signal or the
second signal, wherein the sensor electronics are configured to detect a presence of a level of an interferent, wherein the
sensor electronics are configured to integrate the first signal and the second signal, wherein the sensor electronics are
configured to accord a first weight to the first signal and accord a second weight to the second signal, and wherein a distribution
of the first weight and the second weight determined at least in part by detection of the presence of the level of the interferent.

US Pat. No. 9,078,626

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A transcutaneous system for measuring an analyte concentration in a host, the system comprising:
a mounting unit configured for placement and adherence to a skin of a host prior to sensor use, wherein the mounting unit
is configured to receive an electronics unit, wherein the mounting unit comprises a hinge that allows the mounting unit to
pivot between a first position configured for sensor insertion and a second position configured for sensor use; and

an analyte sensor configured for transcutaneous placement through a skin of a host, wherein the sensor is configured to extend
from the mounting unit into the host.

US Pat. No. 9,457,146

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. An integrated system for managing diabetes, the system comprising:
a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose
concentration in a host, and to provide sensor data associated with the glucose concentration in the host; and

an insulin delivery device configured to deliver insulin to the host as determined by a controller module, wherein the controller
module is configured to:

continuously instruct the basal insulin therapy at a pre-programmed insulin delivery rate responsive to the sensor data meeting
one or more predetermined basal criteria;

adaptively calculate a bolus insulin therapy responsive to the sensor data meeting a present or predicted hyperglycemic glucose
value or range of values, wherein the bolus insulin therapy is calculated based on the sensor data; and

immediately terminate insulin therapy responsive to the sensor data meeting one or more predetermined off criteria.

US Pat. No. 9,364,173

SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for processing sensor data from a continuous analyte sensor, comprising:
receiving sensor data from a continuous analyte sensor for a first time period, wherein the sensor data comprises at least
one sensor data point;

processing, using one or more processors, the at least one sensor data point to obtain a range of target analyte values for
a future time period; and

providing, using the one or more processors, output, wherein providing output comprises the one or more processors selecting
whether or not to display an object representative of the range of target analyte values on a user interface based at least
in part on a variability analysis of the sensor data using the one or more processor.

US Pat. No. 9,328,371

SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES

DexCom, Inc., San Diego,...

1. An implantable continuous glucose sensor system configured for implantation in a host, the system comprising:
an electrode comprising an electroactive surface, wherein the electrode is configured for implantation and is configured to
generate in vivo a signal indicative of glucose concentration in a host;

a membrane comprising:
a first domain configured to reduce a flux of glucose therethrough;
a second domain comprising an enzyme configured to react with glucose to produce a measured species, wherein the second domain
is located less distant to the electroactive surface than the first domain; and

a third domain comprising an architecture that permits access to the electroactive surface only for species that have a molecular
weight less than or about equal to a molecular weight of the measured species, wherein the third domain is located less distant
to the electroactive surface than the second domain; and

sensor electronics operably connected to the electrode and configured to measure the signal from the electrode.

US Pat. No. 9,119,528

SYSTEMS AND METHODS FOR PROVIDING SENSITIVE AND SPECIFIC ALARMS

DexCom, Inc., San Diego,...

1. A method of activating a hypoglycemic indicator based on continuous glucose sensor data, the method comprising:
evaluating sensor data using a first function to determine whether a real time glucose value meets one or more user settable
first criteria;

evaluating sensor data using a second function to determine whether a predicted glucose value meets one or more non user settable
second criteria;

activating a hypoglycemic indicator if either the one or more user settable first criteria or the one or more non user settable
second criteria are met; and

providing an output based on the activated hypoglycemic indicator.

US Pat. No. 9,119,529

SYSTEMS AND METHODS FOR DYNAMICALLY AND INTELLIGENTLY MONITORING A HOST'S GLYCEMIC CONDITION AFTER AN ALERT IS TRIGGERED

DexCom, Inc., San Diego,...

1. A method of transitioning between states associated with a host's glycemic condition, the method comprising:
evaluating sensor data from a continuous glucose sensor and activating an alert state based on the sensor data meeting one
or more active transition criteria associated with a hypoglycemic condition or hyperglycemic condition;

providing an output associated with the active alert state, wherein the output is indicative of the hypoglycemic condition
or hyperglycemic condition;

transitioning from the active state to an acknowledged state for a time period responsive to at least one of a user acknowledgment
of the alert state or data indicative of the host's glucose trending toward euglycemia;

actively monitoring data associated with the host's hypoglycemic or hyperglycemic condition for a time period in the acknowledged
state; and

transitioning from the acknowledged state to the inactive state responsive to receiving insulin data and/or meal information.

US Pat. No. 9,498,165

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for displaying glucose information to a user using a hand-held computing device, comprising:
displaying on a touch-sensitive display of a computing device a glucose chart including a trend line indicative of a glucose
level of a host over a first time period;

displaying one or more event indicators on the chart, each event indicator positioned on the chart to indicate when an associated
event occurred in time, wherein the associated event includes one or more of a calibration reference event, an insulin delivery
event, a meal event, an activity event, a sleep event, or an illness event, and wherein displaying the one or more event indicators
includes presenting an icon illustrative of the associated event proximate to the trend line of the glucose chart corresponding
to the particular point in time; and

changing the time period of the chart from the first time period to a second, different time period, wherein changing the
time period causes the event indicators to move on the chart so that the one or more event indicators continue to indicate
when the associated event occurred in time.

US Pat. No. 9,463,277

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to a host, comprising:
a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose
concentration in a host, and to provide sensor data associated with the glucose concentration in the host;

an electronics module comprising:
a basal controller module configured to iteratively determine a basal insulin therapy instruction in response to an evaluation
of a relationship of internally derived data and a basal profile, wherein the basal profile comprises at least one time block
associated with a maximum insulin delivery rate,

a bolus controller module configured to iteratively determine a bolus insulin therapy instruction in response to an evaluation
of a relationship of internally derived data and an engageable bolus constraint, wherein a relationship of internally derived
data to the bolus constraint is evaluated in response to engagement of the bolus constraint, and wherein the bolus constraint
comprises a maximum total insulin dose that can be delivered within a predefined time period in response to engagement of
the bolus constraint, and

an on/off controller module configured to iteratively determine an on/off insulin therapy instruction in response to an evaluation
of a relationship of internally derived data and a glucose boundary, wherein the insulin therapy instruction comprises an
instruction selected from the group consisting of on and off; and

an insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one
of physically connected to a receiver and operably connected to a receiver, wherein the insulin delivery device is configured
to receive the insulin therapy instruction from the basal controller module, the bolus controller and/or the on/off controller
module.

US Pat. No. 9,414,777

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. An analyte measuring system, the system comprising:
a mounting unit comprising a first side adapted for mounting on the skin of a host and a second side, opposing the first side,
wherein the second side comprises an opening, and wherein the mounting unit comprises electrical contacts;

an electronics unit detachably connectable to the opening in the second side of the mounting unit, wherein the electronics
unit comprises electrical contacts;

a sensor for measuring a level of the analyte comprising an in vivo portion configured for insertion through the skin at an
exit site of the host and an ex vivo portion comprising electrode terminals configured for operable connection to the electrical
contacts of the electronics unit via the electrical contacts of the mounting unit, whereby the sensor is operably connected
to the electronics unit when the electronics unit is detachably connected to the mounting unit; and

an elastomeric sealing member that fits in the opening on the second side of the mounting unit and is configured to protect
the electrical contacts of the mounting unit from moisture, wherein the elastomeric sealing member is non-conductive.

US Pat. No. 9,282,925

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A method for processing sensor data from a continuous glucose sensor, the method comprising:
receiving data at an electronics unit from a continuous glucose sensor indicative of a host's glucose concentration;
determining, using a signal reliability module operating on a processor in the electronics unit, a level of reliability of
the continuous glucose sensor based on the data received from the continuous glucose sensor, wherein the level of reliability
is selected by the processor from three or more predetermined reliability levels stored in a memory in the electronics unit;
and

controlling the administration of a medicament, using a medicament administration device, based on the level of reliability.

US Pat. No. 9,173,607

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A device for continuous measurement of an analyte concentration, the device comprising:
a sensing mechanism configured to continuously measure a signal associated with an analyte concentration in a host; and
a membrane located over the sensing mechanism;
wherein the device is configured to provide, at analyte concentrations of from about 40 mg/dL to about 80 mg/dL, a level of
accuracy of a mean absolute relative difference of no more than about 10% over a sensor session of at least about 3 days,
wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined
by analysis of blood; and

wherein the device is configured to provide, at analyte concentrations of from about 40 mg/dL to about 400 mg/dL, a level
of accuracy of a mean absolute relative difference of no more than about 10% over the sensor session, wherein one or more
reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of
blood.

US Pat. No. 9,149,220

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

DexCom, Inc., San Diego,...

1. A method for determining whether an analyte sensor system is functioning properly, the method comprising:
applying a stimulus signal to the analyte sensor;
measuring a response to the stimulus signal;
estimating a value of a sensor property based on the signal response;
correlating the sensor property value with a predetermined relationship of the sensor property and a sensor sensitivity profile,
the sensor sensitivity profile representative of a predicted change in sensitivity of the analyte sensor over time; and

initiating an error routine if the correlation does not exceed a predetermined correlation threshold.

US Pat. No. 9,357,951

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A sensor device for measuring an analyte concentration, the sensor device comprising:
a sensor unit configured for direct press insertion, wherein the sensor unit comprises an in vivo portion comprising a sensor
body and a tissue piercing element configured to pierce a skin of a host to open and define a passage for insertion of the
sensor body, wherein the sensor body and the tissue piercing element form a unitary piece, wherein the sensor body comprises
at least one electrode, wherein the sensor body further comprises a membrane covering at least a portion of the at least one
electrode;

an on-skin unit configured to support the sensor on an exterior surface of a host's skin, wherein the on-skin unit is configured
to receive a pressure from a user for insertion of the sensor unit through the skin; and

a skin tensioner configured to stretch the skin surface to create tension thereto sufficient to permit needle-less sensor
insertion.

US Pat. No. 9,211,092

END OF LIFE DETECTION FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A system for determining an end of life of a continuous analyte sensor, the system comprising sensor electronics configured
to be operably connected to a continuous analyte sensor, the sensor electronics configured to:
evaluate a plurality of risk factors associated with end of life symptoms of a sensor;
determine an end of life status of the sensor based on the evaluation of the plurality of risk factors; and
provide an output related to the end of life status of the sensor,
wherein the plurality of risk factors comprise at least two risk factors selected from the group consisting of a number of
days the sensor has been in use a rate of change of sensor sensitivity, end of life noise, oxygen concentration, glucose patterns,
error between reference values and sensor values in clinical units, wherein one of the at least two risk factors comprises
a rate of change of sensor sensitivity, and wherein the sensor electronics are configured to evaluate a rate of change of
sensor sensitivity by evaluating at least one of a direction of rate of change of sensor sensitivity, an amplitude of rate
of change of sensor sensitivity, a derivative of rate of change of sensor sensitivity, or a comparison of the rate of change
of sensor sensitivity to a priori rate of change sensitivity information.

US Pat. No. 9,155,496

LOW OXYGEN IN VIVO ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A transcutaneous glucose monitoring system comprising:
an in vivo portion and an ex vivo portion;
wherein the in vivo portion comprises:
an implantable body comprising an electrode configured to measure a glucose level in a host;
a membrane disposed over the electrode and configured to limit transport of glucose to the electrode, wherein the membrane
comprises polyurethaneurea, wherein the membrane is configured to provide the system with substantial linearity at glucose
concentration of up to 400 mg/dL at an oxygen concentration of 0.45 mg/L;

a layer comprising an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid surrounding the
membrane; and

wherein the ex vivo portion comprises a sensor electronics unit operably connected to the electrode and configured to measure
a current produced by the electrode.

US Pat. No. 9,351,668

SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

11. A device for processing continuous glucose sensor data, the device comprising:
a housing;
a receiver configured for receiving sensor data from a continuous glucose sensor;
a processor; and
a non-transitory computer readable memory comprising:
instructions configured to cause the processor to process sensor data received from the continuous glucose sensor for a first
time period so as to generate real-time glucose readings from the sensor data for the first time period;

instructions configured to cause the processor to detect an approaching clinical risk based at least in part on an acceleration
determined from the sensor data and to determine a first possibility of avoiding the approaching clinical risk;

instructions configured to cause the processor to wait a predetermined amount of time to determine a second possibility of
avoiding the detected clinical risk when the first possibility meets a criterion; and

instructions configured to cause the processor to activate an alarm when the first or second possibility meets a second, different
criterion.

US Pat. No. 9,351,677

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

DexCom, Inc., San Diego,...

1. An implantable electrochemical sensor for measuring an analyte concentration in a host, comprising:
a working electrode configured to measure a concentration of an analyte; and
a silver/silver chloride reference electrode, wherein at least a portion of the silver/silver chloride reference electrode
is covered with an enzyme layer, wherein the enzyme layer is configured, in vivo, to generate hydrogen peroxide upon exposure
to a substrate, whereby the hydrogen peroxide regenerates silver chloride of the reference electrode such that a reference
capacity of the reference electrode is increased.

US Pat. No. 9,336,353

SYSTEMS AND METHODS FOR COMMUNICATING SENSOR DATA BETWEEN COMMUNICATION DEVICES OF A GLUCOSE MONITORING SYSTEM

DexCom, Inc., San Diego,...

1. A method for configuring alert settings of a glucose monitoring system, comprising:
providing a receiver module having a set of configurable alert settings, wherein each of the set of configurable alert settings
is initially set to a first, default setting configuration;

coupling the receiver module to a secondary display device having a user interface capable of receiving user input;
receiving user input from the secondary display device indicative of one or more alert setting modifications;
modifying one or more of the set of alert settings in accordance with the user input into a second configuration that is different
than the first, default setting configuration and

automatically resetting the set of configurable alert settings to the first, default setting configuration upon a detection
of a predetermined event, wherein the predetermined event comprises a data corruption error or a device hacking indication.

US Pat. No. 9,498,155

SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for processing glucose sensor data, the method comprising:
obtaining a glucose measurement using a glucose sensor in contact with a biological fluid, wherein the glucose sensor comprises
a first electrode, a second electrode, and an enzyme-containing film, the obtaining comprising:

applying a potential to the glucose sensor at a first setting,
measuring a first signal from the glucose sensor at the first setting,
switching the potential from the first setting to a second setting, wherein the first setting is different from the second
setting,

measuring a second signal from the glucose sensor at the second setting, and
generating a glucose concentration value, using a processor coupled to a memory of a sensor electronics unit, based at least
in part on the measured first signal and the measured second signal;

displaying, using a display, a first screen presenting generated glucose concentration data over a first time period;
displaying, using the display, a second screen presenting generated glucose concentration data over a second time period,
wherein the second time period is different in length from the first time period;

displaying, using the display, a third screen presenting a single generated real-time glucose concentration value;
receiving an input from a user to toggle between the first screen, the second screen, and the third screen of the display;
receiving an input from the user related to mealtime information, wherein the mealtime information is displayable on the display;
receiving information from the user related to a glucose concentration target range, wherein the glucose concentration target
range is represented by an upper boundary and a lower boundary, and wherein the upper boundary and the lower boundary are
user configurable; and

generating an alert responsive to detection of a hyperglycemic condition or a hypoglycemic condition based at least in part
on the single generated real-time glucose concentration value being outside the glucose concentration target range,

wherein the sensor electronics unit is configured to modify a glucose concentration determined from the first signal by accounting
for an adjustment derived from the second signal.

US Pat. No. 9,452,259

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. A method for diabetes management of a host, the method comprising:
receiving sensor data generated by a continuous glucose monitoring device, wherein the sensor data is indicative of a glucose
concentration; tracking and/or evaluating a system error of the continuous glucose monitoring device over time;

determining an insulin therapy instruction, using a controller module of a processor, based on the sensor data and a system
error; and

delivering insulin, using an insulin infusion device, to the host based on the insulin therapy instruction from the controller
module.

US Pat. No. 9,420,968

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A method for processing data from a glucose sensor, the method comprising:
receiving sensor data from a glucose sensor for a time period;
evaluating, using one or more processors, the sensor data to detect signal artifacts, the evaluating comprising performing
a first derivative analysis of the sensor data and performing a second derivative analysis of the sensor data;

determining, using the one or more processors, a level of confidence based on the evaluation;
generating insulin administration instructions based on the sensor data;
outputting an indication of the level of confidence; and
administering, using the insulin administration device, insulin to a host based on the insulin administration instructions.

US Pat. No. 9,375,065

APPARATUS AND METHODS FOR MAINTAINING A MEDICAL DEVICE IN A CLEAN AND DISINFECTED STATE, AND FOR CLEANING AND DISINFECTING A MEDICAL DEVICE

DexCom, Inc., San Diego,...

18. A method for reprocessing a reusable receiver of an analyte monitoring system, the method comprising:
receiving a receiver from a first user, wherein the receiver is contained in a first protective enclosure, wherein the receiver
has a communication port, wherein the receiver is configured to wirelessly receive sensor data and display glucose concentration
information, wherein the first protective enclosure has substantially no impact on RF performance, wherein the first protective
enclosure is configured to protect against liquid ingress, wherein the first protective enclosure is sized and shaped to conform
to a shape of the receiver;

removing the receiver from the first protective enclosure;
inserting the receiver into a second protective enclosure through an opening in the second protective enclosure, wherein the
second protective enclosure has substantially no impact on RF performance, wherein the second protective enclosure is configured
to protect against liquid ingress, wherein the second protective enclosure is sized and shaped to substantially conform to
a shape of the receiver;

adhering a cover to the second protective enclosure over the opening; and
providing the receiver contained within the second protective enclosure to a second user.

US Pat. No. 9,339,223

DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS

DexCom, Inc., San Diego,...

1. A device for measuring a glucose concentration in a host, the device comprising:
an implantable sensor operably connected to an electronic circuit and configured to continuously measure a signal indicative
of a glucose concentration in a host for a period of time; and

a membrane located over at least a portion of the sensor, wherein the membrane is configured to control a flux of oxygen and
glucose, wherein the membrane comprises a product of a reaction of a compound comprising an isocyanate group with a compound
comprising a hydroxyl group and/or a compound comprising an amine group;

wherein the device during in vitro testing is capable of exhibiting, at a glucose concentration of 400 mg/dL, no more than
a 10% drop in sensor output in response to a change of dissolved oxygen concentration from a pO2 of 150 mm Hg to 30 mm Hg.

US Pat. No. 9,192,328

SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for estimating analyte values from a continuous analyte sensor, the method comprising:
receiving a data stream from a continuous analyte sensor for a time period; and
estimating, using a processor module, one or more analyte values for a future time period, wherein estimating comprises predicting
one or more analyte values for the future time period based on the data stream, applying one or more physiological parameters
to the predicted one or more analyte values, and obtaining the estimated one or more analyte values based on the application
of the one or more physiological parameters to the predicted one or more analyte values.

US Pat. No. 9,155,843

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. A diabetes management system for semi-automated integration of a continuous glucose sensor and a medicament delivery device
to maintain a host's glucose levels within a desired target range, the system comprising:
a continuous glucose sensor configured to continuously measure glucose in a host and to output a data stream including one
or more sensor data points;

a processor module operably connected to the continuous glucose sensor, wherein the processor module is configured to receive
the data stream, evaluate a clinical risk, determine whether to operate in either a first mode or a second mode based on whether
the clinical risk meets one or more predetermined criteria, and send therapy instructions to a medicament delivery device
in the first mode but not in the second mode; and

a medicament delivery device operably connected to the processor module and configured to receive and execute the therapy
instructions.

US Pat. No. 9,452,258

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to a host, the system
comprising:
a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose
concentration in a host, and to provide sensor data associated with the glucose concentration in the host;

an electronics module comprising an on/off controller module configured to iteratively determine an insulin therapy instruction
in response to an evaluation of a relationship of internally derived data and a glucose boundary, wherein the insulin therapy
instruction comprises an instruction selected from the group consisting of on and off, wherein the glucose boundary associated
with the on instruction is different from the glucose boundary associated with the off instruction; and

an insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one
of physically connected to a receiver and operably connected to a receiver, wherein the insulin delivery device is configured
to receive the insulin therapy instruction from the controller.

US Pat. No. 9,420,965

SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. An analyte monitoring system, the system comprising:
an analyte sensor configured to generate a stream of sensor data over a time period;
a processor module configured to:
receive the sensor data;
receive reference data generated by a reference analyte monitor;
match one or more sensor data points of the sensor data with one or more data points of the reference data;
calibrate at least some of the sensor data using the matched data;
determine a first time lag of the calibrated sensor data associated with a first portion of the time period and determine
a second time lag of the calibrated sensor data associated with a second, discrete portion of the time period, wherein the
first time lag is different than the second time lag; and

estimate analyte values based on the calibrated sensor data and the first and second time lags; and
an output module configured to output information representative of the estimated analyte values.

US Pat. No. 9,258,350

ANALYTE DATA RETRIEVER

DexCom, Inc., San Diego,...

1. A method comprising:
retrieving, using a first processing system comprising an interface, analyte sensor data from an analyte sensor system configured
to measure an analyte concentration level in a host; and

forwarding, by the interface, the received analyte sensor data as a pass-through by at least forwarding the received analyte
sensor data to a second processing system coupled to the interface via a network including an internet, wherein the pass-through
comprises forwarding the received analyte sensor data without storing the received analyte sensor data in a persistent storage
at the first processing system comprising the interface so that the received analyte sensor data is automatically deleted
from any computer memory of the first processing system after the forwarding of the received analyte data to the second processing
system.

US Pat. No. 9,504,430

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for displaying healthcare information to a user using a hand-held computing device, comprising:
displaying on a touch-sensitive display of a computing device a first window comprising a plurality of charts including at
least one glucose trend line and a target range, the target range comprising a lower boundary and an upper boundary, the lower
boundary associated with a first glucose concentration value and the upper boundary associated with a second glucose concentration
value, wherein the second glucose concentration value is greater than the first glucose concentration value, wherein the at
least one glucose trend line and the target range are displayed simultaneously in the first window, wherein the trend line
is indicative of a glucose level of a host over a first time period;

generating a first event indicator on the plurality of charts in response to a first user input, wherein the first event indicator
is positioned on the plurality of charts proximate to the at least one glucose trend line of the plurality of charts to indicate
when an insulin delivery event occurred in time;

generating a second event indicator on the plurality of charts in response to a second user input, wherein the second event
indicator is positioned on the plurality of charts proximate to the at least one glucose trend line of the plurality of charts
to indicate when a meal event occurred in time;

detecting on the touch-sensitive display a user selection of at least one of the first or second event indicator;
displaying on the touch-sensitive display information associated with the selected at least one of the first or second event
indicator in a second window in response to detecting the user selection of the at least one of the first or second event
indicator, wherein the second window is separate from the first window, wherein the second window replaces the first window;
and

changing a time period of the chart from the first time period to a second, different time period in response to a third user
input detected by the computing device, wherein changing the time period causes the first and second event indicators to move
on the plurality of charts so that the first and second event indicators continue to indicate when the insulin delivery event
and the meal event occurred in time.

US Pat. No. 9,474,478

END OF LIFE DETECTION FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A method for determining an end of life of a continuous analyte sensor, comprising:
evaluating a plurality of risk factors associated with end of life symptoms of a sensor;
translating outputs of the plurality of risk factor evaluations to end of life risk factor values;
determining a likelihood of recovery based on the end of life risk factor values;
determining an end of life status of the sensor based on the likelihood of recovery; and
providing an output related to the end of life status of the sensor.

US Pat. No. 9,149,233

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for calibration of a continuous glucose sensor, the method comprising:
receiving, using electronic circuitry, sensor data from a continuous analyte sensor, the sensor data comprising one or more
sensor data points;

receiving and processing, using the electronic circuitry, calibration information to generate a calibration function;
evaluating, using the electronic circuitry, a predictive accuracy of the calibration information to determine a predictive
accuracy metric;

calibrating, using the electronic circuitry, sensor data using the calibration function;
comparing, using the electronic circuitry, the predictive accuracy metric to one or more thresholds; and
processing, using the electronic circuitry, the calibrated sensor data to generate output, wherein the processing is performed
differently depending upon the comparison of the predictive accuracy metric to the one or more thresholds, wherein the processing
comprises controlling insulin delivery and/or insulin therapy instructions differently based on the comparison of the predictive
accuracy metric to the one or more thresholds.

US Pat. No. 9,107,623

SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A glucose sensor system for monitoring glucose concentration in a biological sample of a host, the system comprising:
a continuous glucose sensor configured to produce sensor data indicative of a host's glucose concentration, wherein the continuous
glucose sensor comprises a sensing region and a sensing membrane located over the sensing region, and wherein at least a portion
of the glucose sensor is configured for transcutaneous implantation; and

an electronics module configured to receive sensor data from the continuous glucose sensor over a current time period, the
electronics module comprising a processor configured to process continuous glucose sensor data based solely from the host
over a past time period using a pattern recognition algorithm to recognize a time of day associated with a physiological pattern
of the host's glucose concentration over the past time period, and to detect an approaching clinical risk associated with
the recognized pattern based on a comparison of the sensor data over the current time period with the recognized pattern,

wherein the system is configured to present, on a display, a recommendation to aid the host in proactively avoiding the clinical
risk associated with the recognized pattern.

US Pat. No. 9,480,401

INDICATOR AND ANALYTICS FOR SENSOR INSERTION IN A CONTINUOUS ANALYTE MONITORING SYSTEM AND RELATED METHODS

DexCom, Inc., San Diego,...

1. A method for continuous analyte monitoring including a continuous analyte monitoring system having a sensor, the method
comprising:
initiating a sensor session with a transmitter and a device having a display;
displaying, using an input module, a diagram of a body on the display;
receiving as an input, via the diagram, a location on the body where the sensor was inserted into skin of a host;
storing the location; and
correlating data from the sensor for the sensor session with the location.

US Pat. No. 9,433,376

SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

DexCom, Inc., San Diego,...

1. A method of processing sensor data output by a continuous analyte sensor implanted within a body, comprising:
generating sensor data using a continuous analyte sensor implanted within a body of a host;
receiving and processing the sensor data output by the sensor using sensor electronics including a processor;
measuring a change in sensitivity or baseline of the sensor over a time interval;
determining a drift compensation function to be applied to a plurality of time-spaced data points output by the sensor over
a next interval of time, wherein the drift compensation function is based at least in part on sensitivity information from
a previous sensor session of the host; and

applying the drift compensation function continuously to the data points over the next interval of time.

US Pat. No. 9,427,183

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A method for processing data from a continuous glucose sensor, the method comprising:
providing a glucose sensor operably connected to electronic circuitry;
monitoring, using the electronic circuitry, a signal generated by a working electrode of the glucose sensor, the signal comprising
a glucose sensor data point;

further monitoring, using the electronic circuitry, an output of a counter electrode of the glucose sensor;
detecting, using the electronic circuitry, a signal artifact associated with the glucose signal based on the monitoring of
the output of the counter electrode, wherein the detecting includes determining a first state of severity from a plurality
of state of severities of the signal artifact;

selecting a first signal estimation algorithm from a group of one or more signal estimation algorithms based on the determination
of the first state of severity of the signal artifact, wherein the first signal estimation algorithm is different from the
other plurality of signal estimation algorithms and wherein each of the plurality of signal estimation algorithms use historical
and/or present signal data to estimate unknown signal data;

applying using the electronic circuitry, the selected first signal estimation algorithm;
generating an estimated sensor data point based on the application of the selected first signal estimation algorithm; and
replacing, using the electronic circuitry, the sensor data point with the estimated sensor data point.

US Pat. No. 9,143,569

SYSTEMS AND METHODS FOR PROCESSING, TRANSMITTING AND DISPLAYING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for transmitting glucose data generated by a continuous glucose sensor to a display device, comprising:
providing a plurality of predefined delivery options stored in memory of a sensor electronics module, each of the plurality
of predefined delivery options including a transmission protocol by which to transmit sensor data;

storing glucose sensor data in memory at a sensor electronics module, the glucose sensor data generated by a continuous glucose
sensor coupled to the sensor electronics;

receiving, by the sensor electronics module, a request for particular sensor data of the stored sensor data from a display
device; and

transmitting, using the sensor electronics module, the requested sensor data to the display device,
wherein the requested sensor data is transmitted according to a first, default delivery option of the plurality of predefined
delivery options when no request for particular delivery options is indicated in the request, and

wherein the requested data is transmitted according to a second delivery option of the plurality of predefined delivery options
when the request includes an indication of the second delivery option, the second delivery option using a different transmission
protocol than the default delivery option.

US Pat. No. 9,135,402

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

DexCom, Inc., San Diego,...

1. A system for processing data from a continuous analyte sensor, comprising:
a continuous analyte sensor configured to continuously measure a concentration of analyte in a host and provide continuous
analyte sensor data associated therewith; and

a processor module configured to set a mode selected from a plurality of predetermined modes, each mode of the plurality of
modes comprising alarm criteria associated with a plurality of alarms,

wherein the processor module is configured to determine whether one or more of the alarm criteria associated with the set
mode is met, and initiate an alarm associated with met alarm criteria,

wherein the processor module comprises programming configured to cause the processor module to automatically set the selected
mode at least in part responsive to an adaptive mode learning module,

wherein the adaptive mode learning module is configured to process historic sensor data and the time-corresponding set mode
over time to determine patterns or trends, and modify the automatic mode-setting programming to cause the processor module
to set the mode responsive to detecting similar patterns or trends in sensor data subsequent to the historic sensor data.

US Pat. No. 9,572,936

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to the host, the system
comprising:
a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose
concentration in a host, and to provide sensor data associated with the glucose concentration of the host;

an electronics module comprising a bolus controller module configured to iteratively determine an insulin therapy instruction
in response to an evaluation of a relationship of internally derived data and an engageable bolus constraint, wherein a relationship
of internally derived data to the bolus constraint is evaluated in response to engagement of the bolus constraint, and wherein
the bolus constraint comprises a maximum total insulin dose that can be delivered within a predefined time period in response
to engagement of the bolus constraint; and

an insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one
of physically connected to a receiver and/or operably connected to a receiver, and wherein the insulin delivery device is
configured to receive the insulin therapy instruction from the controller module.

US Pat. No. 9,445,445

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for transmitting data between a first communication device associated with an analyte sensor and a second communication
device configured to provide user access to sensor-related information, comprising:
activating a transceiver of a first communication device associated with an analyte sensor, wherein the activating comprises
waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device;

establishing a two-way communication channel with the second communication device at a first time;
sending sensor-related information to the second communication device using the two-way communication channel during a transmission
window;

deactivating the transceiver of the first communication device at a second time; and
periodically repeating the establishing, sending and deactivating, wherein a difference between the first time and the second
time is less than or equal to one minute, and wherein the periodic repeating is performed at least once every 30 minutes,
and wherein the forced wakeup is out of sync with the periodic establishing, sending, and deactivating.

US Pat. No. 9,055,901

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A system for inserting an analyte sensor into a host, comprising:
an assembly configured to insert an analyte sensor into a host, wherein the assembly comprises:
the analyte sensor;
a housing configured to receive the analyte sensor and to maintain the analyte sensor in the host after insertion; and
an applicator configured to releasably connect with the housing, wherein the applicator comprises a trigger, and wherein the
applicator is configured to insert the analyte sensor into the host and to automatically release the applicator from the housing
responsive to activation of the trigger, wherein the housing comprises an adhesive pad located on an underside of the housing
and is configured to adhere the housing to the host's skin prior to sensor insertion.

US Pat. No. 9,149,219

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A computer-implemented method for administering a medicament therapy to a host, comprising:
monitoring a data stream from a glucose sensor, the data stream indicative of a glucose concentration of a host;
calibrating the data stream;
detecting transient non-glucose related signal artifacts and evaluating a severity thereof;
replacing with an electronic device at least some of the signal artifacts with one or more physiologically feasible estimated
glucose values in response to the evaluated severity, wherein replacing at least some of the signal artifacts comprises estimating
a glucose concentration value, wherein estimating utilizes physiological information along with the data stream in order determine
the one or more physiologically feasible estimated glucose values; and

controlling administration of a medicament to the host, using a medicament delivery device, based on the one or more physiologically
feasible estimated glucose values.

US Pat. No. 9,504,413

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host, the
sensor comprising:
a first working electrode comprising a first electroactive surface, wherein the first working electrode is configured to generate
a first signal, wherein the first working electrode is configured to switch from a first bias potential to a second bias potential,
wherein the first bias potential is a glucose measurement potential and the second bias potential is a non-glucose-measurement
potential;

a second working electrode comprising a second electro active surface wherein the second working electrode is configured to
generate a second signal; and

sensor electronics configured to compare the first signal with the second signal and determine a level of glucose in the host
based at least in part on the comparison of the first signal with the second signal.

US Pat. No. 9,585,608

CONTINUOUS ANALYTE MONITOR DATA RECORDING DEVICE OPERABLE IN A BLINDED MODE

DexCom, Inc., San Diego,...

1. A system for monitoring glucose concentration, the system comprising:
a continuous glucose sensor, the continuous glucose sensor configured to continuously measure glucose concentration and output
a data stream associated with glucose concentration; and

a mobile device configured to:
operatively connect with the continuous glucose sensor;
receive the data stream from the continuous glucose sensor;
process the data stream from the continuous glucose sensor; and
further receive user input indicative of calibration information via a user interface; wherein the mobile device performs
the reception and the processing of the data stream while operating in a blinded mode that prevents display of the data stream
associated with the continuous glucose sensor, but enables display of the calibration information via the user interface.

US Pat. No. 9,585,609

END OF LIFE DETECTION FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A system for determining if a continuous analyte sensor has been reused based on an end of sensor life evaluation, the
system comprising sensor electronics configured to be operably connected to a continuous analyte sensor, the sensor electronics
configured to: evaluate sensor data obtained by the continuous analyte sensor with a plurality of risk factors associated
with end of life symptoms of a previously-used sensor, wherein the plurality of risk factors comprise at least two risk factors
selected from the group consisting of a rate of change of sensor sensitivity, end of life noise, a magnitude of sensor values
in clinical units, analyte patterns, and error between reference values and sensor values in clinical units; produce a sensor
profile of the continuous analyte sensor by performing an end of life function on the evaluated sensor data with the plurality
of risk factors, the produced sensor profile including two or more metrics associated with sensor sensitivity, noise, signal
magnitude, analyte pattern, or calibration error; determine a sensor reuse status of the continuous analyte sensor by comparing
the sensor profile to a standard profile of a sensor associated with a new sensor session; and provide an output related to
the reuse status of the continuous analyte sensor; wherein the sensor electronics is configured to disable displaying of sensor
data in response to the provided output.

US Pat. No. 9,517,025

ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY

DexCom, Inc., San Diego,...

1. An electrochemical sensor for measuring an analyte concentration in a host, comprising:
a working electrode configured to measure a concentration of an analyte; and
a reference electrode comprising a material that depletes during sensor use, wherein the material is configured to be regenerated
during sensor use, and wherein a rate of material depletion during sensor use substantially correlates with a rate of material
regeneration during sensor use over a time period.

US Pat. No. 9,179,869

TECHNIQUES TO IMPROVE POLYURETHANE MEMBRANES FOR IMPLANTABLE GLUCOSE SENSORS

DexCom, Inc., San Diego,...

1. A method for preparing an implantable membrane for an implantable glucose sensor, the method comprising:
forming a composition comprising a dispersion of a first polymer within a matrix of a second polymer, wherein the first polymer
comprises a hydrophilic segment, wherein the second polymer comprises polyurethaneurea;

applying the composition to at least one of a substrate or a layer on the substrate to form a film thereon; and
drying the film to form a membrane configured to cover at least a portion of an electrode of the implantable glucose sensor,
whereby the membrane is configured to reduce passage of glucose therethrough, whereby the membrane is configured to change
a ratio of oxygen to glucose from a concentration ratio in a body fluid to a new ratio in which there is a stoichiometric
excess of oxygen in an enzyme layer of the implantable glucose sensor, whereby the membrane is configured to extend an upper
limit of linearity of glucose measurement to a higher value than that which could be achieved without the membrane.

US Pat. No. 9,597,027

OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES

DexCom, Inc., San Diego,...

1. A system for continuous in vivo measurement of a glucose concentration in a host, the system comprising:
an implantable sensor configured to generate in vivo a signal indicative of a concentration of glucose in a host;
a membrane located over the sensor, the membrane comprising:
a first domain comprising an enzyme configured to catalyze a reaction that has glucose as a reactant; and
a second domain configured to control a flux therethrough of glucose to the first domain, wherein the second domain comprises
a polyurethane-containing material having an oxygen permeability of from about 3 Barters to about 1000 Barters; and

sensor electronics configured to operatively connect with the implantable sensor and to process the signal and determine a
glucose concentration value.

US Pat. No. 9,498,164

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for presenting an interactive glucose chart on a display device, comprising:
displaying on a touch-sensitive display of a computing device a glucose trend chart displaying monitored glucose levels of
a host over a first time range;

displaying on the display a navigation bar simultaneously with the glucose trend chart, the navigation bar displaying a graph
of the monitored glucose levels of the host over a second time range that is greater than and encompasses the first time range,
wherein predetermined user interaction with the navigation bar detected by the computing device changes the first time range
of glucose data; and

displaying event data associated with the monitored glucose levels on the glucose trend chart at a particular point in time
when a corresponding event occurred, the event data including one or more of a calibration reference event, insulin delivery
event, a meal event, or an activity event,

wherein the displaying the event data includes presenting an icon illustrative of the event type proximate to a glucose trend
line of the glucose trend chart corresponding to the particular point in time.

US Pat. No. 9,585,607

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A method of analyzing data from an analyte sensor using a continuous analyte monitoring system, comprising:
receiving data from an analyte sensor, the data comprising at least one sensor data point;
filtering the received data to generate filtered data;
comparing the received data with the filtered data to obtain at least one residual;
determining a first signal artifact event has occurred when the at least one residual is exceeds a first threshold value;
determining a second signal artifact event has occurred when the at least one residual exceeds a second, different threshold
value;

disabling or enabling display of a first graphical representation of the received data based on the determination that the
first signal artifact has occurred, wherein the first graphical representation is selected from a group consisting of a graphical
indication of glucose trend, a numerical estimated analyte value, and a range of glucose values; and

disabling or enabling display of a second graphical representation of the received data based on the determination that the
second signal artifact has occurred,

wherein the second graphical representation is selected from the group consisting of the graphical indication of glucose trend,
the numerical estimated analyte value, and the range of glucose values,

wherein the selected second graphical representation is different than the selected first graphical representation, and
wherein the selected second graphical representation is according to the second threshold value that is higher than the first
threshold value, and corresponds to the second signal artifact event that indicates a higher severity than the first signal
artifact event.

US Pat. No. 9,451,908

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for processing analyte sensor data, the method comprising:
exposing an analyte sensor of an analyte sensor system to a biological fluid, wherein the sensor system comprises the sensor
and sensor electronics, wherein the sensor is configured to measure a signal associated with an analyte concentration of a
host; and

providing a fail-safe module comprising a processor for executing computer program code stored in memory to cause the processor
to:

perform a steady state analysis and a transient analysis of the signal;
evaluate a relationship between the steady state analysis and the transient analysis; and
detect a malfunction of the sensor system based on the relationship.

US Pat. No. 9,610,013

INDICATOR AND ANALYTICS FOR SENSOR INSERTION IN A CONTINUOUS ANALYTE MONITORING SYSTEM AND RELATED METHODS

DexCom, Inc., San Diego,...

1. A method for continuous analyte monitoring, comprising:
detecting, by a continuous analyte monitoring system, continuously monitored analyte data using a sensor of the continuous
analyte monitoring system inserted into skin of a host for a first sensor session of the continuous analyte monitoring system;

providing, by the continuous analyte monitoring system, the detected continuously monitored analyte data to one or both of
a user computing device and a cloud-based server;

determining quantitative data associated with the continuously monitored analyte data relating to the first sensor session;
correlating the quantitative data with the insertion location to form sensor location performance data;
analyzing the sensor location performance data with one or more other sensor location performance data associated with a different
insertion location to generate a recommended location for a second sensor session;

displaying, on the user computing device having a display, a diagram of a body; and
indicating, on the diagram, the recommended location for insertion of a sensor of the continuous analyte monitoring system
for the second sensor session.

US Pat. No. 9,586,004

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. A method for diabetes management, the method comprising:
receiving sensor data generated by a continuous glucose monitoring device, wherein the sensor data is indicative of glucose
concentration;

calculating an insulin therapy instruction based on the sensor data, using a controller module of a processor;
comparing the determined insulin therapy instruction to one or more criteria;
constraining the determined insulin therapy instruction if the insulin therapy instruction fails the one or more criteria;
and

providing the constrained insulin therapy instruction if the insulin therapy instruction fails the one or more criteria wherein
the one or more criteria comprises a predetermined basal profile comprising a schedule of one or more time blocks, wherein
each time block is associated with a maximum insulin delivery rate.

US Pat. No. 9,314,196

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

DexCom, Inc., San Diego,...

1. A system for calibrating a continuous analyte sensor, comprising:
a continuous analyte sensor configured to provide sensor data indicative of an analyte concentration in a host; and
a processor module configured to determine a conversion function, wherein the conversion function comprises a slope representative
of a sensor sensitivity, wherein the slope is determined by selecting a most probable slope from a distribution of slopes,
and wherein the processor module is configured to convert the sensor data using the conversion function.

US Pat. No. 9,610,031

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. An assembly, comprising:
a sensor;
a mounting unit for placement on a skin of a host;
a sensor introducer coupled to the sensor and to the mounting unit, the sensor introducer configured to transcutaneously introduce
a portion of the sensor through the skin of the host to a first predetermined location relative to the mounting unit; and

a data processing unit configured to be coupled to the mounting unit by the host or a caretaker, the data processing unit
pushing the sensor forward to a second predetermined location relative to the mounting unit upon coupling to the mounting
unit.

US Pat. No. 9,566,026

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A device for continuous in vivo measurement of a glucose concentration, the device comprising:
an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host, wherein
the implantable sensor comprises an electroactive surface; and

a membrane located over the implantable sensor, wherein the membrane comprises a first domain comprising an enzyme configured
to react with glucose to produce a measured species configured to be oxidized at the implantable sensor, wherein the membrane
comprises a second domain comprising a blend comprising:

a polymer comprising a hydrophilic segment, and
a polyurethane comprising a plurality of repeating hard segments and repeating soft segments, wherein a soft segment of the
plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons, wherein a hard
segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about 10,000 Daltons,
wherein the blend of the polymer and the polyurethane comprises both hydrophilic and hydrophobic regions; and

sensor electronics operably connected to the implantable sensor, wherein the sensor electronics are configured to measure
a current flow produced by the sensor to generate sensor data indicative of glucose concentration.

US Pat. No. 9,839,353

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method for remote monitoring of a patient's analyte concentration state, the method comprising:
receiving from a user device, at a secure server system, a primary remote monitor device identifier and a secondary remote
monitor device identifier, the primary remote monitor device identifier identifying a primary remote monitor device to receive
a first data set from a continuous analyte sensor device, the secondary remote monitor device identifier identifying a secondary
remote monitor device to receive a second data set from the continuous analyte sensor device, the first and second data sets
including at least some analyte data generated by the continuous analyte sensor device, the user device being local to the
continuous analyte sensor device;

receiving, from the user device, at the secure server system, a first set of notification rules associated with the primary
remote monitor device and a second set of notification rules associated with the secondary remote monitor device, the first
set of notification rules indicating that the secure server system is to provide an alert to the primary remote monitor device
when the at least some analyte data exceeds a first threshold, the second set of notification rules indicating that the secure
server system is to provide the alert to the secondary remote monitor device if the primary remote monitor device does not
respond within a predetermined period of time after previously providing the alert;

storing, at the secure server system, the at least some analyte data associated with an analyte concentration state of the
patient;

authorizing, at the secure server system, the primary remote monitor device and the secondary remote monitor device, the primary
monitor device being authorized to have access to the first data set to remotely monitor the analyte concentration state of
the patient, the secondary remote monitor device being authorized to have access to the second data set to remotely monitor
the analyte concentration state of the patient; and

associating, at the secure server system, the first set of notification rules with the first remote monitor device based in
part on the primary remote monitor device identifier received from the user device and associating the second set of notification
rules with the second remote monitor device based in part on the secondary remote monitor device identifier received from
the user device.

US Pat. No. 10,028,683

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A system for continuous in vivo measurement of glucose in a host, the system comprising:a continuous glucose sensor configured for implantation in a host and configured to measure in vivo a signal indicative of a glucose concentration, wherein the continuous glucose sensor comprises an electrode, wherein the electrode comprises a glucose-impermeable material and conductive particles distributed within the glucose-impermeable material, wherein each of the conductive particles has a three-dimensional electroactive surface;
a biocompatible membrane located over at least a portion of the electrode, wherein the biocompatible membrane is configured to reduce a flux of glucose therethrough; and
sensor electronics operably connected to the continuous glucose sensor, wherein the sensor electronics are configured to process the signal from the continuous glucose sensor.

US Pat. No. 9,808,190

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

DexCom, Inc., San Diego,...

1. A method for identifying failure of an analyte sensor using a sensor system electronically coupled to the analyte sensor,
the method comprising:
generating a data stream indicative of an analyte concentration of a host by applying a bias voltage to a first analyte sensor
at least partially positioned within tissue of the host;

applying a stimulus signal to the first analyte sensor, wherein the stimulus signal is a time-varying signal;
measuring a signal response to the stimulus signal generated by the first analyte sensor;
determining, by the sensor system, that the signal response satisfies one or more predetermined sensor fault criteria associated
with membrane damage; and

initiating an error routine via the sensor system in response to determining that the signal response satisfies the one or
more predetermined sensor fault criteria.

US Pat. No. 9,737,250

MEMBRANE FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A device for measurement of an analyte concentration, the device comprising:
a sensor configured to generate a signal indicative of a concentration of an analyte in vivo, wherein the analyte is glucose;
and

a sensing membrane located over the sensor, the sensing membrane comprising an outermost domain and an enzyme domain comprising
an enzyme, a base polymer, and a polymer comprising a hydrophilic segment; wherein the polymer comprising the hydrophilic
segment comprises from about 5 wt. % to about 30 wt. % of the enzyme domain, the enzyme domain comprises a betaine.

US Pat. No. 10,029,043

PACKAGING SYSTEM FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A package for receiving and securing a product, the package comprising:at least one product, each product comprising:
an on-skin assembly comprising an adhesive patch configured to adhere to a host's skin;
a transcutaneous glucose sensor operably connected to the on-skin assembly, wherein the glucose sensor comprises an electrode surrounded by a membrane configured to be exposed to interstitial fluid;
at least one first container configured to receive and secure the at least one product therein, wherein the at least first container is configured to be permeable to water vapor;
a second container configured to receive the at least one first container; and
a retainer configured to secure the at least one first container in a fixed position and fixed orientation within the second container such that movement of the second container does not result in substantial movement of the first container within the second container.

US Pat. No. 10,007,473

CONTINUOUS GLUCOSE MONITOR COMMUNICATION WITH MULTIPLE DISPLAY DEVICES

DexCom, Inc., San Diego,...

1. A method for establishing communication between a plurality of display devices and a transmitter coupled to an analyte sensor of a continuous glucose monitoring system, comprising:receiving a request to connect the transmitter with a first display device, the request identifying a first type of the first display device;
comparing the first type of the first display device with a first list including a plurality of allowed types of display devices;
determining whether a display device having the first type is actively connected with the transmitter;
initiating pairing of the transmitter with the first display device when fewer than a predetermined number of display devices with the first type are included in the first list;
storing bonding information associated with the first display device as a result of pairing the first display device with the transmitter in a second list that is different from the first list;
establishing a first data communication channel to allow transmission of analyte values generated by the analyte sensor from the transmitter to the first display device;
receiving a request to connect the transmitter with a second display device, the request identifying a second type of the second display device;
comparing the second type of the second display device with the first list including a plurality of allowed types of display devices;
determining whether a display device having the second type is actively connected with the transmitter;
initiating pairing of the transmitter with the second display device when fewer than the predetermined number of display devices with the second type are included in the first list;
storing bonding information associated with the second display device as a result of pairing the second display device with the transmitter in the second list; and
establishing a second data communication channel to allow transmission of the analyte values generated by the analyte sensor from the transmitter to the second display device.

US Pat. No. 9,833,143

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. An analyte measuring system, comprising:
a mounting unit adapted for mounting on a skin of a host;
an electronics unit comprising contacts, wherein the electronics unit is detachably connectable to the mounting unit, wherein
the electronics unit comprises electronic circuitry encapsulated within a substantially seamless body comprising the contacts
exposed on an exterior of the substantially seamless body;

a sensor configured for measuring a level of an analyte, the sensor comprising an in vivo portion for insertion through the
skin at an exit site of the host and an ex vivo portion connected to the contacts when the electronics unit is detachably
connected to the mounting unit; and

an elastomeric sealing member configured to form a watertight seal around the exposed contacts on the exterior of the substantially
seamless body and at electrical connection areas on the ex vivo portion of the sensor, wherein the elastomeric sealing member
is connected to the mounting unit, wherein the elastomeric sealing member comprises at least one conductive elastomer contact
disposed within the elastomeric sealing member.

US Pat. No. 9,750,441

SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for processing glucose sensor data, the method comprising:
applying a potential to a glucose sensor at a first setting;
measuring a first signal from the glucose sensor at the first setting;
switching the potential to a different setting;
measuring a second signal from the glucose sensor at the different setting;
modifying a glucose concentration associated with the first signal by accounting for an adjustment derived from the second
signal;

generating glucose concentration data, using a processor coupled to a memory of a sensor electronics unit, based at least
in part on sensor data received from the glucose sensor;

displaying, using a display, a first screen presenting generated glucose concentration data over a first time period;
displaying, using the display, a second screen presenting generated glucose concentration data over a second time period,
wherein the second time period is different in length from the first time period;

displaying, using the display, a third screen presenting a single generated real-time glucose concentration value;
receiving an input from a user to toggle between the first screen, the second screen, and the third screen of the display;
receiving an input from the user related to mealtime information, wherein the mealtime information is displayed on the display;
receiving information from the user related to a glucose concentration target range, wherein the glucose concentration target
range is represented by an upper boundary and a lower boundary, and wherein the upper boundary and the lower boundary are
user configured; and

generating an alert responsive to detection of a hyperglycemic condition or a hypoglycemic condition based at least in part
on the single generated real-time glucose concentration value being outside the glucose concentration target range.

US Pat. No. 9,649,069

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A method for processing data from an electrochemical glucose sensor, the method comprising:
applying a voltage to an electrochemical glucose sensor configured to measure a glucose concentration of a biological sample
of a host, wherein applying the voltage comprises at least one process selected from the group consisting of switching a voltage
applied to the electrochemical glucose sensor, cycling a voltage applied to the electrochemical glucose sensor, and pulsing
a voltage applied to the electrochemical glucose sensor;

measuring a signal response of the electrochemical glucose sensor responsive to the at least one process; and
detecting, using a processor, a signal artifact based on the signal response of the electrochemical glucose sensor to the
switching, cycling, or pulsing of the applied voltage, wherein the signal artifact is associated with at least one condition
selected from the group consisting of ischemia, a pH change, a temperature change, a change in available electrode surface
area, and an interfering species.

US Pat. No. 9,668,682

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A sensor system for measuring an analyte concentration in a host, the system comprising:
a sensor configured for insertion into the host's tissue, wherein the sensor is configured to continuously measure an analyte
concentration in a host;

a housing configured to receive the sensor, wherein the housing is adapted for placement adjacent to the host's skin, wherein
the housing has a height from 0.075 inches to 1.5 inches; and

an electronics unit comprising a circuit board comprising a processor configured to provide a signal associated with the analyte
concentration, wherein the electronics unit is attached to the housing and operatively connected to the sensor wherein the
electronics unit and the housing are configured such that the housing physically breaks upon release of the electronics unit.

US Pat. No. 9,597,453

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. A method for diabetes management, the method comprising:
controlling insulin delivery to a host, using a processor comprising a controller module;
iteratively evaluating internally derived data relative to a predetermined glucose boundary; and
selectively turning the controller on or off responsive to the iterative evaluation,
wherein the internally derived data comprise processed glucose data and insulin on-board information, and wherein the interatively
evaluating comprises interatively evaluating the insulin on board information.

US Pat. No. 10,112,011

TIME AVERAGED BASAL RATE OPTIMIZER

DexCom, Inc., San Diego,...

1. A method for optimizing a basal rate profile for use with continuous insulin therapy, comprising:providing a programmed basal rate profile for insulin therapy, wherein the basal rate profile comprises an insulin delivery schedule that includes one or more blocks of time, and wherein each block of time defines an insulin delivery rate;
periodically or intermittently updating the programmed basal rate profile based on a retrospective analysis of continuous glucose sensor data over a predetermined time window; and
adjusting the basal rate profile of the updated programmed basal rate profile in response to real time continuous glucose sensor data indicative of actual or impending hyperglycemia or hypoglycemia, wherein adjusting comprises dynamically increasing or decreasing the basal rate of the updated programmed basal rate profile in real time in response to real time continuous glucose sensor data indicating actual hyperglycemia, impending hyperglycemia, actual hypoglycemia, or impending hypoglycemia.

US Pat. No. 9,827,372

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. A method for diabetes management, the method comprising:
receiving measured glucose data from a continuous glucose monitor;
receiving external data; and
controlling insulin delivery to a host, using a processor, by iteratively evaluating the received glucose data and the received
external data relative to a predetermined glucose boundary and selectively controlling the insulin delivery responsive to
the iteratively evaluating, wherein the external data comprises one or more of time of day, meals, sleep, calories, exercise,
or sickness, whereby outside influences are considered in therapy instructions.

US Pat. No. 9,730,160

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for exchanging analyte information among communication devices, the method comprising:
periodically opening, using a first communication device associated with an analyte sensor, a communication window for a duration
of time within which the first communication device can exchange data with one or more second communication devices configured
to provide user access to analyte values and/or information derived from analyte values, and wherein the first communication
device comprises a sensor electronics module configured to couple to the analyte sensor and generate a data stream representative
of a measured analyte level of a host;

establishing a communication channel with a primary device of the one or more second communication devices only during a first
time period dedicated to connecting with a primary device within the duration of time, wherein establishing the communication
channel with a primary device comprises determining if a received request for establishing a communication channel is from
a primary device; and

establishing a communication channel with one or more secondary devices of the one or more second communication devices only
during a second time period dedicated to connecting with a secondary device within the duration of time different from the
first time period, wherein establishing the communication channel with the one or more secondary devices comprises determining
if a received request for establishing a communication channel is from a secondary device.

US Pat. No. 10,004,437

INDICATOR AND ANALYTICS FOR SENSOR INSERTION IN A CONTINUOUS ANALYTE MONITORING SYSTEM AND RELATED METHODS

DexCom, Inc., San Diego,...

1. A method for continuous analyte monitoring including a continuous analyte monitoring system having a sensor, the method comprising:upon insertion of a sensor into skin of a host, automatically initiating a new sensor session with a transmitter and a device having a display, the automatically initiating triggered by one or more of the group selected from: the transmitter engaging the sensor, or the transmitter or sensor engaging a mechanical switch upon engagement;
displaying, using a user interface associated with an input module, a diagram of a body on the display;
receiving as an input, via the diagram, a location on the body where the sensor was inserted into skin of a host; and
storing the location.

US Pat. No. 9,801,541

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method comprising:
receiving, at a wireless mobile remote monitor, an alert notification message from a server system, the alert notification
message representative of a detected event, the event being based on analyte concentration sensor data obtained from a receiver
monitoring an analyte state of a host, the analyte concentration sensor data indicating a concentration of an analyte of the
host, the wireless mobile remote monitor being remote to the host and the server system;

presenting, at the wireless mobile remote monitor, the alert notification message, wherein the wireless mobile remote monitor
or a user of the wireless mobile remote monitor is specifically authorized by the host to receive the alert notification message
to augment the receiver monitoring of the analyte state of the host, wherein the wireless mobile remote monitor or the user
of the wireless mobile remote monitor is authenticated by the server system;

receiving, at the wireless mobile remote monitor, user input indicative of acknowledgment of the presented alert notification
message;

sending an acknowledgment message from the wireless mobile remote monitor to the server system indicating acknowledgement
of the presented alert notification message to enable the server system to confirm that the alert notification message has
been received;

after sending the acknowledgment accessing, by the wireless mobile remote monitor, at least some of the analyte concentration
sensor data from the server system; and

receiving, in response to the accessing, information the at least some of the analyte concentration sensor data including
historical data, the at least some of the analyte concentration sensor data being generated by the receiver monitoring the
analyte state of the host;

wherein the event is detected by the server system based on one or more sets of recommended alert rules settings configured
by the host using the receiver, at least one of the sets of recommended alert rules settings being modifiable by the user
of the wireless mobile remote monitor using the wireless mobile remote monitor.

US Pat. No. 9,763,608

ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME

DexCom, Inc., San Diego,...

1. A continuous analyte sensor configured for in vivo use, the continuous analyte sensor comprising:
an elongated conductive body comprising a working electrode, wherein the elongated conductive body has an ultimate tensile
strength of from about 80 kPsi to about 500 kPsi and a yield strength from about 800 MPa to about 3,000 MPa; and

a membrane covering at least a portion of the working electrode, wherein the membrane comprises an enzyme.

US Pat. No. 9,700,253

SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for processing sensor data of a continuous analyte sensor implanted within a body, wherein the continuous analyte
sensor measures glucose levels, and the measurements are processed via sensor electronics, comprising:
initializing the sensor, the sensor in electrical communication with the sensor electronics configured to receive and process
sensor data by the sensor;

acquiring sensor data, using the sensor, to measure an analyte level in a body fluid over a first interval based on a first
elapsed time since the sensor was implanted;

adjusting the acquired sensor data by applying, using the sensor electronics, a first set of time-dependent algorithmic functions
to the sensor data associated with the first interval, wherein the first set of time-dependent algorithmic functions comprise
a first boundary of acceptability, wherein the first boundary comprises a first drift rate of the sensitivity over time, wherein
the first boundary comprises a first drift of the baseline over time;

acquiring further sensor data, using the sensor, to measure the analyte level in the body fluid over a second interval based
on a second elapsed time since the sensor was implanted and after the first interval;

adjusting the acquired further sensor data by applying, by the sensor electronics, a second set of time-dependent algorithmic
functions to the sensor data associated with the second interval, wherein the second set of time-dependent algorithmic functions
comprise a second boundary of acceptability, wherein the second boundary comprises a second drift rate of the sensitivity
over time, wherein the second boundary comprises a second drift of the baseline over time, thereby adapting the system to
compensate for sensor drift of the sensor.

US Pat. No. 9,940,846

ADAPTIVE INTERFACE FOR CONTINUOUS MONITORING DEVICES

DexCom, Inc., San Diego,...

1. An electronic device for monitoring a glucose concentration in a host, the device comprising:a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure the glucose concentration in the host, and to provide continuous sensor data associated with the glucose concentration in the host; and
a processor module configured to:
obtain first behavioral or contextual information associated with the host;
obtain second behavioral or contextual information associated with a plurality of hosts having a common characteristic with the host;
generate one or more behavioral or contextual criteria for a goal based on the obtained first information and the obtained second information; and
generate the goal based on the generated criteria;
provide the generated goal for presentation via a human detectable interface; and
receive a message activating the goal.

US Pat. No. 9,931,065

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

DeXCom, Inc., San Diego,...

1. A device for applying an on-skin sensor assembly to skin of a host, the device comprising:a base configured to secure a housing, wherein the housing is configured to receive an electronics unit, wherein the electronics unit is configured to generate analyte information based on a signal from a sensor;
a sensor insertion assembly configured to insert the sensor into the host;
a resistance feature configured to prevent securement of the electronics unit to the housing; and
a trigger configured, in response to being activated, to cause the sensor insertion assembly to insert the sensor into the host, to cause the electronics unit to secure to the housing by releasing the resistance feature from preventing the securement of the electronics unit to the housing such that the sensor electrically contacts the electronics unit, and to cause the housing to detach from the base.

US Pat. No. 9,044,199

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A device for measurement of an analyte concentration in a host, the device comprising:
a sensor comprising a first electrode and a second electrode coaxially located with the first electrode, wherein the sensor
comprises an in vivo portion configured for insertion into a host and an ex vivo portion configured for electrical connection
to sensor electronics located outside of the host, wherein the ex vivo portion comprises a first electrical connection area
associated with the first electrode and a second electrical connection area associated with the second electrode;

a membrane system disposed on an electroactive portion of the first electrode; and
a contact subassembly configured to electrically connect the sensor with sensor electronics, wherein a first electrically
conductive portion of the contact subassembly circumscribes at least a portion of a periphery of the first electrical connection
area, and wherein a second electrically conductive portion of the contact subassembly circumscribes at least a portion of
a periphery of the second electrical connection area.

US Pat. No. 10,052,050

SYSTEMS AND METHODS FOR MONITORING AND MANAGING LIFE OF A BATTERY IN AN ANALYTE SENSOR SYSTEM WORN BY A USER

DexCom, Inc., San Diego,...

1. An analyte sensor system configured to be worn by a user, comprising:an analyte sensor;
a transceiver configured to transmit and receive wireless signals;
a battery; and
a processor configured to:
measure a value indicative of a current power level of the battery,
predict a remaining useful life of the battery based on the measured value and an assumed future usage of the analyte sensor system,
wherein the assumed future usage is determined based on stored history of prior usage of the analyte sensor system, and wherein the prior usage is related to a number of data transmission events, and different types of data transmission events that occurred within a predetermined number of past update cycles,
determine that the remaining useful life of the battery is below a predefined power level, and
cause a change in one or more data transmission operations of the analyte sensor system.

US Pat. No. 9,974,018

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for authorizing analyte sensor data exchange between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to analyte values and/or information derived from analyte values, comprising: sending a challenge value from a first communication device associated with an analyte sensor to a second communication device; generating a first hash value in the second communication device using, at least in part, one or more of the challenge value, an identifier of the first communication device, or a key value; sending the first hash value from the second communication device to the first communication device; generating, using the first communication device, a second hash value and a third hash value; comparing, using the first communication device, the second hash value and the third hash value to the first hash value; and sending analyte sensor data only if at least one of the second hash value or the third hash values matches the first hash value.

US Pat. No. 9,801,575

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

DexCom, Inc., San Diego,...

1. A system for measuring an analyte, the system comprising sensor electronics configured to be operably connected to a continuous
analyte sensor, the sensor electronics configured to:
apply a time-varying signal to the analyte sensor;
measure a peak current from the sensor in response to the applied signal;
determine a sensitivity of the analyte sensor, the determining comprising correlating the peak current to a predetermined
sensor sensitivity curve that is a representation of a change in sensitivity over time, the determining further comprising
selecting the predetermined sensitivity curve based on the peak current from a plurality of different predetermined sensitivity
curves; and

generate estimated analyte concentration values using the determined sensitivity and sensor data generated by the analyte
sensor.

US Pat. No. 9,788,765

ZWITTERION SURFACE MODIFICATIONS FOR CONTINUOUS SENSORS

DexCom, Inc., San Diego,...

1. A device for measurement of an analyte concentration, the device comprising:
a sensor configured to generate a signal associated with a concentration of an analyte; and
a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain and an enzyme-containing
domain, wherein the enzyme-containing domain comprises one or more zwitterionic compounds.

US Pat. No. 9,717,449

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for generating analyte measurements of a host, the method comprising:
generating sensor data during a first time period using an analyte sensor coupled to a sensor electronics unit, wherein the
sensor electronics unit is adhered to a body of a host;

receiving, using a receiver in wireless communication with the sensor electronics unit, a reference analyte value generated
by a reference analyte monitor;

responsive to receiving the reference analyte value, determining a first estimated analyte concentration value to display
using an immediate calibration algorithm that includes matching the reference analyte value to a sensor data point closest
with respect to time, wherein the first estimated analyte concentration value is associated with the analyte concentration
of the host at a point in time;

determining a second estimated analyte concentration value to display using the reference analyte value and the sensor data
for the first time period in a standard calibration algorithm that is different from the immediate calibration algorithm,
wherein the standard calibration algorithm includes re-matching the reference analyte value to an optimal sensor data point
or points, and wherein the second estimated analyte concentration value is associated with the analyte concentration of the
host at the same point in time as the first estimated analyte concentration value; and

displaying, on a display of the receiver, a numerical analyte value selected from the first estimated analyte value and the
second estimated analyte value, wherein the first estimated analyte concentration value is selected as the displayed numerical
value until the second estimated analyte concentration is available, and subsequently selecting the second estimated analyte
concentration value to be the displayed numerical value.

US Pat. No. 9,693,721

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A device for in vivo measurement of a glucose concentration, the device comprising:
a transcutaneous sensor configured to measure a signal indicative of a glucose concentration in a host, wherein the sensor
comprises an electroactive surface; and

a membrane located over the sensor, wherein the membrane comprises:
a second domain comprising a polymer comprising a plurality of repeating hard segments and repeating soft segments, wherein
a soft segment of the plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons,
wherein a hard segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about
10,000 Daltons, wherein the polymer comprises a hydrophilic segment, wherein the second domain comprises both hydrophilic
and hydrophobic regions, whereby diffusion of glucose and oxygen through the second domain is controlled; and

sensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow
produced by the sensor to generate sensor data indicative of glucose concentration.

US Pat. No. 9,668,696

INDICATOR AND ANALYTICS FOR SENSOR INSERTION IN A CONTINUOUS ANALYTE MONITORING SYSTEM AND RELATED METHODS

DexCom, Inc., San Diego,...

1. A system for continuous analyte monitoring, comprising:
a user computing device having a display and a camera, and storing executable instructions in a memory of the user computing
device;

a continuous analyte sensor configured to be implanted within a body of a host; and
sensor electronics unit configured to receive and process sensor data generated by the continuous analyte sensor during a
sensor session, to initialize the continuous analyte sensor, and to transmit the sensor data to the user computing device,

wherein the user computing device is configured to (i) receive, as an input, a location on the body where the continuous analyte
sensor was inserted into the skin of the host via a user indication of the location on the display or via a photograph of
the location by the camera, (ii) store the location, (iii) gather hypoglycemic accuracy data, and (iv) correlate data including
the sensor data for the sensor session and the hypoglycemic accuracy data with the location to produce sensor location performance
data.

US Pat. No. 10,028,684

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A sensor for measuring an analyte concentration in a host, the sensor comprising:an elongated body configured to be implanted at least in part in a host, wherein the elongated body comprises:
a substrate;
a first layer covering at least a portion of the substrate, wherein the first layer comprises a first conductive material, wherein a portion of the first layer comprises a first electroactive surface;
a second layer covering at least a portion of the first layer, wherein the second layer comprises an insulating material;
a third layer covering at least a portion of the second layer, wherein the third layer comprises a second conductive material, wherein a portion of the second layer comprises a second electroactive surface; and
a fourth layer covering at least a portion of the third layer, wherein the fourth layer comprise an insulating material;
wherein the first electroactive surface and the second electroactive surface are separated along a longitudinal axis of the elongated body by at least a portion of the fourth layer.

US Pat. No. 10,004,436

DEVICES AND METHODS FOR CONTINUOUS ANALYTE MONITORING

DexCom, Inc., San Diego,...

1. A method of providing information to a user regarding the user's blood glucose value, the method comprising:determining a hierarchy of a plurality of devices, wherein the plurality of devices include a first electronic device, a second electronic device, and a third electronic device;
transmitting a first signal to the first electronic device using a continuous analyte monitoring system, the first signal comprising alert and/or glucose value information;
if an acknowledgment of the first signal is not received within a first preset time limit, transmitting a second signal to the second electronic device, the second signal comprising the alert and/or glucose value information or an updated version of the alert and/or glucose value information; and
if an acknowledgement of the second signal is not received within a second preset time limit, transmitting a third signal to the third electronic device, the third signal comprising the alert and/or glucose value information or an updated version of the alert and/or glucose value information.

US Pat. No. 10,004,442

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

DexCom, Inc., San Diego,...

1. A method for determining a defective sensor, the method comprising:generating sensor data using an implantable analyte sensor;
generating, using sensor electronics, analyte concentration values using the implantable sensor data generated by the continuous analyte sensor;
applying, to the implantable analyte sensor, a stimulus signal having a particular frequency, multiple stimulus signals having different frequencies, or a stimulus signal comprising a spectrum of frequencies;
measuring a signal response of the implantable analyte sensor to the stimulus signal;
determining a value associated with the signal response;
determining whether the value is within a predefined level;
determining that the implantable analyte sensor has a condition associated with membrane damage when the value exceeds the predefined level; and
notifying a user that the implantable analyte sensor is defective responsive to the determining that the implantable analyte sensor has the condition associated with membrane damage.

US Pat. No. 9,993,186

OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES

DexCom, Inc., San Diego,...

1. A system for continuous in vivo measurement of a glucose concentration in a host, the system comprising:an implantable sensor configured to generate in vivo a signal indicative of a concentration of glucose in a host;
a membrane located over the sensor, the membrane comprising:
a first domain comprising an enzyme configured to catalyze a reaction that has glucose as a reactant; and
a second domain configured to provide an interface with a biological fluid, wherein the second domain comprises a material having an oxygen solubility that is about 3-10 times higher than an oxygen solubility of water;
sensor electronics configured to operatively connect with the implantable sensor and to process the signal and determine a glucose concentration value.

US Pat. No. 9,974,469

SYSTEMS AND METHODS FOR A CONTINUOUS MONITORING OF ANALYTE VALUES

DexCom, Inc., San Diego,...

7. An analyte sensor system configured for a wireless data communication with a plurality of display devices capable of displaying analyte values from the analyte sensor module, the analyte sensor system comprising:an analyte sensor;
a transceiver configured to transmit and receive wireless signals; and
a processor operatively coupled to the analyte sensor, and the transceiver and configured to:
cause the transceiver to transmit a first series of advertisement signals,
receive a first data connection request from a first display device,
determine that the first display device is identified in a first list containing one or more allowed display devices,
establish a first data connection with the first display device,
receive a request from the first display device, wherein the request is for identifying the first display device in a second list, and wherein the second list stores information about a currently active display device configured to receive and display analyte values from the analyte sensor system,
responsive to the request, read from the second list first data identifying a second display device as a currently active display device,
transmit the first data to the first display device,
in response to the transmission of the first data, receive a request to write to the second list second data selecting the first display device as a currently active display device for receiving and displaying analyte values from the analyte sensor system and indicating that the second display device is no longer the active display device,
write the second data to the second list, and
terminate the first data connection with the first display device.

US Pat. No. 9,854,972

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method for remotely monitoring glucose concentration for a plurality of hosts by any number of remote wireless mobile
computing devices in communication with a remote server system, the remote server system storing glucose concentration data
for each of the plurality of hosts, the glucose concentration data of each host being measured by a different glucose monitoring
system, the method comprising:
authorizing, at the remote server system, a request from a first remote monitoring application installed on a first remote
wireless computing device to receive glucose information of a first host;

authorizing, at the remote server system, a request from a second remote monitoring application installed on a second remote
wireless computing device to receive glucose information of a second host;

establishing, at the remote server system, a plurality of rule sets, a first rule set of the plurality of rule sets being
defined by the first host and that can be modified by a first user using the first remote monitoring application, a second
rule set of the plurality of rule sets being defined by the second host and that can be modified by a second user using the
second remote monitoring application, wherein the first rule set comprises a first threshold value associated with a first
host's glucose concentration and wherein the second rule set comprises a second threshold value associated with a second host's
glucose concentration, and wherein the first threshold value is different from the second threshold value;

determining, by the remote server system, that the at least some glucose concentration data indicative of the first host's
glucose concentration received from the first host's glucose monitoring system exceeds or is below the first threshold value;

generating, by the remote server system, a first alert informative of an event based on the determination that the at least
some of the glucose concentration data indicative of the first host's glucose concentration exceeds or is below the first
threshold value;

transmitting, by the remote server system, the first alert to the first remote wireless computing device, wherein the first
remote wireless computing device is configured to display the notification alert regardless of whether the first remote monitoring
application is active or inactive on the first remote wireless computing device and activate the first remote monitoring application
if the first remote monitoring application is inactive;

receiving and confirming, by the remote server system, a first acknowledgement from the first remote monitoring application
indicating that the first user has received the first alert, the remote server system not providing additional glucose concentration
data indicative of the first user's glucose concentration to the first remote monitoring application until the first acknowledgement
is confirmed;

determining, by the remote server system, that the at least some glucose concentration data indicative of the second host's
glucose concentration received from the second host's glucose monitoring system exceeds or is below the second threshold value;

generating, by the remote server system, a second alert informative of an event based on the determination that the at least
some of the glucose concentration indicative of the second host's glucose concentration data exceeds or is below the second
threshold value;

transmitting, by the remote server system, the second alert to the second remote wireless computing device, wherein the second
remote wireless computing device is configured to display the alert regardless of whether the second remote monitoring application
is active or inactive on the second remote wireless computing device and activate the second remote monitoring application
if the second remote monitoring application is inactive; and

receiving and confirming, by the remote server system, a second acknowledgement from the second remote monitoring application
indicating that the second user has received the second alert, the remote server system not providing additional glucose concentration
data indicative of the second user's glucose concentration to the second remote monitoring application until the second acknowledgement
is confirmed.

US Pat. No. 9,724,028

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for monitoring glucose concentration in a biological sample of a host, the method comprising:
producing a data stream indicative of a glucose concentration of a host using a continuous glucose sensor;
prospectively converting, using a first processor, sensor data associated with the data stream to generate real-time calibrated
glucose concentration information, the prospective conversion comprising applying the sensor data to a prospectively-generated
conversion function;

retrospectively converting, using a second processor, the sensor data associated with the data stream to generate historical
calibrated glucose concentration information, the retrospective conversion comprising applying the sensor data to a retrospectively-generated
conversion function, wherein the prospectively-generated conversion function is different than the retrospectively-generated
conversion function; and

selectively displaying a graphical representation of the real-time calibrated glucose concentration or the historical calibrated
glucose concentration information on a display device.

US Pat. No. 9,750,460

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A glucose sensor system that detects a signal artifact that can result in an erroneous glucose concentration measurement,
the system comprising:
an electrochemical glucose sensor comprising a plurality of electrodes and an enzyme-containing membrane, wherein the electrochemical
sensor is configured to be in contact with a biological fluid;

sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics
to:

apply a voltage across the electrodes of the electrochemical glucose sensor,
measure a signal response of the electrochemical glucose sensor responsive to the applied voltage,
determine a level of severity of the signal artifact based at least in part on the measured signal response, and
dynamically select an algorithm or apply a signal estimation algorithm factor based on the level of severity evaluated to
generate:

(i) a first glucose value for display based on the measured signal response from the electrochemical glucose sensor when the
signal artifact is evaluated having a first level of severity, and

(ii) a second glucose value, different from the first glucose value, for display based on the measured signal response from
the electrochemical glucose sensor when the signal artifact is evaluated having a second level of severity different from
the first level of severity, wherein the second level of severity is greater than the first level of severity, wherein the
second glucose value is generated by applying an infinite impulse response filter, wherein the second glucose value is based
at least in part on both the measured signal response and historical data; and

a user interface configured to:
display:
(i) the first glucose value when the signal artifact is detected having the first level of severity,
(ii) the second, different glucose value when the signal artifact is detected having the second level of severity, and
(iii) no glucose value when the signal artifact is detected having a third level of severity, wherein the third level of severity
is greater than the second level of severity.

US Pat. No. 9,603,557

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A system for manufacturing a transcutaneous glucose sensor, comprising:
a plurality of coating stations, wherein the plurality of coating stations are configured to serially deposit a plurality
of membrane layers on an elongated conductive body to form a membrane system, wherein the elongated conductive body comprises
an electroactive surface, wherein the plurality of coating stations each comprise a vessel for holding a coating solution,
wherein at least one station of the plurality of coating stations comprises a solution comprising a biocompatible material,
wherein the at least one station is configured to deposit a layer of the biocompatible material to form a biocompatible membrane
layer, whereby an uncalibrated transcutaneous glucose sensor is obtained;

an automated or semi-automated transport configured to continuously move the elongated conductive body through the plurality
of coating stations;

a station configured to conduct in vitro sensor testing to obtain in vitro sensor information related to in vitro sensor sensitivity
for the uncalibrated transcutaneous glucose sensor; and

a processor configured to process the in vitro testing information to produce prior implantation information including a predicted
in vivo sensitivity determined from a predictive relationship between in vitro sensor sensitivity and in vivo sensor sensitivity,
wherein the processor is configured to associate the uncalibrated transcutaneous glucose sensor with the prior implantation
information, wherein the prior implantation information is employed to calibrate the uncalibrated transcutaneous glucose sensor
completely without a need for reference glucose values obtained after sensor implantation.

US Pat. No. 9,579,053

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A transcutaneous analyte sensor configured for insertion into a host for measuring an analyte in the host, the sensor comprising:
a first conductive layer comprising a working electrode, wherein the working electrode is configured to generate a signal
indicative of an analyte concentration;

a first insulative layer covering at least a portion of the first conductive layer;
a second conductive layer covering at least a portion of the first insulative layer, wherein the second conductive layer comprises
a reference or counter electrode;

a second insulative layer covering at least a portion of the second conductive layer;
a membrane covering at least a portion of the first electrode, wherein the membrane comprises a silicone-urethane copolymer
and an acrylate polymer; and

electronics operably connected to the working electrode and the reference electrode, and configured to process the first signal;
wherein the working electrode and the reference or counter electrode are horizontally displaced along a longitudinal axis
defined by the first conductive layer such that the second electrode extends outwardly beyond the working electrode, wherein
a portion of the first insulative layer is configured to act as a diffusion barrier between the working electrode and the
reference or counter electrode, and wherein the horizontal displacement comprises a distance sufficient to prevent diffusion
of an electroactive species between the working electrode and the reference or counter electrode; and

wherein the sensor comprises an in vivo portion configured for insertion into the host and an ex vivo portion configured for
operable connection with sensor electronics;

wherein the sensor is configured to extend across a skin of the host and to flex in response to a mechanical pressure and
to then to regain its original shape during use.

US Pat. No. 9,510,782

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A method for a continuous analyte monitoring system to output estimated analyte values generated using a continuous analyte
sensor, the method comprising:
receiving sensor data from a continuous analyte sensor for a time period;
determining in substantially real-time, using a processor module, a first level of reliability of the continuous analyte sensor
based on a first portion of the sensor data, wherein the first level of reliability is selected from a plurality of predetermined
levels of reliability;

estimating, using the processor module, at least one analyte value for a first future time period based at least in part on
the first portion of the sensor data;

turning on or maintaining outputting, using the processor module, the estimated at least one analyte value for the future
time period based on the determined first level of reliability;

determining in substantially real-time, using the processor module, a second level of reliability of the continuous analyte
sensor based on a second portion of the sensor data, wherein the second level of reliability is selected from the plurality
of predetermined levels of reliability;

estimating, using the processor module, at least another analyte value for a second future time period based at least in part
on the second portion of the sensor data; and

turning off outputting, using the processor module, the estimated at least another analyte value for the second future time
period based on the determined second level of reliability,

wherein the first level of reliability indicates a higher level of reliability than the second level of reliability.

US Pat. No. 9,953,542

ADAPTIVE INTERFACE FOR CONTINUOUS MONITORING DEVICES

DexCom, Inc., San Diego,...

1. A method for adaptive configuration of an analyte monitoring device, the method comprising:measuring a glucose concentration in a host via a glucose sensor at least partially inserted in the host the glucose sensor configured to provide continuous sensor data associated with the glucose concentration in the host;
transmitting a first report of first physiological information of the host based on the continuous sensor data using a first reporting format, wherein the first reporting format comprises a first reporting format characteristic;
determining at least one of behavioral and contextual information comprising at least one of behavioral and contextual characteristic of the host, wherein the at least one of behavioral and contextual characteristic is associated with a physiological condition of the host;
comparing the at least one of behavioral and contextual characteristic with one or more behavioral or contextual criteria;
adjusting the reporting format based at least in part on said comparing, wherein the reporting format comprises a second reporting format characteristic that is different from the first reporting format characteristic, wherein the second reporting format characteristic includes a change in a level of discretion and a change in a reporting frequency; and
transmitting a second report of second physiological information using the second reporting format.

US Pat. No. 9,937,293

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. A method for monitoring and treating diabetes, the method using a device configured to receive glucose concentration data from a glucose sensor, the glucose sensor configured to continuously monitor glucose concentration in a user over time, the device further configured for outputting data including personalized therapy recommendations, comprising:receiving data from a glucose sensor;
evaluating the received sensor data to determine one or more signal parameters, the signal parameters including one or more of a glucose concentration, a glucose concentration rate of change, or a glucose concentration acceleration;
evaluating the received sensor data to adaptively learn one or more patterns occurring in the received sensor data over time;
determining an output including at least one of an optimum time, amount, or type of medicament based on one or more of the determined signal parameters and at least one adaptively learned pattern; and
repeating, over time, the evaluating the received sensor data to adaptively learn one or more patterns,
wherein the determined output provides a personalized therapy recommendation for the user that improves over time based on the adaptive learning,
wherein the device is in RF communication with, and is configured for semi-automated integration with, a medicament delivery device, wherein the medicament delivery device is a pen or a pump, for delivery of insulin or glucagon or both, and
wherein the device is configured to implement a fail-safe mode, wherein if abnormal conditions are detected, the device reverts from a semi-automated mode to a manual mode.

US Pat. No. 9,931,036

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for transmitting data between devices of an analyte monitoring system, the method comprising:generating sensor data using a sensor electronics module electrically connected to a continuous analyte sensor;
establishing a two-way communication channel between the sensor electronics module and a display device, wherein each of the sensor electronics module and the display device transmit via a first transmission mode at a first transmission power, wherein the transmission includes sending a portion of the sensor data from the sensor electronics module to the display device;
initiating a low power transmission mode responsive to sensing user input at a user interface of the display device indicative of entering the low power transmission mode, wherein the low power transmission mode comprises the sensor electronics module transmitting another portion of the sensor data to the display device at a second transmission power that is lower than the first transmission power;
exiting the low power transmission mode upon receiving instructions via a short-range communication protocol, that is different from the first transmission mode and the low power transmission mode, and transitioning to the first transmission mode upon exiting the low power transmission mode.

US Pat. No. 9,833,176

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A transcutaneous system for measuring an analyte concentration in a host, the system comprising:
a sensor adapted for transcutaneous placement through a skin of a host, the sensor comprising a first terminal end and a second
terminal end, the first terminal end opposite from the second terminal end;

a housing configured to support the sensor during a period of transcutaneous insertion; and
an applicator comprising a needle configured for inserting the sensor into the skin of the host, wherein the needle is configured
to insert the first terminal end of the sensor into the host and slide back over the second terminal end of the sensor, wherein
the needle is configured to be released from the housing during a period of continuous transcutaneous placement, wherein the
needle is fully enclosed around a longitudinal section of the sensor, wherein the first terminal end and second terminal end
of the sensor are sized to fully reside within the needle, and wherein the first terminal end and the second terminal end
have substantially same dimensions.

US Pat. No. 9,804,114

SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES

DexCom, Inc., San Diego,...

1. A sensor for use in a glucose measuring device, the sensor comprising:
a plurality of electrodes, wherein the plurality of electrodes comprises a first electrode and a second electrode, wherein
the first electrode comprises an electrochemically reactive surface;

a non-conductive body located between the first electrode and the second electrode; and
a multi-region membrane covering the plurality of electrodes, wherein the multi-region membrane comprises an immobilized enzyme
domain comprising an enzyme in at least a portion thereof, wherein the immobilized enzyme domain covers and contacts the first
electrode among the plurality of electrodes and does not cover and contact any other electrode of the plurality of electrodes.

US Pat. No. 9,730,621

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method for remotely monitoring glucose levels of one or more hosts who are remote to a remote monitoring apparatus and
who are not in a medical facility, comprising:
executing a software application on a remote monitoring apparatus including a smartphone in communication with a remote server,
the remote server configured to store glucose data associated with a plurality of hosts each measured by a continuous glucose
monitoring system, wherein the software application is configured to be used by the remote monitoring apparatus to receive
and present notifications and data pertaining to a health condition based on a glucose concentration state of one or more
hosts established to be remotely monitored by a remote monitoring user using the remote monitoring apparatus, wherein the
notifications are based on a specific rule set determined by the remote monitoring user for each host of the one or more hosts
that the remote monitoring user is remotely monitoring;

receiving an input using the software application on the smartphone, the input comprising an indication of one of the one
or more hosts that the remote monitoring user is remotely monitoring;

determining, using the software application on the smartphone, a selected host from the one or more hosts based on the indication;
requesting, using the software application on the smartphone, the glucose data associated with the selected host from the
remote server; and

audibly providing and/or visually displaying, using the software application on the smartphone, a state of the selected host
on a user interface of the software application based on the requested glucose data,

wherein the glucose data comprises glucose concentration values of the selected host measured using the selected host's continuous
glucose monitoring system, and

wherein the specific rule set for each host of the one or more hosts that the remote monitoring user is remotely monitoring
is established upon acceptance or modification of a corresponding set of recommended rule settings configured by each respective
host of the one or more hosts.

US Pat. No. 9,717,445

INDICATOR AND ANALYTICS FOR SENSOR INSERTION IN A CONTINUOUS ANALYTE MONITORING SYSTEM AND RELATED METHODS

DexCom, Inc., San Diego,...

1. A method for continuous analyte monitoring including a continuous analyte monitoring system having a sensor coupled to
a transmitter unit in wireless communication with a device having a display, the method comprising:
initiating a sensor session of the sensor with the transmitter unit;
displaying, using an input module of the device, a diagram of a body on the display;
receiving as an input, via the diagram, a location on the body where the sensor was inserted into skin of a host;
storing the location; and
correlating data from the sensor for the sensor session with the location using a correlation engine, wherein the data includes
quantitative data regarding one or more sensor sessions corresponding to one or more sensor insertion locations, wherein the
quantitative data comprises at least one of sensor accuracy, sensor session length, sensor baseline, sensor sensitivity, sensor
sensitivity decline over time, sensor performance vs. past performance in a same person, sensor performance vs. a population
of users, sensor performance by days or wear, sensor performance by geographical location, sensor performance by external
environment, sensor performance by activity level, data indicative of signal noise, time spent out of communication range,
adhesive data, reliability, data capture, noise metrics, detected faults, end of life metrics, or confidence levels.

US Pat. No. 9,585,563

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method comprising:
receiving, at a mobile remote monitoring apparatus configured to be used by a remote monitoring user, an invitation to access
a secure server storing data associated with a mobile receiver that at least periodically monitors an analyte concentration
state of a host and to receive a message on the mobile remote monitoring apparatus regarding a health condition based on the
analyte concentration state of the host who is remote to the mobile remote monitoring apparatus and who is not in a medical
facility, wherein the invitation is triggered to be sent to the mobile remote monitoring apparatus in response to the host
providing, using the mobile receiver, an identifier that identifies the remote monitoring user;

receiving, by the mobile remote monitoring apparatus, a set of recommended rule settings associated with the invitation, the
set of recommended rule settings being configured by the host using the mobile receiver, at least one of the set of recommended
rule settings being modifiable by the remote monitoring user using the mobile remote monitoring apparatus;

receiving, by the mobile remote monitoring apparatus, user input indicative of acceptance of the invitation to access the
secure server and receive the data associated with the analyte concentration state of the host from the mobile receiver, wherein
the access is activated by the secure server after receipt of the acceptance by the secure server; and

modifying, by the mobile remote monitoring apparatus, a rule setting of the set of recommended rules settings defining an
alert, the alert being representative of an event associated with the health condition based on the analyte concentration
state of the host, wherein the alert, when triggered, causes the message to be sent to the mobile remote monitoring apparatus
to notify the remote monitoring user of the event.

US Pat. No. 9,572,935

INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR

DexCom, Inc., San Diego,...

1. An integrated system for monitoring a glucose concentration in a host and for delivering insulin to the host, the system
comprising:
a continuous glucose sensor, wherein the continuous glucose sensor is configured to substantially continuously measure a glucose
concentration in a host, and to provide sensor data associated with the glucose concentration of the host;

an electronics module comprising a basal controller module configured to iteratively determine an insulin therapy instruction
in response to an evaluation of a relationship of internally derived data and a basal profile, wherein the basal profile comprises
at least one time block associated with a maximum insulin delivery rate; and

an insulin delivery device configured to deliver insulin to the host, wherein the insulin delivery device is at least one
of physically connected to a receiver and/or operably connected to a receiver, wherein the insulin delivery device is configured
to receive the insulin therapy instruction from the basal controller module, and wherein the insulin therapy instruction is
constrained by a maximum insulin delivery rate associated with a current time block.

US Pat. No. 10,045,723

ZWITTERION SURFACE MODIFICATIONS FOR CONTINUOUS SENSORS

DexCom, Inc., San Diego,...

1. A device for measurement of a glucose concentration, the device comprising:a sensor configured to generate a signal indicative of a glucose concentration; and
a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain comprises a copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, wherein the copolymer comprises both hydrophilic and hydrophobic regions, wherein an amount of the at least one betaine compound or the derivative thereof in the outermost domain is from about 1% wt. to about 50% wt. of the outermost domain.

US Pat. No. 9,980,646

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method for remote monitoring health data, comprising:presenting a user interface of a software application resident on a remote monitor device, the software application being configured to enable remote monitoring of an analyte concentration state of each of two or more hosts, the two or more hosts including a first host and a second host, wherein an analyte concentration state of each of the two or more hosts is monitored by different continuous analyte concentration sensor devices,the first host having identified a particular user and provided the particular user of the remote monitor device an indication of permission to first permissible data associated with the analyte concentration state of the first host, the first host further providing the particular user an indication of permission to receive notifications associated with the first permissible data of the first host, the second host having identified the particular user and provided the particular user of the remote monitor device an indication of permission to second permissible data associated with the analyte concentration state of the second host, the second host providing an indication that the particular user does not have permission to receive notifications associated with the second permissible data of the second host, the remote monitor device being remote from the first and second host;displaying, in the user interface, a dashboard display, the dashboard display comprising two or more cells, each cell of the two or more cells corresponding to at least one of the two or more hosts configured to be remotely monitored;
displaying, in a first cell of the two or more cells, the first permissible data associated with the analyte concentration state of the first host, the first permissible data being received from a secure server configured to determine that the remote monitor device is authorized to receive the first permissible data based on the first host's indication of the permission to the first permissible data;
displaying, in a second cell of the two or more cells, the second permissible data associated with the analyte concentration state of the second host, the second permissible data being received from the secure server configured to determine that the remote monitor device is authorized to receive the second permissible data based on the second host's indication of the permission to the second permissible data provided to the particular user; and
displaying, in the dashboard display, an interactive icon that, when engaged, navigates in the user interface to a first remote monitoring settings display associated with the first host, the settings page display comprising at least three cells, the first cell of the at least three cells including an option for the particular user to set a first alert based on a first trigger condition of the first permissible data associated with the analyte concentration state of the first host, the second cell of the at least three cells including an option for the particular user to set a second alert based on a second trigger condition of the first permissible data associated with the analyte concentration state of the first host, and the third cell of the at least three cells including an option for the particular user to set a third alert if no data associated with the first host is received over a particular duration of time, the particular duration of time being configurable by the particular user, the first and second trigger conditions being different from each other, the particular user being denied options to set notifications associated with the second host based on the indication that the particular user does not have the permission to receive the notifications associated with the second permissible data of the second host.

US Pat. No. 9,962,081

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method for administering remote monitoring of health data of a patient user and enabling the patient user to control dissemination of the health data and notifications, the method comprising:authorizing, at a secure server, a remote monitor device to remotely monitor an analyte concentration state of the patient user being monitored by a continuous analyte sensor device, the continuous analyte sensor device being capable of notifying a host device of the patient user based on a comparison of the analyte concentration state of the patient user with a first analyte concentration threshold, the authorizing including allowing the remote monitor device to access at least some analyte concentration data stored on the secure server associated with the analyte concentration state of the patient user, wherein the authorizing the remote monitor device is based, at least in part, on authorization information provided by the patient user to the secure server, thereby enabling the patient user to control authorization of the remote monitor device to access the at least some of the analyte concentration data of the patient user;
receiving from the host device, at the secure server, a set of permissions for the remote monitor device indicating permissible data to the secure server to allow the remote monitor device to access the at least some analyte concentration data, wherein the set of permissions are modifiable by the host device and the host device is operable by the patient user or by a caregiver of the patient user, the host device being operable to manage sensor data generated by the continuous analyte sensor device, the continuous analyte sensor device being local to the host device, thereby enabling the patient user to control how much of the analyte concentration data of the patient user is accessible by the remote monitor device; and
establishing, at the secure server, a set of notification rules for the remote monitor device using the host device, the set of notification rules defining a second analyte concentration threshold indicating when to trigger a notification to the remote monitor device based on a comparison of the at least some of the analyte concentration data of the patient user to the second analyte concentration threshold, the first and second analyte concentration thresholds being different from each other thereby enabling different notifications based on different analyte concentration thresholds to be sent to the remote monitor device and the host device, wherein the set of notification rules, including the second analyte concentration threshold, are modifiable by the remote monitor device only within a scope defined by the set of permissions to the data, thereby enabling the host device to set limits to modifications of the set of notification rules for notifications related to the analyte concentration data of the patient user available to be provided to the remote monitor device.

US Pat. No. 9,907,497

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A sensor system for continuous measurement of a glucose concentration in a host, the sensor system comprising:
a first sensor configured to be implanted in a host and configured to continuously measure a glucose concentration and generate
a first signal, wherein the first sensor is associated with a first sensor accuracy during a first time period of a sensor
session;

a second sensor configured to be implanted in the host and configured to continuously measure a glucose concentration and
generate a second signal, wherein the second sensor is associated with a second sensor accuracy during the first time period
of the sensor session; and

sensor electronics configured to determine a glucose concentration value based on at least one of the first or the second
signal, wherein the sensor electronics are configured to integrate the first signal and the second signal by providing a distribution
of weights associated with the first signal and the second signal and by according a first weight to the first signal and
according a second weight to the second signal, wherein the distribution of weights among the first and second sensors is
a function of time associated with the initiation of the sensor session.

US Pat. No. 9,848,809

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

DexCom, Inc., San Diego,...

1. A method for determining a sensitivity of a continuous analyte sensor, the method comprising:
applying a bias voltage to an analyte sensor;
applying a voltage step above the bias voltage to the analyte sensor;
measuring, using sensor electronics, a signal response of the voltage step from the analyte sensor;
determining, using the sensor electronics, a peak current of the signal response;
determining, using the sensor electronics, a sensitivity of the analyte sensor by correlating the peak current to a predetermined
relationship of the peak current to sensor sensitivity, wherein the predetermined relationship is based at least in part on
time of use of the analyte sensor;

receiving, using the sensor electronics, from the analyte sensor sensor data indicative of analyte concentration;
compensating, using the sensor electronics, the sensor data using the determined sensitivity of the analyte sensor;
determining, using the sensor electronics, an analyte concentration value based at least in part on the compensated sensor
data; and

displaying, using a display, the determined analyte concentration value.

US Pat. No. 9,847,038

ADAPTIVE INTERFACE FOR CONTINUOUS MONITORING DEVICES

DexCom, Inc., San Diego,...

1. A method for adaptive configuration of an analyte monitoring device, the method comprising:
measuring a glucose concentration in a host via a glucose sensor at least partially inserted in the host the glucose sensor
configured to provide continuous sensor data associated with the glucose concentration in the host;

transmitting a first report of first physiological information of a host based on the continuous sensor data using a first
reporting format, wherein the first reporting format comprises a first reporting format characteristic;

determining at least one of behavioral and contextual information comprising at least one of behavioral and contextual characteristic
of the host, wherein the at least one of behavioral and contextual characteristic is associated with a physiological condition
of the host, wherein the at least one of behavioral and contextual characteristic includes calibration frequency:

comparing the at least one of behavioral and contextual characteristic with one or more behavioral or contextual criteria;
adjusting the reporting format based at least in part on said comparing, wherein the reporting format comprises a second reporting
format characteristic that is different from the first reporting format characteristic, wherein the second reporting format
characteristic includes a dynamic display of calibration frequency; and

transmitting a second report of second physiological information using the second reporting format.

US Pat. No. 9,839,395

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for processing continuous glucose sensor data, the method comprising:
receiving sensor data from a continuous glucose sensor, wherein the sensor data comprises one or more sensor data points;
obtaining an estimated sensor glucose value from the one or more sensor data points;
determining, using a processor module, a predicted amount of time to hypoglycemia or a predicted amount of time to hyperglycemia,
wherein the determining is based at least in part on the estimated sensor glucose value and a glucose value threshold; and

programmatically producing, using the processor module, insulin delivery and/or insulin therapy instructions based at least
in part on one or both of: a) the predicted amount of time to hyperglycemia meeting a criterion, and b) the predicted amount
of time to hypoglycemia meeting a criterion, wherein the produced insulin delivery and/or insulin therapy instructions are
usable to automate control of an insulin delivery device to automatically administer insulin.

US Pat. No. 9,801,572

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A system for measuring an analyte in a host, comprising:
a sensor electronics housing;
an on-skin assembly configured to releasably attach with the sensor electronics housing; and
a sensor comprising at least one electrode, the sensor comprising:
an in vivo portion adapted for insertion through an exit port of the sensor electronics housing and through an exit site of
the host's skin; and

an ex vivo portion adapted to remain above the host's skin after sensor insertion and to operably connect to the sensor electronics
housing, wherein the ex vivo portion is configured to be bent by attachment of the sensor electronics housing to the on-skin
assembly.

US Pat. No. 9,741,139

INTEGRATED MEDICAMENT DELIVERY DEVICE FOR USE WITH CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A system for processing continuous glucose sensor data comprising:
one or more processors;
computer memory; and
computer-readable instructions stored in the computer memory, wherein the instructions are configured to cause at least one
of the one or more processors, upon execution of the instructions, to:

process sensor data generated using a continuous glucose sensor and display a graphical representation of the processed sensor
data on a display device, wherein the sensor data is indicative of a host's glucose concentration, and wherein the displaying
includes graphing or charting the processed sensor data as a function of a time-related variable;

recommend a medicament therapy based at least in part on the processed sensor data; and
request additional data to validate the recommended medicament therapy to ensure safety or accuracy prior to medicament delivery,
wherein the additional data is not generated using the continuous glucose sensor.

US Pat. No. 9,743,224

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method comprising:
executing an authentication protocol between a first communication device associated with a continuous glucose sensor and
a second communication device associated with a glucose information display;

transmitting by the second communication device to the first communication device a first encrypted message including an identifier,
and a first challenge value provided by the first communication device, wherein the first encrypted message is encrypted using
an encryption method based on the identifier and the first challenge value, and wherein the identifier is associated with
the first communication device;

generating by the first communication device a second encrypted message using at least the information in the first encrypted
message, and upon receiving the first encrypted message; and

verifying by the first communication device the first encrypted message to determine a status of the authentication protocol.

US Pat. No. 9,655,565

SYSTEMS AND METHODS FOR DYNAMICALLY AND INTELLIGENTLY MONITORING A HOST'S GLYCEMIC CONDITION AFTER AN ALERT IS TRIGGERED

DexCom, Inc., San Diego,...

1. A method of avoiding unnecessary hyperglycemic alerts, the method comprising:
initially activating a first alert state based on a first criteria associated with a hyperglycemic condition of a host;
waiting a time period before providing an output associated with the first alert state;
actively monitoring, by a processor module, data associated with the host's hyperglycemic condition during the waiting time
period;

providing an output associated with the first alert state after the waiting time period based on the data associated with
the host's hyperglycemic condition meeting a second criteria, wherein the first criteria includes a first glucose level threshold
and the second criteria includes a second glucose level threshold higher than the first glucose level threshold;

not providing the output associated with the first alert state after the waiting time period based on the data associated
with the host's hyperglycemic condition not meeting the second criteria; and

transitioning from the first alert state to an inactive alert state based on the data associated with the host's hyperglycemic
condition meeting a third criteria, wherein the third criteria includes a third glucose level threshold lower than the first
glucose level threshold.

US Pat. No. 9,549,692

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. An implantable device for continuous measurement of an analyte concentration, the implantable device comprising:
a sensor configured to generate a signal indicative of a concentration of an analyte in a host; and
a membrane located over the sensor, the membrane comprising a first domain configured to reduce a flux therethrough of the
analyte, a second domain that comprises an enzyme, and a third domain configured to reduce passage therethrough of an interferent,
the third domain comprising a plurality of alternating polyelectrolyte layers, wherein the device is configured to exhibit
a selectivity for acetaminophen over hydrogen peroxide of less than about 0.005, wherein the selectivity is determined by
dividing a sensitivity of the device for acetaminophen by a sensitivity of the device for hydrogen peroxide, wherein the acetaminophen
sensitivity is determined in vitro by measuring the device's current response versus concentrations of acetaminophen at 10
?M aqueous acetaminophen, 50 ?M aqueous acetaminophen, and 100 ?M aqueous acetaminophen, and then performing linear regression,
and wherein the hydrogen peroxide sensitivity is determined in vitro by measuring the device's current response versus concentrations
of hydrogen peroxide at 1 ?M aqueous hydrogen peroxide, 2 ?M aqueous hydrogen peroxide, and 3 ?M aqueous hydrogen peroxide,
and then performing linear regression.

US Pat. No. 10,004,435

DEVICES AND METHODS FOR CONTINUOUS ANALYTE MONITORING

DexCom, Inc., San Diego,...

1. A wearable device for providing information to a user regarding the user's blood glucose value, the device comprising:a communication module having an input/output port for receiving data transmitted from a continuous glucose monitoring system including a sensor, a signal from the sensor transformed into the data for transmission, wherein the communication module is configured to receive a first dataset and a second dataset:
a display configured to display a first information based on the first dataset for a set duration; and
an input module for enabling the user to acknowledge that the first information has been viewed,
wherein when the user acknowledges that the first information has been viewed, the communication module sends an acknowledgement signal to the glucose monitoring system,
wherein the display is configured to cease displaying the first information after the continuous glucose monitoring system receives the acknowledgement signal from the communication module, and
wherein, after the set duration elapses, the display is configured to no longer display the first information until the communication module receives the second dataset from the glucose monitoring system.

US Pat. No. 9,999,379

SYSTEMS AND METHODS FOR A CONTINUOUS MONITORING OF ANALYTE VALUES

DexCom, Inc., San Diego,...

1. A method for a wireless data communication between an analyte sensor system and a plurality of display devices capable of displaying analyte values wirelessly received from the analyte sensor system, the method comprising:storing a first list identifying bonding information associated with the plurality of display devices, the bonding information generated during initial pairing of each of the display devices with a transceiver, and a second list identifying whether bonded display devices are allowed to establish data connections with the transceiver, wherein by utilizing the second list, data connection requests from each of the display devices can be rejected or granted promptly at a radio hardware level;
transmitting a first series of advertisement signals;
receiving a first data connection request from a first display device of the plurality of display devices in response to the first series of advertisement signals;
rejecting the first data connection request from the first display device at the radio hardware level when the first display device is identified in the first list but not in the second list indicating that the first display device had previously paired with the transceiver, but not allowed to establish data communication with the transceiver,
receiving a second data connection request from a second display device of the plurality of display devices responsive to the first series of advertisement signals, and
granting the second data connection request at the radio hardware level when the second display device is identified both in the first and second lists indicating that the second display device had previously paired with the transceiver, and also allowed to establish data communication with the transceiver.

US Pat. No. 9,996,668

DATA BACKFILLING FOR CONTINUOUS GLUCOSE MONITORING

DexCom, Inc., San Diego,...

1. A method comprising:receiving, at a receiver, backfill data representative of sensor data stored, at continuous blood glucose sensor and transmitter assembly, due to a loss of a wireless link between the receiver and the continuous blood glucose sensor and transmitter assembly;
generating, at the receiver, at least one of a notification or a graphical indicator for presentation at a display of the receiver, the at least one of the notification or the graphical indicator enabling the backfill data to be graphically distinguished, when presented at the display, from non-backfill data;
generating, at the receiver, a view including the backfill data, the non-backfill data, and the generated at least one of the notification or the graphical indicator; and wherein the backfill data is received as compressed data which comprises a function representative of at least a portion of a curve corresponding to the backfill data.

US Pat. No. 9,974,903

SYSTEM AND METHOD FOR PROVIDING ALERTS OPTIMIZED FOR A USER

DexCom, Inc., San Diego,...

1. A non-transitory computer readable medium, comprising instructions for causing a computing environment to perform a method of dynamically adjusting or tuning user alerts based on a cognitive awareness determination, thereby providing data relevant to treatment of a diabetic state warranting attention, the method comprising steps of:identifying a current or future diabetic state warranting attention, the identifying based at least partially on a glucose concentration value;
estimating or predicting a cognitive awareness of the user of the identified current or future diabetic state warranting attention; and
if the result of the estimating or predicting is that the user is cognitively unaware of the identified current or future diabetic state warranting attention, then transmitting an indication of the diabetic state warranting attention to a medicament pump,
whereby the user is only treated for the diabetic state warranting attention if and at a time that the user is unaware of the diabetic state warranting attention.

US Pat. No. 9,974,470

SYSTEMS AND METHODS FOR A CONTINUOUS MONITORING OF ANALYTE VALUES

DexCom, Inc., San Diego,...

4. A mobile device configured for a wireless data communication with an analyte sensor system, the mobile device comprising:a user interface;
a radio unit for transmitting and receiving wireless signals;
a memory for storing identification information associated with one or more transceivers and a custom application configured to interact with a user of the mobile device via the user interface; and
a processor operatively coupled to the user interface, the radio unit, and the memory and configured to:
cause the custom application to enter a background mode, and while the custom application is in the background mode:
cause the radio unit to search for advertisement signals generated by the analyte sensor system,
perform by the custom application an authentication procedure with a transceiver of the analyte sensor system based on user-entered identification information associated with the transceiver if an advertisement signal is received from the transceiver, and
issue a first notification to the user to bring the custom application into a foreground mode from the background mode, and while custom application is in the foreground mode:
cause the custom application to issue a second notification requesting the user for a confirmation that a data connection with the transceiver is desired,
complete the data connection with the transceiver if the confirmation is received; and
receive an analyte value from the analyte sensor system.

US Pat. No. 9,962,114

APPARATUS AND METHODS FOR MAINTAINING A MEDICAL DEVICE IN A CLEAN AND DISINFECTED STATE, AND FOR CLEANING AND DISINFECTING A MEDICAL DEVICE

DexCom, Inc., San Diego,...

15. A method for reprocessing a reusable electronic medical device, the method comprising:receiving an electronic medical device from a first user, wherein the electronic medical device is contained in a first protective enclosure, wherein the electronic medical device has a communication port, wherein the electronic medical device is configured to wirelessly receive sensor data and display glucose concentration information, wherein the first protective enclosure has substantially no impact on RF performance, wherein the first protective enclosure is configured to protect against liquid ingress, wherein the first protective enclosure is sized and shaped to conform to a shape of the electronic medical device;
removing the electronic medical device from the first protective enclosure;
inserting the electronic medical device into a second protective enclosure through an opening in the second protective enclosure, wherein the second protective enclosure has substantially no impact on RF performance, wherein the second protective enclosure is configured to protect against liquid ingress, wherein the second protective enclosure is sized and shaped to substantially conform to the shape of the electronic medical device;
providing a cover to the second protective enclosure over the opening; and
providing the electronic medical device contained within the second protective enclosure to a second user.

US Pat. No. 9,931,037

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for transmitting data between devices of an analyte monitoring system, the method comprising:generating sensor analyte data using a sensor electronics module electrically connected to a continuous analyte sensor;
establishing a first communication mode between the sensor electronics module and a display device, wherein the first communication mode is associated with a first transmission power;
transmitting the sensor analyte data to the display device via the first communication mode, wherein the transmitting comprises periodically opening and closing a transmission window between the sensor electronics module and the display device;
initiating a second communication mode between the sensor electronics module and the display device responsive to sensing user input at a user interface of the display device indicative of entering the second communication mode; and
upon the initiation of the second communication mode, causing a forced transmission of the sensor analyte data from the sensor electronics module to the display device via the second communication mode during the closing of the transmission window that is associated with the first communication mode, wherein the second communication mode is associated with a second transmission power.

US Pat. No. 9,918,668

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

DexCom, Inc., San Diego,...

1. A method for calibrating a second continuous analyte sensor using sensor data from a first continuous analyte sensor, comprising:
receiving sensor data from a first continuous analyte sensor, wherein the sensor data is indicative of a glucose concentration
in a host;

determining a conversion function, using a processor module, wherein the conversion function comprises a slope and a baseline,
wherein the slope is representative of a sensor sensitivity;

converting the sensor data using the conversion function;
receiving sensor data from a second continuous analyte sensor; and
calibrating the sensor data from the second continuous analyte sensor using the sensor data from the first continuous analyte
sensor, including providing calibration information, including data about the sensor sensitivity, to the second continuous
analyte sensor to increase its intelligence and enhance its performance, wherein the calibrating includes constructing a first
curve from the sensor data from the first continuous analyte sensor and constructing a second curve from the sensor data from
the second continuous analyte sensor and matching the first curve with the second curve.

US Pat. No. 9,844,328

SENSORS FOR CONTINUOUS ANALYTE MONITORING, AND RELATED METHODS

DexCom, Inc., San Diego,...

1. A sensor device for measuring analyte concentration in a host, comprising:
an in vivo portion configured for insertion under a host's skin, wherein the in vivo portion comprises at least one sensor,
a bioactive agent, a biodegradable material, a hardening agent, and a membrane, wherein the hardening agent is integrated
into the membrane, wherein the membrane covers at least a portion of the at least one sensor, wherein the hardening agent
increases a column strength of the sensor, wherein the biodegradable material encapsulates at least a portion of the sensor,
wherein the biodegradable material is configured to biodegrade following insertion into the host, wherein the biodegradable
material is formed of a material that provides the sensor with sufficient column strength to prevent sensor buckling during
insertion of the in vivo portion, wherein the biodegradable material has a Rockwell Hardness of 25 D to 65 D, wherein the
at least one sensor lacks a column strength necessary to be inserted alone through the host's skin without buckling, wherein
the bioactive agent is configured to suppress wounding; and

an ex vivo portion configured to remain above the host's skin surface after insertion of the in vivo portion, wherein the
ex vivo portion is configured to receive pressure from a user to cause insertion of the in vivo portion of the sensor device,
wherein the ex vivo portion comprises an adhesive configured to adhere the ex vivo portion to the host's skin.

US Pat. No. 9,788,354

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method of providing an adjustable integration window, the method comprising:
storing, two or more sensor data points representative of glucose values measured by a sensor, in a memory buffer to create
an integrated data point, wherein each of the sensor data points is associated with a time stamp and the stored data points
define an integration window;

receiving, from a reference glucose monitor, a reference value associated with a time stamp;
adjusting the integration window to correspond to the time stamp for the reference value;
using a calibration function to match the reference value with sensor data points falling within the adjusted integration
window; and

calibrating the integrated data point to generate an estimated analyte value, wherein the estimated analyte value is displayed
on a display device.

US Pat. No. 9,775,543

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A continuous analyte monitoring assembly adapted to assist in determining an analyte level of a fluid, the continuous analyte
monitoring assembly comprising:
a housing having a bottom, the bottom forming a recess;
electronics located within the housing, the electronics being adapted to assist in determining an analyte level of a fluid
sample;

an implantable sensor comprising a sensor body and at least one electrode disposed on the sensor body, wherein the implantable
sensor is adapted to move from a retracted position to an inserted position through the recess, wherein in the retracted position
the implantable sensor is at least partially curved and stowed at least partially inside the housing, wherein in the retracted
position the at least one electrode resides above a host's skin, wherein in the inserted position the implantable sensor extends
at least partially out of the housing, wherein in the inserted position the at least one electrode is adapted to at least
partially reside under the host's skin; and

a cannula being adapted to assist in placing the implantable sensor.

US Pat. No. 9,743,871

MULTIPLE ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR, AND RELATED METHODS

DexCom, Inc., San Diego,...

1. An analyte sensor, comprising:
a first working electrode, wherein the first working electrode is an enzyme electrode;
a second working electrode, wherein the second working electrode is a non-enzyme electrode; and
a membrane system overlying the first working electrode and the second working electrode, wherein the membrane system comprises
a first portion over the first working electrode and a second portion over the second working electrode, wherein a permeability
to hydrogen peroxide of the membrane system over the first working electrode is greater than a permeability to hydrogen peroxide
of the membrane system over the second working electrode, and wherein the permeability to hydrogen peroxide of the membrane
over the first working electrode and the permeability to hydrogen peroxide of the membrane system over the second working
electrode are different by more than 5%.

US Pat. No. 9,717,843

PACKAGING SYSTEM FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A package for receiving and securing a product, the package comprising:
at least one product, each product comprising:
an on-skin assembly comprising an adhesive patch configured to adhere to a host's skin;
a transcutaneous glucose sensor operably connected to the on-skin assembly, wherein the glucose sensor comprises an electrode
surrounded by a membrane configured to be exposed to interstitial fluid;

at least one first container configured to receive and secure the at least one product therein, wherein the at least one first
container is configured to be impermeable to water vapor;

a second container configured to receive the at least one first container; and
a retainer configured to secure the at least one first container in a fixed position and fixed orientation within the second
container such that movement of the second container does not result in substantial movement of the at least one first container
within the second container.

US Pat. No. 9,668,677

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. An applicator system configured to insert a transcutaneous analyte sensor into a host, the applicator system comprising:
a housing configured for placement against a skin of the host; a sensor configured for transcutaneous placement through the
skin of a host;

a needle configured to aid the sensor for placement through the skin; and
an applicator comprising applicator components configured to insert the needle and the sensor into the host, wherein the applicator
components are configured to rotatingly engage one another by a continuous torque which inserts the sensor and needle into
the host the continuous torque configured to subsequently retract the needle from the host, wherein the sensor is inserted
into the host to a predetermined depth.

US Pat. No. 9,615,779

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

DexCom, Inc., San Diego,...

1. A method of applying an on skin sensor assembly to a skin of a host, wherein the on-skin sensor assembly comprises a housing
secured to an applicator, wherein the housing is configured to receive an electronics unit, the method comprising:
positioning an applicator proximate a skin of a host, the applicator comprising a sensor insertion assembly, a trigger, and
a base;

inserting an electronics unit into the housing, wherein the electronics unit is configured to generate analyte information
based on a signal from a sensor;

activating the trigger, thereby causing the sensor insertion assembly to insert the sensor into the host, to cause the electronics
unit to secure to the housing such that the sensor electrically contacts the electronics unit, and to cause the housing to
detach from the base; and

removing the applicator away from the skin of the host, whereby the on-skin sensor assembly comprising the housing, the electronics
unit, and the inserted sensor remains on the skin of the host.

US Pat. No. 9,538,946

INTEGRATED RECEIVER FOR CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A glucose sensor system for monitoring glucose concentration in a biological sample of a host, the system comprising:
a receiver, the receiver comprising a housing, the receiver housing comprising:
a radio frequency receiver located within the housing and configured to wirelessly receive sensor data from a continuous glucose
sensor, the sensor data indicative of a host's glucose concentration;

electronic circuitry located within the housing and configured for processing data from both the continuous glucose sensor
and data from a single point glucose monitor when the single point glucose monitor is operatively connected to the receiver,
wherein the data from the single point glucose monitor is a glucose concentration in a biological sample, wherein the electronic
circuitry is configured to determine a severity of signal artifacts associated with the continuous sensor data based at least
in part on a frequency content of the signal artifacts, wherein processing sensor data from the continuous glucose sensor
includes processing the sensor data from the continuous glucose sensor responsive to evaluation of information associated
with calibration of the sensor; and

a user interface integral with the housing, operably connected to the electronic circuitry and configured for providing input
and output associated with both the continuous glucose sensor and the single point glucose monitor, including simultaneously
displaying the processed data from the continuous glucose sensor and the glucose concentration of the biological sample measured
by the single point glucose monitor on the user interface, wherein the user interface is configured to prompt a user to obtain
a single point glucose monitor value based upon predetermined events.

US Pat. No. 9,532,741

MEMBRANE FOR USE WITH IMPLANTABLE DEVICES

DexCom, Inc., San Diego,...

1. An implantable device for continuous measurement of a glucose concentration, comprising:
a sensing region configured to continuously measure a signal indicative of a glucose concentration in a host; and
a membrane located over the sensing region, wherein the membrane comprises a first layer and a second layer, wherein the first
layer comprises an enzyme configured to catalyze a reaction with glucose as a reactant, wherein the second layer is formed
of a blend comprising a polyurethane polymer and an acrylate polymer.

US Pat. No. 9,980,223

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for transmitting data between a communication device associated with an analyte sensor and another communication device configured to provide user access to analyte values and/or information derived from analyte values, comprising:generating sensor data using a first communication device coupled to a continuous analyte sensor of an analyte sensor system;
switching the first communication device among a plurality of transmission window states, the plurality of transmission window states including:
a first transmission window state in which the first communication device does not open a transmission window,
a second transmission window state in which the first communication device periodically opens a transmission window at a first frequency to facilitate communication with a display device configured to provide user access to analyte values or information derived from analyte values, and
a third transmission window state in which the first communication device periodically opens a transmission window at a second frequency that is less than the first frequency, wherein the first communication device switches from the second transmission window state to the third transmission window state responsive to a determination of a successful pairing of the first communication device with the display device, and availability of the sensor data generated from the continuous analyte sensor of the analyte sensor system; and
transmitting one or more beacons during one of the transmission window state.

US Pat. No. 9,977,010

END OF LIFE DETECTION FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A system for determining end of life of a continuous analyte sensor, the system comprising sensor electronics configured to be operably connected to a continuous analyte sensor, the sensor electronics configured to:evaluate a rate of change of sensor sensitivity factor associated with end of life symptoms of the continuous analyte sensor, wherein the rate of change of sensor sensitivity factor is based at least in part on a skew moving average of uncalibrated sensor data;
determine an end of life status of the continuous analyte sensor by comparing the evaluated rate of change of sensor sensitivity factor to a rate of change threshold; and
provide an output related to the end of life status of the continuous analyte sensor, wherein the sensor electronics are configured to provide the output by disabling display of sensor data.

US Pat. No. 9,936,909

ZWITTERION SURFACE MODIFICATIONS FOR CONTINUOUS SENSORS

DexCom, Inc., San Diego,...

1. A device for measurement of a glucose concentration, the device comprising:a sensor configured to generate a signal indicative of a glucose concentration; and
a sensing membrane located over the sensor, wherein the sensing membrane comprises an outermost domain, wherein the outermost domain is configured to interface with a biological fluid when implanted in a host, wherein the outermost domain comprises a polyurethane copolymer, wherein the copolymer comprises at least one betaine compound or a derivative thereof, wherein the at least one betaine compound or a derivative thereof comprises 0.1 to 5% by weight of the outermost domain, and wherein the polyurethane copolymer comprises both hydrophilic and hydrophobic regions.

US Pat. No. 9,901,292

SYSTEMS AND METHODS FOR A CONTINUOUS MONITORING OF ANALYTE VALUES

DexCom, Inc., San Diego,...

1. A method for transmitting data between a first communication device associated with an analyte sensor and one or more display
devices configured to provide user access to analyte values and/or information derived from analyte values, comprising:
switching among a plurality of communication states, wherein a first communication state includes:
periodically opening a first transmission window according to a first time interval to provide a first display device with
sensor data from the first communication device that is associated with the analyte sensor;

determining to vary the first time interval based on one or more criteria, wherein the one or more criteria is selected from
a group consisting of: sensor data, monitored battery life of the first communication device, type of the first display device,
user instructions received from the first display device, and timing of sensor session;

switching to a second communication state from the first communication state responsive to the determination, wherein the
second communication state includes:

varying the first time interval to a second time interval; and
periodically opening a second transmission window according to the second time interval to continue to provide the display
device with updated sensor data from the first communication device.

US Pat. No. 9,833,199

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

DexCom, Inc., San Diego,...

1. A continuous analyte monitoring system configured to determine an end of life of a continuous analyte sensor, the system
comprising sensor electronics configured to be operably connected to the continuous analyte sensor, the sensor electronics
configured to:
evaluate one or more factors associated with remaining sensor life of a sensor;
determine a remaining sensor life of the sensor based on the evaluation of the factors; and
provide an output related to the remaining sensor life of the sensor,
wherein the one or more factors include at least one of: accuracy of the glucose sensor data; noise associated with the glucose
sensor data; and an algorithmic determination of sensor end-of-life based on sensor data.

US Pat. No. 9,814,414

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A method for inserting a transcutaneous analyte sensor into a host using an applicator, the method comprising the steps
of:
adhering a base of a mounting unit to a skin of a host before insertion of a transcutaneous sensor into the host;
pushing on a first component of an applicator for inserting the transcutaneous analyte sensor into the host, so as to insert
an introducer and the sensor into the skin of the host by using a first springless force, wherein the pushing comprises pushing
on a plunger; and

pulling on a second component of the applicator so as to retract the introducer from the skin of the host by using a second
springless force, while leaving the sensor in the host;

wherein pushing is performed by a user, wherein the first component and the second component of the applicator are configured
to interact so as to enable insertion of the sensor and retraction of the introducer.

US Pat. No. 9,801,574

TECHNIQUES TO IMPROVE POLYURETHANE MEMBRANES FOR IMPLANTABLE GLUCOSE SENSORS

DexCom, Inc., San Diego,...

1. An implantable device for measuring an analyte in a biological fluid, comprising:
an implantable sensor comprising an electrochemically reactive surface; and
a membrane disposed over at least a portion of the electrochemically reactive surface, wherein the membrane comprises a matrix
comprising a first polymer and a second polymer dispersed throughout the matrix, wherein the first polymer is polyurethane
urea, wherein the second polymer comprises at least one hydrophilic component, wherein the hydrophilic component of the second
polymer forms in the membrane hydrophilic segments along which the analyte diffuses.

US Pat. No. 9,763,609

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Dexcom, Inc., San Diego,...

1. An electrochemical continuous glucose sensor configured for implantation in a host, the glucose sensor comprising:
an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises
a glucose-related component and a non-glucose related component; and

an enzyme-containing membrane covering at least a portion of the electrode, wherein the enzyme-containing membrane comprises
an outer domain comprising a discontinuously hydrophilic surface, wherein the outer domain is formed from a blend, wherein
the outer domain comprises at least about 5 wt. % of a hydrophilic component;

wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.

US Pat. No. 9,736,210

ANALYTE DATA RETRIEVER

DexCom, Inc., San Diego,...

1. A method comprising:
inhibiting access to analyte sensor data indicative of measured analyte concentration levels in a host, when a command is
received to place in a blind mode one or more of an interface and a sensor system configured to measure the analyte concentration
level in the host;

forwarding the analyte sensor data to an analyte processing system; and deriving analyte concentration values using the analyte
sensor data,

wherein the inhibiting access to the analyte sensor data prevents one or more of the interface and the sensor system from
displaying a numerical representation of the analyte concentration values derived using the analyte sensor data stored in
memory therein.

US Pat. No. 9,724,045

SYSTEMS AND METHODS FOR REPLACING SIGNAL ARTIFACTS IN A GLUCOSE SENSOR DATA STREAM

DexCom, Inc., San Diego,...

1. A glucose sensor system that detects a signal artifact that can result in an erroneous glucose concentration measurement
and responds to the detected signal artifact differently depending on a corresponding evaluated level of severity, the system
comprising:
an electrochemical glucose sensor comprising a plurality of electrodes and an enzyme-containing membrane, wherein the enzyme-containing
membrane is positioned to provide a medium for a conductive pathway between electrodes of the plurality of electrodes when
a voltage is present across the electrodes while the electrochemical glucose sensor is in contact with a biological sample;
and

sensor electronics comprising a processor for executing a computer program code stored in a memory to cause the sensor electronics
to:

apply a voltage across the electrodes of the electrochemical glucose sensor,
measure a signal response of the electrochemical glucose sensor responsive to the applied voltage, the measured signal response
having a signal content associated with a local environment at the electrodes, wherein the local environment contributes to
a signal artifact in a glucose signal generated by the electrochemical glucose sensor,

evaluate a level of severity of the signal artifact based at least in part on the signal content of the measured signal response,
and

dynamically adjust the sensor electronics based on the level of severity evaluated to generate:
(i) a first glucose value for display based on an output from the electrochemical glucose sensor when the signal artifact
is evaluated having a first level of severity, and

(ii) a second glucose value, different from the first glucose value, for display based on the output from the electrochemical
glucose sensor when the signal artifact is evaluated having a second level of severity different from the first level of severity,
wherein the second glucose value accounts for the signal artifact affecting glucose measurement.

US Pat. No. 9,681,807

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

DexCom, Inc., San Diego,...

1. A method for transmitting data between devices of an analyte monitoring system, the method comprising:
generating sensor data using a sensor electronics module electrically connected to a continuous analyte sensor during a first
power mode;

establishing a two-way communication channel between the sensor electronics module and a display device, and the sensor electronics
module transmitting during the first power mode;

transitioning to a second power mode, wherein the second power mode comprises the sensor electronics module being at a lower
power than at the first power mode;

providing a sleep pulse signal with a first current value to a sleep current circuit of the sensor electronics module upon
the transition to the second power mode from the first power mode; and

detecting, by the sleep current circuit during the second power mode, a resultant current value that is the summation of the
first current value of the sleep pulse signal and a second current value of a sleep current of the sensor electronics module,
wherein the second current value of the sleep current is generated based on a difference between the resultant current value
and the first current value of the sleep pulse signal that is provided to the sleep current circuit,

comparing the resultant current value with a predetermined threshold value during the second power mode,
verifying whether an error associated with a normal battery drain of the sensor electronics module has occurred during the
second power mode, wherein determining the error has occurred is based on said comparing indicating that the resultant current
value is larger than the predetermined threshold value,

transitioning to the first power mode from the second power mode, prior to the determination of the occurrence of the error
in the sensor electronics module.

US Pat. No. 9,572,523

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A device for continuous in vivo measurement of a glucose concentration, the device comprising:
an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host, wherein
the implantable sensor comprises an electroactive surface;

a membrane located over the sensor, wherein the membrane comprises a first domain comprising an enzyme configured to react
with glucose to produce a measured species configured to be oxidized at the sensor, wherein the membrane comprises a second
domain comprising a blend comprising:

a polymer comprising a hydrophilic segment, wherein the molecular weight of the polymer is from about 25,000 daltons to about
5,000,000 daltons, and

a polyurethaneurea,
wherein the blend of the polymer and the polyurethaneurea comprises both hydrophilic and hydrophobic regions; and
sensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow
produced by the sensor to generate sensor data indicative of glucose concentration.

US Pat. No. 9,549,693

SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS

DexCom, Inc., San Diego,...

1. An implantable continuous analyte sensor, comprising:
a working electrode; and
a membrane system disposed over the working electrode, the membrane system comprising:
a first domain configured to have a greater selectivity for reducing permeability therethrough of a first interfering species
than a second interfering species;

a second domain, different from the first domain, configured to have a greater selectivity for reducing permeability therethrough
of the second interfering species than the first interfering species; and

a third domain comprising an enzyme configured to react with an analyte; and
wherein the first and second interfering species are molecules that would be electro-reduced or electro-oxidized by the working
electrode if they reached an electroactive surface the working electrode.

US Pat. No. 9,549,699

POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A device for continuous in vivo measurement of a glucose concentration, the device comprising:
an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host;
an enzyme-containing membrane located over the sensor, wherein the enzyme-containing membrane comprises both hydrophilic and
hydrophobic regions, and wherein the enzyme-containing membrane comprises:

an enzyme configured to catalyze a reaction that has glucose as a reactant; and
a polyurethane comprising a plurality of repeating hard segments and repeating soft segments, wherein a soft segment of the
plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons, wherein a hard
segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about 10,000 Daltons;
and

sensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow
produced by the sensor to generate sensor data indicative of glucose concentration.

US Pat. No. 10,039,480

MEMBRANE FOR USE WITH IMPLANTABLE DEVICES

DexCom, Inc., San Diego,...

1. An implantable device for continuous measurement of a glucose concentration, comprising:a sensing region configured to continuously measure a signal indicative of a glucose concentration in a host; and
a membrane system located over the sensing region, wherein the membrane comprises a sensing membrane and a biointerface membrane, wherein the sensing membrane comprises an enzyme configured to catalyze a reaction with glucose as a reactant, wherein the biointerface membrane is configured to resist cellular attachment and is impermeable to cells and cell processes.

US Pat. No. 9,986,942

ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. An analyte sensing device for detecting an analyte in a host, comprising:a transcutaneous continuous sensor configured to measure a clinically useful analyte concentration in a tissue of a host for a time period from one day to fifteen days post implantation, the sensor comprising:
a sensor configured to measure an analyte in a host;
a sensing membrane located over the sensor; and
a biointerface membrane disposed on the sensing membrane, wherein the biointerface membrane is configured to interface with biological fluid, wherein the biointerface membrane has a dry thickness from 0.2 microns to 5 microns, wherein the biointerface membrane comprises a material that has from 20 wt. % to about 80 wt. % water during sensor use,
wherein the sensor has a sensitivity of 1 pA/mg/dL to 100 pA/mg/dL during a sensor session.

US Pat. No. 9,931,067

DEVICE AND METHOD FOR DETERMINING ANALYTE LEVELS

DexCom, Inc., San Diego,...

1. An implantable sensor system for measuring glucose, the system comprising:an optical absorbance sensor configured to measure glucose;
sensor electronics operably connected to the sensor; and
a membrane disposed on at least a portion of the sensor, wherein the membrane comprises an outermost domain, wherein the outermost domain is configured to interface with tissue or a biological fluid, wherein the outermost domain comprises a metal portion.

US Pat. No. 9,901,307

SYSTEMS AND METHODS FOR PROCESSING SENSOR DATA

DexCom, Inc., San Diego,...

1. A system for processing continuous analyte sensor data, comprising:
a continuous analyte sensor configured to continuously measure a concentration of analyte in a host; and
a computer system configured to receive sensor data from the continuous analyte sensor, to determine a level of reliability
of the sensor data, the level of reliability of the sensor data based at least in part on transient non-glucose related signal
artifacts in the sensor data, and to provide insulin delivery instructions and/or insulin therapy instructions, based on a
comparison of the determined level of reliability with one or more thresholds, to automatically control an insulin pump.

US Pat. No. 9,788,766

ANALYTE SENSING BIOINTERFACE

DexCom, Inc., San Diego,...

1. A transcutaneous continuous glucose sensor system, comprising:
a substantially planar sensor, the sensor comprising:
a first non-conductive layer;
a first conductive layer comprising a first electrode, wherein the first conductive layer is disposed over the first non-conductive
layer;

a second non-conductive layer disposed over the first conductive layer;
a second conductive layer comprising a second electrode, wherein the second conductive layer is disposed over the second non-conductive
layer;

a third non-conductive layer disposed over the second conductive layer;
a third conductive layer comprising a third electrode, wherein the third conductive layer is disposed over the third non-conductive
layer;

wherein at least one of the first electrode, second electrode, or third electrode is a working electrode configured to measure
a signal indicative of a glucose concentration;

a membrane disposed on at least a portion of the sensor; and
electronics electrically coupled to the working electrode.

US Pat. No. 9,730,620

REMOTE MONITORING OF ANALYTE MEASUREMENTS

DexCom, Inc., San Diego,...

1. A method for wireless communication between computing devices of a health monitoring system, comprising:
receiving, using a gateway, a heartbeat message from a receiver of an analyte monitoring system, the heartbeat message triggering
connection logic;

requesting, using the gateway, a latest analyte concentration value and a receiver time from the receiver;
identifying, using the gateway, sensor data gaps of analyte concentration data stored at a remote server;
requesting, using the gateway, one or more timeframes of sensor data from the receiver based on the identified data gaps;
and

providing, using the gateway, the sensor data to the server;
wherein identifying the sensor data gaps includes reading a predetermined number of past analyte concentration values stored
at the receiver, storing the read predetermined number of past analyte concentration values at the gateway, requesting analyte
concentration value data from the remote server, and identifying corresponding analyte concentration values between the past
analyte concentration values of the receiver and the analyte concentration value data of the remote server.

US Pat. No. 9,451,910

TRANSCUTANEOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A sensor system for measuring an analyte concentration in a host, the system comprising:
a sensor configured to continuously measure an analyte concentration in a host;
a sensor electronics module configured to electrically couple to the sensor, wherein the sensor electronics module comprises
sensor electronics configured to provide a signal associated with the analyte concentration in the host, a radio frequency
identification device, an internal power supply configured to supply power to the electronics module, and a switch operatively
connected to the power supply, the switch configured to switch between a first state and a second state, wherein the internal
power supply is configured to be in a first power mode when the switch is in the first state and in a second power mode when
the switch is in the second state, the first power mode supplying less power to the sensor electronics module than the second
power mode, and wherein the internal power supply provides power to the sensor electronics sufficient to provide a bias voltage
for the sensor so to generate the signal associated with the analyte concentration; and

a receiver device having a power supply configured to inductively power the radio frequency identification device when the
receiver is placed in proximity to the sensor electronics module, a processor configured to generate estimated analyte concentration
values, and a display configured to display the estimated analyte data values,

wherein the radio frequency identification device is configured to transmit the information representative of the measured
analyte concentration and a calibration code responsive to the receiver device interrogating the sensor electronics module,
wherein the external power source provides the power to the radio frequency identification device so transmission of the information
from the radio identification device to the receiver results in little or no impact on the internal power supply, and

wherein generating the estimated analyte concentration values is based on the information representative of the measured analyte
concentration and the calibration code.

US Pat. No. 10,237,389

SYSTEM AND METHOD FOR WIRELESS COMMUNICATION OF GLUCOSE DATA

DexCom, Inc., San Diego,...

4. A method for connecting an analyte sensor system to an analyte display device and a second display device, the method comprising:during a first time segment within an advertisement duration, transmitting a first set of advertisement messages to the second display device according to a first advertisement interval;
during a second time segment within the advertisement duration, transmitting a second set of advertisement messages to an analyte display device according to a second advertisement interval;
wherein one or more of the first advertisement interval, the second advertisement interval, a length of the first time segment, a length of the second time segment, the advertisement duration, and a sequence of the first and second time segments, is configurable.