US Pat. No. 9,704,628

FERROFLUID-MWCNT HYBRID NANOCOMPOSITE IN LIQUID STATE

COUNCIL OF SCIENTIFIC AND...

1. A Fe3O4-MWCNT hybrid nanocomposite in liquid state comprising water based ferrofluid in fixed volume concentration and MWCNT, wherein
the water based ferrofluid ranges between 1 to 30 in volume to 1 volume of MWCNT.
US Pat. No. 9,150,892

PROCESS OF PRODUCING ARGININE EMPLOYING CORYNEBACTERIUM GLUTAMICUM ATCC 21831 OR CORYNEBACTERIUM GLUTAMICUM ATCC 21493 IN AN AFERMANTATION MEDIUM COMPRISING CASSAVA BAGASSE OR JACKFRUIT SEED AS A CARBON SOURCE

Colgate-Palmolive Company...

1. A method of making arginine by fermentation of agro-wastes wherein said agro-waste is Cassava bagasse, Jack fruit powder,
and a mixture thereof, comprising:
Subjecting the agro-waste to fermentation in the presence of at least one of Corynebacterium glutamicum ATCC 21831 or Corynebacterium glutamicum ATCC 21493, to produce a fermented liquor,

wherein the agro-waste is a source of carbon produced by hydrolyzing Cassava bagasse, Jack fruit powder, and a mixture thereof
with a starch saccharifying enzyme.

US Pat. No. 9,403,869

?5?1 INTEGRIN BINDING RGD-LIPOPEPTIDES WITH GENE TRANSFER ACTIVITIES

Council of Scientific and...

1. A ?5?1 integrin receptor specific RGD-lipopeptide having the generic structure A

wherein:
each of R1 and R2 is independently hydrogen or a lipophilic moiety, provided both R1 and R2 are not hydrogen simultaneously, the lipophilic moiety being selected from group consisting of alkyl group, mono-unsaturated
alkenyl group, di-unsaturated alkenyl group and tri-unsaturated alkenyl group, each of which having at least eight carbon
atoms;

R3 is selected from group consisting of hydrogen, straight chain alkyl group having 1 to 5 carbon atoms, and branched alkyl chain
alkyl group having 1 to 5 carbon atoms;

n is an integer having value between 1 and 7;
and X is optionally a halogen moiety; and
M is selected from the group consisting of hydrogen, sodium and potassium.

US Pat. No. 9,701,646

SMALL MOLECULE INHIBITORS OF PI3-KINASE SIGNALING

TUFTS UNIVERSITY, Boston...

1. A compound represented by formula (II), or a pharmaceutically acceptable salt thereof
wherein:
R1 represents methyl or —CF3;

R2 represents hydrogen, halogen, —OH, methyl, or —CF3; and

X represents O or S.

US Pat. No. 9,611,255

PROCESS FOR TOTAL SYNTHESIS OF FLAVONOID COMPOUNDS AND ISOMERS THEREOF

Council of Scientific and...

1. A process for total synthesis of flavonoid compound of formula I and isomers thereof,
wherein R1 and R2 is OH; R3?H, or
the process comprising the steps of:
i. protecting the hydroxyl groups of phloroglucinol and hydroxyl groups of caffeic acid as ethers by using a protecting group
and a base in a solvent to get 1,3,5-tris(methoxymethoxy) benzene (5) and (E)-methyl3-(3,4-dihydroxyphenyl) acrylate (6) respectively;


 where MOMO is methoxymethoxy and OMOM is also methoxymethoxy;
ii. hydrolyzing of the (E)-methyl 3-(3,4-dihydroxyphenyl)acrylate (6) obtained in step (i) by using a hydrolyzing agent to
get (E)-3-(3,4-bis(methoxymethoxy) phenyl)acrylic acid (7);


iii. acylating the 1,3,5-tris(methoxymethoxy)benzene (5) and (E)-3-(3,4-bis (methoxymethoxy) phenyl)acrylic acid (7) obtained
in steps (i & ii) in presence of an acylating agent in a solvent at a temperature ranging between ?5° C. to 0° C. to get (E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(2,4,6-tris(methoxymethoxy)phenyl)
prop-2-en-1-one (8);


iv. oxidizing (E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(2,4,6-tris(methoxymethoxy) phenyl)prop-2-en-1-one (8) obtained in step
(iii) with an oxidizing agent to get racemic epoxide
((3-(3,4-bis(methoxymethoxy)phenyl)oxiran-2-yl)(2,4,6-tris(methoxymethoxy)phenyl) methanone) (9);

v. reacting the epoxide compound ((3-(3,4-bis(methoxymethoxy)phenyl)oxiran-2-yl)(2,4,6-tris (methoxymethoxy) phenyl)methanone)
(9) obtained in step (iv) by using excess of acid in different ratio of mixture of solvent ranging in the ratio of 0:1/1:0
to 5:1/1:5 to obtain racemic taxifolin 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one(+/?Taxifolin) (10);


vi. optionally separating the racemic taxifolin 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychroman-4-one(+/?Taxifolin) by chromatographic
method to obtain (?) taxifolin and (+) taxifolin (11) and (12); and


vii. refluxing the racemic or (+)taxifolin or (?)taxifolin obtained in steps (v) and (vi) in a solvent and D-glucose in presence
of a Lewis acid at a temperature ranging between 85° C. to 90° C. for a period ranging between 24 h to 48 hr to get diastereomeric
mixture of taxifolin-glucopyranosides or (2R,3R)-Taxifolin-6-C-beta-D-Glucopyranoside or Ulmoside A respectively; separating
the diastereomeric mixture of taxifolin-glucopyranosides to obtain (2R,3R) taxifolin-6-C-?-D-glucopyranoside (2) and (2S,3S)
taxifolin-6-C-?-D-glucopyranoside (ulmoside A) pure product


US Pat. No. 9,718,773

SUBSTITUTED 5 MEMBERED HETEROCYCLIC COMPOUNDS AND PREPARATION THEREOF

Council of Scientific and...

1. A novel substituted 5 membered heterocyclic compounds of Formula I and its enantiomers,
wherein,
i) when, U is CH2 then A is Ts; W is NHBoc; R is aryl, substituted aryl or heteroaryl (wherein substituents are seleceted from Br, Cl, F, CF3, CH3, —OCH3, and —SCH3); and

a) X is OH, Y and Z are Hydrogen; or
b) X is H, Y is —CH2COOEt and Z is —COOEt;

ii) when, U is NCOOR? then A is COOR?; W is H; R is H, aryl, substituted aryl (wherein substituents are selected from —OCH3, —SCH3, CH3, NO2, and —OCH2O—), alkyl, linear or branched alkyl substituted by —OBn; X is —CH2COOEt; Y is H; Z is H and R? is alkyl-linear or branched.

US Pat. No. 9,192,589

CHALCONES AS ENHANCER OF ANTIMICROBIAL AGENTS

Colgate-Palmolive Company...

1. A composition comprising a carrier and as active ingredients
an antimicrobial agent selected from zinc citrate, triclosan, tetrahydrocannabinol, cetyl pyridinium chloride, magnolia, magnolol,
honokiol and butyl magnolol, and

one chalcone compound selected from the group consisting of 3-(4?-Hydroxy-3?-methoxy-phenyl)-1-(2?hydroxy-5? methoxy-phenyl)-prop-2-ene-1-one,
3-(4?-Hydroxy-3?-methoxy-phenyl)-1phenyl-prop-2-ene-1-one, 3-(2?,3?-Dimethoxy-phenyl)-1-furan-2-yl-prop-2-ene-1-one, 3-(2?,5?-dimethoxy-phenyl)-1-(1H-pyrrol-2-yl)-prop-2-ene-1-one,
and mixtures thereof.

US Pat. No. 9,290,518

WATER SOLUBLE METAL-ORGANIC FRAMEWORKS (MOFS)

Council of Scientific and...

1. Metal organic frameworks (MOFs) of Formula I
[M(l/d-Lx)(X)](H2O)2  Formula I

wherein
M is a metal selected from the group consisting of Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Cd,
La, W, Os, Ir, Pt, Au, Hg, Sm, Eu, Gd, Tb, Dy, Ho, Al, Ga, In, Ge, Sn, Pb), Li, Na, K, Rb, Cs, Mg, Ca, Sr or Ba;

L is derivatives of an amino acid ligand of Formula II

wherein R1 is methyl or isopropyl; R2 is selected from the group consisting of pyridyl, bipyridyl, imidazolyl, pyrimidinyl, 4-(pyridin-4-yl)phenyl, napthalyl, quinolinyl,
and tetrazolyl;

X is CH3COO or HCOO when R1 is isopropyl; and

X is Cl, Br, CH3COO or HCOO when R1 is methyl.

US Pat. No. 9,056,775

PROCESS FOR THE PREPARATION OF INORGANIC HYDROGELS WITH ALKALI HALIDES

Council of Scientific and...

1. A process for the preparation of an inorganic hydrogel of formula M3(H2O)4(PO4) wherein M is selected from alkali metals for the corresponding alkali halides under mild conditions and the process comprising
the steps of:
(i) adding alkali halide in water, a solution of sodium phosphate and a solution of alkali hydroxide and stirring for 1 to
2 minutes at temperature in the range of 30 to 35° C.;

(ii) stirring the reaction mixture as obtained in step (i) at a speed in the range of 400 to 1000 rpm for 15 to 20 minutes
and maintaining the temperature in the range of 40 to 80° C.;

(iii) cooling the solution as obtained in step (ii) for a period of 4 to 6 hours to obtain inorganic hydrogel; and
(iv) storing the inorganic hydrogel as obtained in step (iii) for 15 to 20 hours to transform the inorganic hydrogel into
crystalline form.

US Pat. No. 9,353,077

ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES

Council of Scientific and...

1. A process for the preparation of Stagonolide C:
the process comprising:
i. enantioselective allylboration of aldehyde (1):CH3CHOin presence of allyldiisopinocamphenylborane at temperature in the range of ?120° C. to ?80° C. for 1-2 hours in non-polar
organic solvents selected from the group consisting of diethyl ether, pentane, cyclopentane, benzene, toluene, 1,4-dioxane,
chloroform, and mixtures thereof followed by treatment with NaOH and aqueous H2O2 to obtain chiral allylic alcohol (3):

ii. protecting chiral allylic alcohol (3) as obtained in step (i) with TBS by treating with TBSCl, imidazole, in a polar aprotic
solvents selected from the group consisting of DMF, DCM, THF, ethyl acetate, acetone, and DMSO to obtain compound (4):

followed by Wittig reaction by reacting Wittig reagent Ph3P?CHCO2Et in a polar aprotic solvents preferably THF to obtain corresponding ?-? unsaturated ester (5):

iii. reducing ?-? unsaturated ester (5) as obtained in step (ii) in presence of DIBAL-H in toluene at temperature range ?80°
C. to ?50° C. to obtain ?,?-unsaturated aldehyde (6):

followed by organocatalytic Jørgensen epoxidation of ?,?-unsaturated aldehyde (6) in presence of a chiral bisaryl-silyl-protected
pyrrolidine preferably bis(3,5-bis(trifluoromethyl)phenyl)trimethyl silyloxy) methyl] pyrrolidine in the range of 5% to 20%
and hydrogen peroxide and polar aprotic solvents selected from the group consisting of DMF, DCM, THF, ethyl acetate, acetone,
and DMSO at ambient temperature ranging between 25-35° C. for a period followed by reduction in presence of NaBH4 in lower alcohol selected from the group consisting of methanol, ethanol, n-propanol, iso-propanol, and n-butanol at temperature
range ?5° C. to 5° C. to obtain enantiomerically enriched epoxy alcohol compound (7):

iv. stirring epoxy alcohol (7) in presence of triphenylphosphine, iodine and imidazole reagent in an organic solvent selected
from the group consisting of diethyl ether, DMF, DCM, THF, ethyl acetate, acetone, acetonitrile, methanol, ethanol, and mixtures
thereof followed by treatment with Zn and NaI in methanol to obtain allylic alcohol (9):

and further protecting allylic alcohol (9) with MOM in presence of MOMCl, DIPEA in DCM solvent to obtain compound (10) followed
by deprotection of TBS to afford MOM protected allylic alcohol (11):

v. esterification of MOM protected allylic alcohol (11) with MOM protected carboxylic acid compound (12):
in presence of EDCl and DMAP in a polar solvent DCM to obtain ester compound (13):
and ring-closing metathesis of ester compound (13) with Grubbs second generation carbene complex, followed by deprotection
of MOM to obtain Stagonolide C:

US Pat. No. 9,073,860

AROMATIC AMIDES AS POTENTIATORS OF BIOEFFICACY OF ANTI-INFECTIVE DRUGS

COUNCIL OF SCIENTIFIC AND...

1. A method for inhibiting growth of a bacterial cell that employs an efflux pump resistance mechanism, comprising administering
to a subject in need thereof a pharmaceutical composition comprising an effective amount of a potentiating compound of general
formula 1 a-c including geometrical isomers and/or salts thereof:
wherein R represents normal or branched chain C1 to C10 alkyl group and R1, R2 and R3 independently represent hydrogen, methoxyl, hydroxyl, halogen, or nitro; or where R2 and R3 together (R2+R3) represent —OCH2O—, —OCH2CH2O—, —CH2CH2CH2O—, or —CH2CH2C(CH3)2O—; R4 represents hydrogen or methoxyl; R5 represents hydrogen, normal or branched chain C1 to C8 alkyl, phenyl or benzyl; and R6 represents hydrogen, or C1 to C8 normal or branched chain alkyl group; or where NR5R6 together (R5+R6) represent an amino acid radical or a heterocyclic amine radical; and where dotted lines indicate the presence of double
and/or single bonds.

US Pat. No. 9,056,817

ARYLATED ?-DICARBONYL COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A one pot, process for C-arylation of ?-dicarbonyl compounds of Formula I at temperature in the range of 20 to 30° C. comprising
the steps of:
i. reacting benzyne precursor with compound of formula I in the ratio ranging between 1:1 to 1:8 in presence of 0.5 to 5 molar
concentration solvent, and fluoride source to obtain a reaction mixture;


ii. concentrating reaction mixture as obtained in step (a) in vacuo followed by purifying to obtain compound of formula II
yielding in the range of 40-97%


wherein R1 and R2 is independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl; substituted or unsubstituted
aryl;

R3=Ar or H; and
Ar is selected from phenyl; halo substituted phenyl wherein halo group is selected from fluro, chloro or bromo; alkyl substituted
phenyl wherein alkyl is selected from methyl, ethyl, propyl or butyl.

US Pat. No. 9,057,091

SYNERGISTIC COMPOSITION USEFUL AS MICROBIOLOGICAL GROWTH MEDIUM FOR RAPID SCREENING OF PHOSPHATE ACCUMULATING MICROORGANISMS

Council of Scientific and...

1. A synergistic composition useful as a microbiological growth medium for rapid screening of phosphate accumulating microorganisms,
wherein said composition comprises:
1.0 to 10.0 g/l of sodium citrate,
1.0 to 5.0 g/l of (NH4)2SO4,

0.1 to 10.0 g/l of NaCl,
0.1 to 1.0 g/l of CaCl2,

0.1 to 1.0 g/l of MgSO4.7H2O,

5.0 to 15.0 g/l of Na2HPO4,

1.0 to 30.0 g/l of KH2PO4,

0.05 to 10.0 g/l of Maltose, and
0.01 to 0.1 g/l of Toluidine Blue-O.

US Pat. No. 9,051,244

DEPOLYMERIZATION OF LIGNIN USING SOLID ACID CATALYSTS

COUNCIL OF SCIENTIFIC AND...

1. A process for the conversion of lignin to substituted phenolic compounds, said process comprising the steps of:
i. charging lignin and a catalyst in the ratio ranging between 0.1:1 to 1:0.1 into a reactor followed by charging a solvent,
wherein the catalyst consists of a heterogeneous solid acid catalyst;

ii. optionally flushing the reactor with nitrogen, argon, helium, hydrogen or air;
iii. adjusting the reactor to operate at atmospheric pressure and heating the reactor to a temperature in the range of 50
to 300° C. with stirring;

iv. raising the stirring speed to 10 to 2000 rpm after stabilizing at the temperature; and
v. carrying out a reaction for a period in the range of 0.1 to 96 hours to obtain substituted phenolic compounds.

US Pat. No. 9,617,159

PROCESS FOR SYNTHESIZING REDUCED GRAPHENE OXIDE ON A SUBSTRATE FROM SEEDLAC

Council of Scientific and...

1. A process for synthesizing reduced graphene oxide from seedlac on a substrate, the process comprising:
preparing a seedlac solution in a C2-C4 alcohol;
dipping the substrate into the seedlac solution one or more times; and
heating the substrate in the temperature range of 400° C. to 1200° C. under a controlled atmosphere of Ar, N2, Ar—H2, and/or N2—H2 at the flow rate of 100 to 500 sccm for a period of 10 to 120 minutes.

US Pat. No. 9,352,394

NANO AGGREGATES OF MOLECULAR ULTRA SMALL CLUSTERS OF NOBLE METALS AND A PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. Capped spherical nano aggregates of size 10-22 urn comprising: molecular ultra small clusters of 1-6 atoms of noble metals
selected from the group consisting of Au, Ag, Pt and Pd, wherein the clusters are stabilized by a surfactant and capping groups
from a reducing agent and the clusters are the nano aggregates showing UV emission at 300-335 nm, no surface plasmon resonance,
and visible 2nd harmonic emission at 590-650 nm.
US Pat. No. 9,263,174

SINTERED COBALT FERRITES COMPOSITE MATERIAL WITH HIGH MAGNETOSTRICTION

Council of Scientific and...

1. Sintered cobalt ferrite composite material comprising of nano and/or micron sized powders of cobalt ferrite, wherein particle
size of the nano sized powder of cobalt ferrite powder is in the range 3 to 40 nm and particle size of micron sized powder
of cobalt ferrite is in the range of 1 to 10 ?m, wherein the ratio of nano sized powder of cobalt ferrite to the micron sized
powder of cobalt ferrite in said composite is in the ratio ranging between 70:30 to 95:5, and the ratio of nano-nano sized
powder of cobalt ferrite in said composite is in the ratio ranging between 90:10 to 50:50 wherein said composite material
has density in the range of 79-84% compared to theoretical density and magnetostriction is in the range of 240-400 ppm.

US Pat. No. 9,095,839

CONFINEMENT OF NANOSIZED METAL ORGANIC FRAMEWORK IN NANO CARBON MORPHOLOGIES

Council of Scientific and...

1. A hybrid composite of Metal Organic Frameworks (MOF) encapsulated in nanocarbon tubes, wherein the MOFs are grown inside
or outside or both side of nano carbon morphologies of the hybrid composite.

US Pat. No. 9,260,781

PROCESS TO DEPOSIT DIAMOND LIKE CARBON AS SURFACE OF A SHAPED OBJECT

Council of Scientific and...

1. A process for deposition of diamond like carbon (DLC) films having enhanced adhesion and reduced stress as a protective
coating on an inner surface of a shaped object such as a container, said process comprising the steps of:
i. cleaning the inner surface of the shaped object using an inert gas and placing the object inside a hollow cathode plasma
enhanced chemical vapor deposition apparatus kept in a vacuum chamber;

ii. applying a base pressure of 10?5 to 10?6 torr to the vacuum chamber for removing the residual gases;

iii. injecting a hydrocarbon gas diluted in argon at a partial pressure in the range of 10-90% into the shaped object through
holes of an inner electrode;

iv. applying a radio frequency of 13.56 MHz for a time period in the range of 8 to 10 mins to an outer electrode of the hollow
cathode, wherein the outer electrode is in contact with the body of the shaped object and is connected to a power supply and
the inner electrode lying inside the shaped object being used for delivery of the hydrocarbon gas, the outer electrode being
insulated from outside using an insulating sheet and entire assembly being covered with a metal sheet which is at ground potential;

v. depositing the DLC films at a power density in the range of 50-2000 mW/cm2 to the outer electrode, gas flow in the range of 5-100 sccm, chamber pressure in the range of 5-100 m torr and applying a
self bias in the range of 50-200 volts such that initially the self bias is in the range of 50-70 volts and gradually increasing
the self bias in the range of 150-200 volts, and temperature in the range of 25-30° C.; and

vi. breaking of vacuum by inserting air, to take out the DLC coated shaped object from the chamber;
wherein a thin layer consisting of hydrogenated amorphous silicon (a- Si:H) is deposited using silane (SiH4) plasma discharge prior to deposition of a thick DLC layer of about a micron wherein the thick DLC layer on an inner surface
of a plastic or metallic object facilitates better adhesion of DLC with the inner surface of the plastic or metallic object.

US Pat. No. 9,198,986

WDR13 AS A NOVEL BIOMARKER USEFUL FOR TREATING DIABETES AND CANCER

Council of Scientific and...

1. An expression construct comprising SEQ ID NO: 2 useful for targeting WDR13 gene represented by SEQ ID NO: 1, wherein SEQ
ID NO: 2 comprises:
a) a nucleic acid sequence encoding Neomycin with polyA as positive selection marker,
b) a 1.6 kb 5? homology region for 5? recombination, and
c) a 4.1 kb 3? homology region for 3? recombination, and the expression construct further comprises a nucleic acid sequence
encoding HSV-tk as negative selection marker.

US Pat. No. 9,085,557

QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A Quinolylpiperazino substituted thiolactone compound of the formula:
wherein, n=5-12, n1=0, or 1, and R=CF3, or Cl.

US Pat. No. 9,335,332

NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NMPRTASE) INHIBITOR FOR GLIOMA THERAPY

COUNCIL OF SCIENTIFIC AND...

1. A method for treating glioblastoma multiforme, wherein the said method comprising administrating to the patient suffering
from glioblastoma multiforme cancer the compound 3-amino-2-benzyl-7-nitro-4-(2-quinolyl)-1,2-dihydroisoquinolin-1-one represented
by formula A.

US Pat. No. 9,062,019

PROCESS FOR THE EPOXIDATION OF FATTY ACIDS, THEIR ESTERS AND MIXTURES THEREOF

Council of Scientific and...

1. An improved process for the epoxidation of mono and polyenic fatty acids, their esters or mixtures thereof using solid
catalyst and the said process which comprises contacting mono and polyenic fatty acids, their esters or mixtures thereof with
a peroxide in the presence of a solid catalyst for a period in the range of 0.5 to 6 hr at a temperature in the range of 40
to 120° C. followed by separation of the epoxide product from the reaction mixture to obtain mono and poly epoxy functionalized
fatty acids, their esters or mixtures thereof wherein the amount of side products of the process is less than 1% and said
solid catalyst is a supported group VIB metal oxide, said support comprising silica, alumina and mixtures thereof, optionally
with a promoter from group VA wherein the group VIB metal oxide content in the catalyst is 5-20 wt % of support.

US Pat. No. 9,305,777

CATALYST FREE SYNTHESIS OF VERTICALLY ALIGNED CNTS ON SINW ARRAYS

Council of Scientific and...

1. A catalyst free chemical vapor deposition (CVD) process to obtain one dimensional, direct, nano-heterojunction arrays of
silicon nanowire-carbon nanotube (SiNW-CNT) comprising reacting sublimed aromatic hydrocarbons as carbon precursor with vertically
aligned SiNW to grow a single vertically aligned CNT at nanoscale nucleation site at the tip of each single vertically aligned
SiNW and provide direct contact between each CNT and SiNW.
US Pat. No. 9,327,009

PEPTIDE INHIBITORS AS NOVEL ANTI-HIV THERAPEUTICS

Council of Scientific and...

1. A synthetic peptide useful as anti-Human Immunodeficiency Virus (anti-HIV) therapeutic having the sequence of SEQ ID NO.
69.
US Pat. No. 9,127,080

PROTEIN-CODING RNA TO CORRECT MITOCHONDRIAL DYSFUNCTION

Council of Scientific and...

1. A recombinant polyribonucleotide segment comprising the full sequence of SEQ ID NO:9, the full sequence of SEQ ID NO:10
or the full sequence of SEQ ID NO:11, wherein the full sequence comprises an operably linked signal tag.
US Pat. No. 9,115,210

MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS

COUNCIL OF SCIENTIFIC AND...

1. A purified mutant streptokinase polypeptide having a cysteine residue substituted for at least one amino acid selected
from the group consisting of: H16, A17, D62, G80, G166, S157, A181, I205, S210, D212, D213, D219, D222, D237, K238, D239,
E265, K273, D290, D291, L296, D298, S322, I371, N372, K373, K374, S375, L377, E398, K399, F404, D420, L438, L443, A450, D464,
D477, R489, H518, A519, D564, and G582, relative to the sequence of SEQ ID NO: 24, and wherein said mutant has biological
activity as measured by a standard assay.

US Pat. No. 9,102,646

PROCESS FOR THE PRODUCTION OF 4-SUBSTITUTED CHROMANES VIA GOLD CATALYSIS

Council of Scientific and...

6. A single step process for the synthesis of 4-aryl substituted chromane of formula:
comprising subjecting a 3-aryloxy-1-phenylpropan-1-ol of formula:
to gold (III) chloride-catalyzed intramolecular Friedel-Crafts reaction to obtain a 4-aryl substituted chromane of formula:

US Pat. No. 9,068,189

RECOMBINANT STRAIN OF TRICHODERMA USEFUL FOR ENHANCING NUTRITIONAL VALUE AND GROWTH OF PLANTS

COUNCIL OF SCIENTIFIC AND...

1. A novel recombinant strain of Trichoderma harzianum having accession number MTCC 5659.
US Pat. No. 9,434,668

PROCESS FOR THE PRODUCTION OF TERTIARY BUTYL PHENOLS

Council of Scientific and...

1. An improved process for production of tertiary butyl phenols by selective alkylation of phenols by reacting said phenols
with methyl tertiary butyl ether (MTBE) in the molar ratio 1:1 to 1:5 using sulfonic acid functionalized polymer supported
carbon composite solid acid catalyst in 0.5-10 wt % with respect to total weight of phenol and MTBE, under the temperature
in the range of 100-160° C. at atmospheric pressure for 1 to 5 h, provided more than 99% conversion with 70-80% selectivity
for the p-tert. butyl phenol with the facile recovery and recycling of the recovered catalyst for at least seven runs.

US Pat. No. 9,422,230

PROCESS FOR THE PREPARATION OF AN ANTICONVULSANT AGENT PREGABALIN HYDROCHLORIDE

Council of Scientific and...

1. A process for the synthesis of Pregabalin hydrochloride formula S-1

comprising the steps of:
a. subjecting an epoxide of formula (S)-2 to regioselective ring opening with isopropyl magnesium chloride in presence of
copper iodide (CuI) to afford a secondary alcohol of formula (R)-3;


b. subjecting the secondary alcohol of formula (R)-3 as obtained in step (a) to its corresponding mesylate using methanesulfonyl
chloride and triethyl amine (TEA) in dichloromethane(DCM) at temperature in the range of 0 to 10° C. followed by displacement
using trimethylsilyl cyanide (TMSCN) in presence of tetrabutylammonium fluoride (TBAF) in acetonitrile to obtain a cyano derivative
of formula (S)-4;


c. subjecting the cyano derivative of formula (S)-4 of step (b) to hydrogenation and concomitant Boc-protection using (Boc)2O and Raney-Ni as a catalyst to furnish a amino alcohol of formula (S)-5;


d. oxidizing the amino alcohol of formula (S)-5 of step (c) using sodium chlorite catalyzed by 2,2,6,6-Tetramethyl-1-piperidinyloxy
(TEMPO) and bleach at temperature in the range of at 30 to 40° C. to afford a compound of formula (S)-6;


e. subjecting the compound of formula (S)-6 of step (d) for Boc-deprotection using hydrochloride (HCl) and acetone at temperature
in the range of 55 to 65° C. to afford Pregabalin hydrochloride of formula (S)-1.

US Pat. No. 9,267,181

ONE POT AND SINGLE STEP HYDROLYTIC PROCESS FOR THE CONVERSION OF LIGNOCELLULOSE INTO VALUE ADDED CHEMICALS

Council of Scientific and...

1. One pot and single step hydrolytic process for the conversion of lignocellulosic xylan to value added derivative products
selected from the group consisting of xylose and arabinose
wherein said process comprises:
a. charging the xylan in a reactor followed by charging a solvent and at least one heterogeneous solid acid catalyst;
b. adjusting the pressure to 1-70 bar and temperature in the range of 50-250° C. of the reactor, under stirring;
c. raising the stirring speed to 10-2000 rpm after stabilizing the temperature of the reactor in the range 50-250° C.; and
d. carrying the above said reaction for a period of 0.1 to 96 hours to obtain said value added derivative product
wherein said heterogeneous solid acid catalyst is selected from the group consisting of HUSY™ (Si/Al=15), Cs0.25H0.5PW12040,
Nb205, Al203, SO42-/ZRO2, A1-MCM-41 (Si/Al=50), A1-SBA-15 (Si/Al=10), an ion exchange resin sold under the trademark Amberlyst-15,
SiO2-Al03 (Si/A1=15), Ga-MCM-41, sulfonated MCM-41, and Montmorillonite K10 (clay).

US Pat. No. 9,255,222

FLUORESCENT MATERIAL FOR SELF-ERASABLE WRITING, AUTHENTIC SECURITY LABELING, CURRENCY COUNTERFEIT PREVENTION AND PROCESSES FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A process for the preparation of fluorescent material or paper for self-erasable writing comprising the steps of:
i) dissolving 0.1 to 0.2 wt % compound of formula 1

wherein R is the group:

in chloroform to obtain a solution;
ii) spraying the solution on the material or paper; and
iii) drying the material or paper under vacuum to obtain fluorescent a coated material or paper.
US Pat. No. 9,217,140

FUNGAL STRAIN BEAUVERIA SP. MTCC 5184 AND A PROCESS FOR THE PREPARATION OF ENZYMES THEREFROM

COUNCIL OF SCIENTIFIC AND...

1. A process for preparation of enzymes comprising at least one enzyme selected from protease, carbohydrase and lipase from
Beauveria species bearing accession number MTCC 5184, said process comprising:
a) culturing Beauveria species MTCC 5184 in a medium comprising 0.15 to 80% of a carbon source, 0.15 to 80% of a nitrogen source and an inducer,
wherein the carbon and nitrogen source are optionally inducers under aerobic conditions at pH ranging from 5.0 to 9.0 and
temperature ranging between 15° to 32° C. for a period ranging between 2 to 7 days;

b) harvesting the medium as obtained in step (a); and
c) separating/extracting the enzyme in liquid phase by conventional methods.

US Pat. No. 9,273,039

SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS

Council of Scientific and...

1. A benzothiazole compound selected from the group consisting of formula 3a-p, 4a-h, 6a-t and 8a-d set forth below:

R=H, CH3, OCH3, CF3, OCF3, F, Cl, NO2
X=O, S

R=H, CH3, OCH3, CF3, OCF3, F, Cl, NO2

Ar=Phenyl, 4-methylphenyl, 4-methoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-fluorophenyl, 4-chlorophenyl,
2-chloro-3-methoxyphenyl, 3,5-dimethoxyphenyl, 3,4,5-trimethoxyphenyl, pyridyl, nicotinyl, isonicotinyl, 5-nitro-2-furyl,
styryl, 4-fluorostyryl, 4-methylstyryl, 4-methoxystyryl, 4-trifluorostyryl, 4-trifluoromethoxystyryl


Ar=5-nitro-2-furyl, 1-methyl-4-nitro-1H-2-pyrrolyl, 1-methyl-5-nitro-1H-2-imidazolyl, 1-methyl-3-nitro-1H-2-pyrazolyl.
US Pat. No. 9,212,350

METHOD OF CLONING STABLE STRESS TOLERANT SUPEROXIDE DISMUTASE USING UNIVERSAL PRIMERS

Council of Scientific and...

1. A degenerate primer set comprising at least as primers two polynculeotides comprising SEQ ID NOs:24 and 25 or SEQ ID NOs:26
and 27, wherein the primer set is adapted to amplify stress tolerant superoxide dismutase (SOD) from plant species.

US Pat. No. 9,558,403

CHEMICAL STRUCTURE RECOGNITION TOOL

Council of Scientific and...

1. A Chemical Structure Recognition Tool (CSRT) to extract chemical data from an input image of a hand drawn chemical structure,
said Chemical Structure Recognition Tool comprising an image scanner, and an image manipulator and analyzer coupled to the
image scanner, wherein:
the image scanner is to receive a live feed of the input image from a camera and load the input image into the image manipulator
and analyzer, wherein the input image is one of a photograph and a video frame of the hand drawn chemical structure sketched
on a surface and captured live by the camera; and

the image manipulator and analyzer is to:
convert each color pixel of said input image into a grayscale pixel using color conversion coefficients and normalize each
pixel for obtaining a grayscale image with chemically significant regions highlighted, wherein the color conversion coefficients
include a red color conversion coefficient of 0.2125, a green color conversion coefficient of 0.7154, and a blue color conversion
coefficient of 0.0721;

binarize said grayscale image into a binary image;
smoothen said binary image by Gaussian Smoothing;
extract chemical data from the smoothened input image by:
recognizing a shape in said binary image to be a circle to identify presence of a circle bond inside a ring;
predicting an Optical Character Recognition (OCR) region to find zones containing text;
thinning the binary image using a hit or miss morphological operation to identify specific shapes within said binary image;
detecting edges of the image by using at least one of sobel operator and canny edge detector; and
detecting a double bond and a triple bond; and
obtain output files in a digital format with the extracted chemical data from the input image.
US Pat. No. 9,408,888

HIGH AFFINITY BIVALENT HELICALLY CONSTRAINED PEPTIDE AGAINST CANCER

COUNCIL OF SCIENTIFIC AND...

1. A synthetic peptide comprising Sequence SEQ ID NO: 10.

US Pat. No. 9,266,818

PROCESS FOR PURIFICATION OF FREE BIO-AMINO ACIDS

Council of Scientific and...

1. A process for purification of free bio amino acids, said process comprising:
a. extracting plant parts rich in free amino acids with deionized water or double distilled water to obtain an aqueous extract,
b. filtering the aqueous extract obtained in step (a) through cotton filters to obtain a filtered aqueous extract,
c. passing the filtered aqueous extract of step (b) through a first column packed with polymethacrylate based resin with particle
size of 100-300 microns and saturated with water to obtain a polyphenol free effluent,

d. passing the obtained polyphenol free effluent of step (c) through a second column packed with a polystyrene divinylbenzene
polymer based resin with particle size of 120 microns saturated with deionized water or double distilled water to form a second
effluent,

e. concentrating the second effluent of step (d) containing free bio amino acids with a rotary evaporator followed by spray
drying or through lyophilization by freeze drying to a obtain a white to light brown colored free amino acid rich powder.

US Pat. No. 9,199,930

PROCESS FOR THE PREPARATION OF (S)-2-ETHYL-N-(1-METHOXYPROPAN-2-YL)-6-METHYL ANILINE

Council of Scientific and...

1. A process for enantioselective preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline [(S)-1] from (R)-epichlorohydrin,
wherein the process comprises the steps of:
i) refluxing a solution of (R)-epichlorohydrin [(R)-2] with 2-ethyl-6-methyl aniline in mole ratio ranging between 1:1 to
1:3 in lower alcohol for a period ranging between 6-8 hours at temperature ranging between 60-80° C., followed by addition
of crushed KOH to the mixture at a temperature of 0° to 25° C., stirring vigorously at room temperature ranging between 25-35°
C. to obtain (R)-1-((2-ethyl-6-methylphenyl)amino)-3-methoxypropan-2-ol [(R)-3];


ii) adding dropwise solution of DIAD (Diisopropyl azo dicarboxylate) in dry toluene to a solution of [(R)-3] of step (i) and
triphenylphosphine in dry toluene under N2 atmosphere at 0-10° C., followed by refluxing at temperature ranging between 100-130° C. for a period ranging between 3-5
hours to obtain (S)-1-(2-ethyl-6-methylphenyl)-2-(methoxymethyl) aziridine [(S)-4];


iii) catalytic hydrogenating of solution [(S)-4] of step (ii) in a solvent in presence of a catalyst under hydrogen atmosphere
in the range of 30-50 psi under refluxing at temperature ranging between 20 to 30° C. for a period ranging between 1-3 hours
to obtain (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methylaniline [(S)-1]:


US Pat. No. 9,642,815

BIOCOMPATIBLE GRAPHENE QUANTUM DOTS FOR DRUG DELIVERY AND BIOIMAGING APPLICATIONS

COUNCIL OF SCIENTIFIC AND...

1. Biocompatible composition with reduced cytotoxicity comprising graphene quantum dots (GQDs) with a particle size ranging
from 5-10 nm embedded in polyethylene glycol (PEG) matrix with a particle size ranging from 80-100 nm, for drug delivery and
biomedical applications.
US Pat. No. 9,611,450

PROCESS FOR THE REMOVAL OF POLYMER THERMOSETS FROM A SUBSTRATE

Council of Scientific and...

7. A method of removing polymer thermosets from a substrate, comprising:
applying biomolecules to the substrate which comprises peptides, proteins, enzymes glutathione, thioredoxin, peroxiredoxin
or dithiothreitol (DTT) or combination thereof thereby removing polymer thermosets from the substrate, without damaging the
substrate, wherein polymer thermoset is an epoxy resin containing cross linker having at least one S—S bond.

US Pat. No. 9,487,482

3,4,5-TRIMETHOXYSTYRYLARYLAMINOPROPENONES AS POTENTIAL ANTICANCER AGENTS

Council of Scientific and...

1. A novel 3,4,5-trimethoxystyrylarylaminopropenone of general formulae A

wherein:
R=H, OMe, Cl, F, OH, Me
X=aryl, heteroaryl.

US Pat. No. 9,409,836

PROCESS FOR HYDROGENATION OF OLEFINIC OR ACETYLENIC BONDS

Council of Scientific and...

1. A process for hydrogenation of olefinic or acetylenic bonds, said process comprising:
a. activating a catalyst in a flow of hydrogen gas in a solvent 10 times volume of a reactant at room temperature ranging
between 20-30° C.,

b. reacting the catalyst of step (a) with the reactant of step (a) in the range of 1-10 wt % with respect to said reactant
by stirring for 0.5-15 hours at atmospheric pressure and room temperature (20-30° C.) and

c. obtaining the desired product from step (b), wherein said catalyst used in step (a) comprises an elemental metal or a metal
salt supported on a solid acidic support comprising a metal oxide, mixed metal oxides or modified metal oxides, prepared by
a process comprising:

i. preparing a slurry of solid acidic metal oxide, mixed metal oxides or modified metal oxides in water,
ii. adding an aqueous, acidic solution of elemental metal salt to solution of step (i), allowing water to evaporate to obtain
the catalyst, and

iii. heating the catalyst obtained in step (ii) at 150° C. for 3 h.
US Pat. No. 9,364,566

AQUEOUS FORMULATION FOR SELECTIVE TARGETING AND DELIVERING GENE TO CANCER CELLS

Council of Scientific and...

1. An aqueous formulation useful for targeted gene expression in human cancer cells expressing glucocorticoid receptors and
delivery of genetic material to said cancer cells, the formulation comprising:
(a) a cationic lipid,
(b) a glucocorticoid steroid and
(c) a neutral co-lipid,wherein the glucocorticoid steroid improves an efficiency of delivery of the genetic material to human cancer cells expressing
glucocorticoid receptors, wherein the cationic lipid, steroid and neutral co-lipid are mixed in a molar ratio in the range
of 0.75:0.5:1 to 1:2:1, and wherein the glucocorticoid steroid is selected from the group consisting of dexamethasone, prednisolone,
fluprednisolone, betamethasone, methylprednisolone, and triamcinolone.

US Pat. No. 9,550,719

PROCESS FOR THE PREPARATION OF 3-ARYL-2-HYDROXY PROPANOIC ACID COMPOUNDS

Council of Scientific and...

1. A process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds of formula (S)-1, wherein R1 represents H or (C1-C5) alkyl groups and R2 represents (C1-C5) alkyl groups, comprising the steps of;

a) subjecting an epoxide (S)-2 to regioselective ring opening with 4-methoxyphenylmagnesium bromide in presence of copper
iodide to obtain a secondary alcohol (S)-3;


b) O-alkylating the secondary alcohol (S)-3 using ethyl iodide and a base in anhydrous DMF to give ethylated derivative (S)-4;

c) debenzylating (S)-4 in presence of a debenzylating agent to obtain primary hydroxy compound (S)-5;

d. oxidizing the compound (S)-5 in presence of an oxidizing agent to obtain compound (S)-6; and

e. demethylating the compound (S)-6 using sodium ethanethiolate to obtain (S)-7 followed by esterification using EtOH and
HCl to give (S)-1a;

f. optionally, esterificating of (S)-7 as obtained in step (e) using anhydrous 2-propanol and SOCl2 to give (S)-1b.

US Pat. No. 9,517,943

INTEGRATED PROCESS OF PRODUCTION OF POTASSIUM SULPHATE AND AMMONIUM SULFATE FROM KAINITE MIXED SALT

COUNCIL OF SCIENTIFIC AND...

1. An integrated process for the production of potassium sulphate and ammonium sulfate from a kainite mixed salt, dispensing
with magnesium hydroxide production, the process comprising the steps of:
i. adding hydrochloric acid in calcium carbonate to produce 30-40% w/v concentrated calcium chloride and pressurized carbon
dioxide (CO2);

ii. decomposing the kainite mixed salt with water to obtain solid schoenite and schoenite end liquor (SEL) as a liquid stream;
iii. desulphatizing the SEL as obtained in step (ii) using the calcium chloride as obtained in step (i) to produce desulphated
SEL and gypsum;

iv. subjecting the gypsum as obtained in step (iii) and the pressurized CO2 as released in step (i) together with ammonia for the production of ammonium sulphate liquor and solid calcium carbonate,
the latter being recycled in step (i);

v. producing carnallite from the desulphated SEL as obtained in step (iii), decomposing the carnallite to obtain carnallite
decomposed product (CDP) along with carnallite decomposed liquor (CDL), the latter being recycled in desulphated SEL;

vi. wet sieving the CDP as obtained in step (v) followed by aqueous leaching of fines fraction, obtained upon wet sieving,
to obtain potassium chloride (KCl) (purity >98%);

vii. utilizing the potassium chloride, as obtained in step (vi) in the preparation of sulphate of potash (SOP) from the schoenite
as obtained in step (ii).

US Pat. No. 9,419,232

NANOSTRUCTURED ORGANIC MATERIALS AND A PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A composition for improving the device efficiency at atmospheric condition, comprising a nano structured organic material,
said nano structured organic material comprising hydrazine doped zinc (II) complex of N,N?-Di-(phenyl-3,5 dicarboxylic acid)-perylene-3,4,9,10-tetracarboxylic
acid diimide, said nanostructured organic material prepared by a process comprising the steps of:
a) reacting 3,4,9,10 perylene tetracarboxylic dianhydride with 5-amino isophthalic acid in presence of imidazole and zinc
acetate at temperature range 130° C. to 160° C. for a period in the range of 15-50 hrs under argon atmosphere;

b) precipitating the mixture of step a) in presence of 2N HCl, followed by washing with solvent selected from the group consisting
of water, methanol, ethanol, propanol, isopropanol, butanol, DMF, anhydrous chloroform either alone or combination thereof
and drying to obtain N,N?-Di-(phenyl-3,5 dicarboxylic acid)-perylene-3,4,9,10-tetracarboxylic acid diimide (PTCDI-TC);

c) dissolving zinc nitrate hexahydrate and (PTCDI-TC) as obtained in step (b) in a mixture of DMF/1,4-dioxane/H2O in the ratio ranging between 1:1:1 to 3:1:1 followed by heating at temperature in the range of 100-150° C. for a period
in the range of 2-6 days and subsequently cooling and washing with solvent selected from the group consisting of water, methanol,
ethanol, propanol, isopropanol, butanol, DMF, anhydrous chloroform either alone or combination thereof to obtain Zn complex
of PTCDI-TC; and

d) doping the Zn complex of PTCDI-TC as obtained in step (c) with hydrazine hydrate at a temperature in the range of 100°-180°
C. for a period in the range of 30-250 min.

US Pat. No. 9,174,919

PROCESS FOR PREPARING BIODEGRADABLE LUBRICANT BASE OILS

Council of Scientific and...

1. A process for preparation of fatty acid esters with 100 mol % selectivity as biodegradable lubricant base oils wherein
the said process comprising the steps of:
(a) providing recyclable, solid, hydrophobic, acido-basic bifunctional, phosphonate catalyst of molecular formula
M(X)2-nYn.mH2O
wherein X refers to phenyl phosphonate, Y refers to HPO42? or HPO32?, M refers to a metal ion, said metal being of Zr, the value of n varies from 0.2 to 1.8 and the value of m varies from 0
to 5;
(b) contacting a fatty compound with an alcohol in a molar ratio ranging between 0.3 and 9 in presence of 3 to 10% catalyst
by weight of fatty compound as provided in step (a); and

(c) subjecting the reaction mixture as obtained in step (b) to a temperature in the range of 110 to 200° C. and for a period
in the range of 0.5 to 8 h followed by separating the catalyst from liquid products and separating the fatty acid esters from
unreacted starting materials.

US Pat. No. 9,651,491

SELECTIVE PROCESS FOR THE DETECTION OF FLUORIDE IONS

Council of Scientific and...

1. A selective process for the detection of fluoride ions in solution or gaseous form using CdTe-MPA-Eu3+ quantum dots, wherein the steps comprise:
a) step by step addition of Eu (NO3)3 to 2 mL solution (2 mg/mL) CdTe MPA QDs to get quenching of photoluminescence (PL) intensity in the sample at excitation wavelength
of 380 nm and emission of 550 nm wherein over 90% of the PL of CdTe-MPA is quenched by the addition of 56 ?M Eu3+ ions;

b) adding 1.4 mM to 79 mM fluoride ions to the sample of step (a) and measuring the fluorescence at excitation wavelength
of 380 nm and emission of 550 nm obtained due to the restoration of the PL intensity, wherein a linear relationship between
the enhanced PL intensity of the CdTe-MPA-Eu+3 and the concentration of fluoride ions is observed.

US Pat. No. 9,357,777

METHOD FOR EFFECTIVE MANAGEMENT OF HELICOVERPA ARMIGERA

Council of Scientific and...

1. A method for effective management of Helicoverpa armigera using inhibitory repeat domain IRD-9, a Pin-II type proteinase inhibitor (PI), comprising:
a. Providing Pichia pastoris expressing IRD-9 having Seq Id no. 2,

b. purifying IRD-9 protein,
c. feeding purified IRD-9 protein to Helicoverpa armigera in an artificial diet, and

d. calculating growth parameters for antibiosis effect of IRD-9.

US Pat. No. 9,809,566

ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES

Council of Scientific and...

1. An organo catalytic process for the preparation of decanolides of Formula Ic

wherein the said process comprising the steps of:
i) allylboration of aldehyde (1)

 in presence of allyldiisopinocamphenylborane at temperature in the range of ?120° C. to ?80° C. for 1-2 hours in non-polar
organic solvents selected from the group consisting of diethyl ether, pentane, cyclopentane, benzene, toluene, 1,4-dioxane,
chloroform, and mixtures thereof followed by treatment with NaOH and aqueous H2O2 to obtain chiral allylic alcohol (3)


ii) esterification of allylic alcohol (3) with butyldimethylsilyl(TBS) protected carboxylic acid (15)

 in presence of N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride, 4-dimethylaminopyridine in DCM at temperature
range 0° to 30° C. for 5 to 8 hours with subsequent deprotection of TBS in presence of tetra-n-butylammonium fluoride in THF
for 6-8 hours yields allylic alcohol (17)

and
iii) ring closing metathesis reaction of compound (17) in presence of Grubbs II catalyst (5 to 15%) in dry CH2Cl2 for 18-24 hours to obtain decanolides of Formula Ic.

US Pat. No. 9,580,452

ANTIOXIDANT COMPOUND HAVING ANTI ATHEROSCLEROTIC EFFECT AND PREPARATION THEREOF

Council of Scientific and...

1. An antioxidant compound having the general formula 1:
wherein
X=is a C1 to C30 carbon chain;

Z=any halogen; and
R=H.

US Pat. No. 9,505,794

RUTHENIUM (II) COMPLEXES, PREPARATION AND USES THEREOF

Council of Scientific and...

1. A Ruthenium (II) polypyridyl complex having formula I
wherein, X is selected from hydrogen or fluorine.

US Pat. No. 9,421,270

SURFACTANT-COPOLYMER COMPLEXES USEFUL FOR SUSTAINED DRUG RELEASE

COUNCIL OF SCIENTIFIC AND...

1. A hydrophobic compound loaded surfactant-copolymer complex for sustained and controlled release of hydrophobic compounds,
the surfactant-copolymer complex comprising a hydrophobic compound in the range of 0.1% to 10% (by weight), a surfactant in
the range of 0.1% to 30% (by weight) and a mucoadhesive copolymer in the range of 0.1% to 30% (by weight) and the remaining
being a solvent, wherein the complex is constituted to perform the sustained release of the hydrophobic compounds over a period
of 13-23 hours, prepared by a process comprising the steps of:
a) dispersing mucoadhesive copolymer in solvent in a ratio ranging between 1% to 40% to obtain turbid solution of mucoadhesive
copolymer;

b) dissolving the hydrophobic compound in surfactant in a ratio ranging between 1% to 50% (weight of hydrophobic compound
by weight of the surfactant) at temperature in the range of 10° C. to 80° C. to obtain hydrophobic compound-surfactant mixture;

c) adding hydrophobic compound-surfactant mixture as obtained in step (b) in water to obtain surfactant solution loaded with
hydrophobic compound;

d) adding surfactant solution loaded with hydrophobic compound as obtained in step (c) to the turbid solution of mucoadhesive
copolymer as obtained in step (a) to obtain hydrophobic compound loaded surfactant-copolymer complex.

US Pat. No. 9,187,467

2-PHENYL BENZOTHIAZOLE LINKED IMIDAZOLE COMPOUNDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A compound of formula A

wherein

US Pat. No. 9,650,683

PRIMER FOR AMPLIFYING FARNESYL PYROPHOSPHATE SYNTHASE FROM MANGO

Council of Scientific and...

1. A population of degenerate primers for amplifying farnesyl pyrophosphate synthase, wherein the population has a sequence
selected from the group consisting of SEQ ID NO: 1, SEQ ID NO:2, and SEQ ID NO:3.

US Pat. No. 9,598,649

SINGLE STEP CATALYTIC PROCESS FOR THE CONVERSION OF N-PARAFFINS AND NAPHTHA TO DIESEL RANGE HYDROCARBONS

COUNCIL OF SCIENTIFIC AND...

1. A single step catalytic process for the conversion of n-paraffins and naphtha (90-140° C.) to diesel range hydrocarbons
using Pt—Sn-ZSM-5 catalyst, wherein the said process comprises loading of Pt—Sn-ZSM-5 catalyst in a reactor followed by reducing
the catalyst using hydrogen at 500-600° C. for 6-10 h with 6-16 l/h hydrogen gas flow further, introducing the feed in a continuous
flow rate 2-10 h?1 WHSV (weight hourly space velocity) at temperatures ranging between 400° C.-450° C. with a carrier gas, at flow rate 5-50
l/h at pressure ranging between 2-30 bar to obtain liquid products and gas products, wherein liquid products are diesel range
hydrocarbons and gasoline.

US Pat. No. 9,572,893

NANOCOMPLEX CONTAINING CATIONIC PEPTIDE FOR BIOMOLECULE DELIVERY

Council of Scientific and...

1. A nanocomplex containing cationic peptide CR5H4R4H3C (SEQ ID NO.: 1) and CR(RH)7RC (SEQ ID NO.: 2).

US Pat. No. 9,522,922

PROCESS FOR THE PREPARATION OF INTERMEDIATE FOR THE PREPARATION OF OSELTAMIVIR PHOSPHATE

Council of Scientific and...

1. A process for the preparation of an intermediate for the preparation of oseltamivir phosphate comprising the steps of:
a) providing allyl compound A from cysteine by a known method;

b) adding Zinc dust and saturated aq. solution of ammonium chloride to a solution of allyl compound A of step (a) in tetra
hydro furan (THF) to obtain the reaction mixture;

c) refluxing the reaction mixture as obtained in step (b) to obtain thiol compound 5;

d) stirring the crude thiol 5 of step (c) at room temperature in the range of 25-30° C. in water to afford seven membered
cyclic sulphide 7;


e) oxidising sulphide 7 of step (d) at room temperature in the range of 25-30° C. by oxone to afford sulfone 8;

f) subjecting sulfone 8 of step (e) to Ramberg-Backlund reaction to furnish the cyclohexene urea 4;

g) reducing urea 4 of step (f) with LAH to furnish imidazolidine and subjecting imidazolidine without purification to hydrolysis
in 1% HCl to afford corresponding crude vicinal diamine;

h) masking the crude diamine of step (g) as its carbamate derivative with neat Boc anhydride to afford diboc 9;

i) subjecting compound 9 of step (h) to debenzylation under Birch conditions to obtain debenzylated compound 10;

j) epoxidation of compound 10 of step (i) furnishing ?-carbamate directed stereospecific epoxide 11 as a single diastereomer;

k) rearranging epoxide 11 of step (j) to allylic alcohol 12 in one pot two steps protocol without isolation of the intermediate;

l) DMP oxidation of allylic alcohol 12 of step (k) on DMP in DCM affording an ?, ?-unsaturated ketone intermediate for the
preparation of oseltamivir phosphate.

US Pat. No. 9,174,200

PROCESS FOR PREPARATION OF AG—W OXIDE CATALYST FOR THE SELECTIVE CONVERSION OF PROPYLENE TO PROPYLENE OXIDE WITH MOLECULAR OXYGEN

Council of Scientific and...

1. A process for the preparation of Ag—W oxide catalyst, said process comprising the steps of:
a. mixing a salt of Ag, WO3.2H2O, a surfactant, a reducing agent hydrazine and H2O to obtain a gel;

b. mixing gel as obtained in step (a) with constant stirring for 2-6 h at room temperature ranging between 25-35° C.;
c. filtering the gel as obtained in step (b) and washing with excess water and dried in an oven with temperature ranging between
100-120° C. for a period ranging between 6-18 hours; and

d. calcining the dried product as obtained in step (c) at temperature ranging between 300-750° C. for a period ranging between
4-10 h to obtain Ag—W oxide catalyst.

US Pat. No. 9,790,526

CDNA ENCODING ENONE OXIDOREDUCTASE FROM MANGO

Council of Scientific and...

1. A bacterial host cell comprising a vector comprising a promoter operably linked to a cDNA comprising SEQ ID NO: 14.
US Pat. No. 9,695,408

MUTANTS OF STREPTOKINASE AND THEIR COVALENTLY MODIFIED FORMS

COUNCIL OF SCIENTIFIC AND...

1. A mutant streptokinase polypeptide comprising substitution of one to six amino acid residues of SEQ ID NO: 1 with cysteine
residue, wherein the amino acid residue substituted with said cysteine residue is selected from the group consisting of G49,
S57, A64, 188, S93, D95, D96, D102, S105, D120, K121, D122, E148, K156, D173, D174, L179, D181, S205, A251, 1254, N255, K256,
K257, S258, L260, E281, K282, F287, D303, L321, L326, A333, D347, D360 and R372.

US Pat. No. 9,659,759

QUANTITATION OF STRUCTURAL ISOMERS USING MALDI MS/MS

COUNCIL OF SCIENTIFIC AND...

1. A method for quantitatively determining structural isomers comprising:
a) subjecting an equimolar mixture containing the reference isomers to ionization and selecting precursor ions having a mass
to charge ratio in an m/z range between 1 to 40000 (z=1) followed by fragmentation to generate product ions that are both
common and unique in nature to the reference isomers;

b) selecting product ions that are common to the isomer pairs to normalize the unique product ions followed by measuring the
peak area/peak intensity ratios of the unique and common product ions to generate equimolar concentration response curves
for each individual isomer pair as a function of equimolar ratios; and

c) subjecting a sample containing unknown quantities of the isomers/isomer pairs in context to ionization and selecting precursor
ions having a mass to charge ratio in an m/z range between 1 to 40000 (z=1) followed by fragmentation to generate product
ions that are both common and unique in nature as in step (a); measuring the unique to common product ion ratio(s), and determining
the corresponding equimolar ratio(s) of the isomer pairs present based on the equimolar concentration response curve(s) generated
in step (b).

US Pat. No. 9,631,066

HIGHLY FLUORESCENT MONODISPERSE, CROSS-LINKED POLYMER MICROBEADS

COUNCIL OF SCIENTIFIC AND...

1. A fluorescent cross-linked polymer, comprising:
a fluorescent chromophore as a cross linker incorporated into polystyrene (PS), wherein the cross linker is a combination
of: PBITEGA


wherein the fluorescent cross-linked polymer emits white light fluorescence in solid state and solution state, and has a quantum
yield in the range of (?Powder) 0.25 to 0.71 at an excitation wavelength of about 350 nm to about 490 nm.

US Pat. No. 9,610,569

PROCESS FOR THE PREPARATION OF NI—CEMGAL2O4 CATALYST FOR DRY REFORMING OF METHANE WITH CARBON DIOXIDE

COUNCIL OF SCIENTIFIC AND...

6. A process for dry reforming of methane with carbon dioxide using Ni—CeMgAl2O4 catalyst as obtained by the process as claimed
in claim 1, wherein the said process comprises reducing the catalyst at 10-20% H2/He mixture at temperature ranging between 800-1000° C. for a period ranging between 1-4 hrs. subsequently contacting 10-15%
Methane, 10%-15% Carbon dioxide and 70-80% Helium at gas hours space velocity 10,000 cm3 g?1 h?1 to 15,000 cm3 g?1 h?1 over the catalyst at temperature ranging between 500-800° C. at atmospheric pressure to obtain syngas.

US Pat. No. 9,569,906

PCDA-PHBV ELECTROSPUN ADHERENT MATS AS AUTHENTICATION FEATURE

COUNCIL OF SCIENTIFIC AND...

3. A process for preparation of electrospun nanofiber adherent mats comprising the steps of:
a. sonicating a supersaturated solution of 10,12-Pentacosadiynoic acid (PCDA) in chloroform for a period of time in the range
of 25 to 30 min, followed by extruding the solution using PTFE syringe filter to obtain a solution;

b. stirring the solution of copolymer polyhydroxybutyrate-co-valerate (PHBV) in dichlorobenzene for a period of time in the
range of 5 to 6 hr.;

c. mixing the solution as obtained in step (a) with solution of copolymer polyhydroxybutyrate-co-valerate (PHBV) as obtained
in step (b) in the ratio ranging between 1:9 to 4:6 followed by stirring for a period of time in the range of 50 to 60 minutes
to obtain a solution;

d. depositing the mixture on a substrate by applying 15 kV potential at a distance of 10 to 15 cm between a syringe and a
collector wherein the syringe contains a solution as obtained in step (c) to obtain electrospun nanofiber adherent mats.

US Pat. No. 9,550,710

PROCESS FOR DEPOLYMERIZATION OF LIGNIN

Council of Scientific and...

1. A process for the depolymerization of lignin to obtain aromatic products comprising the steps of:
a. adding dealkaline lignin and Brönsted ionic liquid having —SO3H group in the range of 1:0.25 to 1:1 to a mixture of water and methanol wherein the ratio of methanol to water is in the
range of 0:1 to 5:1 to obtain a reaction mixture;

b. stirring the reaction mixture obtained in step (a) at a temperature range of 100 to 170° C. for a period of 0.5 to 6 hrs
to afford the aromatic products with 95-97% yield and a mass balance of >90%.

US Pat. No. 9,656,927

PROCESS FOR THE SYNTHESIS OF CARBOXYLIC ACID DERIVATIVES

COUNCIL OF SCIENTIFIC AND...

1. A one-step, one-pot process for the synthesis of carboxylic acid or carboxylic acid derivatives comprising the steps of:
a. stirring the solution of 0.9-1.1 equivalent aryl halides in dimethylformamide (DMF) optionally in the presence of 0.9-1.3
equivalent nucleophile followed by addition of 1.0-1.2 equivalent sodium cyanide and 10-20 mol % of 1, 10-phenanthroline and
5-25 mol % of copper bromide; and

b. quenching the reaction mixture of step (a) to obtain carboxylic acid or carboxylic acid derivatives,
wherein the nucleophile is selected from the group consisting of water, phenol, 4-nitro-phenol, 4-methoxybenzyl alcohol, aniline,
2-chloro-aniline, 4-methoxy-aniline, and 2-chloro-benzylamine.

US Pat. No. 9,657,037

PYRROLE COMPOUNDS WITH SILICON INCORPORATION

COUNCIL OF SCIENTIFIC AND...

1. A novel silicon incorporated pyrrole compounds of Formula I and or pharmaceutically acceptable salts thereof

wherein R1 and R2 are selected from hydrogen, halogen, alkyl, haloalkyl, hydroxyalkyl, thioalkyl, aryl, heteroaryl, C1-C5 alkoxy, C1-C5 alkoxyalkyl,
—NR?R?, —CH2NR?R?—CONR?R?, —COOR??;

R?, R? are independently selected from hydrogen or alkyl, aryl which may be substituted or unsubstituted or R? and R? together
may form a ring up to six carbon atoms which optionally may be substituted and/or may contain hetero atoms;

R?? is selected from hydrogen or alkyl, aryl which may be substituted or unsubstituted;
R3, R4 and R5 each are individually selected from alkyl;

R6 is selected from hydrogen, alkyl, or R6 together with any of R3, R4 and R5 may form a ring;

Ar1 and Ar2 represent independently a aryl or heteroaryl unsubstituted, or substituted with one or more substituents selected independently
from halo, hydroxy, alkyl, aralkyl, cycloalkyl, alkoxy, alkylthio, alkyl sulfinyl, alkyl sulfonyl, heterocyclyl, aryl, nitro,
sulfonyl, —NR?R?, —CONR?R?, —COOR?? wherein positions of substituent Ar2 and R2 are interchangeable;

Y represents CO, CS, CONH or CR1R2; wherein R1R2 are independently selected from hydrogen or alkyl, aryl which may which may be substituted or unsubstituted; or R1 and R2 together form a ring up to six carbon atoms which optionally may be substituted and/or may contain hetero atoms.

US Pat. No. 9,650,330

PROCESS FOR THE SYNTHESIS OF ARYL SULFONES

Council of Scientific and...

1. A room temperature single step process for synthesis of compound of Formula I

wherein, R is selected from H, alkyl (C1-C6), aryl, heteroaryl, O-, S-, N-, P-alkyl/unsubstituted and substituted aryl;

R? is selected from alkyl (C1-C6), aryl, heteroaryl, O-, S-, N-, P-alkyl/unsubstituted and substituted aryl;

comprising the steps of:
a. adding benzyne precursor of Formula II to a stirred solution of fluoride ion source and compound of Formula III in the
ratio ranging between 1:1 to 1:1.1 in anhydrous acetonitrile to obtain a reaction mixture;


wherein, R is selected from H, alkyl, aryl, heteroaryl, O-, S-, N-, P-alkyl/unsubstituted and substituted aryl;
R? is selected from, alkyl, aryl, heteroaryl, O-, S-, N-, P-alkyl/unsubstituted and substituted aryl;
X is selected from H, Li, Na, K, Cs;
b. stirring the reaction mixture of step (a) for the period in the range of 1 to 8 hours followed by purification to obtain
the desired product I.

US Pat. No. 9,663,548

10-?/?-D-ARABINOFURANOSYL-UNDECENES AS POTENTIAL ANTI-MYCOBACTERIAL AGENTS AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A compound of general Formula (II)

wherein, R? represents 10-undecenyl;
R1 represents hydrogen or ?-D-Arabinofuranosyl or ?-D-Arabinofuranosyl of Formula (A?)


R in the general Formula (II) and in (A?) is selected independently from the group consisting of hydrogen, acetyl, benzyl,
alkoxy, methane sulfonyl, carboxyl, unsubstituted or substituted phenyl as given below:


alkyl, alkenyl, alkynyl, and heterocycles.

US Pat. No. 9,527,800

PROCESS FOR TOTAL SYNTHESIS OF VENLAFAXINE

Council of Scientific and...

1. A process for the synthesis of venlafaxine of formula 1 or its enantiomer,
wherein the process comprising the steps:
a. homologating carbonyl of cyclohexanone with two carbon Wittig ylide with heating at 50° C. to 140° C. in toluene to obtain
?, ?-unsaturated ester;

b. subjecting the ester of step (a) to selective ester reduction by Red-Al to give allyl alcohol;
c. subjecting allyl alcohol of step (b) for epoxidation reaction to afford epoxide;
d. treating the epoxide of step (c) with methane sulphonyl chloride and triethyl amine to obtain crude mesylate, which on
subsequently subjecting for amination in 40% aqueous dimethyl amine solution at room temperature to affords the epoxy amine;
and

e. treating epoxy amine of step (d) with p-methoxyphenyl magnesium bromide in presence of catalytic copper iodide to furnish
venlafaxine.

US Pat. No. 9,688,686

PORPHYRIN CONTAINING COVALENT ORGANIC FRAMEWORKS AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A covalent organic frameworks (COFs) comprising porphyrin linked with hydroxyl aromatic compound by intramolecular O—H—N?C
bonding wherein porphyrin used is tetra(p-amino-phenyl)porphyrin (Tph) and hydroxyl aromatic compound is Triformylphloroglucinol(Tp).
US Pat. No. 9,670,523

NITRITE-REDUCTASE (NIRB) AS POTENTIAL ANTI-TUBERCULAR TARGET AND A METHOD TO DETECT THE SEVERITY OF TUBERCULOSIS DISEASE

Council of Scientific and...

1. A method for detecting the severity of tuberculosis in humans comprising:
(a) providing sputum from said subject;
(b) adding reagents A and B to the sputum obtained in step (a) to obtain a solution;
(c) detecting color intensity of the solution obtained in step (b), wherein a detected color of magenta indicates that the
disease is most severe while a detected color of faintly pink indicates that it is least severe; and

(d) detecting the titre of bacilli present in the solution obtained in step (b), wherein the color level is determined by
comparing with color coded strips or standard color codes wherein the reagent A is sulphanilic acid and the reagent B is N-(1-naphthyl)ethylenediamine
dihydrochloride (NEDD).

US Pat. No. 9,499,555

POROUS CRYSTALLINE FRAMEWORKS, PROCESS FOR THE PREPARATION THEROF AND THEIR MECHANICAL DELAMINATION TO COVALENT ORGANIC NANOSHEETS (CONS)

COUNCIL OF SCIENTIFIC AND...

1. Two dimensional, porous, crystalline, stable covalent organic frameworks (COFs) of formula-I

wherein ‘A’ ring is selected from the group consisting of:
wherein R, R1, R2, R3 and R4 are the same or different and independently selected from the group consisting of hydrogen, (C1-C6) alkyl, aryl, aralkyl,
halogen, NO2, and (C1-C6) alkoxy.

US Pat. No. 9,757,713

PROCESS FOR THE PREPARATION OF 2, 5-DIMETHYLEFURAN AND FURFURYL ALCOHOL OVER RUTHENIUM SUPPORTED CATALYSTS

Council of Scientific and...

1. An improved process for the preparation of compound of formula 1 wherein the said process comprising reaction of compound
of formula 2 in presence of ruthenium catalyst at 160-250° C. for 0.2-3 hours under hydrogen pressure in the range of 2-30
bar in a solvent wherein improvement is characterized in using ruthenium catalyst which comprises ruthenium nanoparticles
in combination with transition metal supported on NaY zeolite
wherein,
R=CH3 or H

R?=CH3 or CH2OH

wherein,
R=CH2OH or H.

US Pat. No. 9,695,431

PROCESS FOR TRANSFORMATION IN WITHANIA SOMNIFERA PLANTS TO INCREASE SECONDARY METABOLITE CONTENT

Council of Scientific and...

1. A process for genetic transformation in Withania somnifera plants to increase secondary metabolite content in green house acclimatized plants, comprising:
a) immersing a pre-cultured Withania somnifera explant in a bacterial suspension comprising an Agrobacterium tumefaciens harboring a plasmid carrying a cDNA sequence of squalene synthase (WsSQS) comprising SEQ ID NO: 1 for 10-20 mins and co-cultivating
the pre-cultured explant and the Agrobacterium for 24-48 h in dark;

b) transferring the co-cultivated explant to a proliferation medium containing cefotaxime for 8-10 days so as to provide a
tissue;

c) determining Gus expression in the tissue by Gus assay followed by transferring Gus positive tissue to hygromycin B selection
medium, thereby providing shoots;

d) maintaining the shoots on hygromycin B while reducing the concentration of cefotaxime; and
e) transferring the shoots to rooting medium to provide transformed plantlets and subjecting the transformed plantlets to
greenhouse conditions;

wherein the explant is an apical or nodal segment from a seedling shoot.
US Pat. No. 9,663,624

BLEND MEMBRANES BASED ON POLYBENZIMIDAZOLE (PBI) AND POLYMERIC IONIC LIQUIDS (PILS) AND A PROCESS FOR THE PREPARATION THEREOF

Council Of Scientific And...

1. A stable blend membrane comprising polybenzimidazole (PBI) and polymeric ionic liquid (PIL) Poly (diallyl dimethyl ammonium)
trifluoromethane sulphonate P[PDADMA][TFMS] with enhanced proton and hydroxyl ion conductivity.

US Pat. No. 9,745,240

METAL FREE PROCESS FOR ALLYLIC OXIDATION

COUNCIL OF SCIENTIFIC AND...

1. A metal free process for the synthesis of a phenol compound of Formula I or a ketone compound of Formula II,

wherein, R is selected from CHO, COR3, COOR4, COOH, CN, NO2, Ts, nitroethene, ?,? unsaturated ketone, or ?,?-unsaturated ester;

R1 is selected from halides, phenyl or p-F-Ph;

R2 is selected from H or alkyl;

R3 is selected from alkyl, allyl or phenyl;

R4 is selected from alkyl, allyl or benzyl;

the process comprising:
a. mixing a substituted cyclohexene of formula III

wherein, R, R1, R2, R3 and R4 are as above and a solvent, with continuous bubbling of molecular oxygen at 50 to 100° C. for 5 to 60 hours;

b. extracting the product of step (a); and
c. purifying the product of step (b) to obtain the phenol compound of Formula I or ketone compound of Formula II which is
substantially purified.

US Pat. No. 9,757,696

POROUS ABPBI [PHOSPHORIC ACID DOPED POLY (2, 5-BENZIMIDAZOLE)] MEMBRANE AND PROCESS OF PREPARING THE SAME

COUNCIL OF SCIENTIFIC AND...

1. A membrane comprising:
ABPBI in the form of a membrane and defining pores therethrough;
wherein the membrane is stable to acids, bases, organic solvents and autoclaving.
US Pat. No. 9,669,104

NANOCOMPLEX CONTAINING AMPHIPATHIC PEPTIDE USEFUL FOR EFFICIENT TRANSFECTION OF BIOMOLECULES

Council of Scientific and...

1. A nanocomplex useful for efficient transfection comprising the amino acid sequence SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5
or SEQ ID NO:6.

US Pat. No. 9,562,030

PROCESS FOR THE SYNTHESIS OF OLOPATADINE

Council of Scientific and...

1. An improved process for synthesis of olopatadine comprising the steps of:
a. treating Isoxepac (5), 2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid with thionyl chloride in the ratio ranging
between 2 to 4 in the presence of an alcohol at room temperature in the range of 15 to 30° C. for period in the range of 12
to 24 hours to yield the corresponding ester;


b. treating the ester of step (a) with allyl bromide using Zn in a solvent conducting Barbier reaction to obtain the allylic
alcohol 4;


c. Hydroborating the allyl alcohol (4) as obtained in step (b) using 9-BBN (9-Borabicyclo(3.3.1)nonane)/diborane quenched
by sodium hydroxide and hydrogen peroxide to obtain diol 6;


d. treating diol 6 as obtained in step (c) with catalytic p-toluenesulfonic acid to form a spiro tetrahydrofuran ring 3 in
almost quantitative yield;


e. treating compound 3 as obtained in step (d) with AlCl3 as Lewis acid in dichloromethane to yield olefin 2 and satisfactory E/Z ratio of 1 to 1.5;


f. subjecting compound 2 of step (e) to mesylation and dimethyl amination to result in compound 7

in the range of 55 to 60%;
g. treating compound 7 as obtained in step (f) with aqueous NaOH to yield the corresponding carboxylic acid, treating the
acid with p-toluenesulfonic acid to yield the corresponding p-toluenesulfonate, crystallizing the p-toluenesulfonate to isolate
the Z-isomer of the p-toluenesulfonate, treating the Z-isomer of the p-toluenesulfonate with NaHCO3 to yield the free base 8


and treating free base 8 with aqueous HCl to give 1 with E:Z ratio of 1:1.5

US Pat. No. 9,803,349

MECHANICAL AUTOMATIC URINAL-TOILET FLUSHER AND ITS MECHANISM THEREOF

COUNCIL OF SCIENTIFIC AND...

1. A system for facilitating an automatic urinal toilet flushing comprising:
a pipe (P) connected to a water reservoir on a first end and a urinal toilet at a second end and having an intermediate enlarged
inner diameter area, said pipe comprising:

a first portion P1 having a first diameter d1;

a second portion P2 having a second diameter d2;

a third portion P3 having a third diameter d3; wherein the first, the second and the third portions are sequential and the diameter d2 is greater than diameter d1 and diameter d3;

a tapered fourth portion P4 connecting the first portion P1 to the second portion P2; and

a tapered fifth portion P5 connecting the second portion P2 to the third portion P3;

a valve mechanism located within the pipe (P), the said valve mechanism comprising an inlet dual valve (1), an outlet dual valve (2) and a connecting rod connecting the inlet dual valve (1) and outlet dual valve (2); and

an actuating mechanism for operating the valve mechanism to perform a flushing operation, the actuating mechanism comprising:
a mechanical platform (10) mounted upon a base in a movable manner, and separated from the base by a set of resilient means, such that the mechanical
platform moves closer to the base under weight of person; and

a connecting cable (8) adapted to connect both the dual-valve with the mechanical platform (10).

US Pat. No. 9,765,048

ORGANOCATALYTIC PROCESS FOR ASYMMETRIC SYNTHESIS OF DECANOLIDES

Council of Scientific and...

1. An organo catalytic process for preparation of a compound of Formula Ib

wherein, the said process comprising the steps of:
i) protecting one of the terminal hydroxyl group of diol (21)

with benzyl group by using benzyl bromide in dry THF to obtain corresponding mono-benzyl ether (22),

followed by oxidization in presence of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl and iodobenzene diacetate in organic solvent
selected from DCM, DMF to obtain benzyl protected aldehyde (23)


ii) proline-catalyzed direct asymmetric ?-aminoxylation of benzyl protected aldehyde (23) using nitrosobenzene in acetonitrile
as an oxygen source, followed by treatment with NaBH4 in methanol further treating with copper (II) acetate in methanol for 24 hours (10-20 mins) at temperature ranging between
to obtain chiral diol (24),


which is further treated with dibutyl tin oxide and tosyl chloride, triethylamine in DCM furnishes the mono tosylated compound,
which is further treated with potassium carbonate in dry methanol at 0-25° C. for 20-40 mins to obtain epoxy compound (25)


iii) reducing epoxy compound (25) in presence of LAH to chiral secondary alcohol (26),

subsequently protecting with TBS by using TBS-Cl, imidazole in DCM followed by deprotection of benzyl in presence of palladium
catalyzed reduction in ethyl acetate gives TBS protected alcohol (28);


followed by oxidization in presence of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl and iodobenzene diacetate in organic solvent
preferably DCM to obtain aldehyde compound (29)


iv) contacting compound (29) with L-proline, PhNO, MeCN, then triethyl phosphonoacetate, DBU, LiCl then Cu(OAc)2 to yield hydroxyl ester (30),


further protecting with MOM in presence of MOMCl and DIPEA in DCM to corresponding protected ester (31)

v) reducing the protected ester (31) using DIBAL-H in dry DCM at temperature range from ?70° C. to ?85° C. to obtain aldehyde
(32),


followed by Wittig reaction in dry THF at temperature range from ?70° C. to ?85° C. to obtain corresponding ester (33);

further deprotecting of TBS in presence of TBAF in THF to secondary alcohol (34),

followed by alkali hydrolysis of the ester with LiOH in methanol and water to carboxylic acid (35)

vi) contacting (35) with 2,4,6 trichloro benzoyl chloride and triethylamine in THF and DMAP in toluene to obtain the MOM protected
decanolide (36)


subsequently deprotecting of MOM to obtain decanolides of Formula Ib.

US Pat. No. 9,815,934

ISOHEXIDE-DIACETAL BASED POLYMERS AND A PROCESS THEREOF

COUNCIL OF SCIENTIFIC AND...

1. An isohexide-diacetal based polymer having a molecular weight between 3,200 and 27,600 g/mol, comprising Formula 1

wherein m ranges from 10-200.

US Pat. No. 9,751,911

SOLOMONAMIDE ANALOGUE COMPOUNDS, PHARMACEUTICALS CONTAINING SOLOMONAMIDE ANALOGUE COMPOUNDS, AND PROCESSES FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A compound comprising:
a solomonamide analogue of Formula I

wherein the Ring A is selected from the group consisting of a substituted or an unsubstituted aryl, a substituted or an unsubstituted
heteroaryl, a substituted or an unsubstituted cycloalkyl, a substituted or an unsubstituted bicyclic compound, or a substituted
or an unsubstituted heterocyclic compound;

wherein the dipeptide is selected from the group consisting of two natural amino acids or two unnatural amino acids;
wherein X is selected from the group consisting of O, NRa, S, —S(O), S(O)2, C(O), C(O)O, C(O)NRa, CRaRb;

wherein the bond between X and an adjacent carbon atom is optionally a double bond; and wherein the bond between X and the
adjacent carbon atom is optionally part of a 3 to 6-membered cycle having 1 or 2 hetero atoms;

wherein R1 and R2 is independently selected from the group consisting of H, OH, OR, NRa, alkyl, aralkyl, substituted heteroatoms, unsubstituted heteroatoms, and amino acids; and wherein R1 and R2 substituents are attached to carbon atom optionally expresses chirality;

wherein n is 0, 1, 2, or 3;
wherein the ‘R’ substituent is selected from the group consisting of alkyl, aralkyl, C(O)ORa, or C(O)NRaRa;

‘Ra’ is selected from the group consisting of H, OH, alkyl, and aralkyl; and

‘Rb’ is selected from the group consisting of H, OH, alkyl, aralkyl, OR, and NRaRa
with a proviso that when the dipeptide is Gly-D-Ala, Ring A is the substituted aryl, X is C(O) and n is 1, then the solomonamide
analogues chosen from


US Pat. No. 9,763,881

RICE BRAN-LIPIDS BASED FORMULATION AND PROCESS FOR PREPARATION THEREOF FOR SELECTIVE DELIVERY OF GENES TO CANCER CELLS

COUNCIL OF SCIENTIFIC AND...

1. A liposomal formulation for selective targeting and delivery of genes or genetic products to cancer cells, comprising:
(a) a gene or genetic product;
(b) a cationic lipid in the range of 7-40 mole % of all constituent lipids;
(c) a co-lipid in the range of 7-40 mole % of all constituent lipids, the co-lipid being capable of facilitating an intracellular
delivery of the gene or genetic product to cancer cells; and

(d) rice bran glycolipids and, optionally, rice bran phospholipids, as adjuvant lipids in the range of 20-85 mole % of all
constituent lipids, the adjuvant lipids being capable of enhancing the transfection efficiency of the formulation and effectively
enable selective delivery of the gene or genetic product to cancer cells.

US Pat. No. 10,072,009

N-SUBSTITUTED BETA-CARBOLINIUM COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS

Council of Scientific and...

1. A compound represented by general formula A
wherein, D ring may be cyclized or in open form,
when D ring is cyclized, the dotted line indicates a single bond connected from ortho-position of aromatic ring E (Ar) to the nitrogen atom of ring C, making a five-membered ring, wherein another dotted bond shown on nitrogen of C ring is not present;
when D ring is open, the dotted line connecting aromatic ring E (Ar) to the nitrogen atom of ring C indicates no bond, wherein another dotted bond shown on nitrogen of ring C indicates presence of single bond connecting nitrogen atom to the methyl group;
wherein, R1 and R2 groups are selected from halogens or trifluoromethyl; R3 group is selected from hydrogen or methyl; X is selected from halogens; and Ar is selected from aryl and heteroaryl; and
R1 and R2 groups may be attached to any position on ring E.

US Pat. No. 9,845,302

ANTICANCER COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

9. A method of inhibiting cellular adhesion in a human subject having cancer, inflammation or bacterial infection, comprising
administering a compound having formula I, according to claim 1, optionally along with a pharmaceutically acceptable excipient and/or vehicle, effective to inhibit cellular adhesion resulting
from the cancer, inflammation or bacterial infection in the subject.

US Pat. No. 9,857,376

ONE POT PROCESS FOR THE PREPARATION OF GOLD QUANTUM CLUSTERS

COUNCIL OF SCIENTIFIC AND...

1. A facile one-pot process for the synthesis of fluorescent L-cysteine labeled gold (Au) quantum clusters (QCs) of different
core size, the process consisting essentially of;
a) mixing a solution of a gold salt with a solution of L-cysteine, followed by the addition of a base, to obtain brown coloured
reaction mixture; and

b) allowing said reaction mixture to stand at ambient temperature ranging between 20-35° C. for a period ranging between 5-10
min for complete reduction of gold ions to obtain L-cysteine labeled gold (Au) quantum clusters.

US Pat. No. 9,861,653

SYNERGISTIC ANTI-CANCER COMPOSITION AND A PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A synergistic anti-cancer composition for simultaneous non-viral delivery of an anti-cancer drug and genetic material to
glucocorticoid receptor expressing cancer cells comprising complexes comprising:
a) a cationic liposome; comprising
i. a cationic lipid;
ii. a neutral co-lipid;
iii. dexamethasone for selective targeting of Glucocorticoid receptors; and
iv. a lipophilic anti-cancer drug;wherein, the cationic lipid, the neutral co-lipid, the dexamethasone and the lipophilic anti-cancer drug are formulated in
the range of 1:1:0.75:0.1 to 1:1:0.75:0.5, and
b) genetic material encoding a gene or antisense nucleic acid, the expression of which in tumor cells has an anti-tumor effect;
wherein the genetic material is complexed with the cationic liposome in the range of 1:2 to 1:8 molar charge ratio, wherein
the cationic lipid comprises DODEAC (N, N-dihydroxyethyl, N, N-dioctadecyl ammonium chloride) or the neutral co-lipid comprises
cholesterol, and wherein the anti-cancer drug is ESC8 or nutilin.

US Pat. No. 9,856,500

METHOD OF CONSOLIDATED BIOPROCESSING OF LIGNOCELLULOSIC BIOMASS FOR PRODUCTION OF L-LACTIC ACID

Council of Scientific and...

1. A method of consolidated bioprocessing for production of L (+)-lactic
acid and/or lactate comprising:
a) providing a fermentation medium consisting of:
a carbon source;
ammonium sulphate;
yeast extract;
magnesium chloride;
calcium chloride; and
trace salts;
b) inoculating the fermentation medium obtained in step a) with a microbial culture, wherein said microbial culture is a Gram
positive thermophilic and cellulolytic bacterial isolate Paenibacillus macerans IIPSP3 (MTCC 5569);

c) incubating said fermentation medium at a temperature in the range of 40° C. to 55° C.;
d) adding sterile neutralizing agent to said fermentation medium during range of 4 to 8 hours of incubation to maintain pH
of the medium in the range of about 5.5 to 7.2; and

e) contacting said medium obtained in step a) with Paenibacillus macerans IIPSP3 (MTCC 5569) for a period of 6 to 48 hours for the production of L (+)-lactic acid and/or lactate.

US Pat. No. 9,834,570

ONE STEP PROCESS FOR REGIOSELECTIVE SYNTHESIS OF ?-ACYLOXY CARBONYLS

COUNCIL OF SCIENTIFIC AND...

1. A single-step, one pot process for the preparation of an ?-acyloxy carbonyl compound of general formula (I);

wherein R is selected from H, alkyl, aryl, Bn; R1 is selected from H, alkyl, substituted aryl, unsubstituted aryl, —CH2OTBS (TBS=Tertiary butyl silyl), —CH2OBn, —OR, OMOM (Methoxy methelene); Ar is selected from unsubstituted/substituted phenyl group or pyridine group; R and R1 optionally can combine to form a ring structure containing 3 to 6 carbon atoms and may optionally contain a heteroatom;

comprising the steps of: reacting alkene of formula (II) with an aldehyde of formula (III)

in the presence of a N-Heterocyclic carbene catalyst (NHC) selected from

wherein for IVb, Ar=2,4,6-(CH3)3C6H2; for IVc, Ar=2,6-iPr2C6H3, a halogen source, tri-ethyl amine and a solvent in oxygen atmosphere at a temperature in the range of 15-30° C. by stirring
for a period in the range of 10-50 hours to obtain a compound of general formula (I); wherein R is selected from H, alkyl,
aryl, Bn; R1 is selected from H, alkyl, substituted aryl, unsubstituted aryl —CH2OTBS (TBS=Tertiary butyl silyl), —CH2OBn, —OR, OMOM (Methoxy methelene); Ar is selected from unsubstituted/substituted phenyl group or pyridine group.

US Pat. No. 9,969,763

1,2,3-TRIAZOLE-TETHERED CARBOHYDRATE-DI AND TRI LIPIDATED CYSTEINE CONJUGATES USEFUL AS VACCINE ADJUVANTS AND PROCESS FOR PREPARATION THEREOF

Council of Scientific and...

1. A vaccine adjuvant conjugate of Formula (1)whereinR is selected from the group consisting of a pyranose or furanose monosaccharide, pyranose or furanose disaccharides, and di- or polyhydroxy-alkyl, wherein the monosaccharide or disaccharide is linked to the 1,2,3-triazolyl methyl amine moiety through alpha or beta linkage;
R1 and R2 are selected from the group consisting of alkyl (C4-C18), alkenyl (C4-C18), alkynyl (C4-C18) either linear or branched, arylalkyl (C4-C18), cycloalkyl (C4-C18), and triterpinyl(C4-C18) lipid entity;
R3 is selected from the group consisting of hydrogen, alkyl (C4-C18), alkenyl (C4-C18), alkynyl (C4-C18) either linear or branched, arylalkyl (C4-C18), cycloalkyl (C4-C18), and triterpinyl(C4-C18) lipid.

US Pat. No. 9,951,040

1,3,5 -TRIAZINE BASED PI3K INHIBITORS AS ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A compound of formula 1
wherein substituent S1 is selected from one of formula Ia or Ib

and substituent S2 is represented by formula Ic

wherein X is independently selected from any of NR3, O, and CH2,
R1, R2 are independently selected from any of substituted or unsubstituted alkyl C1-C14, substituted or unsubstituted acyl C2 to C14, substituted or unsubstituted phenyl ring and wherein the substitution is one or more of F, Cl, Br, I, CN, NR4R, CF3, CHCF2, CH2F, OCF3, OCH2CF3, OR6, NO2, NO, CHR7R8, alkyl chain from C1 to C14, COOR9, CHO, COR10, COCF3, COCH2CF3, SR11, SOR12, SO2R13, SONR14R15, SO2NR14R17, cycloalkyl at any of the available position,
R3 is independently selected from any of H, substituted or unsubstituted alkyl C1-C14, substituted or unsubstituted acyl C2 to C14, substituted or unsubstituted phenyl ring and wherein the substitution is one or more of F, Cl, Br, I, CN, NR4R5, CF3, CHCF2, CH2F, OCF3, OCH2CF3, OR6, NO2, NO, CHR7R8, alkyl chain from C1 to C14, COOR9, CHO, COR10, COCF3, COCH2CF3, SR11, SOR12, SO2R13, SONR14R15, SO2NR14R17, cycloalkyl at any of the available position,
is independently selected from any of following substituted or unsubstituted N-heterocycles selected from indolyl, triazolyl, pyrrolyl, imidazoyl, benzotriazolyl, benzoimidazolyl, and thiazoyl attached though the N-atom or through any of the available ring positions and further optionally substituted by any of F, Cl, Br, I, CN, NR4R5, CF3, CHF2, CH2F, OCF3, OCH2CF3, OR6, NO2, NO, CHR7R8, alkyl chain from C1 to C14, COOR9, CHO, COR10, COCF3, COCH2CF3, SR11, SOR12, SO2R13, SONR14R15, SO2NR14R17, or cycloalkyl,Ar is independently selected from any of substituted or unsubstituted phenyl, substituted or unsubstituted napthyl and attached through any of the available ring position and wherein the substitution is selected from F, Cl, Br, I, CN, NR4R5, CF3, CHCF2, CH2F, OCF3, OCH2CF3, OR6, NO2, NO, CHR7R8, alkyl chain from C1 to C14, COOR9, CHO, COR10, COCF3, COCH2CF3, SR11, SOR12, SO2R13, SONR14R15, SO2NR14R17, and cycloalkyl,
Hetero-Ar is independently selected from any of substituted or unsubstituted pyridyl, triazolyl, triazinyl, pyrimidinyl, pyridazinyl, oxazolyl, furanyl, benzofuranyl, thiophenyl, pyrrolyl, imidazoyl, thiazoyl, quinolinyl, isoquinolinyl, benzooxazolyl, and benzothiazolyl, indolyl, benzotriazolyl, and benzoimidazolyl and attached through any of the available ring position and further optionally substituted by any of F, Cl, Br, I, CN, NR4R5, CF3, CHCF2, CH2F, OCF3, OCH2CF3, OR6, NO2, NO, CHR7R8, alkyl chain from C1 to C14, COOR9, CHO, COR10, COCF3, COCH2CF3, SR11, SOR12, SO2R13, SONR14R15, SO2NR14R17, and cycloalkyl,
R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R14 and R17 are independently selected from the group consisting of H, linear alkyl chain C1-C10, branched alkyl chain C3-C10, and substituted or unsubstituted phenyl ring.
US Pat. No. 10,035,914

INORGANIC BLUE PIGMENTS FROM COBALT DOPED MAGNESIUM HAVING TRANSITION ELEMENT OXIDES AND A PROCESS FOR THE PREPARING THE SAME

Council of Scientific and...

1. A Blue pigment having the general formula Mg1-xCoxWO4 (x=0.1 to 0.5).

US Pat. No. 10,029,240

SYNTHESIS OF FUNCTIONALIZED CARBON MICROSPHERES AND THEIR CATALYST ACTIVITY IN C—O AND C—N BOND FORMATION REACTIONS

COUNCIL OF SCIENTIFIC AND...

1. A process for preparation of functionalized carbon microspheres by grafting catalytically active functional groups on to carbon microspheres obtained from bagasse to generate an acidic or basic surface wherein said process comprises the steps of:a) heating bagasse, water and oxalic acid at a temperature ranging between 150 to 180 ° C. for a time period ranging between 6 to 12 hours to obtain carbon microspheres; and
b) refluxing of carbon microspheres as obtained in step (a) and an organic solvent selected from the group consisting of n-pentane, n-hexane, toluene, and lower alcohols in the presence of a functional group grafting agent at a temperature ranging between 80-120 ° C. for a time period in the range of 8 to 12 hours to obtain functionalized carbon microspheres,
wherein the functionalized carbon microspheres catalyze C—O and C—N bond formation reactions in high selectivity of 90% to 100% and conversion rate of 45 to 95% or 10 to 98%.
US Pat. No. 10,005,747

PROCESS FOR THE PRODUCTION OF ?-VALEROLACTONE

Council of Scientific and...

1. A process for the production of ?-valerolactone comprising the steps:a) precipitating a hydrotalcite support from an aqueous solution of nitrate salts of aluminum and magnesium that are present in a molar ratio of 80:20;
b) impregnating the hydrotalcite support with a solution of Pt(NH3)4(NO3)2 (1-3%) to yield a Pt loaded hydrotalcite;
c) calcining the Pt loaded hydrotalcite as obtained from step (b) at 260-550° C. in air;
d) reducing the Pt loaded hydrotalcite as obtained from step (c) in hydrogen gas at 260-480° C. to obtain a platinum supported hydrotalcite;
e) hydrogenating levulinic acid in water in the presence of the platinum supported hydrotalcite catalyst as obtained in step (d) in a high pressure stirrer reactor at 25° C. to 100° C. and 20-50 bar hydrogen gas while stirring for a period of 2-100 h to obtain ?-valerolactone.

US Pat. No. 10,000,527

11-SUBSTITUTED BILE ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND USE OF THESE COMPOUNDS AS MEDICAMENTS

Council of Scientific and...

1. A compound or a pharmaceutically acceptable salt thereof selected from the group consisting of

US Pat. No. 9,899,687

PROCESS FOR THE SYNTHESIS OF NITROGEN-DOPED CARBON ELECTRO-CATALYST

COUNCIL OF SCIENTIFIC AND...

1. A process for the synthesis of nitrogen-doped carbon electro-catalyst, the process comprising the steps of:
(a) boiling a protein rich precursor in excess of deionized (DI) water to obtain a slurry or in a colloidal silica nanoparticle
dispersion in water, wherein said dispersion is boiled up to dryness to obtain a dried product;

(b) filtering the slurry of step (a) through a Whatman filter paper to obtain a filtered product;
(c) pyrolyzing the filtered product of step (b) or the dried product of step (a) to obtain a pyrolyzed product wherein the
pyrolysis is carried out at 800-1100° C. for 2-4 hours;

(d) treating the pyrolyzed product of step (c) with concentrated hydrofluoric acid [HF] to remove oxide impurities to obtain
a porous carbon product; and

(e) washing the porous carbon product of step (d) with deionized water by centrifugation and drying in oven followed by pyrolysis
at 800-1100° C. for 2-4 hours to obtain the nitrogen-doped carbon electro-catalyst having nitrogen doping in the range of
0.8 to 1.25%, wherein pore size of said electro-catalyst is in the range of 10 to 300 Å, surface area of said electro-catalyst
is in the range of 600-800 m2/g.

US Pat. No. 9,879,331

GREEN PROCESS FOR THE PREPARATION OF PURE IRON

Council of Scientific and...

1. A green process for the preparation of pure iron from iron oxide without using carbon, wherein the said process comprises
the steps of:
a) mixing iron ore fines with 1 to 15% by weight non-carbon additives to obtain iron oxide granules of size 0.2 to 6 mm as
a feed material;

b) loading iron oxide granules as obtained in step a) in water cooled copper crucible with options for feeding iron oxide
granules with varying feed rate during the course of operation through a feeder;

c) introducing Ar gas at flow rate in the range of 5-50 liters per minute (1 pm) into the reaction chamber for a period in
the range of 1 to 2 minutes followed by establishing an electric arc to obtain molten iron ore; and

d) passing H2 gas at flow rate in the range of 2-40 lpm to the reaction chamber with magnetic stirring for a period in the range of 30-180
min to obtain slag and pure iron.

US Pat. No. 9,879,354

ELECTROCHEMICAL PROCESS FOR WATER SPLITTING USING POROUS CO3O4 NANORODS

Council of Scientific and...

1. An electrochemical process for water splitting using porous Co3O4 nanorods as anode material for production of oxygen comprising placing an anode and a cathode in an electrolyte solution comprising
a mixture of water and an acid salt that is present in a concentration between 0.05 and 0.15 M at pH ranging between 4-14,
applying a potential across the anode and cathode sufficient to produce oxygen;
wherein the Co3O4 nanorods has an overpotential in the range of 385 mV to 400 mV at 1 mA/cm2 and exchange current density in the order of 10?6 A/cm2 (5-8×10?6 A/cm2).

US Pat. No. 9,834,515

PROCESS FOR SYNTHESIS OF PIPERIDINE ALKALOIDS

Council of Scientific and...

1. A process for the preparation of piperidine alkaloids, the process comprising:
a) dissolving gluconolactone compound (1) in methanolic ammonia solution followed by stirring at room temperature in the range
of 20 to 35° C. for 1 to 1.5 h to afford 5-?-hydroxy amide (2);


b) stirring a solution of compound 2 as obtained in step (a) in DMSO and Ac2O at room temperature in the range of 20 to 35° C. for period in the range of 22 to 23 h followed by addition of water to
afford ?-keto amide (3);


c) adding formic acid and sodium cyanoborohydride to a solution of compound 3 as obtained in step (b) in acetonitrile followed
by refluxing at temperature in the range of 80 to 85° C. for period in the range of 4 to 4.5 h to afford glycolactam compound
(5);


d) adding lithium aluminium hydride to a solution of compound 5 as obtained in step (c) in tetrahydrofuran followed by stirring
the reaction mixture for period in the range of 3.5 to 4 h at temperature in the range of 65 to 70° C. and purification to
afford protected piperidine compound (6);


e) adding palladium on active charcoal to a solution of piperidine compound 6 as obtained in step (d) in acetic acid followed
by stirring the mixture for overnight for period in the range of 10 to 12 hr at room temperature in the range of 20 to 35°
C. under hydrogen atmosphere to afford piperidine alkaloids (7);


f) adding Et3N to a solution of glycolactam (5) as obtained in step (c) in dichloromethane followed by cooling to 0° C. and further adding
Boc2O, DMAP followed by stirring at temperature in the range of 20 to 25° C. for period in the range of 8 to 9 h to afford N-Boc
protected lactam (8);


g) dissolving N-Boc protected lactam (8a) of step (d) in toluene and cooling to ?76° C. under inert atmosphere and adding
superhydride and ammonium chloride solution at ?76° C. followed by stirring the reaction mixture for period in the range of
9 to 10 h at room temperature to afford lactamol compound 9a;


h) stirring a mixture of compound of step (e) and HCl in methanol at 70° C. for 5 h followed by basifying the reaction mixture
to afford 3-deoxynojirimycin (10a);


i) dissolving N-Boc protected lactam (8a) of step (d) in dry toluene and cooled at ?76° C. under inert atmosphere and adding
superhydride with stirring followed by addition of TFAA, DIPEA, catalytic amount of DMAP and purification to afford Boc-iminoglycal
(11a/11b); and

j) adding Boc-iminoglycal (11a) to a solution of (DHQ)2AQN, K3Fe(CN)6, K2CO3, K2OsO2(OH)4 and CH3SO2NH2 in tert-butyl alcohol and water cooled at 0° C. followed by stirring the mixture at 0° C. for 60 to 66 h to afford iminoglycal
compound (12a).

US Pat. No. 9,820,968

ANTI-LEUKEMIC AGENT USEFUL FOR INDUCING DIFFERENTIATION IN MYELOID LEUKEMIA CELLS

COUNCIL OF SCIENTIFIC AND...

1. A method for the treatment of a human having a myeloid leukemia, the method comprising:
contacting a myeloid leukemia cell of the human with a subapoptotic concentration of ormeloxifene or salt thereof that induces
differentiation in the myeloid leukemia cell, wherein the subapoptotic concentration is less than 5 ?M and wherein the expression
of cd11b markers in the cell is at least 10.74%.

US Pat. No. 10,003,075

CARBON NANOTUBE-METAL NANOCOMPOSITES AS FLEXIBLE, FREE STANDING, BINDER FREE HIGH PERFORMANCE ANODE FOR LI-ION BATTERY

Council of Scientific and...

1. A process for the preparation of flexible, free standing, anode material in the form of paper,wherein the paper comprises Carbon Nano Tubes (CNT) and metal in the ratio ranging between 99:1 to 50:50 having specific capacity in the range of 136 to 417 mAh/g after 50 cycles by C/10 rate; and
wherein said process consists of the steps of:
(i) dispersing the carbon nanotubes in a solvent by using ultrasonication for 3 hours;
(ii) dissolving inorganic metallic salts in distilled water by ultrasonication;
(iii) mixing the solution obtained from step (i) and (ii) using magnetic stirrer for 1 hour;
(iv) refluxing of the solution obtained from step (iii) in air at 100° C. for 4 hours;
(v) filtering of solution obtained from step (iv) in a vacuum filtration unit to obtain a metal oxide/carbon nanotube nanocomposite;
(vi) washing of filtrate obtained in step (v) using Deionized water;
(vii) drying of composite obtained from step (vi) in vacuum oven; and
(viii) obtaining the flexible, free standing, anode material in the form of paper through paper making technology using vacuum filtration.

US Pat. No. 9,891,200

METAL COORDINATION COMPLEX FOR DETECTION OF VAPORS AND ANIONS AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A complex of formula X

Wherein R1, R2, R3 and R4 is selected from H2O or NO3;

Provided that when R1, and R3 is NO3 then R2 and R4 is absent.

US Pat. No. 9,988,413

PROCESS FOR CONVERSION OF HEMICELLULOSE INTO C5 SUGARS USING IONIC LIQUIDS

COUNCIL OF SCIENTIFIC AND...

1. A single step, one pot process for conversion of a substrate comprising Rice Husk-1, Rice Husk-2, Wheat straw, hemicellulose and Bagasse, to C5 and C6 sugars, the process comprising: mixing the substrate, solvent and ionic liquid catalyst at a temperature in the range of 130 to 180° C. for a time in the range of 10 min to 12 h to obtain C5 and C6 sugars, whereinC5 sugars yields is in the range of 70%-95%, and
the ionic liquid catalyst is selected from 1-methyl-3-(3-sulfopropyl)-imidazolium hydrogensulfate, 1-methyl-3-(3-sulfopropyl)-imidazolium para-toluenesulfonate, or 1-methyl-3-(3-sulfopropyl)-imidazolium chloride.
US Pat. No. 9,975,101

PROCESS FOR PREPARATION OF SELF HEALING MICROCAPSULES

Council of Scientific and...

1. A process for the preparation of self-healing microcapsules with polyurethane as capsule wall material prepared by in-situ polymerization using non-aqueous continuous phase comprising the steps of:a) preparing a mixture of epoxy components to be encapsulated and polyisocyante;
b) preparing a solution of diol or polyol with a cross-linker in aliphatic hydrocarbon;
c) dispersing the mixture of step a) in a solution of a stabilizer and a catalyst in an aliphatic hydrocarbon;
d) adding the solution of step (b) drop wise to the dispersion of step c) under agitation followed by treatment with anti-agglomerating agent to obtain microcapsules; and
e) filtering and/or centrifuging, washing the microcapsules as obtained in step (d), with the aliphatic hydrocarbon and drying the microcapsules under vacuum at ambient temperature to obtain microcapsules with polyurethane as capsule wall material.

US Pat. No. 9,963,476

ANTIOXIDANT COMPOUND HAVING ANTI ATHEROSCLEROTIC EFFECT AND PREPARATION THEREOF

Council of Scientific and...

1. A process for the preparation of antioxidant compound F,said process comprising the steps of:a) providing bromomethyl 9-bromononanoate as compound A and making a solution in dry THF at ?75 to ?80° C.;
b) providing a solution of t-butyl lithiate as compound B and mixing with THF under nitrogen atmosphere at ?75 to ?80° C. and adding a solution of LDA to the resulting mixture slowly for 1-2 hr;
c) adding the mixture obtained in step b) to compound A as obtained in step a) at ?75 to ?80° C. for 1-2 hr to obtain reaction mixture;
d) working up of the reaction mixture as obtained in step c) by quenching and extracting with ethylacetate to obtain organic extracts;
e) washing the organic extracts as obtained in step d) with water and drying over anhydrous Na2SO4 and filtering by known methods to give crude product, compound C as tert-butyl 11-bromo-3-oxoundecanoate;
f) adding benzene-1-2,4-triyl triacetate as compound D to compound C as obtained in step e) in H2SO4 at room temperature for 18-20 hr to obtain the reaction mixture;
g) working up of the reaction mixture as obtained in step f) by diluting with water and extracting with ethyl acetate to obtain organic extracts;
h) washing the organic extracts as obtained in step g with water and drying over anhydrous Na2SO4 and filtering and purifying by known methods to give crude compound E as 4-(8-bromooctyl)-6,7-dihydroxy-2H-chromen-2-one; and
i) mixing of compound E as obtained in step h) in DMF and triphenylphosphine to obtain a reaction mixture and heating the reaction mixture at 150-170° C. for 5-8 hr and further purifying by known methods to obtain the final product compound F as an esculetin analogue.

US Pat. No. 9,988,272

LASER-INDUCED DISSOCIATIVE STITCHING (LDS) FOR SYNTHESIS OF CARBON AND CARBON BASED NANOCOMPOSITES

COUNCIL OF SCIENTIFIC AND...

1. A process for the synthesis of carbon and carbon based nanocomposites using Laser-induced Dissociative Stitching (LDS) of liquid halogen containing aromatic compounds at room temperature, wherein halogen based free radicals are dissociated from the aromatic compounds and introduced to a graphitic network.
US Pat. No. 9,988,337

SINGLE STEP PROCESS FOR THE PREPARATION OF BUTYL ACETATE

Council of Scientific and...

1. A single step transesterification process for the preparation of butyl acetate comprising heating a reaction mixture of n-butanol, ethyl acetate and boron loaded zeolite B-USY catalyst for the period in the range of 1 to 10 hr, wherein the yield of butyl acetate is 50-96%.

US Pat. No. 9,949,970

SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS

COUNCIL OF SCIENTIFIC AND...

1. A method of treating a tuberculosis infection, wherein said method comprises administering a to a patient a composition comprised of a benzothiazole compound of general formulae A
wherein X=—N?CH—, —NH—CO—, —CO—,
wherein Ar=Phenyl, 4-methylphenyl, 4-methoxyphenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-fluorophenyl, 4-chlorophenyl, 2-chloro-3-methoxyphenyl, 3,5-dimethoxyphenyl, 3,4,5-trimethoxyphenyl, pyridyl, nicotenyl, isonicotinyl, 5-nitro-2-furyl, styryl, 4-fluorostyryl, 4-methylstyryl, 4-methoxystyryl, 4-trifluorostyryl, 4-trifluoromethoxystyryl, 5-nitro-2-furyl, 1-methyl-4-nitro-1H-2-pyrrolyl, 1-methyl-5-nitro-1H-2-imadazolyl, 1-methyl-3-nitro-1H-2-pyrazolyl, and
wherein R=Hydro, Methyl, Methoxy, Trifluoromethyl, Trifluoromethoxy, Fluoro, Chloro, Nitro, 5-Nitrofuran-2-carboxamide, 5-Nitrothiophene-2-carboxamide, 1-methyl-4-nitro-1H-2-pyrrolcarboxamide, 1-methyl-5-nitro-1H-2-imadazolcarboxamide, 1-methyl-3-nitro-1H-2-pyrazolcarboxamide.

US Pat. No. 9,950,983

TRICYCLIC COMPOUNDS AND PROCESS FOR PREPARATION THEREOF

Council of Scientific and...

1. A compound of formula (I)
wherein
R1, R3, and R4 are selected from the group consisting of hydrogen, alkyl (C1 to C2), COOH, COR, CONRR, CH2OR, and NRR;
R2, R6, R7 and R8 are selected from group consisting of hydrogen, alkyl (C1 to C4), COOH, COR, CONRR, CH2OR, NRR;
R5 is selected from group consisting of hydrogen, COOH, CONRR, CH2OR, and NRR;
wherein any two of R1, R2, R3, R4, R5, R6, R7, R8 may form a 3 to 8 membered carbocyclic ring which may optionally be substituted or may contain a heteroatom selected from O or N;
X is selected from C?O; C?S or C—R—R;
R is hydrogen;
‘’ represents a single or double bond;
either of the rings in formula (I) may additionally contain at least one carbonyl group or salt thereof.

US Pat. No. 10,307,734

WATER SPLITTING ACTIVITY OF LAYERED OXIDES

COUNCIL OF SCIENTIFIC AND...

1. A photocatalytic water splitting process for H2 generation, the process comprising:a) dispersing a catalyst powder having the formula InA(ZnO)m in a reactant solution to provide a reactant mixture in a gas closed irradiation system, wherein A is FeO3 or GaO3 and m=1-5, and wherein the reactant solution comprises water and methanol in ratio of 4:1; and
b) irradiating the reactant mixture as obtained in step (a) in the visible light range, in the UV light range, or both the visible and UV light range, to obtain hydrogen;
wherein the catalyst powder of the reactant mixture irradiated in the visible light range is selected from the group consisting of InFeO3(ZnO)m, InFeO3(ZnO)m co-catalyzed with Pt, and InGaO3(ZnO)m co-catalyzed with CuO; and
wherein the catalyst powder of the reactant mixture irradiated in the UV light range or both the visible light range and the UV light range is selected from the group consisting of InFeO3(ZnO)m, InFeO3(ZnO)m co-catalyzed with Pt, InGaO3(ZnO)m, InGaO3(ZnO)m co-catalyzed with NiO, and InGaO3(ZnO)m co-catalyzed with CuO.

US Pat. No. 10,287,527

ECO-FRIENDLY PROCESS FOR THE ISOLATION OF BIOPOLYMERS FROM AGRICULTURAL RESIDUES

Council of Scientific and...

1. A process for the isolation of biopolymers from agricultural residues, wherein the process comprises the steps:a) obtaining and pulverizing dried biomass to size in the range of 0.1 to 0.15 mm and extracting using petroleum ether (60-80 degree C.) or hexane in a first phase and one or more alcohol in a second phase to obtain a de-waxed biomass extract;
b) partitioning the de-waxed biomass extract with water to obtain a nonpolar soluble portion and a raffinate portion;
c) treating the nonpolar soluble portion with fuller's earth followed by filtration and concentration of filtrate to obtain neutral lipids;
d) the raffinate portion is subsequently concentrated and solubilized with aqueous alcohol followed by partition with one or more organic solvent to obtain an organic solvent soluble portion, and an aqueous portion;
e) treating the organic solvent soluble portion with fuller's earth followed by filtration and concentration of filtrate to obtain polar lipids;
f) mixing imidazole with one or more organic acid in equimolar ratio in alcohol followed by refluxing or stirring at a temperature in the range of 65 to 90 degree C. for a period of 30 minutes to 1 hour to obtain an organic acidified imidazole:water (2:1 to 1:1) solvent system after removing the alcohol and adding water content;
g) treating the aqueous portion as obtained in step [d] with the organic acidified imidazole:water (2:1 to 1:1) solvent system as obtained in step [f] at a temperature in the range of 90 to 120 degree C. for a period of 30 minutes to 2 hours without stirring to obtain a de-lignified biomass and a solution containing lignin;
h) precipitating lignin from the solution as obtained in step [g] by dilution with water and filtering or centrifuging and washing the precipitate to isolate pure lignin;
i) mixing 0.1 M of imidazole solution with 0.1 M of one or more alkali in water followed by refluxing or stirring at a temperature in the range of 90 to 110 degree C. for a period of 30 minutes to 1 hour to obtain a solvent system of 0.1M to 0.2M imidazole-alkali in water;
j) treating the de-lignified biomass as obtained in step [g] with the solvent system as obtained in step [i] at a temperature in the range of 60 to 90 degree C. for a period of 30 minutes to 2 hours without stirring followed by filtering to obtain a filtrate containing hemicellulose and a residue containing cellulose;
k) neutralizing the filtrate as obtained in step [j] with one or more organic acid followed by addition of one or more alcohols to precipitate the hemicellulose followed by filtration or centrifugation and washing the precipitate with alcohol to obtain pure hemicellulose;
l) washing the residue as obtained in step [j] with water to obtain the pure cellulose.
US Pat. No. 10,227,589

METHOD FOR INHIBITING TUMOR GROWTH THROUGH RNA-INTERFERENCE USING LIPOSOMALLY ASSOCIATED CDC20 SIRNA

COUNCIL OF SCIENTIFIC AND...

1. An in-vivo method for treating cancer in a warm-blooded animal, comprising administering a therapeutically effective amount of cationic liposomal composition to an animal, the therapeutically effective amount of the liposomal composition comprising a cationic lipid, a neutral co-lipid and a small RNA molecule, wherein the small RNAs selected from the group comprising small interfering RNA (siRNAs), plasmid DNA encoded short hairpin ribonucleic acid (shRNA) against Cdc20 (a key cell cycle regulator), wherein the molar ratio of cationic lipid to neutral lipid is 1:1; the administration of the therapeutically effective amount of the cationic liposomal composition inhibits tumour growth, wherein the tumour comprises a solid tumor or a secondary lung tumour and wherein the cdc20si RNA comprises a sequence selected from the group comprising SEQ ID No. 1 and SEQ ID No. 2.

US Pat. No. 10,227,355

QUINOLINE DERIVATIVES AND PREPARATION THEREOF

Council of Scientific and...

1. A compound of formula (I),or pharmaceutically acceptable salts, thereof, wherein:R2 represents mono, di or tri substituents, wherein each such substituent is independently selected from the group consisting of H, alkyl (linear or branched), cycloalkyl, —ORa, ORaO—, —O(Ra)nO— (crown ether type and long/short chain poly ethers), NRaRb, NHRa, alkylamino (mono or di), arylamino (mono or di), —SRa, aryl (which may be further substituted), heterocyclyl, heteroaryl, alkylcycloalkyl, alkylaryl, alkylheterocyclyl, alkylheteroaryl, alkenyl, alkynyl, halogen, trifluromethyl, nitro, amide, ester (—CO2Ra, —OC(O)Ra, —OC(O)CF3, —OSO2Ra, —OSO2CF3) cyano, an inorganic support and a polymeric moiety;
R3 is selected from the group consisting of H, alkyl (linear or branched), alkenyl, allyl, proporgyl, alkynyl, cycloalkyl, aryl (which may be further substituted), heterocyclyl, heteroaryl, alkylcycloalkyl, alkylaryl, alkylheterocyclyl, and alkylheteroaryl, alkenyl, alkynyl, halogen, trifluromethyl, nitro, amide, R(O)C—, ester (—CO2Ra, —OC(O)Ra, —OC(O)CF3, —OSO2Ra, —OSO2CF3), and cyano;
R4 is selected from the group consisting of H, alkyl (linear or branched), alkenyl, allyl, proporgyl, alkynyl, cycloalkyl, aryl (which may be further substituted), heterocyclyl, heteroaryl, alkylcycloalkyl, alkylaryl, alkylheterocyclyl, and alkylheteroaryl, alkenyl, alkynyl, halogen, trifluromethyl, nitro, amide, ester (—CO2Ra, —OC(O)Ra, —OC(O)CF3, —OSO2Ra, —OSO2CF3), and cyano;
when R3 is —CO2Rc and R4 is H then R2 is selected from mono, di or tri substituents, wherein each such substituent is independently selected from the group consisting of H, alkyl (linear or branched), cycloalkyl, —O(Ra)nO— (crown ether type and long/short chain poly ethers), NRaRb, NHRa, alkylamino (mono or di), arylamino (mono or di), —SRa, aryl (which may be further substituted), heterocyclyl, heteroaryl, alkylcycloalkyl, alkylaryl, alkylheterocyclyl, alkylheteroaryl, alkenyl, alkynyl, halogen, trifluromethyl, nitro, amide, ester (—CO2Ra, —OC(O)Ra, —OC(O)CF3, —OSO2Ra, —OSO2CF3) cyano, an inorganic support and a polymeric moiety;
R represents alkoxy (—ORa), alkyl (linear and branched), cycloalkyl, aryl (which may be further substituted);
Ra and Rb are each independently selected from the group consisting of alkyl (linear and branched), alkenyl, alkynyl, cycloalkyl, aryl (which may be further substituted), heterocyclyl, heteroaryl, alkylcycloalkyl, alkylaryl, alkylheterocyclyl, and alkylheteroaryl; and
Rc is selected from methyl or ethyl,
wherein the compound of formula (I) is:

or pharmaceutically acceptable salts, thereof.
US Pat. No. 10,208,353

BIOMARKERS USEFUL FOR DETECTION OF TYPES, GRADES AND STAGES OF HUMAN BREAST CANCER

Council of Scientific and...

1. A microarray consisting of a panel of probes for miRNAs affixed to the microarray, which panel is useful for screening and detection for the type, grade and stage of breast cancer, wherein the miRNAs consist of SEQ ID Nos. 1-107, or a subset thereof consisting of SEQ ID Nos. 30-42 or SEQ ID Nos. 51-55.

US Pat. No. 10,144,712

QUINOLINES AND PROCESS FOR THE PREPARATION THEREOF

Council of Scientific and...

1. A heterocyclic compound of formula A
wherein,
R1 is independently selected from the group consisting of hydrogen, alkyl (linear and branched), cycloalkyl, aryl, heterocyclyl, heteroaryl, alkylcycloalkyl, alkylaryl, alkylheterocyclyl, alkylheteroaryl, alkenyl, halogen, triflurometyl, nitro, amide, ester, cyano, alkoxy, alkylamino, arylamino, an inorganic support and a polymeric moiety;
R is selected from the group consisting of H, alkyl (linear, branched), cycloalkyl, aryl, heterocyclyl, heteroaryl, alkylcycloalkyl, alkylaryl, alkylheterocyclyl, alkylheteroaryl, alkenyl, halogen, triflurometyl, nitro, amide, ester, cyano, alkoxy, alkylamino, arylamino, an inorganic support and a polymeric moiety;
R2 is H or the heterocyclic compound is 8-(3-(triisopropylsilyl)prop-2-ynyl)quinoline (3a).
US Pat. No. 10,100,082

HEXAPEPTIDE FOR NEUROPROTECTION AGAINST A ? TOXICITY

Council of Scientific and...

1. A nanovesicle having a size in the range of 50-600 nm comprising monomeric units of a peptide consisting of the amino acid sequence as set forth in SEQ ID NO:1.

US Pat. No. 10,318,839

METHOD FOR AUTOMATIC DETECTION OF ANATOMICAL LANDMARKS IN VOLUMETRIC DATA

Council of Scientific and...

1. A computer-implemented method for fully automatic detection of a plurality of 3D cephalometric landmarks on anatomical structures in volumetric data comprising of prior knowledge derived from mathematical entities and steps, wherein the method comprises:receiving three dimensional model data, wherein the three dimensional model data includes one or more of: computed tomography data (CT) produced by a CT scanner, cone beam computed tomography (CBCT) data produced by a CBCT scanner, or magnetic resonance imaging (MRI) data produced by an MRI scanner generating scan volumetric data of the skull of a patient;
detecting a Reference Point in a given volume in the three dimensional model data;
estimating an Empirical Point in the given volume based on a first vector distance from the Reference Point, wherein the Empirical Point comprises a point of maximum distance from the reference point;
estimating a VOI (Volume of Interest) in the given volume based on a second vector distance from the Empirical Point, wherein the VOI comprises a subset of the given volume;
cropping the three dimensional model data for the VOI;
detecting structural three-dimensional contours in the cropped VOI using the mathematical entities applied individually on each 2D slice stacked as three dimensional model data;
detecting a landmark on one of the detected structural three-dimensional contours by performing a hierarchical search of a plurality of mathematical entities that includes:
identifying a first point based on a first mathematical entity from the Reference Point, wherein the identifying includes identifying a point on the one of the detected structural three-dimensional contours from the Reference Point in Y-axis direction as the first point;
identifying a second point based on a second mathematical entity from the first point, wherein the identifying includes identifying a point on the one of the detected structural three-dimensional contours from the first point in the Z-axis direction as the second point; and
identifying the landmark based on a third mathematical entity from the second point, wherein the identifying includes identifying a mid-point between the second point and a third point as the landmark; and
transmitting the landmark to a display for displaying the first point, the second point, and the detected landmark on the three dimensional model data to a user in order to facilitate 3-D cephalometric analysis of the anatomical structure, wherein the display is configured to display a plurality of two-dimensional slices of volumetric data stacked into a three-dimensional model and further display the first point, the second point, and the landmark within the three-dimensional model.

US Pat. No. 10,131,727

SOLID STATE MATRIX, PROCESS OF PREPARATION THEREOF, AND PROCESS OF PREPARATION OF THEAFLAVINS

COUNCIL OF SCIENTIFIC AND...

1. A process for converting a tea substrate to theaflavins comprising the steps:a) incubating a mixture of a tea substrate dissolved in water and a solid state matrix, the solid state matrix being of formula III,
wherein X is up to about 30, Z is one per carboxyl group in a polymer chain length: E is polyphenol oxidase enzyme (PPO), at a temperature ranging between 25° C. to 37.5° C. for a period ranging between 30 minutes to 2 hour, andb) separating the matrix from the mixture to obtain filtrate containing the product theaflavins and recycling the matrix after washing with acetone followed by water, wherein the PPO used is selected from an enzyme obtained from tea or litchi.

US Pat. No. 10,336,703

PROCESS FOR THE SYNTHESIS OF IVACAFTOR AND RELATED COMPOUNDS

Council of Scientific and...

1. A one pot process for the preparation of compounds of formula (I) and formula (II);wherein, Ar1 is a 5-6 membered aromatic/hetero aromatic ring, which could be further substituted by alkyl, aryl, hetero aryl and having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is optionally fused to a 5-12 membered monocyclic or bicyclic, aromatic, partially unsaturated, or saturated ring, wherein each ring contains 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein Ar1 has m substituents, each selected independently from —WRW; W is a bond or is an optionally substituted C1-C6 alkylidene chain wherein up to two methylene units of W are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR?—, —CONR?NR?—, —CO2—, —OCO—, —NR?CO2—, —O—, —NR?CONR?—, OCONR?, —NRTSIR?, —NR?NR?CO—, —NR?CO—, —S—, —SO, —SO2—, —NR?—, —SO2NR?—, NR?SO2—, or —NR?SO2NR?—; RW is independently R?, halo, NO2, CN, CF3, or OCF3; m is 0-5; each of R1, R2, R3, R4, and R5 is hydrogen, —X—RX; X is a bond or is an optionally substituted C1-C6 alkylidene chain wherein up to two methylene units of X are optionally and independently replaced by —CO—, —CS—, —COCO—, —CONR?—, —CONR?NR?—, —CO2—, —OCO—, —NR?CO2—, —O—, —NR?CONR?—, —OCONR?—, —NRTSIR?, —NR?NR?CO—, —NR?CO—, —S—, —SO, —SO2—, —NR?—, —SO2NR?—, NR?SO2—, or —NR?SO2NR?—; RX is independently R?, halo, NO2, CN, CF3, or OCF3; R6 is hydrogen, CF3, —OR?, —SR?, or an optionally substituted C1-6 aliphatic group; R7, R8 is hydrogen or a C1-6 aliphatic group optionally substituted with —X—RX; R? is independently selected from hydrogen or an optionally substituted group selected from a C1-C8 aliphatic group, a 3-8-membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-12 membered saturated, partially unsaturated, or fully unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or two occurrences of R? are taken together with the atom(s) to which they are bound to form an optionally substituted 3-12 membered saturated, partially unsaturated, or fully unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; its tautomers or pharmaceutically acceptable salts thereof comprising the steps of;a) coupling indole acetic acid with corresponding amines using suitable coupling agent to obtain indole amides;
b) oxidizing indole amides of step (a) using suitable oxidizing agent followed by treatment with base to obtain desired quinolone carboxamides with 40 to 65% yield, wherein the base is an organic base selected from pyridine, 2,6-lutidine, DMAP (4-dimethylaminopyridine), Et3N (triethylamine), DIPEA (N,N-diisopropyl ethyl amine), N,N-dimethylaniline, DBN (1,5-diazabicyclo(4.3.0)non-5-ene), DABCO (1,4-diazabicyclo[2.2.2]octane) and DBU (1,8-diazabicycloundec-7-ene) or mixture thereof.
US Pat. No. 10,266,478

PROCESS FOR THE PREPARATION OF HYDROXYL FUNCTIONAL ESTERS AND POLYESTERS THEREFROM

Council of Scientific and...

1. A novel process for the preparation of a alkyl lactyl lactate comprising the following steps:a) stirring the reaction mixture of alkyl lactate, condensing reagents in anhydrous solvent at 0° C.;
b) adding a solution of acid in solvent to a reaction mixture of step (a) slowly over a period of 1 to 3 hours;
c) stirring the reaction mixture at temperature 27° C. for 10 to 12 hours to afford the product of monomer of alkyl lactyl lactate.

US Pat. No. 10,266,621

METAL-PHOSPHINESULFONATE ACETONITRILE COMPLEX FOR INSERTION COPOLYMERIZATION OF FUNCTIONAL OLEFINS

Council of Scientific and...

1. A one-step process for preparation of a complex of formula (I)
comprising:
mixing a sodium-salt phosphinesulfonate ligand and a reagent at 25-40°C. followed by adding acetonitrile at the same temperature to obtain the complex of formula (I),
wherein
M is Pd, Pt, Ni or Ru;
R is methyl;
the reagent comprises Pd, Pt, Ni or Ru; and
the sodium-salt phosphinesulfonate ligand has a structure (1)

US Pat. No. 10,260,023

PREPARATION OF FUNCTIONALIZED CASTOR OIL DERIVATIVES USING SOLID ACID AND BASE CATALYSTS

Council of Scientific and...

1. A process for the preparation of functionalized castor oil derivatives from epoxidized castor oil (ECO) via ring-opening and/or transesterification, wherein conversion percentage of epoxidized castor oil is in the range of 82 to 91% comprising the steps of:(i) mixing epoxidized castor oil with a nucleophile at room temperature in the range of 20 to 30° C. to obtain a mixture;
(ii) adding heterogeneous catalyst(s) to the mixture as obtained in step (i) in the range of 0.5-20 wt. % with respect to oil to obtain a mixture;
(iii) stirring the mixture as obtained in step (ii) at temperature in the range of 27-105° C. for period in the range of 1 to 7 hours followed by decanting/filtering the catalyst(s) to obtain a product mixture;
(iv) removing unreacted reagents and solvent from the mixture obtained in step (iii) by rotary evaporation, and if optionally preceded by solvent extraction with hexane to obtain functionalized castor oil derivatives; and
(v) optionally mixing functionalized castor oil derivative as obtained in step (iv) with the nucleophile as in step (i) and following the steps (ii) to (iv) to obtain functionalized castor oil derivatives,
wherein the functionalized castor oil derivatives are selected from the group consisting of ring-opened glyceryl ricinoleates, epoxy alkyl ricinoleates and ring-opened alkyl ricinoleates.
US Pat. No. 10,262,764

ADVANCED NON-TOXIC RED MUD BASED NANO GEL TYPE FUNCTIONAL RADIATION SHIELDING MATERIALS AND THE PROCESS THEREOF

Council of Scientific and...

1. A red mud based nano gel type functional radiation shielding material comprising:a) 55.6 wt %-66.7 wt % of red mud; and
b) 44.4 wt %-33.3 wt % of crushed citrus peel waste.

US Pat. No. 10,195,599

SYNTHESIS OF FUNCTIONALIZED CARBON MICROSPHERES AND THEIR CATALYST ACTIVITY IN C—O AND C—N BOND FORMATION REACTIONS

COUNCIL OF SCIENTIFIC AND...

1. A process for preparation of functionalized carbon microspheres by grafting catalytically active functional groups on to carbon microspheres obtained from bagasse to generate an acidic or basic surface wherein said process comprises the steps of:a) heating bagasse, water and oxalic acid at a temperature ranging between 150 to 180° C. for a time period ranging between 6 to 12 hours to obtain carbon microspheres; and
b) refluxing of carbon microspheres as obtained in step (a) and an organic solvent selected from the group consisting of n-pentane, n-hexane, toluene, and lower alcohols in the presence of a functional group grafting agent at a temperature ranging between 80-120° C. for a time period in the range of 8 to 12 hours to obtain functionalized carbon microspheres,
wherein a C—O formation reaction is an epoxidation process which comprises mixing an olefin, an oxidant H2O2, an organic solvent acetonitrile and amine functionalized carbon microspheres to obtain a reaction mixture followed by immersing the reaction mixture in a thermostat oil bath at a temperature ranging between 60-80° C. for a time period ranging between 24 to 48 hours to obtain an epoxide with yield in the range of 45-90%.
US Pat. No. 10,426,728

SYNERGISTIC LIPOSOMAL FORMULATION FOR THE TREATMENT OF CANCER

Council of Scientific and...

1. A synergistic liposomal formulation for the treatment of cancer, wherein said synergistic liposomal formulation consists of drug-free phosphatidylcholine (PC) and stearylamine (SA) liposomes, and camptothecin (CPT), doxorubicin (DOX), or combinations thereof, and wherein phosphatidylcholine, stearylamine, and camptothecin w/w molar ratio in said synergistic liposomal formulation is 7(PC):2(SA):0.7(CPT) or wherein phosphatidylcholine, stearylamine, and doxorubicin w/w molar ratio in said synergistic liposomal formulation is 7(PC):2(SA):0.5(DOX).
US Pat. No. 10,428,038

SINGLE STEP PROCESS FOR THE SYNTHESIS OF FURFURYL ETHYL ETHER

COUNCIL OF SCIENTIFIC AND...

1. A single step process for the synthesis of furfuryl ethyl ether comprises refluxing the reaction mixture of furfuryl alcohol, ethanol and Zr incorporated SBA-15 catalyst at temperature in the range of 80 to 120° C. for the period in the range of 3 to 7 hrs to afford furfuryl ethyl ether, wherein selectivity of said reaction towards furfuryl ethyl ether is in the range of 85 to 95%.

US Pat. No. 10,357,939

HIGH PERFORMANCE LIGHT WEIGHT CARBON FIBER FABRIC-ELECTROSPUN CARBON NANOFIBERS HYBRID POLYMER COMPOSITES

Council of Scientific and...

1. A carbon fiber fabric-carbon nanofiber epoxy resin hybrid polymer composite comprising unidirectionally aligned continuous carbon nanofiber sheet derived from polyacrylonitrile (PAN) based electrospun nanofibers, sandwiched between carbon fiber fabric laminates, wherein the thickness of composite is 2 to 3 mm and contains 30±2 wt % of carbon fibers.

US Pat. No. 10,467,068

AUTOMATED REMOTE COMPUTING METHOD AND SYSTEM BY EMAIL PLATFORM FOR MOLECULAR ANALYSIS

Council of Scientific and...

1. An automated method for remote computing of molecular docking and dynamics from one or more jobs in a network of a plurality of users, by employing a remote computing system comprising at least one user device, a remote server and a remote computing database, wherein duplication of jobs is avoided, and wherein said method is implemented even during offline status of the user/s, comprising:i. sending at least one job/input from a remote location from at least one user device to the remote server, each job/input defining one or more action tags;
ii. tracking the job by a job tracker of said remote server;
iii. feeding the jobs to a job analyzer by a job feeder of said remote server;
iv. receiving and scanning the jobs accumulated in said remote server by a job scanner of said remote server;
v. performing a semantic analysis of the action tags contained with said jobs by a job analyzer of said remote server;
vi. distinguishing between customized and non-customized tasks defined in said action tags by said job a analyzer:
vii. expanding said action tags in a job preparation phase by said job analyzer, said job preparation phase including cavity prediction and extracting active site center co-ordinates from a predefined list of a remote computing database;
ix. transforming said job preparation phase into a job render phase;
x. transforming the render phase into an action phase, wherein said action phase includes triggering said remote computing system into action and running said jobs with continuous monitoring for updating said user via e-mail by a job runner of said remote server;
xi. packaging a data analysis in a standard compressed format by said job analyzer;
xii. updating status using email messages back to the user via email and providing a hyperlink to said remote computing storage system with authentication;
xiii. retrieving the results and a mode of its delivery to the user by sending the status of the job and availability of data;
xiv. uploading the resultant data to any backup space server, a file server, a data server or a cloud server in a compressed and an encrypted format;
xv. generating a public link for download of results, wherein said link is sent to the user over the network via email; and
xvi. disabling said downloaded link after a specific time interval or a first download event to enhance data access security.

US Pat. No. 10,465,019

CATALYSTS FOR PREPARATION OF ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE (UHMWPE) AND PROCESS FOR PREPARATION THEREOF

Council of Scientific and...

1. An olefin polymerization catalyst comprising a metal complex of Formula (I)whereinM is a transition metal atom of Group 3 to Group 11 of the periodic table;
A is sulfonate (SO3) or carboxylate (CO2);
when n=0, D=N?CH—or when n=1, D=N;
X=Cl, Br, I, BF4, or OAc; and
R, and R1 to R4 are the same or different, and are each a hydrogen atom, a halogen atom, a hydrocarbon group, a heterocyclic group, an oxygen-containing group, a nitrogen-containing group, a boron-containing group, a sulfur-containing group, a phosphorus-containing group, a silicon-containing group, a germanium-containing group or a tin-containing group, and two or more of them may be bonded to each other to form a ring.

US Pat. No. 10,463,065

ENZYME-ASSISTED EXTRACTION OF STEVIOL GLYCOSIDES FROM THE LEAVES OF STEVIA REBAUDIANA BERTONI

COUNCIL OF SCIENTIFIC AND...

1. A process for extraction, separation, and purification of steviosides from Stevia leaves, the process comprising:powdering dried Stevia leaves to 10-20 mesh size to form a Stevia leaf powder;
removing surface wax and extracting color pigments from the Stevia leaf powder with hexane to form prepared Stevia leaf powder;
pretreating the prepared Stevia leaf powder with an aqueous buffer having a pH of 4-7 and one or more enzymes to form a mixture and incubating the mixture for 1-6 hours to form enzyme-treated Stevia leaf powder;
extracting steviosides from the enzyme pre-treated Stevia leaf powder via pressurized hot water extraction for 20-30 minutes in a reactor, wherein the pressurized hot water extraction comprises soaking the enzyme-treated Stevia leaf powder in hot water in a pH range of 6-9, a temperature of 100-120° C., and a pressure of 10-20 lb to form a crude extract of steviosides;
passing the crude stevioside extract through a micro-filtration membrane to form an aqueous Stevia extract;
passing the aqueous Stevia extract through an ultra filtration membrane (UF) to form a clarified Stevia permeate;
passing the clarified Stevia permeate through a nano filtration membrane (NF) in order to concentrate the steviosides in an NF retentate;
extracting the NF retentate into a first polar solvent comprising n-butanol or n-propanol to form a separated organic layer comprising the steviosides;
alternatively washing the separated organic layer comprising the steviosides with water of pH 2-10 and at least one of a basic material or a mineral acid at 30-45° C. temperature; and
purifying the steviosides to 95-98% purity by concentrating the steviosides by spray drying with an organic solvent or by solvent crystallization using at least one of a second polar solvent or a non-polar solvent.

US Pat. No. 10,370,271

COLUMN THICKENER AND A PROCESS THEREOF FOR DEWATERING OF IRON ORE SLURRY

Council of Scientific and...

1. A column thickener for dewatering of iron ore tailings slurry comprising:a) a tall column with large aspect ratio at the top made up of a non-magnetic material, comprising an outlet for clarified water, feed slurry inlet, a provision for multiple feed inlets, and a bubble cap arrangement;
b) a metallic section made up of a metallic material comprising a matrix; and
c) a conical discharge system having a conical bottom containing an auxiliary inlet, a discharge valve for taking out underflow slurry, and a high concentration slurry at the bottom portion of the system.