US Pat. No. 9,356,183

OPTOELECTRONIC DEVICE WITH ENHANCED EFFICIENCY AND METHOD OF USE

CALIFORNIA INSTITUTE OF T...

1. A method for an improved III/V optoelectronic device comprising:
applying a sulfur surfactant to exposed edges of the III/V optoelectronic device to improve passivation of the III/V optoelectronic
device;

wherein the exposed edges are created by cracks in, or intentional fracturing of, the III/V optoelectronic device.

US Pat. No. 9,285,027

SYSTEMS AND METHODS FOR IMPLEMENTING BULK METALLIC GLASS-BASED STRAIN WAVE GEARS AND STRAIN WAVE GEAR COMPONENTS

California Institute of T...

1. A strain wave gear comprising:
a wave generator;
a flexspline that itself comprises a first set of gear teeth; and
a circular spline that itself comprises a second set of gear teeth;
wherein at least one of the wave generator, the flexspline, and the circular spline, comprises a bulk metallic glass-based
material having an elastic limit of greater than or equal to approximately 1%.

US Pat. No. 9,272,051

METHODS AND SYSTEMS FOR MODULATING HORMONES AND RELATED METHODS, AGENTS AND COMPOSITIONS

California Institute of T...

1. A composition comprising a combination of 6-n-propylthiouracil and a complementary molecule, wherein the complementary
molecule interferes with systemic absorption and release of 6-n-propylthiouracil upon enteral administration, wherein the
complementary molecule is polyethylene glycol, wherein the polyethylene glycol is conjugated to the 6-n-propylthiouracil,
and wherein the combination results in prolonged activation of bitter taste receptors in the gut.

US Pat. No. 9,409,023

SPINAL STIMULATOR SYSTEMS FOR RESTORATION OF FUNCTION

California Institute of T...

1. A device for use with a plurality of electrodes, and one or more sensors, the device comprising:
a stimulation assembly connectable to the plurality of electrodes, wherein the plurality of electrodes are configured to connect
to a spinal cord at a location below a lesion of the spinal cord; the stimulation assembly being configured to deliver stimulation
to selected ones of the plurality of electrodes when the stimulation assembly is connected to the plurality of electrodes;

a sensor interface connectable to the one or more sensors, the sensor interface being configured to receive signals from the
one or more sensors when the sensor interface is connected to the one or more sensors, wherein the one or more sensors are
selected from an electromyography sensor, an evoked potential sensor, a joint angle sensor, a flex sensor, an accelerometer,
a gyroscope sensor, a flow sensor, a pressure sensor, a load sensor, a temperature sensor, or a combination thereof;

at least one processor connected to both the stimulation assembly and the sensor interface, the at least one processor being
configured to direct the stimulation assembly to deliver at least one complex stimulation pattern to the selected ones of
the plurality of electrodes, and to receive the signals from the sensor interface, the at least one processor being further
configured to modify the at least one complex stimulation pattern by performing a machine learning method implementing a Gaussian
Process Optimization operable to determine the stimulation parameters delivered by the stimulation assembly based on the signals
received from the sensor interface.

US Pat. No. 9,173,564

SYSTEM AND METHOD FOR SENSING INTRAOCULAR PRESSURE

California Institute of T...

1. A method for sensing pressure, the method comprising:
establishing a gap between first and second membranes at a first pressure, the first and second membranes comprising nanophotonic
components;

transmitting a first beam of light to the nanophotonic components;
measuring a first reflectance of the light off of the nanophotonic components at the first pressure and determining a first
resonance by detecting a dip in reflectance;

changing the gap between first and second membranes in response to a second pressure;
transmitting a second beam of light to the nanophotonic components;
measuring a second reflectance of the light off of the nanophotonic components at the second pressure and determining a second
resonance by detecting a dip in reflectance; and

calculating the second pressure using the difference between the first resonance and second resonance.

US Pat. No. 9,130,742

KEY AGREEMENT IN WIRELESS NETWORKS WITH ACTIVE ADVERSARIES

CALIFORNIA INSTITUTE OF T...

1. A network of computers with error correction code configured to transmit keys secretly and securely by:
encoding a key on a first single computer-based workstation,
forwarding a plurality of encoded files via a plurality of computer-based workstations, and
decoding the plurality of encoded files on a second single computer-based workstation using a decoding algorithm to retrieve
the key; and the network comprising:

the first single computer-based workstation operating as a source node and configured to encode the key and forward, via a
first plurality of intermediate transmission links, a distinct encoded file to each intermediate node within a plurality of
intermediate nodes of the network,

the plurality of computer-based workstations operating as intermediate nodes and configured to receive via the first plurality
of intermediate transmission links the encoded source files from the source node and forward via a second plurality of intermediate
transmission links the encoded files to a receiver node when requested, and

the second single computer-based workstation operating as a receiver node and configured to receive, via the second plurality
of intermediate transmission links, encoded files from the plurality of intermediate nodes and decode the encoded files to
retrieve the key,

wherein a particular intermediate node, with corresponding intermediate transmission links from the first and second plurality
of intermediate transmission links, forms a two-hop path between the source node and the receiver node, and

wherein one or more of the encoded files received by the receiver node may be erroneous due to an erroneous intermediate transmission
link and/or an erroneous intermediate node.

US Pat. No. 9,150,418

METHOD AND SYSTEM FOR GRAPHENE FORMATION

CALIFORNIA INSTITUTE OF T...

1. A method of forming a film of graphene, the method comprising:
placing a substrate on a holder in a processing chamber at a reduced pressure, wherein the processing chamber includes at
least one atmospheric gas;

performing a room temperature surface treatment process on at least a portion of the substrate;
providing a carbon containing material in the processing chamber;
exposing the substrate to the carbon containing material; and
converting, at room temperature, a portion of the carbon containing material to a film of graphene.

US Pat. No. 9,191,371

NETWORK CODING-BASED ANONYMOUS COMMUNICATION

CALIFORNIA INSTITUTE OF T...

1. A computer-based method for constructing an overlay subgraph, the computer-based method comprising:
providing a set of available computer-based relay nodes communicating over a plurality of transmit and/or receive links;
selecting, via a computer-based source, a random subset of the available computer-based relay nodes;
based on the selecting, arranging, via the computer-based source, the selected computer-based relay nodes into an overlay
subgraph, comprising a plurality of layers of width larger than or equal to two;

based on the selecting and the arranging, creating, via the computer-based source, a message for each computer-based relay
node, wherein the message comprises information particular to the each computer-based relay node;

based on the creating, generating, via the computer-based source, a first layer coded packets;
based on the generating, transmitting, through the subgraph, coded packets of a same size to the plurality of layers of the
overlay subgraph;

based on the transmitting, decoding the message for each computer-based relay node of the overlay subgraph via the each computer-based
relay node;

wherein a mutual information between an observation of a computer-based relay node of the overlay subgraph and information
of a message not intended for said computer-based node is of calculable value.

US Pat. No. 9,182,387

METHODS FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS

California Institute of T...

1. A system for isolating a circulating tumor cell, said system comprising:
a microfilter device comprising a membrane filter consisting of a substrate having an array of holes with a predetermined
shape and dimension, wherein the holes on the membrane filter have a rectangular shape each with a dimension of 6 ?m by about
40 ?m; and

a constant pressure delivery system coupled to the microfilter device for maintaining a constant pressure, wherein the isolated
circulating tumor cells are isolated with at least 90% efficiency and with an enrichment of at least 200-fold, and wherein
the isolated circulating tumor cells have at least a 90% cell viability.

US Pat. No. 9,091,807

COMPACT TUNABLE PHOTONIC CRYSTAL NANOBEAM CAVITY WITH LOW POWER CONSUMPTION

CALIFORNIA INSTITUTE OF T...

1. A device comprising:
a substrate;
a nanobeam cavity element on the substrate, wherein the nanobeam cavity element comprises a row of periodically spaced holes,
wherein the row of periodically spaced holes has a tapered pattern;

a waveguide element on the substrate;
a spacing element on the substrate, separating the waveguide element from the nanobeam cavity element;
a spacing layer, covering the nanobeam cavity element, covering the waveguide element, and covering the spacing element; and
a heater element on the spacing layer.

US Pat. No. 9,126,175

HIGH-THROUGHPUT SCREENING AND DEVICE FOR PHOTOCATALYSTS

California Institute of T...

1. A device comprising
a single transparent fluorine-doped tin oxide coated substrate that has been etched to generate at least fifty etched regions,
wherein each etched region comprises an addressable conductive lead, and wherein the surface of the substrate comprising the
etched regions is hydrophobic or has been treated to be hydrophobic;

a plurality of photoconductive mixed metal-oxides disposed on the conductive leads;
a layer of insulating epoxy applied to the surface of the substrate not covered by the mixed metal-oxides;
a chamber comprising an electrolyte buffer;
a light source; and
a measuring apparatus,wherein the measuring apparatus is electrically coupled to the conductive leads and is configured to measure a change in voltage
or current, the chamber configured to receive the substrate and wherein the light source illuminates one or more of the regions
of photoconductive mixed metal-oxides.

US Pat. No. 9,086,536

TALBOT IMAGING DEVICES AND SYSTEMS

California Institute of T...

1. A Talbot imaging device comprising:
a Talbot element configured to repeat a Talbot image at a distance from the Talbot element; and
a phase gradient generating device configured to scan the Talbot image by incrementally changing a phase gradient of a light
field incident the Talbot element.

US Pat. No. 9,147,844

SOLVENT-FREE ENYNE METATHESIS POLYMERIZATION

California Institute of T...

1. A method of metathesizing unsaturated organic compounds, said method comprising contacting at least one feedstock vapor
or gas comprising at least one acetylenic precursor with a solid transition metal-based metathesis catalyst to form a polymer
product, wherein the transition metal-based metathesis catalyst is in a solid form and the contacting is done in the absence
of a liquid.

US Pat. No. 9,105,548

SPARSELY-BONDED CMOS HYBRID IMAGER

California Institute of T...

1. A device structure, comprising:
a first chip comprising a detector array, the detector array comprising a plurality of pixels disposed in rows and columns,
each of the pixels including a light sensor and transistors, and the transistors comprising a buffer transistor, a select
transistor, and a reset transistor;

interconnects having a number corresponding to less than one of the interconnects per light sensor, including:
one or more reset interconnects including one reset interconnect per row of pixels, wherein the reset transistors in a same
row are connected to a same one of the reset interconnects;

one or more select interconnects including one select interconnect per row of pixels, wherein the select transistors in a
same row are connected to a same one of the select interconnects;

one or more common column interconnects including one common column interconnect per column of pixels, wherein one or more
outputs of the select transistors in a same column are connected to a same one of the common column interconnects; and

a second chip interconnected with the first chip, wherein:
the interconnects interconnect the second chip with the first chip; and
the second chip comprises a Read Out Integrated Circuit (ROIC) that reads out one or more signals produced by the light sensors.

US Pat. No. 9,180,050

IMPLANTABLE INTRAOCULAR PRESSURE DRAIN

California Institute of T...

1. A method of fabricating an intra-ocular pressure drain, the method comprising:
providing a workpiece;
patterning a first parylene layer over the workpiece;
forming a first sacrificial layer on the first parylene layer;
patterning a second parylene layer on the first sacrificial layer;
forming a second sacrificial layer on the second parylene layer and on the first sacrificial layer;
patterning a third parylene layer on the second sacrificial layer;
forming a third sacrificial layer on the third parylene layer and on the second sacrificial layer;
forming a fourth parylene layer on the third sacrificial layer;
removing the first, second, and third sacrificial layers to form a hollow parylene tube; and
releasing the first parylene layer from the workpiece.

US Pat. No. 9,149,805

MICROFLUIDIC FLUID SEPARATOR AND RELATED METHODS

UNIVERSITY OF SOUTHERN CA...

1. An array of microfluidic filter chips comprising a plurality of microfluidic filter chips, each microfluidic filter chip
for separating target components of a fluid by filtration, the target components adapted to exit though a plurality of output
terminals of the microfluidic filter chip, the microfluidic filter chip comprising:
a plurality of filtering stages comprising a stack of perforated surfaces including a top perforated surface and a bottom
perforated surface,

wherein:
a flow channel is provided above and below each perforated surface,
each perforated surface comprises a plurality of openings through which components of the fluid commensurate with the openings
are adapted to pass,

the diameter of the openings in the perforated surfaces decreases sequentially from the top perforated surface to the bottom
perforated surface, such that the diameter of the openings of the top perforated surface is larger than the diameter of the
openings of all other perforated surfaces in the stack,

an input of the microfluidic filter chip is provided at an entrance of the uppermost flow channel,
an output terminal of the microfluidic filter chip is provided at an end of each flow channel, and
for each stacked perforated surface, the flow channel above the stacked perforated surface is narrower and shallower than
the flow channel below the stacked perforated surface,

wherein the plurality of microfluidic filter chips is stacked and a corresponding output terminal of a flow channel of each
microfluidic filter chip of the array corresponding to a same filtered particle size range for the microfluidic filter chips
of the array is joined together with corresponding output terminals of the microfluidic filter chips of the array.

US Pat. No. 9,169,521

POINT-OF-COLLECTION SAMPLE PREPARATION DEVICE AND METHOD

The Boeing Company, Chic...

1. An analyte detection device, the device comprising:
a multilayer member configured to receive a fluid-borne sample comprising at least one analyte in combination with one or
more non-analyte components, the multilayer member comprising at least:

a sample preparation layer comprising consecutive filter layers of a cell lysis layer and a concentrating layer, both configured
to dissolve upon receiving at least a portion of the fluid-borne sample to produce a solution comprising at least a portion
of the fluid-borne sample; and

an analysis cartridge in microfluidic communication with the multilayer member, the analysis cartridge configured to determine
a presence and/or a concentration of the analyte in the solution and

a microfluidic system providing microfluidic communication between the sample preparation layer and the analysis cartridge,
the microfluidic system comprising at least one of: a capillary tube; an electro-osmatic pump contact in communication with
a capillary tube; or a heater in thermal communication with a capillary tube.

US Pat. No. 9,249,170

CYCLIC ALKYL AMINO CARBENE (CAAC) RUTHENIUM COMPLEXES AS IMPROVED CATALYSTS FOR ETHENOLYSIS REACTIONS

California Institute of T...

1. A compound, wherein the compound is
(A) a compound of Formula I:

wherein, independently for each occurrence,
X is, independently for each occurrence, alkoxy or halo;
R2 is, independently for each occurrence, alkyl;

R3 is alkyl;

R4 is alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl;

or R3 and R4, taken together with the carbon atom to which they are attached, form a five-, six-, or ten-membered cycloalkyl or heterocyclyl
ring;

R5 is alkyl;

R6 is H or alkyl, provided that (i) R5 and R6 are not the same, and (ii) R6 has fewer atoms than R5; and

R7 is alkyl;

(B) a compound of Formula II:

wherein, independently for each occurrence,
X is, independently for each occurrence, alkoxy or halo;
R2 is, independently for each occurrence, alkyl;

R3 is alkyl;

R4 is alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl;

or R3 and R4, taken together with the carbon atom to which they are attached, form a five-, six-, or ten-membered cycloalkyl or heterocyclyl
ring;

R5 is, independently for each occurrence, alkyl; and

R7 is alkyl;

(C) a compound of Formula III:

wherein, independently for each occurrence,
X is, independently for each occurrence, alkoxy or halo;
R2 is alkyl;

R3 is alkyl;

R5 is, independently for each occurrence, methyl or ethyl;

R7 is alkyl; and

R8 is aryl or heteroaryl; or

(D) a compound of Formula IV:

wherein, independently for each occurrence,
X is, independently for each occurrence, alkoxy or halo;
R2 is alkyl;

R3 is alkyl;

R5 is, independently for each occurrence, alkyl;

R7 is alkyl; and

R9 is C2-C6 alkyl;

or R3 and R9, taken together with the carbon atom to which they are attached, form a five-, or ten-membered cycloalkyl or heterocyclyl
ring.

US Pat. No. 9,046,525

METHOD OF DETERMINING THE OLIGOMERIC STATE OF A PROTEIN COMPLEX

California Institute of T...

1. A method of determining the number of protein subunits in a protein complex, the method, comprising:
tagging a protein subunit of the protein complex to form a tagged protein subunit comprising a peptide tag and a protease
cleavage site between the peptide tag and the protein subunit;

expressing the tagged protein subunit in a cell culture or a cell-free extract to form a tagged protein complex comprising
expressed tagged protein subunits;

selectively digesting the tagged protein complex at at least two different time points with a protease to form an analyte
mixture comprising undigested protein complex, intermediate reaction products, and/or digested protein complex;

separating the undigested protein complex, the intermediate reaction products, and/or the digested complex of the analyte
mixture; and

determining the number of protein subunits in the protein complex by analyzing the presence of, or the progressive loss of,
the peptide tag in each of the undigested protein complex, the intermediate reaction products, and/or the digested protein
complex.

US Pat. No. 9,464,001

ENGINEERED AGGREGATES FOR METAMATERIALS

California Institute of T...

1. A structural metamaterial comprising:
a matrix formed of a cement compatible mortar matrix material having a matrix density; and
a plurality of engineered aggregates each formed of a geometric multilayer body disposed within the matrix material, each
geometric multilayer body comprising at least an inner core surrounded by at least one polymeric compliant layer, wherein
the inner core is formed of a metallic core material having a core density of at least 7000 kg/m3 and selected from the group consisting of steel, tin, brass, nickel, iron, lead, gold, and tungsten carbide, and wherein the
compliant layer is formed of at least one compliant material selected from the group consisting of silicone, rubber, polyethylene,
polypropylene, polystyrene, nylon, and urea formaldehyde, and having a compliant layer density that is lower than both the
matrix density and the core density, and an elastic modulus that is less than both the matrix elastic modulus and the core
elastic modulus and at least 10?1 GPa, adapted to induce a kinetic oscillation in the inner core when exposed to an energy wave that imparts mechanical energy
to the geometric multilayer body within at least one target frequency range, such that the engineered aggregate exhibits a
negative effective mass to trap at least a portion of the mechanical energy within the engineered aggregate such that the
stress experienced by the surrounding matrix material is reduced; and

wherein the plurality of engineered aggregates are randomly disposed within the matrix in a mixture.

US Pat. No. 9,148,173

DISTRIBUTED REED-SOLOMON CODES FOR SIMPLE MULTIPLE ACCESS NETWORKS

CALIFORNIA INSTITUTE OF T...

1. A computer-based network with distributed error correction code (DECC) comprising:
a distributed network of a plurality of computer-based workstations configured to encode a plurality of source files according
to a provided DECC encoding algorithm; and

a single computer-based decoder workstation configured to decode the plurality of source files according to a provided DECC
decoding algorithm corresponding to a standard single-source Reed-Solomon error correcting code decoder.

US Pat. No. 9,267,140

METHOD FOR PRODUCING TRANSGENIC ANIMALS

CALIFORNIA INSTITUTE OF T...

1. A method of producing a transgenic mouse comprising:
transfecting a packaging cell line with:
a first retroviral construct comprising the R and U5 sequences from a 5? lentiviral LTR, a self-inactivating 3?LTR, a transgene
of interest, and a promoter operably linked to the transgene of interest;

a second retroviral construct comprising the HIV-1 packaging vector with the env, nef, 5?LTR, 3?LTR, and vpu sequences deleted;
and

an expression plasmid encoding a pseudotyped envelope glycoprotein;
recovering recombinant pseudotyped retrovirus from the packaging cell line;
infecting an oocyte or single cell embryo with the recombinant pseudotyped retrovirus, wherein the recombinant pseudotyped
retrovirus comprises the R and U5 sequences from a 5? lentiviral long terminal repeat (LTR) and a self-inactivating lentiviral
3? LTR; and

implanting the oocyte once fertilized or single cell embryo in a pseudopregnant female to produce a transgenic mouse,
wherein the pseudotyped retrovirus is integrated into the genome of the mouse embryo, and
wherein the transgenic mouse is able to pass the transgene of interest to a progeny of the transgenic mouse such that the
progeny expresses the transgene of interest.

US Pat. No. 9,234,985

BIREFRINGENT POLYMER BRUSH STRUCTURES FORMED BY SURFACE INITIATED RING-OPENING METATHESIS POLYMERIZATION

California Institute of T...

1. A polymer brush structure exhibiting birefringence, said polymer brush structure comprising a plurality of substantially
parallel oriented polymers and characterized by a longitudinal z-direction, parallel to the direction of the substantially
oriented polymers and having a first refractive index, nz, and a lateral x,y-direction, perpendicular to the direction of the substantially oriented polymers and having a second refractive
index, nx,y, the difference, ?n, between the first refractive index and the second refractive index is in a range of about 0.1 to about
0.6, as measured by ellipsometry and fit to a Cauchy analytical model, said plurality of polymers having alkylene, alkenylene,
or both alkylene and alkenylene linkages.

US Pat. No. 9,165,971

ATOMICALLY PRECISE SURFACE ENGINEERING FOR PRODUCING IMAGERS

California Institute of T...

1. An imager comprising:
an imager substrate having at least a first surface at one end thereof, said surface being passivated with a passivation layer
comprising at least a delta-doped layer, the delta-doped passivation layer having an atomic monolayer composition profile
having an out-of-plane atomic size scale precision of less than 2 nm, and forming a passivated substrate surface such that
the delta-dope passivation layer does not interrupt the imager substrate epitaxy;

an anti-reflective coating formed on at least a portion of said passivated substrate surface, said anti-reflective coating
formed of at least one dielectric material selected to allow imaging across a selected spectral range, and being chemically
compatible with the delta-doped layer;

wherein the anti-reflective coating is formed of a plurality of layers of the at least one dielectric material, each layer
being formed with a thickness of from 0.1 to 3 Angstroms, the anti-reflective coating being disposed on the passivated substrate
surface with a density sufficient to ensure that the anti-reflective coating covers the passivated surface continuously on
an atomic size scale, such that the anti-reflective coating has a low density of atomic scale defects;

wherein where the anti-reflective coating is formed of a material that is chemically reactive with the imager substrate further
comprising an optically inactive barrier layer disposed between the imager substrate and the anti-reflective coating;

wherein at least the barrier layer and the layers of the anti-reflective coating disposed proximal to the passivated substrate
surface conform to the passivated substrate surface such that an interfacial region having an out-of-plane roughness of less
than about 3 nm is formed between said passivated substrate surface and the barrier layer and anti-reflective coating; and

wherein the imager is formed having an absolute quantum efficiency of at least 50% over at least a portion of the wavelength
range of 100 to 300 nm.

US Pat. No. 9,065,292

METHODS AND SYSTEMS FOR CHARGING ELECTROCHEMICAL CELLS

CALIFORNIA INSTITUTE OF T...

22. A battery charging system comprising:
two or more electrodes for making an electrical connection to terminals of an electrochemical cell;
a power supply positioned in electrical communication with said two or more electrodes for providing a controllable time varying
charging voltage to said two or more electrodes; and

a processor for controlling said charging voltage provided by the power supply, wherein said processor provides a time varying
charging voltage to said electrochemical cell, thereby generating a charging current resulting in charging of said electrochemical
cell; wherein said time varying charging voltage has a non-linear time dependency provided by V=V0±k(t)t and Vmin?V?Vmax; wherein V is the time varying charging voltage, t is time, V0 is an initial voltage, k(t) is a time dependent voltage rate, Vmin is a minimum voltage and Vmax is a maximum voltage.

US Pat. No. 9,177,774

CONTINUOUS FLOW MOBILITY CLASSIFIER INTERFACE WITH MASS SPECTROMETER

California Institute of T...

9. A method for analyzing a sample comprising:
(a) ionizing analyte molecules in a sample using a first ionization system;
(b) analyzing the ionized analyte molecules in a first dimension by separating the ionized analyte molecules by mobility using
a continuous flow radial differential mobility analyzer (RDMA) that employs axial electric fields, wherein:

(i) the RDMA is coupled to the first ionization system;
(ii) the RDMA is coupled to a mass spectrometer; and
(iii) the sample is introduced into the RDMA;
(c) introducing a continuous flow of the ionized analyte molecules that have been separated by mobility to the mass spectrometer;
(d) analyzing the ionized analyte molecules in a second dimension by mass analyzing the ionized analyte molecules that have
been separated by mobility using the mass spectrometer to determine a mass-to-charge ratio of a charged particle within the
mobility separated ionized analyte molecules; and

wherein:
a sheath flow rate provided by the RDMA is lower as compared to a sheath flow rate produced by a continuous flow mobility
classifier-mass spectrometer system without the RDMA;

an instrument resolution of the RDMA has a value of at least seven (7);
a sample outlet of the RDMA is aligned with an atmospheric pressure inlet (API) of the mass spectrometer; and
a gap between the sample outlet and the API is minimized by adjusting a position of the RDMA.

US Pat. No. 9,238,709

LATENT, HIGH-ACTIVITY OLEFIN METATHESIS CATALYSTS CONTAINING AN N-HETEROCYCLIC CARBENE LIGAND

MATERIA, INC., Pasadena,...

1. A method for catalyzing an olefin metathesis reaction, comprising contacting an olefinic reactant with a complex having
the structure of formula (I)

wherein:
? and ? represent single bonds or unsaturated bonds, with the proviso that ? and ? cannot both be unsaturated bonds;
M is a Group 8 transition metal;
R1 and R2 are independently selected from hydrogen, hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, substituted
heteroatom-containing hydrocarbyl, and functional groups;

Q is an organic diradical;
X1 and X2 are anionic ligands, and may be the same or different;

L1 is a neutral electron donor ligand, and p is zero or 1;

when ? is a single bond, L2 is selected from NR7R8, PR7R8, N?CR7R8, and R7C?NR8, where R7 and R8 are independently selected from substituted and/or heteroatom-containing C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, and C5-C24 aryl, or R7 and R8 can be taken together to form a heterocyclic ring;

when ? is an unsaturated bond, L2 is selected from NR? and PR7, where R7 is as defined previously, or L2 and Z represent adjacent atoms in an aromatic ring;

Y and Z are linkages independently selected from hydrocarbylene, substituted hydrocarbylene, heteroatom-containing hydrocarbylene,
substituted heteroatom-containing hydrocarbylene, —O—, —S—, —NR9, and —PR9—, wherein R9 is selected from hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, and substituted heteroatom-containing
hydrocarbyl, and further wherein Y and Z may represent adjacent atoms in an aromatic ring;

m is zero or 1;
n is zero or 1; and wherein
L2 and the ligand containing Q are bonded to M in a trans orientation, and wherein the olefinic reactant and the complex having
the structure of formula (I) are contacted under reaction conditions selected to enable olefin metathesis; and wherein the
complex having the structure of formula (I) exhibits a latency period when contacted with the olefinic reactant.

US Pat. No. 9,070,268

WIRELESS SENSOR NODE FOR AUTONOMOUS MONITORING AND ALERTS IN REMOTE ENVIRONMENTS

California Institute of T...

1. A personal alert and tracking system comprising one or more nodes, wherein each of the one or more nodes comprises:
(a) a first radio transceiver chip operating at a first frequency range and a second radio transceiver chip operating in a
second frequency range, wherein:

(1) the first radio transceiver chip and the second radio transceiver chip enable the node to operate as either a mobile sensor
node or a relay base station node;

(2) the second radio transceiver chip provides a relay link between the one or more nodes;
(b) a power amplifier that increases a line-of-sight communication between the one or more nodes;
(c) one or more sensors for providing sensor information, wherein the one or more sensors comprise:
(1) a global positioning system (GPS) module for providing a location;
(2) a temperature sensor for determining a temperature; and
(3) an accelerometer for triggering an alert condition;
(d) a first display for displaying alert information;
(e) embedded software configured to:
(1) capture and process the sensor information;
(2) provide a multi-hop packet routing protocol to relay the sensor information to a command center;
(3) receive alert information from the command center; and
(4) display the alert information on the display.

US Pat. No. 9,285,652

POINT-WISE PHASE MATCHING FOR NONLINEAR FREQUENCY GENERATION IN DIELECTRIC RESONATORS

CALIFORNIA INSTITUTE OF T...

1. An optical resonator, comprising:
a birefringent crystal having an optical axis, said birefringent crystal cut so that said optical axis is disposed at an angle
different from 0 degrees relative to a direction perpendicular to a cut face of said birefringent crystal, said birefringent
crystal configured to operate in a whispering gallery mode of optical propagation, said birefringent crystal configured to
receive an input electromagnetic signal having a first frequency f1 and configured to provide in response to said input electromagnetic signal an output electromagnetic signal having a second
frequency f2, said first frequency and said second frequency being related according to the relation

f2=N×f1 where N is an integer greater than 1.

US Pat. No. 9,225,069

EFFICIENT ACTIVE MULTI-DRIVE RADIATOR

California Institute of T...

1. A multi-port driven antenna, comprising:
an antenna structure having a length L, said antenna structure comprising a conductor and configured to radiate electromagnetic
radiation, said radiator structure having at least one ground contact point and a plurality S of input ports, where S is a
positive integer greater than or equal to 2, each of said plurality S of input ports having a respective electrical connection
to said antenna at a respective selected location along the antenna length L;

a respective signal input terminal of each of said plurality S of input ports, each signal input terminal configured to receive
a respective input signal having a predetermined phase relationship with respect to another input signal applied to an adjacent
signal input terminal, said predetermined phase relationship dependent on said location of said respective electrical connection
to said antenna, said respective signal input terminal configured to apply said received respective signal to said antenna
structure at said respective selected location of said input port; and

a source of input signals, said source configured to provide to each of said respective signal input terminal of each of said
plurality S of input ports said respective input signal having a predetermined phase relationship with respect to another
input signal applied an adjacent signal input terminal, and configured to provide a ground signal at each of said at least
one ground contact point; said multi-port driven antenna and said source of input signals when active defining a multiport-driven
radiator.

US Pat. No. 9,205,423

HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION OF MATERIALS

California Institute of T...

1. A method of priming a microfluidic device with a liquid material, the method comprising:
loading a plurality of wells on an upper surface of a microfluidic device with a liquid material;
biasing a holder piece against the upper surface such that a continuous raised rim of the holder piece presses against the
upper surface surrounding the wells, such that a chamber is created over the wells; and

applying a positive pressure to the chamber to drive the material from the wells into an active area of the microfluidic device.

US Pat. No. 9,173,605

FABRICATION OF IMPLANTABLE FULLY INTEGRATED ELECTROCHEMICAL SENSORS

CALIFORNIA INSTITUTE OF T...

29. A monolithically integrated miniaturized implantable device comprising:
a substrate for monolithic integration of the miniaturized implantable device comprising a plurality of metal layers separated
via a plurality of insulating layers;

a monolithically integrated electrochemical sensor comprising a plurality of electrodes;
a monolithically integrated electronic system;
a plurality of wells in correspondence of the plurality of electrodes, wherein a depth of a well of the plurality of wells
extends across one or more metal layers of the plurality of metal layers and/or one or more insulating layers of the plurality
of insulating layers; and

a monolithically integrated coil,
wherein during operation of the implantable device, the electronic system is configured to:
interface with the electrochemical sensor and sense a current in correspondence of a reaction,
communicate with an external device over a wireless communication link provided by the coil, and,
extract power for the miniaturized implantable device from the wireless communication link.

US Pat. No. 9,085,814

BULK NICKEL-BASED CHROMIUM AND PHOSPHOROUS BEARING METALLIC GLASSES

California Institute of T...

1. A metallic glass alloy comprising:
Ni(68.6?w?x?y?z)Cr8.7+wNb3+xP16.5+yB3.2+z,
where w, x, y, and z are positive or negative atomic percentages that represent a deviation from the base composition having
absolute values that satisfy:
0.21|w|+0.84|x|+0.96|y|+1.18|z|<1.89, and
wherein the alloy has a critical rod diameter of at least 3 mm.
US Pat. No. 9,133,504

REAL TIME MICROARRAYS

California Institute of T...

1. A method of measuring at least one parameter of a binding reaction of an analyte with a probe on a microarray, comprising
the steps of:
contacting a fluid volume comprising an initial concentration C of at least one analyte that is labeled with a quencher with
a solid substrate comprising a number Po of unbound molecules of at least one probe that has been labeled with a donor and
affixed thereto at a probe spot, said at least one probe and said at least one analyte configured to bind together, wherein
the at least one analyte is not labeled with a metal cluster;

measuring kinetically in real-time a plural number of values for the number P(t) of unbound molecules of said probe at time
t, during a time interval when said reaction of said at least one probe and said at least one analyte is occurring, wherein
said reaction is not competitive;

determining by using said measured plural number of values P(t) fitted to an exponential curve at least one parameter descriptive
of a binding reaction of said at least one probe and said at least one analyte; and

performing a selected one of storing, manipulating and displaying to a user data comprising said at least one parameter,
wherein said contacting and measuring are performed in the absence of a washing step.

US Pat. No. 9,067,848

NANOSTRUCTURED CARBON MATERIALS FOR ADSORPTION OF METHANE AND OTHER GASES

California Institute of T...

30. A stored gas composition comprising a porous adsorbent and a gas adsorbed on an exposed surface of the porous adsorbent,
wherein the porous adsorbent has a first chemical composition and a first plurality of ordered pore structures characterized
by a first pore size distribution, wherein the first pore size distribution provides a constant or increasing isosteric enthalpy
of adsorption as a function of uptake of the gas on the exposed surface of the porous adsorbent for a pressure of the gas
exposed to the porous adsorbent selected from the range of 1 MPa to 12 MPa and at a temperature the range of ?169° C. to 125°
C.; wherein the gas is adsorbed on the exposed surface of the porous adsorbent to an absolute uptake amount selected from
the range of 0.5 mmol g?1 to 50 mmol g?1.

US Pat. No. 9,140,612

MEASURING SEEBECK COEFFICIENT

California Institute of T...

1. An apparatus for measuring a Seebeck coefficient of a sample, comprising:
a first heater assembly having a first bore therethrough exiting at a first substantially perpendicular surface for contacting
and producing a first isothermal sample surface;

a first thermocouple having a first axis of a first slender geometry where temperature and voltage are sensed at an end of
the first axis, the first thermocouple disposed in the first bore of the first heater assembly to contact the first isothermal
sample surface;

a second heater assembly having a second bore therethrough exiting at a second substantially perpendicular surface for contacting
and producing a second isothermal sample surface on a sample side opposite the first isothermal sample surface; and

a second thermocouple having a second axis of a second slender geometry where temperature and voltage are sensed at an end
of the second axis, the second thermocouple disposed in the second bore of the second heater assembly to contact the second
isothermal sample surface.

US Pat. No. 9,334,544

CELLULASE COMPOSITIONS HAVING IMPROVED THERMOSTABILITY AND SYNERGY

CALIFORNIA INSTITUTE OF T...

1. A composition, comprising:
a variant Cel5a endoglucanase having a temperature at which half of the maximal protein activity remains (T50) higher than a T50 of wild type Cel5a endoglucanase and having increased enzymatic activity relative to enzymatic activity of the wild type Cel5a
endoglucanase, the variant Cel5a endoglucanase comprising point mutations in a wild type Cel5a amino acid sequence of SEQ
ID NO: 7 selected from the group consisting of

(a) G293A and S318P/Q/E and
(b) G293A and S318P/Q/E and one or more residues selected from the group consisting of E53D, T57N, S79P, T80E, V101I, S133R,
N153D, N155E, T156E, G189S, F191V, T233V, G239E, V265T, D271Y, and S309W/L, in which the amino acid residue numbering is based
on the numbering of SEQ ID NO: 6; and

a cellobiohydrolase selected from the group consisting of Cel6a encoded by SEQ ID NO: 4, Cel7a encoded by SEQ ID NO: 5, and
combinations thereof.

US Pat. No. 9,313,423

DEEP TISSUE FOCAL FLUORESCENCE IMAGING WITH DIGITALLY TIME-REVERSED ULTRASOUND-ENCODED LIGHT

California Institute of T...

1. A method of irradiating a scattering medium, comprising:
encoding light with one or more signals, in one or more regions of a scattering medium, to form encoded light;
collecting a portion of the encoded light, comprising one or more encoded fields, in a digital optical phase conjugation (DOPC)
device comprising a spatial light modulator (SLM) connected to a camera;

producing, in the DOPC device, one or more time reversed fields that are phase conjugates of the encoded fields;
irradiating the scattering medium with the time reversed fields, wherein the time reversed fields include a desired component
that converges back to the one or more regions, and a background component due to incomplete time reversal resulting from
only the portion of the encoded light being collected;

detecting, on a detector, first output radiation based on an interaction between the time reversed fields and the scattering
medium, to produce a first detected signal;

irradiating the scattering medium with one or more background fields that at least approximate the background component;
detecting, on a detector, second output radiation based on an interaction between the background fields and the scattering
medium, to produce a second detected signal; and

subtracting, in a computer, the second detected signal from the first detected signal, to obtain an output that at least approximates
an interaction between a complete time reversed light field, comprising phase conjugates of all of the encoded light's fields,
and the scattering medium.

US Pat. No. 9,154,235

SYSTEMS AND METHODS FOR OPTICALLY POWERING TRANSDUCERS AND RELATED TRANSDUCERS

CALIFORNIA INSTITUTE OF T...

1. A fiber optic power delivery system, comprising:
at least one monitoring system;
at least one optical fiber;
at least one transducer adapted to be optically powered by the at least one monitoring system through the at least one optical
fiber; and

a multi-functional light source connected to the at least one optical fiber and configured to a) support an optical data communications
link between the at least one transducer and the at least one monitoring system, and b) provide light for a non-communication
function.

US Pat. No. 9,144,490

HIGH-LEAD COUNT IMPLANT DEVICE AND METHOD OF MAKING THE SAME

CALIFORNIA INSTITUTE OF T...

1. A method for fabricating a flexible thin-film substrate for attachment of a device to be implanted, the method comprising:
depositing a first thin-film layer on a silicon-wafer to form a bottom thin-film layer;
depositing a metal to the bottom thin-film layer to form an electrical connection;
depositing a second thin-film layer adjacent to the metal to form a top thin-film layer and to thereby form a thin-film metal
thin-film sandwich;

providing a mask adjacent to the second thin-film layer;
directing an etching beam onto the mask to fabricate the flexible thin-film for attachment of the device,
detaching the silicon-wafer from the flexible thin-film substrate and attaching the device, wherein the device is an integrated
circuit chip (IC Chip), which electrically connects the flexible thin-film substrate to the IC Chip, and wherein the flexible
thin-film substrate and device are encapsulated for biocompatibility.

US Pat. No. 9,186,327

CARRIER NANOPARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS

California Institute of T...

1. A polymer conjugate comprising a boronic acid of formula:

wherein
R3 and R4 are independently (CH2CH2O)t, where t is from 2 to 2000,

X1 is —NH—C(?O)—, —C(?O)—NH—CH2, —C(?O)—NH—, —S—S—, —O—C(?O)— or —C(?O)—O—;

Y1 is an alkylene with a carbon number of at least 1 or is an aromatic group;

Functional group 1 and Functional group 2 are the same or different and independently comprise —OCH3, —OH, —B(OH)2, —COOH, —NH2, or —(X1)—(Y1)—B(OH)2;

r is in a range of from 1 to 1000;
a is 0, 1, 2, or 3; and
b is 1, 2 or 3; and
a polyol polymer having a repeating structure of:

where n is from 1 to 20,
wherein the boronic acid polymer is coupled to the polyol polymer with at least one reversible borate ester linkage that replaces
the hydroxyl groups of the Y1—B(OH)2 moiety.

US Pat. No. 9,127,096

METHODS AND SYSTEMS FOR SYNTHESIS OF AN ULTRA HIGH MOLECULAR WEIGHT POLYMER

CALIFORNIA INSTITUTE OF T...

1. A method to synthesize an ultra-high molecular weight polymer, the method comprising:
combining an ethylene monomer, an additive, and a catalyst suitable for polymerization of monomers with a solvent in a mixture
comprising a liquid phase,

whereinthe additive is a colloidal stabilizer capable of a crystal forming interaction with a nascent polymer comprising the monomer,
the colloidal stabilizer comprising a solvophilic portion soluble in the solvent and a crystalphilic portion capable of interacting
with the polymer to form a co-crystal comprising the polymer and the crystalphilic portion;
the additive being chemically inert with respect to the catalyst, the monomers, the nascent polymer and the ultra-high molecular
weight polymer; and

the combining is performed in the liquid phase for a time and under conditions to allow synthesis of the nascent polymer,
and co-crystallization of the nascent polymer with the additive thereby resulting in a colloidal suspension of the ultra-high
molecular weight polymer comprising detectable crystals.

US Pat. No. 9,067,258

FORMING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE FORGING

California Institute of T...

1. A method of shaping an amorphous metal formed of an alloy comprising:
heating the entirety of the amorphous metal at a rate of at least 500 K/sec to a temperature between the glass transition
temperature of the amorphous metal and the equilibrium melting point of the alloy;

applying a deformational force to the amorphous metal to shape the amorphous metal into an amorphous article; and
cooling said amorphous article to a temperature below the glass transition temperature of the amorphous metal.

US Pat. No. 9,413,461

HIGH BANDWIDTH OPTICAL LINKS FOR MICRO-SATELLITE SUPPORT

California Institute of T...

1. A high bandwidth satellite downlink communication system comprising:
an onboard tracking detector, installed in a satellite, that detects a position of an incoming optical beam from a first ground
station of one or more ground stations;

tracker electronics that determines orientation information of the incoming optical beam based on the position;
control electronics that receive the orientation information from the tracker electronics, and control a waveguide drive electronics
based on the orientation information;

the waveguide drive electronics that controls a voltage provided to an electro-optic waveguide beam steering device; and
the electro-optic waveguide beam steering device that steers an outgoing optical beam from the satellite to one of the one
or more ground stations based on the voltage, wherein the electro-optic waveguide beam steering device steers the outgoing
optical beam by applying the voltage to an electrode having an interface to a beam propagation direction, and wherein as voltage
is applied, an index under the electrode is changed relative to a surrounding area and the outgoing optical beam is steered
via Snell's law refraction.

US Pat. No. 9,315,862

APTAMER REGULATED NUCLEIC ACIDS AND USES THEREOF

California Institute of T...

1. A nucleic acid comprising (i) a substrate sequence that can form a hairpin RNA stem as a substrate for an RNaseIII family
nuclease, and (ii) an aptamer that binds to a ligand, wherein said aptamer comprises a sequence that can form an aptamer stem,
the formation of said aptamer stem competes with the formation of said hairpin RNA stem,
wherein binding of the ligand to said aptamer causes a conformational change to render the substrate sequence non-functional
by destabilizing the hairpin RNA stem, through stabilizing the aptamer stem, and,

wherein said RNaseIII family nuclease processes said hairpin RNA through an RNA interference (RNAi) mechanism in attenuating
expression of a target gene.

US Pat. No. 9,487,551

SMALL MOLECULE COMPOUNDS THAT CONTROL MAMMAL-PATHOGENIC NEMATODES

California Institute of T...

1. A method of modifying nematode behavior, comprising:
providing a composition comprising a compound of the formula:
or a salt thereof;
wherein:
R1 is H, —C(R)3, —OR, —N(R)2 halogen, an alkyl, a haloalkyl, an alkenyl, or a haloalkenyl; wherein each R is independently H, halogen, an alkyl, or an
alkenyl;

R1? is absent, H, —C(R)3, —OR, —N(R)2, halogen, an alkyl, a haloalkyl, an alkenyl, or a haloalkenyl; wherein each R is independently H, halogen, an alkyl, or an
alkenyl;

R2 is a moiety of the formula:


R3 is H, —CR6R7R8, —C(O)R8, an alkyl, a haloalkyl, an alkenyl, a haloalkenyl, an aryl, a heteroaryl, a heterocyclyl, a cycloalkyl, a cycloalkenyl, an
acyl, an amino acid, a nucleoside, a monosaccharide having 5 or 6 carbon atoms, or a bond connecting to R5 of another unit of Formula I;

R4 is H, —CR6R7R8, —C(O)R8, an alkyl, a haloalkyl, an alkenyl, a haloalkenyl, an aryl, a heteroaryl, a heterocyclyl, a cycloalkyl, a cycloalkenyl, an
acyl, an amino acid, a nucleoside, a monosaccharide having 5 or 6 carbon atoms, or a bond connecting to R5 of another unit of Formula I;

R5 is H, —OH, —OR6, —OCR6R7R8, —CR6R7R8, —NH2, —NHR6, —NR6R7, halogen, an alkyl, a haloalkyl, an alkenyl, a haloalkenyl, an aryl, a heteroaryl, an arylalkyl, a heterocyclyl, a cycloalkyl,
a cycloalkenyl, an acyl, an amino acid, a nucleoside, a monosaccharide having 5 or 6 carbon atoms, or a bond connecting to
R3 or R4 of another unit of Formula I;

R6 and R7 are each independently H, —CR3, —OR, —N(R)2, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, or cycloalkenyl, where the
alkyl, alkenyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, or cycloalkenyl is optionally substituted with one or more substituents
independently selected from —OR8, —C(O)R8, —NHC(O)R8, alkyl, haloalkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl;

R8 is H, —C(R)3, —[C(R)2]n4NHC(O)R9, —[C(R)2]n4C(O)(NH)R9, —OR, —N(R)2, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkenyl, purine, pyrimidine,
or a monosaccharide having 5 or 6 carbon atoms, where the alkyl, alkenyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkenyl,
purine, pyrimidine, or monosaccharide is optionally substituted with one or more substituents independently selected from
—C(R)3, —OR9, —C(O)R9, —NHC(O)R9, halogen, alkyl, haloalkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, and a monosaccharide having 5 or 6 carbon atoms;

R9 is H, —C(R)3, —OR, —N(R)2, halogen, alkyl, haloalkyl, alkenyl, haloalkenyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkenyl, purine, pyrimidine,
or a monosaccharide having 5 or 6 carbon atoms, where the alkyl, alkenyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkenyl,
purine, pyrimidine, or monosaccharide is optionally substituted with one or more substituents independently selected from
—C(R)3, —OR, —C(O)R, halogen, alkyl, haloalkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl;

each R is independently H, halogen, alkyl, or alkenyl;
n1, n2, and n3 are each independently an integer of 0 to 30;

n4 is an integer of 1 to 30; and

the sum of n1, each n2, and each n3 is 1 to 30; and

administering an effective dosage of the composition to the nematode;
wherein the nematode is in contact with a mammal; and
further wherein the nematode is not a Caenorhabditis species.

US Pat. No. 9,355,360

SYSTEMS AND METHODS FOR THE DETERMINING ANNOTATOR PERFORMANCE IN THE DISTRIBUTED ANNOTATION OF SOURCE DATA

California Institute of T...

1. A method for clustering annotators via a distributed data annotation process, comprising:
obtaining a set of source data using a distributed data annotation server system, where a piece of source data in the set
of source data comprises at least one identifying feature;

determining a training data set representative of the set of source data using the distributed data annotation server system,
where each piece of source data in the training data set comprises source data metadata describing the ground truth for the
piece of source data, where the ground truth for a piece of source data describes the features contained in the piece of source
data and a correct label associated with each feature;

obtaining sets of annotations from a set of annotators for a portion of the training data set using the distributed data annotation
server system, where an annotation identifies one or more features within a piece of source data in the training data set;

for each annotator:
determining annotator recall metadata based on the set of annotations provided by the annotator for the training data set
using the distributed data annotation server system, where the annotator recall metadata comprises a measure of the number
of features within a piece of source data identified with a label in the set of annotations by the annotator; and

determining annotator precision metadata based on the set of annotations provided by the annotator for the training data set
using the distributed data annotation server system, where the annotator precision metadata comprises a measure of the number
of correct annotations associated with each piece of source data based on the ground truth for each piece of source data;
and

grouping the annotators into annotator groups based on the annotator recall metadata and the annotator precision metadata
using the distributed data annotation server system.

US Pat. No. 9,212,994

FLUORESCENCE DETECTOR, FILTER DEVICE AND RELATED METHODS

CALIFORNIA INSTITUTE OF T...

1. A microfluidic filtering device for filtering fluid comprising:
a sealed, single-piece cast polymer structure made of transparent polymer material, the cast polymer structure having
a vertical microfluidic inputting channel at one end of the cast polymer structure, into which fluid is adapted to be input,
a vertical microfluidic outputting channel at another end of the cast polymer structure, from which filtered fluid is adapted
to be output, and

a filter element embedded within an internal empty space of the cast polymer structure, the filter element being located underneath
the microfluidic inputting channel and above the microfluidic outputting channel,

wherein the microfluidic inputting channel is axially aligned with the microfluidic outputting channel and the microfluidic
outputting channel is adapted to be connected with a microfluidic circuit.

US Pat. No. 9,215,114

DOUBLE-SAMPLING RECEIVER WITH DYNAMIC OFFSET MODULATION FOR OPTICAL AND ELECTRICAL SIGNALING

California Institute of T...

1. An apparatus for signal receiving, comprising:
a front-end for signal communication including:
a double sampling circuit for sampling an input voltage, at the end of two consecutive bit times, producing a voltage difference
used to determine a signal received on the front end; and

a dynamic offset modulation (DOM) circuit for applying a dynamic offset voltage to the voltage difference, wherein the DOM
circuit avoids input-dependent performance degradation and the front-end has a bandwidth that is at least an order of magnitude
less than a bandwidth of the signal.

US Pat. No. 9,352,136

DRUG DELIVERY AND SUBSTANCE TRANSFER FACILITATED BY NANO-ENHANCED DEVICE HAVING ALIGNED CARBON NANOTUBES PROTRUDING FROM DEVICE SURFACE

CALIFORNIA INSTITUTE OF T...

1. A method of transferring a substance, comprising:
(a) applying a device to a body of a patient, the device comprising a substrate and an array of carbon nanotubes with each
carbon nanotube in the array having two ends,

wherein the array of carbon nanotubes is anchored within the substrate with at least one end of each carbon nanotube protruding
from the substrate,

wherein the carbon nanotubes within the array are grouped in clusters such that each cluster effectively functions as a needle,
wherein the clusters are arranged as a plurality of rings with all of the carbon nanotubes of the clusters being in a ring
periphery, and

wherein application of the device to the body causes the clusters to enter tissue of the patient's body; and
(b) allowing the transfer of the substance through the substrate and into the tissue.
US Pat. No. 9,207,532

PHOTOINITIATED OLEFIN METHATHESIS POLYMERIZATION

California Institute of T...

1. A method of metathesizing an unsaturated organic precursor comprising irradiating a Fischer-type carbene ruthenium catalyst
with at least one wavelength of light in the presence of at least one unsaturated organic precursor, so as to metathesize
at least one alkene or one alkyne bond;
wherein the Fischer-type carbene ruthenium catalyst comprises a ruthenium carbene moiety, Ru?C(R1)—Y—R2, and where

R1 and R2 are independently hydrogen, optionally substituted hydrocarbyl or an optionally substituted heteroatom-containing hydrocarbyl,
or may be linked to form a cyclic group, which may be aliphatic or aromatic, and may contain substituents and/or heteroatoms;
and

Y is O, N—R1, or S.

US Pat. No. 9,141,878

DETECTING FACIAL SIMILARITY BASED ON HUMAN PERCEPTION OF FACIAL SIMILARITY

AOL Inc., Dulles, VA (US...

1. A method for identifying images in an online dating service, the method comprising:
determining, using at least one processor, inequalities between a plurality of training faces associated with one or more
images based on received indications of similarity between a plurality of image groupings;

determining, using the at least one processor, a mapping function between an objective feature space and a psychological feature
space that indicates human perception of facial similarity based on the inequalities;

receiving a query from a user of an online dating website;
identifying, using the at least one processor, one or more other users of the online dating service responsive to the query
based on the mapping function; and

providing search results to the user of the online dating website based on the identified one or more images associated with
other users.

US Pat. No. 9,290,761

MICRORNA INHIBITION FOR THE TREATMENT OF INFLAMMATION AND MYELOPROLIFERATIVE DISORDERS

CALIFORNIA INSTITUTE OF T...

1. A method of modulating the expression of Bach1 gene in a subject having or suspected of suffering from inflammation or
an inflammatory-related condition, comprising:
administering to the subject an miR-155 antisense compound comprising a modified oligonucleotide consisting of 12 to 30 linked
nucleosides in an amount effective to modulate the expression of Bach1 gene, wherein the nucleobase sequence of the modified
oligonucleotides is complementary to a sequence at least 90% identical to mature microRNA-155 (SEQ ID NO: 73).

US Pat. No. 9,263,854

NON-LINEAR VERTICAL-CAVITY SURFACE-EMITTING LASER EQUALIZATION

CALIFORNIA INSTITUTE OF T...

1. A computing device to perform a non-linear equalization of a data signal to be output from a vertical-cavity surface-emitting
laser (VCSEL), the computing device comprising:
a memory;
a processor coupled to the memory, the processor configured to execute an equalization module, wherein the equalization module
is configured to:

derive an isolated-pulse-VCSEL-response to isolated data pulses of the data signal based on a VCSEL model of the isolated
data pulses of the data signal;

determine, based on the isolated-pulse-VCSEL-response and a data rate associated with the data signal, rising edges of the
isolated data pulses and falling edges of the isolated data pulses;

determine an equalization delay based on the isolated-pulse-VCSEL-response and a value of a bias current of the data signal;
adjust the value of the bias current to match the isolated-pulse-VCSEL-response; and
send the data signal to the VCSEL.

US Pat. No. 9,246,529

PHOTONIC RF DOWN-CONVERTER BASED ON OPTOMECHANICAL OSCILLATION

CALIFORNIA INSTITUTE OF T...

1. An optomechanical RF frequency converter, comprising:
a microtoroid optomechanical oscillator configured to provide a self-generated RF local oscillation frequency and configured
to provide a RF mixing functionality, said microtoroid optomechanical oscillator having an optical input port configured to
receive an optical signal having an optical frequency carrier and an RF frequency sub-carrier that carries a lower frequency
single-tone, modulated thereon, and an optical output port configured to provide an optical signal modulated with said low
frequency single-tone without said RF carrier.

US Pat. No. 9,288,915

IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT

CALIFORNIA INSTITUTE OF T...

1. A method of fabricating a high pressure nano-liquid chromatography system on-a-chip, the method comprising:
providing a substrate having a front first side and having a back second side; wherein the substrate has a layer disposed
on the front first side;

etching in two places the substrate from the back second side to form two holes and two diaphragm regions in the substrate
adjacent to the holes; wherein the two diaphragm regions have the layer disposed on the front first side disposed on two diaphragms;

from the front first side, etching the layer disposed on the front first side above the two diaphragm regions in the substrate
to remove the layer over the diaphragms;

patterning a sacrificial material on the front first side of a substrate to define a column region which covers the diaphragm
regions,

forming an encapsulant over the front first side of the substrate and the sacrificial material; wherein forming the encapsulant
comprises depositing Parylene, and prior to deposition of Parylene, a moat is etched into the substrate adjacent to the channel
to receive and anchor the deposited Parylene;

etching through the diaphragm regions from the back second side to open an inlet hole and an outlet hole;
removing the sacrificial material defining a column region through the inlet hole and the outlet hole to form the column region,
wherein the method further comprises forming a epoxy passivating layer over the encapsulant,
wherein the system provides a pressure limit of 1000 psi or greater.

US Pat. No. 9,261,597

REAL-TIME AND POST-PROCESSED ORBIT DETERMINATION AND POSITIONING

CALIFORNIA INSTITUTE OF T...

1. A method comprising:
receiving, by one or more computers, measurements from at least one global navigation satellite system (GNSS) receiver;
analyzing, by the one or more computers, the measurements, thereby detecting and flagging anomalous measurements and phase
breaks;

calculating, by the one or more computers, high-fidelity satellite and signal models that approximate the measurements, wherein
the models comprise a plurality of model parameters having a priori values;

estimating, by the one or more computers, values for the plurality of model parameters affecting orbital and clock states
of a GNSS satellite or affecting reception of said measurements by the at least one GNSS receiver, wherein the estimating
is based on the measurements, thereby obtaining a plurality of estimated model parameters;

calculating, by the one or more computers, improved orbital and clock states based on the plurality of estimated model parameters
and the measurements;
calculating, by the one or more computers, refined model parameters, additionally to the improved orbital and clock states,
based on the plurality of estimated model parameters and the measurements; and
transmitting, by the one or more computers, the improved orbital and clock states and the refined model parameters to the
at least one GNSS receiver.

US Pat. No. 9,133,457

METHODS OF INCORPORATING AMINO ACID ANALOGS INTO PROTEINS

California Institute of T...

1. A polynucleotide encoding a modified tRNAPhe, wherein the modified tRNAPhe comprises a modified anticodon sequence that forms Watson-Crick base-pairing with a wobble degenerate codon for a natural
amino acid and wherein the modified tRNAPhe has a higher affinity for the wobble degenerate codon than a corresponding wild-type tRNAPhe.

US Pat. No. 9,101,769

HIGH DENSITY EPIDURAL STIMULATION FOR FACILITATION OF LOCOMOTION, POSTURE, VOLUNTARY MOVEMENT, AND RECOVERY OF AUTONOMIC, SEXUAL, VASOMOTOR, AND COGNITIVE FUNCTION AFTER NEUROLOGICAL INJURY

The Regents of the Univer...

1. A method comprising:
positioning a human patient in a training device, the patient having a neurologically derived paralysis in a portion of the
patient's body, the training device being configured to assist with physical training that is configured to induce neurological
signals in the portion of the patient's body having the paralysis, the patient having a spinal cord with at least one selected
spinal circuit that has a first stimulation threshold representing a minimum amount of stimulation required to activate the
at least one selected spinal circuit, and a second stimulation threshold representing an amount of stimulation above which
the at least one selected spinal circuit is fully activated and adding the induced neurological signals has no additional
effect on the at least one selected spinal circuit, the induced neurological signals being below the first stimulation threshold
and insufficient to activate the at least one selected spinal circuit; and

applying electrical stimulation to a portion of a spinal cord of the patient, the electrical stimulation being below the second
stimulation threshold such that the at least one selected spinal circuit is at least partially activatable by the addition
of at least one of (a) a second portion of the induced neurological signals, and (b) supraspinal signals.

US Pat. No. 9,293,887

CHIP-BASED LASER RESONATOR DEVICE FOR HIGHLY COHERENT LASER GENERATION

CALIFORNIA INSTITUTE OF T...

1. A laser source comprising:
(a) a pump laser source and an optical fiber arranged to launch pump laser power to propagate along the optical fiber past
a tapered segment thereof; and

(b) a semiconductor oxide disk optical resonator positioned on a semiconductor substrate so as to enable optical coupling
of at least a portion of the pump laser power from the optical fiber into the disk optical resonator, wherein:

(c) the disk optical resonator rests on a circumscribed, flat-topped protrusion from a surface of the substrate;
(d) the pump laser source and the disk optical resonator are arranged so that a selected optical frequency of the pump laser
power substantially coincides with an optical frequency of a resonant optical mode of the disk optical resonator;

(e) the disk optical resonator is arranged with a substantially frusto-conical outer circumferential surface, characterized
by a slope angle greater than about 27°, so as to exhibit a Q-factor greater than about 107 at the pump laser optical frequency; and

(f) the disk optical resonator is arranged so as to exhibit a free spectral range that substantially coincides with an optical
frequency of a stimulated Brillouin gain spectrum of the semiconductor oxide disk optical resonator, so that the portion of
the pump laser power coupled into the disk optical resonator, with the pump laser power above a pump laser power threshold
level, results in stimulated Brillouin laser oscillation in the disk optical resonator.

US Pat. No. 9,063,002

BROADBAND, COMMON-PATH, INTERFEROMETRIC WAVEFRONT SENSOR

CALIFORNIA INSTITUTE OF T...

1. A hybrid wavefront sensor comprising:
a Shack-Hartmann wavefront sensor having a SH-input pupil and a re-imaged SH-output pupil comprising at its distal end a lenslet
array for dicing an incident image wavefront into separate segments;

a Zernike wavefront sensor having a Z-input pupil and a Z-output pupil, the Zernike wavefront sensor being capable of dynamically
shifting the phase of a portion of the image wavefront having a diameter on the order of ?/D, where D is the SH-input pupil
diameter;

a relay optical system disposed proximal to the lenslet array and designed such that the image wavefront from the SH-input
pupil is relayed one-to-one to the Z-input pupil and the Z-output pupil is relayed one-to-one to the lenslet array of the
SH-output pupil;

a detector in optical alignment with the distal side of the lenslet array for imaging the incident image wavefront; and
an electronic controller in signal communication between the Zernike wavefront sensor and the detector for correlating the
phase shift imposed on the imaged wavefront.

US Pat. No. 9,409,011

METHOD OF CONSTRUCTING AN IMPLANTABLE MICROELECTRODE ARRAY

California Institute of T...

1. A method of constructing an implantable electrode array assembly, the method comprising:
applying electrically conductive material to a frame layer forming a patterned layer of electrically conductive material defining
a plurality of electrodes and a plurality of traces, at least one trace being connected to each of the plurality of electrodes,
wherein at least a portion of the electrically conductive material is applied to a sacrificial material, wherein the portion
of the conductive material is removed with the sacrificial material;

forming a first layer of a substantially electrically nonconductive material, the first layer being adjacent the patterned
layer;

forming a plurality of first openings in the first layer, the first openings providing access to the plurality of electrodes
through the first layer, a different grid defining portion of the first openings being adjacent each of the electrodes, each
grid defining portion exposing a plurality of contacts of the electrode to which the grid defining portion is adjacent; and

forming a plurality of second openings in the first layer, the second openings providing access to the plurality of traces
through the first layer.

US Pat. No. 9,279,972

SPATIAL FREQUENCY SWEPT INTERFERENCE ILLUMINATION

California Institute of T...

1. A spatial frequency swept interference illumination device, comprising,
a spatial light modulator for displaying two interlaced diffraction patterns; and
an optical system for transforming the displayed interlaced diffraction patterns into a plurality of illumination sheets with
sweeping spatial frequency.

US Pat. No. 9,255,993

PROCESSING SATELLITE DATA FOR SLANT TOTAL ELECTRON CONTENT MEASUREMENTS

California Institute of T...

1. A method for estimating ionospheric observables using space-borne observations, comprising:
obtaining space-borne global positioning system (GPS) data of ionospheric delay from a space-borne satellite receiver;
obtaining ground-based GPS observations;
combining the space-borne GPS data with the ground-based GPS observations; and
utilizing the combination in a model to estimate a global three-dimensional (3D) electron density field.
US Pat. No. 9,156,921

ORGANOCATALYZED PHOTOREDOX MEDIATED POLYMERIZATION USING VISIBLE LIGHT

California Institute of T...

1. A method of forming a polymer comprising exposing a mixture that is substantially free of photoredox catalysts comprising
metals or metalloids, the mixture comprising:
(a) an organic pre-polymer,
(b) an organic photoredox catalyst, and
(c) an organic initiator to a source of visible light under conditions and for a time sufficient to polymerize the organic
pre-polymer; wherein

the organic photoredox catalyst, upon exposure to and activation by the visible light, is capable of reversibly reducing the
organic initiator to form a reduced organic initiator capable of forming an organic radical species, the organic radical species
capable of initiating a polymerization reaction with the organic prepolymer; and wherein

the organic photoredox catalyst, upon exposure to and activation by the visible light, reduces the organic initiator to form
the organic radical species, which initiates a polymerization reaction with the organic prepolymer.

US Pat. No. 9,234,884

MICROFLUIDIC DEVICE

California Institute of T...

1. A method for analyzing cells, the method comprising:
a) introducing a blood sample comprising fluorescently labeled cells and fluorescently labeled control beads to an inlet of
a first microfluidic channel that gradually narrows, wherein the fluorescently labeled cells are labeled with a fluorophore
different than a fluorophore label of the control beads;

b) flowing the blood sample from the inlet of the first microfluidic channel to an outlet of a second microfluidic channel,
wherein the second microfluidic channel is directly coupled to the first microfluidic channel;

c) exciting the fluorophores of the fluorescently labeled cells and of the fluorescently labeled control beads using an excitation
source;

d) detecting fluorescence of the fluorescently labeled cells and fluorescence of the fluorescently labeled control beads as
they pass through a detection zone in the second microfluidic channel, wherein the detection is performed on individual cells;

e) measuring the fluorescence of the fluorescently labeled cells and of the fluorescently labeled beads using a light sensor;
and

f) using the measured fluorescence to thereby provide a result concerning the blood sample.

US Pat. No. 9,209,375

METHODS AND DEVICES FOR CONTROLLING THERMAL CONDUCTIVITY AND THERMOELECTRIC POWER OF SEMICONDUCTOR NANOWIRES

CALIFORNIA INSTITUTE OF T...

1. A method of improving thermoelectric efficiency of a silicon nanowire, comprising:
providing a silicon nanowire consisting substantially of crystalline silicon;
selecting a thermal conductivity of the silicon nanowire by controlling a diameter of the silicon nanowire within a range
of ten to twenty nanometers and controlling a length of the silicon nanowire to be at least four times the diameter of the
silicon nanowire without substantially changing an electrical conductivity of the silicon nanowire; and

selecting a thermoelectric power of the silicon nanowire by controlling the doping concentration of the silicon nanowire within
a range of 3×1019 cm?3 and 2×1020 cm?3,

such that the silicon nanowire has a thermoelectric efficiency at least one hundred times greater than a thermoelectric efficiency
of bulk silicon,

wherein the silicon nanowire is doped p-type or n-type, but not both, and
wherein the thermoelectric efficiency of the silicon nanowire is greater than or equal to about 0.31 over a temperature range
from about 100K to 200K.

US Pat. No. 9,284,520

INSTRUMENTS FOR BIOLOGICAL SAMPLE PREPARATION DEVICES

CALIFORNIA INSTITUTE OF T...

1. An instrument comprising:
a recess;
a sample preparation device;
a supporting element, configured to attach to the sample preparation device to secure the sample preparation device in the
recess inside the instrument;

at least one motorized actuator, configured to actuate plungers of the sample preparation device that are arranged in a circular
pattern, wherein the at least one motorized actuator comprises

a motor comprising a rotating rod having a rotating axis,
a fixed plate attached to the rotating axis, and
a linear actuator having a first end and a second end, wherein the first end is attached to the fixed plate, and the second
end is attached to an actuator rod, the actuator rod having an axis parallel to the rotating axis of the motor, and wherein
the actuator rod is configured to operate the plungers;

a controlling interface, configured to accept input from a user and operate the at least one motorized actuator based on the
input from the user; and

a housing structure, containing the recess, the supporting element, the at least one motorized actuator, and the controlling
interface.

US Pat. No. 9,233,369

FLUIDIC DEVICES AND FABRICATION METHODS FOR MICROFLUIDICS

CALIFORNIA INSTITUTE OF T...

1. A method of fabricating a fluidic device, the method comprising:
providing a fluidic device including a body having a surface and one or more channels located in the body and defining recesses
on said surface, the one or more channels having respective boundaries, wherein the one or more channels are continuously
open to the surface;

providing the body with protruding walls that protrude from said surface and continuously surround the one or more channels
at the boundaries of the one or more channels;

forming a layer of adhesive including one or more panel-shaped pieces having a pattern based on a pattern of the boundaries
of the one or more channels; and

applying the layer of adhesive on the surface by using a known amount of adhesive, and controlling that the layer of adhesive
has respective boundaries surrounding the boundaries of the one or more channels by applying pressure in a controlled manner
to form a uniformly applied adhesive layer, wherein the protruding walls separate the layer of adhesive from the one or more
channels.

US Pat. No. 9,190,698

LITHIUM-ION ELECTROLYTES WITH IMPROVED SAFETY TOLERANCE TO HIGH VOLTAGE SYSTEMS

CALIFORNIA INSTITUTE OF T...

1. An electrolyte comprising a mixture of:
ethylene carbonate (EC);
ethyl methyl carbonate (EMC) or dimethyl carbonate (DMC);
a flame retardant additive;
a lithium salt comprising lithium hexafluorophosphate (LiPF6); and,

an electrolyte additive, wherein the electrolyte additive comprises lithium bis(oxalato) borate (LiBOB);
wherein the electrolyte comprises 1.0M lithium hexafluorophosphate (LiPF6) in 20% by volume ethylene carbonate (EC) plus 65% to 70% by volume ethyl methyl carbonate (EMC) plus 10% to 15% by volume
of the flame retardant additive of triphenyl phosphate (TPhPh/TPP/TPPa) plus 0.15M lithium bis(oxalato) borate (LiBOB).

US Pat. No. 9,287,435

METHOD OF MAKING PHOTOVOLTAIC DEVICES INCORPORATING IMPROVED PNICTIDE SEMICONDUCTOR FILMS

Dow Global Technologies L...

1. A method of making a photovoltaic device, comprising the steps of:
a. providing a pnictide semiconductor film comprising at least one pnictide semiconductor comprising zinc and phosphorous,
said film having a surface;

b. treating the film, said treating comprising the steps of:
i. contacting the film with a first etching composition in a manner effective to form a phosphorus-rich region on the surface
of the film; and

ii. in the presence of an oxidizing agent, removing at least a portion of the phosphorus-rich region using a second etching
composition that selectively etches the phosphorus-rich region or a derivative thereof relative to the pnictide semiconductor
film.

US Pat. No. 9,138,663

OPPOSED MIGRATION AEROSOL CLASSIFIER GAS AND HEAT EXCHANGER

California Institute of T...

19. A method for changing a property of one or more particles in a sample comprising:
introducing a sample, comprising one or more particles suspended within a sample fluid, through a channel, wherein the channel
comprises two walls that are permeable to a flow of fluid;

introducing a fluid cross-flow of a predetermined chemical composition and/or at a predetermined temperature to the channel
through one of the permeable walls, wherein the fluid cross-flow flows at a first velocity and exits in a first direction
through the other permeable wall;

applying an imposed field on the one or more particles in a second direction counter to the first direction of the fluid cross-flow,
wherein the imposed field causes the one or more particles to migrate at a second velocity opposite and/or equal to the first
velocity of the fluid cross-flow; and

continuously discharging the particles that travel through the channel, wherein the particles that travel through the channel
are discharged in a fluid of the predetermined chemical composition and at the predetermined temperature of the fluid cross-flow,
and wherein a property of the one or more particles of the sample is changed by the predetermined chemical composition and/or
predetermined temperature of the fluid cross-flow while the one or more particles travel through the channel.

US Pat. No. 9,255,120

CONVERSION OF GLUCOSE TO SORBOSE

California Institute of T...

1. A process for preparing sorbose from glucose, said process comprising:
(a) contacting the glucose with a silica-containing structure comprising a zeolite having a topology of a 12 membered-ring
or larger, an ordered mesoporous silica material, or an amorphous silica, said structure containing Lewis acidic Ti4+ or Zr4+ or both Ti4+ and Zr4+ framework centers, said contacting conducted under reaction conditions sufficient to isomerize the glucose to sorbose; and

(b) separating the sorbose from the starting materials and co-products.

US Pat. No. 9,263,612

HETEROJUNCTION WIRE ARRAY SOLAR CELLS

California Institute of T...

1. A microstructure for converting solar energy to electricity comprising:
a vertically aligned array of semiconducting rods of a first semiconductive material epitaxially coated with a coating material
of a second semiconductive material comprising a III-V material having a band-gap wider than the band-gap of the semiconducting
rods of the vertically aligned array of semiconducting rods,

wherein the first semiconductive material directly contacts the second semiconductive material and forms a heterojunction,
wherein the coating material absorbs a first portion of incident light and the semiconducting rods absorb a second portion
of the incident light,

wherein each rod of the vertically aligned array of semiconductor rods has a diameter of 1 to about 10 micrometers and
wherein the coating material is about 0.5 micrometers to about 2.5 micrometers thick and absorbs from 34% to 80% of photons
having energies above the band-gap of the coating material, and

wherein the optical adsorption of the microstructure is enhanced by the coating material having a substantially rough surface.

US Pat. No. 9,427,312

ACCOMMODATING INTRAOCULAR COMPOSITE LENS AND RELATED METHODS

California Institute of T...

1. An implantable intraocular lens comprising:
an outer shell comprising at least a first external-access refill valve;
at least one internal fluid-filled lens including a portion integrated with at least a portion of the outer shell and comprising
at least a second external-access refill valve distinct from the first external-access refill valve, the integrated portion
of the intraocular lens being thicker and less flexible than, and accommodating differently from, unintegrated portions of
the intraocular lens; and

a first fluid at least partially filling the outer shell,
wherein a refractive index of the first fluid, a degree of filling of the outer shell with the first fluid, a curvature of
the outer shell, an axial position of the at least one internal fluid-filled lens, and a curvature of the at least one internal
fluid-filled lens cooperate to define an accommodation and a refractive power of the intraocular lens.

US Pat. No. 9,078,743

3-COIL WIRELESS POWER TRANSFER SYSTEM FOR EYE IMPLANTS

California Institute of T...

1. An inductively-powered eye implant apparatus comprising:
a buffer coil adapted to be affixed external to a sclera of an eye, the buffer coil having a conductor covered by a biocompatible
layer;

a receiver coil comprising a folded electrically insulative sheet of embedded conductor traces, the folded sheet wound into
a spiral form, the receiver coil suitable to be pinched for implantation within a lens capsule of the eye, the receiver coil
adapted for receiving electrical power by electromagnetic induction through the buffer coil from a transmitter coil, the buffer
coil and receiving coil adapted to be electromagnetically coupled when affixed external to and implanted within the eye, respectively;
and

a processing circuit connected with the conductor of the receiver coil and configured to receive electrical power from the
receiver coil.

US Pat. No. 9,248,013

3-DIMENSIONAL PARYLENE SCAFFOLD CAGE

California Institute of T...

1. A three-dimensional implantable apparatus for implanting cells comprising:
a top portion comprising a top face joined to each of four side faces, wherein said top portion is configured to allow microvilli
or other cellular processes to connect to an anatomical structure external to said implantable apparatus;

a bottom portion comprising parylene having a first thickness and a second thickness; and
a gap between the top portion and the bottom portion, wherein the bottom portion is joined with each of the four side faces,
the gap being suitable for growth of cells to be implanted,

wherein said cells are selected from the group consisting of cartilage cells, heart muscle cells, and retinal pigment epithelium
(RPE) cells,

wherein the first thickness of the bottom portion is configured to allow proteins having a molecular weight of 70 kilodaltons
or less to move through the bottom portion and to inhibit movement of proteins having a molecular weight greater and 100 kilodaltons
through the bottom portion, and

wherein the second thickness of the bottom portion is greater than the first thickness of the bottom portion.

US Pat. No. 9,302,922

FILTRATION MEMBRANES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS

CALIFORNIA INSTITUTE OF T...

1. A filtration membrane with embedded polymeric nanoparticles comprising:
hyperbranched polymeric molecules covalently cross-linked to form polymeric nanoparticles embedded in a polymer matrix formed
by a porous polymeric aggregate.

US Pat. No. 9,145,555

INTEGRATED—LIGAND-RESPONSIVE MICRORNAS

California Institute of T...

1. A system comprising a nucleic acid comprising:
(a) an miRNA nucleic acid domain, wherein the miRNA nucleic acid domain has a basal segment region; and
(b) an RNA sensor domain that binds to a ligand, wherein the RNA sensor domain is in the basal segment region;
wherein the basal segment region is formed by:
(1) a first region that, at the 5? end is defined by the 5?-end of the miRNA, and, at the 3? end is defined by
(i) in a first configuration, a 5? Drosha cleavage site, or,
(ii) in a second configuration, a 5? of a guide sequence region, or,
(iii) in a third configuration, a 5? of a complement of a guide sequence region; and,
(2) a second region that, at the 3? end is defined by the 3?-end of the miRNA, and, at the 5? end is defined by
(i) in the first configuration, a 3? Drosha cleavage site, or,
(ii) in the second configuration, a 3? of the complement of the guide sequence region, or,
(iii) in the third configuration, a 3? of the guide sequence region;
wherein said first region base pairs with said second region to form a stem.

US Pat. No. 9,599,584

IMBEDDED CHIP FOR BATTERY APPLICATIONS

CALIFORNIA INSTITUTE OF T...

1. A device for monitoring a condition of an electrochemical cell, the device comprising an integrated circuit comprising:
a voltage monitoring circuit for measuring a plurality of open circuit voltages of said electrochemical cell, said plurality
of open circuit voltages generated upon charging or discharging said electrochemical cell or stopping charging or discharging
said electrochemical cell;

a temperature monitoring circuit for measuring a plurality of temperatures of said electrochemical cell, said plurality of
temperatures generated upon charging or discharging said electrochemical cell or stopping charging or discharging said electrochemical
cell;

a current monitoring circuit for measuring a charging current of said electrochemical cell or a discharging current of said
electrochemical cell; and

a circuit for determining a thermodynamic parameter of said electrochemical cell, wherein said thermodynamic parameter is
one or more of a change in entropy of said electrochemical cell, a change in enthalpy of said electrochemical cell and a change
in free energy of said electrochemical cell, said circuit for determining a thermodynamic parameter positioned in electrical
or data communication with said temperature monitoring circuit to receive temperature measurements from said temperature monitoring
circuit, positioned in electrical or data communication with said voltage monitoring circuit to receive open circuit voltage
measurements from said voltage monitoring circuit and positioned in electrical or data communication with said current monitoring
circuit to receive current measurements from said current monitoring circuit or to provide thermodynamics parameters to said
current monitoring circuit;

wherein said device does not comprise a temperature controller or a means for controlling or establishing said plurality of
temperatures generated upon charging or discharging said electrochemical cell or stopping charging or discharging said electrochemical
cell.

US Pat. No. 9,278,453

BIOSLEEVE HUMAN-MACHINE INTERFACE

California Institute of T...

1. An apparatus for sensing user input, comprising:
an elastic material for fitting tightly to a body portion of a user, the body portion having underlying muscles of the user;
an array of electromyography (EMG) sensors disposed in the elastic material to be proximate to the underlying muscles of the
user in order to sense activity of the underlying muscles and yield EMG electrical signals therefrom;

a plurality of inertial measurement units (IMUs) each disposed on a separately moving portion of the user for determining
position and orientation of each of the plurality of inertial measurement units (IMUs) in order to sense differential movement
between body parts and yielding corresponding IMU data, each IMU providing nine-axis measurements, three for gyrometers, three
for accelerometers and three for magnetic field vector;

a processor for receiving the EMG electrical signals and the IMU data and deriving control data for a robotic device; and
a power supply powering the processor and the plurality of IMUs.

US Pat. No. 9,530,912

THREE-DIMENSIONAL PATTERNING METHODS AND RELATED DEVICES

The California Institute ...

1. A silicon microscale wire solar cell, comprising:
a plurality of aligned microscale wires,
each of the plurality of aligned microscale wires having a length with a first portion and a second portion,
the first portion of the length having a cladding portion on a core portion,
the core portion doped with a first type of dopant and the cladding portion doped with a second type of dopant,
the core portion and the cladding portion defining a radial junction in the first portion of the length, and
the second portion of the length being doped with the first type of dopant but excluding the second type of dopant;
dopant barriers that are each on a different one of the wires such that each barrier is on the second portion of the length
without being positioned on the first portion of the length; and

the second portion of the length being embedded in a polymer;
a plurality of light scattering particles embedded into the polymer and between the wires;
a first electrical contact in electrical communication with the first portion of the length for each of the wires; and
a second electrical contact in electrical communication with the second portion of the length for each of the wires, the second
contact acting as a back reflector.

US Pat. No. 9,781,842

LONG-TERM PACKAGING FOR THE PROTECTION OF IMPLANT ELECTRONICS

California Institute of T...

1. A micropackaged device, said micropackaged device comprising:
a device;
a thin-film substrate for securing said device, said thin-film substrate comprising:
a first thin-film parylene layer, which is 1-10 ?m thick;
a metal adjacent to the first thin-film parylene layer;
a second thin-film parylene layer, which is 20-60 ?m thick, and which is adjacent to the metal to form a thin-film metal thin-film
sandwich, wherein said second layer of thin-film has an opening, said opening having at least one electrical contact provided
on an internal surface thereof, said opening configured to accept at least one electrical circuit device and to provide electrical
communication between said at least one electrical contact and said at least one electrical circuit device;

a corrosion barrier affixed to said substrate with an adhesive, wherein the corrosion barrier is made of a metal, ceramic
or glass, which is disposed above and below the device;

at least one feedthrough disposed in said substrate to permit at least one input and or at least one output line into said
micropackaged device; and

an encapsulation material layer made of parylene, silicone or a combination thereof configured to encapsulate said micropackaged
device, wherein said encapsulation material layer creates an enclosed housing, wherein the corrosion barrier is 30% to 99%
of the total area of the interior of enclosed housing, hermetically sealing said substrate and said corrosion barrier.

US Pat. No. 9,250,453

INTEGRATED LIGHT SOURCE INDEPENDENT LINEWIDTH REDUCTION OF LASERS USING ELECTRO-OPTICAL FEEDBACK TECHNIQUES

California Institute of T...

1. An integrated optical linewidth reduction system comprising:
a phase modulator adapted to modulate the phase of an incoming optical signal in response to a feedback signal thereby to
generate a first optical signal travelling through a first optical path, said feedback signal being a first electrical signal
defined by the first optical signal, wherein an optical linewidth of the first optical signal is less than an optical linewidth
of the incoming optical signal;

a first splitter/coupler adapted to split the first optical signal into at least second and third optical signals travelling
through second and third optical paths said second optical path having a longer propagation delay than said third optical
path;

a second splitter/coupler adapted to generate a fourth optical signal by coupling a first portion of the second optical signal
with a first portion of the third optical signal and deliver the fourth optical signal to a fourth optical path, the second
splitter/coupler being further adapted to generate a fifth optical signal by coupling a second portion of the second optical
signal with a second portion of the third optical signal and deliver the fifth optical signal to a fifth optical path; and

a photo detection circuit comprising first and second photo detectors, said first photo detector being adapted to generate
a second electrical signal in response to the fourth optical signal, said second photo detector being adapted to generate
a third electrical signal in response to the fifth optical signal, said photo detection circuit supplying a fourth electrical
signal in response to the second and third electrical signals; said fourth electrical signal being representative of a phase
noise of the first optical signal.

US Pat. No. 9,401,448

PHOTON DETECTOR AND PROCESS FOR DETECTING A SINGLE PHOTON

NATIONAL INSTITUTE OF STA...

1. A photon detector article comprising:
a photon detector configured to receive a primary waveform, the photon detector comprising:
a multiplication region;
a photon absorption region;
a punch through voltage range; and
a breakdown voltage;
a source in electrical communication with the photon detector and configured to provide the primary waveform that comprises:
a first voltage that is:
less than a maximum value of the punch through voltage range, or
effective to maintain a charge carrier in the absorption region; and
a second voltage that is greater than the breakdown voltage; and
a reference member in electrical communication with the source, the reference member being to provide a reference waveform
in response to receiving the primary waveform.

US Pat. No. 9,322,039

COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS

California Institute of T...

1. A method of preparing a metabolite of tyrosine that is a benzylisoquinoline alkaloid product, the method comprising:
a) culturing an engineered non-plant cell under conditions suitable for protein production, said engineered non-plant cell
comprising three heterologous coding sequences, wherein the three heterologous coding sequences encode a first, second, and
third enzyme, respectively, that are involved in a metabolic pathway that converts the tyrosine into the benzylisoquinoline
alkaloid product, wherein the first, second, and third enzymes are operably connected along the metabolic pathway;

b) optionally adding tyrosine to the cell culture; and
c) recovering the benzylisoquinoline alkaloid product from the cell culture,
wherein the benzylisoquinoline alkaloid product is selected from the group consisting of a norcoclaurine, coclaurine, N-methylcoclaurine,
3?-hydroxy-N-methylcoclaurine, reticuline, 6-O-methyl-norlaudanosoline, 6-O-methyl-laudanosoline, laudanine, scoulerine, tetrahydrocolumbamine,
canadine, salutaridine, salutaridinol, salutaridinol-7-O-acetate, and thebaine, and

wherein each of the first, second, and third enzymes involved in the metabolic pathway that produces the benzylisoquinoline
alkaloid product is selected from the group consisting of L-tyrosine/dopa decarboxylase 1, L-tyrosine/dopa decarboxylase 2,
Cytochrome P450 2D6, NADPH p450 reductase, Polyphenyloxidase, Tyrosine hydroxylase, GTPcyclohydrolase I, Monoamine oxidase
A, Tyramine oxidase, Aromatic amino acid transaminase, Phenylpyruvate decarboxylase, Norcoclaurine synthase, Norcoclaurine
6-O-methyltransferase, Coclaurine-N-methyltransferase, Cytochrome P450 80B1, 4-O-methyltransferase, Berberine bridge enzyme,
Reticuline 7-O-methyltransferase, Scoulerine 9-O-methyltransferase, Canadine synthase, Salutaridine reductase, Salutaridinol
7-O-acetyltransferase, Codeine reductase, and Berbamunine synthase.

US Pat. No. 9,223,929

METHOD AND APPARATUS FOR DETECTION, IDENTIFICATION AND QUANTIFICATION OF SINGLE-AND MULTI-ANALYTES IN AFFINITY-BASED SENSOR ARRAYS

The California Institute ...

1. A method of processing affinity-based array data, comprising:
(a) determining an estimate of a probe and a target interaction in an array comprising (i) analytical expression and (ii)
by calibration of the array using at least one standard probe;

(b) generating a stochastic-matrix that utilizes the estimate in a Markov chain model that comprises modeling hybridization,
cross-hybridization, and unbound transition probabilities between states;

(c) obtaining optical affinity-based array data using a light detection device;
(d) applying the array data to the stochastic-matrix;
(e) applying an optimization algorithm selected from the group consisting of a maximum likelihood estimation algorithm, a
maximum a-posteriori criterion, a constrained least squares calculation, and any combination thereof that exploits and does
not suppress non-specific interactions by considering the non-specific interactions as interference rather than noise; and

(f) outputting optimized affinity-based array data to a user, wherein the optimized affinity-based array data has an improved
signal-to-noise ratio compared to the array data obtained by using the light detection device;

wherein at least one of the steps (d)-(f) is executed by using a suitably programmed computer.

US Pat. No. 9,243,277

SENSOR PROBE FOR BIO-SENSING AND CHEMICAL-SENSING APPLICATIONS

CALIFORNIA INSTITUTE OF T...

1. A method comprising:
placing at least a first protruding portion of a probe at a first desired measurement location that provides contact with
one of a biological specimen or a chemical specimen; and

using a functionalized contact area of at least one first sensing element mounted on the first protruding portion to sense
one of an extracellular field potential or an ionic field potential generated by the one of the biological specimen or the
chemical specimen respectively,

wherein the functionalized contact area is defined at least in part by one of a bulk ionic concentration or a size of a cellular
specimen,

wherein the first at least one sensing element comprises two or more sensing elements separated from each other by a separation
distance that is defined at least in part by the size of the cellular specimen, and

wherein the size of the cellular specimen ranges from about 1 ?m to about 5 ?m in diameter.

US Pat. No. 9,115,424

SIMPLE METHOD FOR PRODUCING SUPERHYDROPHOBIC CARBON NANOTUBE ARRAY

CALIFORNIA INSTITUTE OF T...

1. A method for producing a superhydrophobic carbon nanotube (CNT) array, the method comprising:
synthesizing a vertically aligned CNT array with a chemical vapor deposition (CVD) process; and
performing vacuum pyrolysis on the CNT array to produce the superhydrophobic CNT array,
wherein the vacuum-pyrolysis removes contamination and wherein an outer surface of the superhydrophobic CNT array is at least
85% free from oxygen-containing impurities.

US Pat. No. 9,074,178

ALKANE OXIDATION BY MODIFIED HYDROXYLASES

The California Institute ...

1. An isolated or recombinant polypeptide comprising the amino acid sequence set forth in SEQ ID NO:1 with up to 50 conservative
amino acid substitutions excluding residues 47, 52, 74, 94, 142, 175, 184, 188, 205, 226, 236, 252, 255, 290, 353, 366 and
443 and comprising:
(a) at position 82, a Z1 amino acid residue;
(b) at positions 78 and 328, a Z4 amino acid residue, and
wherein Z1 is an amino acid residue selected from the group consisting of glycine (G), asparagine (N), glutamine (Q), serine
(S), threonine (T), tyrosine (Y), and cysteine (C);

wherein Z4 is an amino acid residue selected from the group consisting of tyrosine (Y), phenylalanine (F), tryptophan (W),
and histidine (H), and

wherein the polypeptide catalyzes the conversion of an alkane to an alcohol.

US Pat. No. 9,128,124

WIRELESS VOLTAGE SENSING DEVICE

California Institute of T...

1. A voltage sensing apparatus, comprising:
a semiconductor substrate having one or more probe areas each having a length of 2000 micrometers or less and a width of 50
micrometers or less;

one or more inputs, comprising one or more metal contacts on the one or more probe areas, wherein the one or more metal contacts
sense voltage comprising one or more voltage waveforms and in response to one or more stimuli;

an output, comprising a laser on the substrate, wherein the laser can transmit one or more signals;
circuitry, on the substrate, electrically connecting and interfacing the one or more inputs to the output, wherein the circuitry
can convert the one or more voltage waveforms into the one or more signals;

a power module on the substrate and electrically connected to the circuitry, wherein the power module can provide power to
the circuitry and the laser; and

wherein the circuitry, the probe areas, the power module, and the laser are within a surface area of the substrate of 4000
micrometers by 1000 micrometers or less.

US Pat. No. 9,234,872

CHEMICAL SENSING AND/OR MEASURING DEVICES AND METHODS

CALIFORNIA INSTITUTE OF T...

1. A method for fabricating a device, the method comprising:
providing a semiconductor substrate with a planar surface;
forming at least one semiconductor nanopillar on the semiconductor substrate and perpendicular to the planar surface;
covering the semiconductor nanopillar with an insulating layer;
depositing a conductive layer on the insulating layer, such that all space between the conductive layer and the semiconductor
nanopillar is completely filled by the insulating layer;

covering a portion of the conductive layer with a masking layer;
removing a conductive layer end of the conductive layer and an insulating layer end of the insulating layer, wherein the conductive
layer end and the insulating layer end are not covered by the masking layer, thus exposing an uninsulated pillar end;

removing the masking layer; and
forming a functional layer on the conductive layer, such that the insulating layer end of the insulating layer protrudes beyond
the conductive layer end of the conductive layer and terminates before the uninsulated pillar end, wherein the functional
layer is a bilayer comprising:

a chemical-attracting layer configured to attract a selected type of chemical species; and
a semi-permeable insulating layer on the attractive layer, the semi-permeable insulating layer configured to allow the selected
type of chemical species to pass through and configured to insulate the attractive layer and the conductive layer of the device.

US Pat. No. 9,294,077

METHOD AND CIRCUIT FOR INJECTING A PRECISE AMOUNT OF CHARGE ONTO A CIRCUIT NODE

California Institute of T...

17. An apparatus for injecting charge onto a circuit node, comprising:
one or more first circuits, each first circuit comprising:
(a) a capacitor having a capacitance C;
(b) a first field effect transistor connected to the capacitor;
(c) a second field effect transistor connected to the capacitor between the capacitor and a circuit node; and
one or more second circuits connected to the first transistor and the second transistor in each of the first circuits, to
control voltage or current levels applied to transistors via one or more voltage or current sources, wherein the voltage or
current levels:

bias first gate of the first field effect transistor at a fixed voltage Vpre above the first field effect transistor's threshold voltage Vt1;

bias a second gate of the second field effect transistor at a voltage below the second field effect transistor's threshold
voltage Vt2;

bring a drain of the first field effect transistor to a reset voltage Vrst to Vrst;

after the resetting, raise the drain of the first field effect transistor to a voltage Vdd, which brings the first transistor into saturation, wherein the capacitor is pre-charged to Vpre?Vt1; and

after the pre-charging, raise the second gate to an injection Voltage Vinj>Vpre wherein the capacitor is charged to Vinj?Vt2 and a charge Q=C(Vinj?Vpre+Vt1?Vt2) is injected through a drain of the second transistor onto the circuit node.

US Pat. No. 9,175,669

V-SHAPED ARRANGEMENTS OF TURBINES

CALIFORNIA INSTITUTE OF T...

1. A V-shaped arrangement of turbines comprising at least six turbines, wherein:
the V-shaped arrangement is adapted to be oriented such that a prevalent crosswind enters the opening of the V-shaped arrangement
and such that the prevalent crosswind direction is substantially parallel to the axis bisecting the V-shape;

the vertex of the V-Shaped arrangement comprises a clockwise rotating turbine from which a first arm of the V-shaped arrangement
extends in a first direction, and a counterclockwise rotating turbine, proximate to the clockwise rotating turbine, from which
a second arm of the V-shaped arrangement extends;

turbines comprised in the first arm extending in the first direction are clockwise rotating turbines;
turbines comprised in the second arm extending in the second direction are counterclockwise rotating turbines;
the turbines in the first arm are arranged in successive pairs of turbines comprising at least one pair of turbines, each
successive pair of turbines arranged in a succession along the first arm, each turbine in the pair of turbines located at
a distance from the other turbine in the pair which is smaller than a distance to other turbines in the array; and

the turbines in the second arm are arranged in successive pairs of turbines comprising at least one pair of turbines, each
successive pair of turbines arranged in a succession along the second arm, each turbine in the pair of turbines located at
a distance from the other turbine in the pair which is smaller than a distance to other turbines in the array.

US Pat. No. 9,354,166

TIME-REVERSAL OF VARIANCE-ENCODED LIGHT (TROVE)

California Institute of T...

1. A method of irradiating a scattering medium, comprising:
transmitting electromagnetic (EM) radiation from an EM radiation source to a target inside the scattering medium, wherein
the target encodes the EM radiation with a variance structure to form encoded EM radiation;

measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through
and exiting the scattering medium;

decoding the transmitted EM radiation, comprising transmitted EM fields, in a computer, comprising selecting one or more of
the transmitted EM fields having the variance structure; and

irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed
EM radiation generated from time reversing the one or more transmitted EM fields having the variance structure, thereby forming
a focus of the time reversed EM radiation in the scattering medium.

US Pat. No. 9,322,007

STABLE FUNGAL CEL6 ENZYME VARIANTS

The California Institute ...

1. An isolated polypeptide comprising at least 80% sequence identity to SEQ ID NO:2 and having one or more amino acid substitutions
at residues selected from the group consisting of N14, S30, V128, V131, M135, C246, Q277, S293, S317, S406, and S413, and
wherein the polypeptide has cellulase activity and comprises increased thermostability compared to a wild-type enzyme of SEQ
ID NO: 4, 6, or 8.
US Pat. No. 9,145,549

REGIO- AND ENANTIOSELECTIVE ALKANE HYDROXYLATION WITH MODIFIED CYTOCHROME P450

The California Institute ...

1. An isolated, recombinant P450 enzyme comprising an amino acid sequence having at least 90% identity to SEQ ID NO:2, wherein
the sequence relative to SEQ ID NO:2 comprises non-naturally occurring mutations of V78A, K94I, P142S, T175I, A184V, F205C,
S226R, H236Q, E252G, R255S, A290V, and L353V, and wherein the enzyme hydroxylates an alkane.

US Pat. No. 9,540,741

LIGHT-DRIVEN HYDROIODIC ACID SPLITTING FROM SEMICONDUCTIVE FUEL GENERATOR

The California Institute ...

1. A device for generating hydrogen gas comprising:
a chamber compartmentalized to have a first subchamber and a second subchamber;
an ionomer membrane sealably separating the first subchamber and second subchamber;
a plurality of elongated structures comprising an Si material extending through the ionomer membrane and having the following
parameter(s):

a bandgap energy of about 0.80 to 1.90 eV,
each elongated structure having a first end and a second end,
wherein the first ends of the plurality of elongated structures are n-Si comprising a p+ emitter layer and extend into the first subchamber and wherein the second end of the plurality of elongated structures are
undoped n-Si and extend into the second subchamber; and

catalyst disposed on the surface of the first end of elongated structures in the first subchamber, wherein the catalyst on
the first end of elongated structure performs the following half reaction:

3I??I3?+2e?,

catalyst disposed on the second end of elongated structures in the second subchamber, wherein the catalyst on the second end
of elongated structure performs a half-reaction:

2H++2e??H2,
when exposed to light.

US Pat. No. 9,190,042

SYSTEMS AND METHODS FOR MUSICAL SONIFICATION AND VISUALIZATION OF DATA

CALIFORNIA INSTITUTE OF T...

1. A method for musical sonification and visualization of data, the method comprising:
receiving grouping rules;
receiving mapping parameters;
receiving at least one set of data comprising data rows, each of said data rows comprising a plurality of data entries;
grouping the data rows into a plurality of groups according to the grouping rules;
mapping the grouped data rows to audible symbols and graphical symbols according to the mapping parameters, such that each
group of the plurality of groups has a corresponding one of the audible symbols and a corresponding one of the graphical symbols;

rendering the audible symbols to an audio output; and
rendering the graphical symbols to a visual output.

US Pat. No. 9,187,812

THERMOPLASTIC JOINING AND ASSEMBLY OF BULK METALLIC GLASS COMPOSITES THROUGH CAPACITIVE DISCHARGE

California Institute of T...

1. A method of joining a plurality of objects comprising:
providing a plurality of objects, each object having at least one metallic glass portion, wherein at least one of the metallic
glass portions of at least one of the plurality of objects is formed from a bulk metallic glass composite material having
both an amorphous matrix phase and at least one crystalline particulate phase;

arranging the objects such that the at least one metallic glass portion of each object is in direct contact with the metallic
glass portion of at least one of the other objects to thereby form at least one contact point;

applying a compressive load such that a force is exerted between the objects at the at least one contact point;
heating an interfacial region immediately surrounding and including each of the at least one contact points in less than about
100 milliseconds to a processing temperature between the glass transition temperature and the liquidus temperature of the
BMG composite such that the metallic glass portions of the plurality of objects soften and interfuse to form a joint at the
at least one contact point;

wherein the heating and joining time is sufficiently short to prevent crystallization of the amorphous matrix and without
altering the microstructure morphology of the crystalline particulate phase; and

wherein the heating is sufficiently localized within the interfacial region such that the joint can be cooled via conduction
through the material surrounding said interfacial region sufficiently fast to ensure re-vitrification of the amorphous matrix
phase within the interfacial region.

US Pat. No. 9,282,007

SYSTEMS AND METHODS OF NETWORK ANALYSIS AND CHARACTERIZATION

California Institute of T...

1. A network analyzer configured to characterize a communication network, comprising:
a processor configured to obtain an initial model of the communication network, where the initial model defines a known network
topology for which capacities of individual network components are known and a maximal data rate of the network cannot be
directly characterized;

wherein the processor is further configured to perform at least one substitution, when a maximal data rate of the network
cannot be directly characterized from the initial model, that replaces a component of the initial network model with an equivalent
or bounding model to produce a simplified network model from which a maximal data rate of the simplified network model can
be directly characterized by the network analyzer;

wherein the processor is also configured to characterize a maximal data rate for the initial model by characterizing the maximal
data rate for the simplified network model; and

wherein obtaining an initial model of the communication network comprises obtaining a definition of the nodes of the network,
a definition of the structure of the network, and a definition of the connections within the network,

wherein a maximal data rate for a network model is a set of maximum possible data rates that a network can deliver; and
wherein a maximal data rate of a network model cannot be directly characterized when the maximal data rate for the network
model cannot be determined based upon known capacities of individual network components.

US Pat. No. 9,352,358

MONOLITHIC FLEXURE PRE-STRESSED ULTRASONIC HORNS

CALIFORNIA INSTITUTE OF T...

1. A method of manufacturing an ultrasonic horn for a high power actuator, comprising the steps of:
forming a monolithic pre-stress portion constructed from a first material, said monolithic pre-stress portion having a first
interior surface and a second interior surface defined therein, said first interior surface and said second interior surface
connected by at least one flexure, said first interior surface, said second interior surface and said configured to provide
a pre-stress cavity for a high power actuator material, said at least one flexure configured to apply a pre-stress that varies
by less than one part in a hundred as a temperature varies over 100 degrees Celsius to an actuator material inserted in said
pre-stress cavity; and

forming a horn portion connected to said monolithic pre-stress portion, said horn portion configured to be driven at a resonance
frequency.

US Pat. No. 9,284,587

STABLE, FUNCTIONAL CHIMERIC CELLOBIOHYDROLASE CLASS I ENZYMES

California Institute of T...

1. A method of treating a biomass comprising cellulose, the method comprising contacting the biomass with a host cell that
expresses a recombinant chimeric polypeptide comprising at least two segments from at least two different parental cellobiohydrolase
I (CBH I) polypeptides, wherein the chimeric polypeptide comprises from N- to C- terminus:(segment 1)-(segment 2)-(segment
3)-(segment 4)-(segment 5)-(segment 6)-(segment 7)-(segment 8);
wherein:
segment 1 comprises a sequence that is at least 98-100% identical to amino acid residue from 1 or from 18 or 19 to x1 of SEQ ID NO:2 (“1”), SEQ ID NO:4 (“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”);

segment 2 comprises a sequence that is at least 98-100% identical to amino acid residue x1 to x2 of SEQ ID NO:2 (“1”), SEQ ID NO:4 (“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”);

segment 3 comprises a sequence that is at least 98-100% identical to amino acid residue x2 to x3 of SEQ ID NO:2 (“1”), SEQ ID NO:4(“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”);

segment 4 comprises a sequence that is at least 98-100% identical to amino acid residue x3 to x4 of SEQ ID NO:2 (“1”), SEQ ID NO:4(“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”);

segment 5 comprises a sequence that is at least 98-100% identical to amino acid residue x4 to x5 of SEQ ID NO:2 (“1”), SEQ ID NO:4 (“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”);

segment 6 comprises a sequence that is at least 98-100% identical to amino acid residue x5 to x6 of SEQ ID NO:2 (“1”), SEQ ID NO:4(“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”);

segment 7 comprises a sequence that is at least 98-100% identical to amino acid residue x6 to x7 of SEQ ID NO:2 (“1”), SEQ ID NO:4(“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”); and

segment 8 comprises a sequence that is at least 98-100% identical to amino acid residue x7 to x8 of SEQ ID NO:2 (“1”), SEQ ID NO:4(“2”), SEQ ID NO:6 (“3”), SEQ ID NO:8 (“4”), or SEQ ID NO:10 (“5”);

wherein x1 is residue 47, 48, 49, 50, 51, or 52 of SEQ ID NO:2, 4, 6, or 8, or residue 48, 49, 50, 51, 52 or 53 of SEQ ID NO:10; x2 is residue 92, 93, 94 95, 96 or 97 of SEQ ID NO:2 or 10, or residue 91, 92, 93, 94, 95, or 96 of SEQ ID NO:4, 6, or 8; x3 is residue 127, 128, 129, 130, 131 or 132 of SEQ ID NO:2, or residue 125, 126, 127, 128, 129 or 130 of SEQ ID NO:4 or 6, or
residue 126, 127, 128, 129, 130 or 131 of SEQ ID NO:8, or residue 123, 124, 125, 126, 127 or 128 of SEQ ID NO:10; x4 is residue 175, 176, 177, 178, 180 or 181 of SEQ ID NO:2, or residue 173, 174, 175, 176, 177 or 178 of SEQ ID NO:4 or SEQ
ID NO:6, or residue 174, 175, 176, 177, 178 or 179 of SEQ ID NO:8, or 171, 172, 173, 174, 175, or 176 of SEQ ID NO:10; x5 is 221, 222, 223, 224, 225, or 226 of SEQ ID NO:2, or residue 219, 220, 221, 222, 223 or 224 of SEQ ID NO:4 or SEQ ID NO:6,
or residue 220, 221, 222, 223, 224 or 225 of SEQ ID NO:8, or 217, 218, 219, 220, 221 or 222 of SEQ ID NO:10; x6 is residue 268, 269, 270, 271, 272 or 273 of SEQ ID NO:2, or residue 266, 267, 268, 269, 270 or 271 of SEQ ID NO:4 or SEQ
ID NO:6, or residue 267, 268, 269, 270, 271 or 272 of SEQ ID NO:8, or 264, 265, 266, 267, 268 or 269 of SEQ ID NO:10; x7 is residue 384, 385, 386, 387, 388 or 389 of SEQ ID NO:2, or residue 385, 386, 387, 388, 389 or 390 of SEQ ID NO:4, or residue
378, 379, 380, 381, 382 or 383 of SEQ ID NO:6, or residue 383, 384, 385, 386, 387 or 388 of SEQ ID NO:8 or 10; and x8 is an amino acid residue corresponding to residue 454 of SEQ ID NO:2, residue 457 of SEQ ID NO:4, residue 458 of SEQ ID NO:6,
residue 453 of SEQ ID NO:8, residue 455 of SEQ ID NO:10 or the C-terminus of the polypeptide having the sequence of SEQ ID
NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8 or SEQ ID NO:10,

wherein the chimeric polypeptide is about 437 or 441 amino acid residues in length, and
wherein the chimeric polypeptide has cellobiohydrolase activity and improved thermostability, pH stability and/or expression
compared to a CBH I polypeptide comprising SEQ ID NO:2, 4, 6, 8 or 10.

US Pat. No. 9,123,622

ATOMIC LAYER DEPOSITION OF HIGH PERFORMANCE ANTI REFLECTION COATINGS ON DELTA-DOPED CCDS

CALIFORNIA INSTITUTE OF T...

1. A silicon photodetector, comprising:
a silicon die having at least one photodetector element configured to detect electromagnetic radiation in a wavelength of
interest, said silicon die having a silicon surface configured to receive said electromagnetic radiation, and having at least
one terminal configured to provide an electrical signal representative of a property of said electromagnetic radiation, said
silicon die having a doped layer situated within 5 nanometers of said surface, said silicon die having a silicon oxide layer
with a first oxide surface adjacent said silicon surface and a second oxide surface on a side opposite said first oxide surface;
and

an antireflection layer comprising Al2O3 configured to be transparent to electromagnetic radiation in said wavelength of interest, said antireflection layer having
a first antireflection layer surface adjacent a defined portion of said second silicon oxide surface and a second antireflection
layer surface on a side opposite said first antireflection layer surface.

US Pat. No. 9,081,252

INTEGRATED TWO-DIMENSIONAL PLANAR OPTICAL PHASED ARRAY

California Institute of T...

1. An optical phased array comprising:
a first array of N optical signal emitters, N being an integer greater than or equal to 2; and
a first array of M optical signal delay elements, each optical signal delay element being associated with and disposed between
a different pair of optical signal emitters and operative to cause a phase/delay shift between optical signals emitted from
its associated pair of optical signal emitters in response to a first input optical signal received by the optical phased
array, wherein M is an integer greater than or equal to one.

US Pat. No. 9,473,115

QUADRATURE-BASED INJECTION LOCKING OF RING OSCILLATORS

CALIFORNIA INSTITUTE OF T...

1. An injection-locked ring oscillator system, comprising:
a plurality of inverters configured to receive an external signal with an injection frequency;
a phase detector module coupled to the plurality of inverters, wherein the phase detector module is configured to:
detect a first phase signal, formed from a coupling of a natural frequency of the injection-locked ring oscillator system
and the injection frequency, from a first inverter of the plurality of inverters;

detect a second phase signal, formed from the coupling of the natural frequency and the injection frequency, from a second
inverter of the plurality of inverters;

detect a mismatch between the injection frequency and the natural frequency; and
identify phase errors in the first phase signal and the second phase signal based on the mismatch; and
a control module coupled to the phase detector module, wherein the control module is configured to:
generate control signal based on the phase errors, wherein the control signal is configured to control the injection-locked
ring oscillator system.

US Pat. No. 9,261,625

ULTRA HIGH RESOLUTION GRAVITY GRADIOMETERY TECHNIQUE

California Institute of T...

1. A method for measuring a relative displacement and rotation, comprising:
continuously shining a first light from a first light source that is fixed on a first entity to a first two-dimensional (2D)
plate fixed on a second entity, wherein a first direction of propagation of the first light does not change relative to the
first entity, and wherein the first 2D plate comprises a first quad cell;

continuously shining a second light from a second light source that is fixed on the first entity to a second 2D plate fixed
on the second entity, wherein a second direction of propagation of the second light does not change relative to the first
entity, and wherein the first direction of propagation is different from the second direction of propagation, and wherein
the second 2D plate comprises a second quad cell; and

monitoring displacement of the first light on the first plate and the second light on the second plate to directly determine
a three-dimensional (3D) displacement vector that represents a relative displacement in three dimensions between the first
entity and the second entity, wherein the monitoring displacement utilizes a quad cell technique to determine the relative
displacement with a resolution of

wherein W represents a width of a light beam of the first light and the second light, and SS represents a signal size of the
first light and the second light.
US Pat. No. 9,090,894

MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146

CALIFORNIA INSTITUTE OF T...

1. A method of modulating development of immune cells in a mammal comprising:
administering a miR-146 oligonucleotide to an immune precursor cell or a hematopoietic cell in the mammal whereby the immune
precursor cell or a hematopoietic cell expresses a miR-146 and develops into one or more immune cells, wherein administering
a miR-146 oligonucleotide comprises administering a miR-146 expression vector to the immune precursor cell or the hematopoietic
cell; and

measuring proliferation of one or more B1 B cells, marginal zone B cells, CD8+cells, B2 cells, CD8?? cells, or natural killer
cells in the mammal.

US Pat. No. 9,089,572

INHIBITORS OF P97

California Institute of T...

1. A method for treating cancer in a patient in need thereof, comprising inhibiting the activity of AAA p97 having the descriptive
name, Valosin-containing protein, by contacting a cell with a therapeutically effective amount of a compound that binds to
and inhibits p97, wherein the compound has a structure of formula (I):
wherein
R1 is —C(O)—CH?CHR6 or —C(O)—CH2—X, X is chloro, R3 is H or —C(O)—CH?CH2, R2 is hydrogen, R4 is aryl, and R5 is lower alkyl,

or pharmaceutically acceptable salts thereof.

US Pat. No. 9,485,076

DYNAMIC POLARIZATION MODULATION AND CONTROL

CALIFORNIA INSTITUTE OF T...

1. A system for sending a data from a radiator by polarization modulation of an electromagnetic wave, the system comprising:
an oscillator adapted to generate an oscillating signal;
a phase shifter coupled to the oscillator and adapted to generate a first phase-shifted oscillating signal having a phase
difference relative to the oscillating signal, wherein the phase shifter is further adapted to vary the phase difference across
a predefined range in response to the data; and

a radiator adapted to receive the first phase-shifted oscillating signal and radiate a first electromagnetic wave having a
first circular polarization and a second electromagnetic wave having a second circular polarization different than the first
circular polarization, the first electromagnetic wave and the second electromagnetic wave forming a third electromagnetic
wave having an angle responsive to the data.

US Pat. No. 9,464,319

MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION OF NUCLEIC ACIDS AND OTHER ANALYTES

CALIFORNIA INSTITUTE OF T...

1. A device, comprising:
a first component and a second component;
a first population of areas disposed in said first component and said second component;
a second population of areas disposed in said first component and said second component; and
an inlet,
wherein the first component and the second component are engageable with one another such that a plurality of the first population
of areas disposed in said first component and a plurality of the first population of areas disposed in said second component
are in fluidic communication with the inlet via a continuous fluidic path within said first and second components, wherein
relative motion between the first component and the second component isolates the plurality of the first population of areas
disposed in said first component from the plurality of the first population of areas disposed in said second component and
exposes at least some of the first population of areas to at least some of the second population of areas so as to form a
plurality of analysis regions, at least some of the analysis regions differing in volume from others of the analysis regions,
and wherein the first component and the second component are engaged with each other before and after the relative motion.

US Pat. No. 9,406,823

METHODS FOR FABRICATING SELF-ALIGNING SEMICONDUCTOR HETEREOSTRUCTURES USING NANOWIRES

CALIFORNIA INSTITUTE OF T...

1. An electronic arrangement comprising:
a semiconductor substrate;
a cleaved semiconductor nanowire on the semiconductor substrate,
wherein the cleaved semiconductor nanowire comprises at least one of a silicon-on-insulator or a bulk silicon structure,
an oxide layer partially coating the cleaved semiconductor nanowire and coating the semiconductor substrate, wherein the oxide
layer and the cleaved semiconductor nanowire define an uncoated region of the cleaved semiconductor nanowire, and

an epitaxial material having a different lattice structure or composition from the cleaved semiconductor nanowire on and bounded
horizontally in the direction of the substrate surface by the uncoated region of the cleaved semiconductor nanowire, wherein
the epitaxial material is a quantum dot.

US Pat. No. 9,340,416

POLYNUCLEOTIDES AND RELATED NANOASSEMBLIES, STRUCTURES, ARRANGEMENTS, METHODS AND SYSTEMS

CALIFORNIA INSTITUTE OF T...

18. A structure comprising a linker polynucleotide attached both to a nanomaterial and to a polynucleotidic platform, the
linker polynucleotide comprising
a toehold moiety formed by a polynucleotide hairpin loop specifically attached to a corresponding single-stranded polynucleotide
moiety presented on the polynucleotidic platform;

a duplex protected labeling polynucleotide domain; and
a nanomaterial attaching moiety directly adsorbed on the nanomaterial via physisorption.

US Pat. No. 9,315,259

MORPHING SURFACES FOR THE CONTROL OF BOUNDARY LAYER TRANSITION

CALIFORNIA INSTITUTE OF T...

1. An aerodynamic surface configured to permit control of boundary layer transition, comprising:
a substrate having a pre-defined strain, said substrate having a first surface configured to be fixed to an airfoil, and having
a second surface;

an overlayer adjacent said second surface of said substrate, said overlayer configured to provide a free surface to an aerodynamic
fluid flow, said overlayer and said substrate having a relative strain mismatch as produced, said overlayer and said substrate
having different respective responses to an applied stress, said overlayer configured to reversibly morph between a smooth
surface and a rough surface, said rough surface comprising wrinkles; and

a stressor configured to apply a stress to at least a selected one of said substrate and said overlayer;
whereby said aerodynamic surface is configured to present a selected one of said smooth surface and said rough surface to
said aerodynamic fluids flow in response to said applied stress.

US Pat. No. 9,316,586

APPARATUS FOR THERMAL CYCLING

California Institute of T...

1. A thermal cycler apparatus comprising:
a heat sink;
a heating component in thermal contact with the heat sink, the heating component having a top surface;
a closed bather sealing in a liquid composition, the closed bather having a top surface and a bottom surface, the top surface
of the closed barrier having a plurality of wells configured to receive a plurality of sample vessels, wherein the wells extend
into the liquid composition, and the bottom surface of the closed barrier being positioned in between the top surface of the
closed barrier and the top surface of the heating component, the bottom surface of the closed barrier being in thermal contact
with the top surface of the heating component; and

a control assembly in communication with the heating component, the control assembly configured to cycle the temperature of
samples in the plurality of sample vessels for nucleic acid amplification.

US Pat. No. 9,289,757

MOLECULAR SIEVES AND RELATED METHODS AND STRUCTURE DIRECTING AGENTS

CALIFORNIA INSTITUTE OF T...

1. A method for preparing an as-synthesized molecular sieve, the method comprising:
preparing a reaction mixture comprising:
a structure directing agent comprising imidazolium cation selected from the group consisting of cations (1)-(5) and (8)-(12):

at least one source of at least one oxide of a tetravalent element;
optionally, one or more sources of one or more oxides selected from the group consisting of oxides of trivalent elements,
pentavalent elements, and mixtures thereof;

optionally, at least one source of an element selected from Groups 1 and 2 of the Periodic Table; and
optionally, hydroxide ions or fluoride ions; and
maintaining the reaction mixture for a time and under conditions suitable to form crystals of the molecular sieve,to thereby obtain an as-synthesized BEA*, MOR, CFI, AFX, or STF molecular sieve.

US Pat. No. 9,214,581

BARRIER INFRARED DETECTORS ON LATTICE MISMATCH SUBSTRATES

CALIFORNIA INSTITUTE OF T...

1. An infrared photodetector comprising:
a substrate formed of a substrate material having a substrate lattice constant;
an infrared barrier detector structure comprising at least one absorber superlattice and at least one contact layer, and at
least one unipolar barrier layer disposed between said at least one absorber layer superlattice and said contact layer, the
detector structure having a detector lattice constant, wherein the substrate and detector lattice constants are mismatched
such that the substrate and detector cannot be strain balanced; and

a transitional structure disposed between the substrate and the detector structure, wherein the transitional structure is
formed from at least one of an interfacial misfit array, a compositionally graded metamorphic buffer layer, and a superlattice
metamorphic buffer layer;

wherein the transitional structure further comprises a template layer formed adjacent the detector structure, wherein the
template layer is formed from a material having a lattice constant strain balanced to the lattice constant of the detector
structure; and

wherein the transitional structure forms a virtual substrate having a lattice constant that is pseudomorphic to the detector
lattice constant.

US Pat. No. 9,143,084

ON-CHIP POWER-COMBINING FOR HIGH-POWER SCHOTTKY DIODE BASED FREQUENCY MULTIPLIERS

California Institute of T...

1. A Monolithic Microwave Integrated Circuit (MMIC) on-chip power-combined frequency multiplier device, comprising:
an integrated circuit comprising two or more multiplying structures integrated on a single chip, wherein:
each of the integrated multiplying structures are electrically identical and each of the multiplying structures include:
one input antenna or input E-probe for receiving an input signal in the millimeter-wave, submillimeter-wave, or terahertz
frequency range inputted on the chip,

one or more stripline based input matching networks electrically connecting the input antenna or the input E-probe to two
or more Schottky diodes in a balanced configuration,

the two or more Schottky diodes used as nonlinear semiconductor devices to generate harmonics out of the input signal and
produce a multiplied output signal,

one or more stripline based output matching networks for transmitting the multiplied output signal from the Schottky diodes
to an output antenna or an output E-probe, and

the output antenna or the output E-probe for transmitting the multiplied output signal off the single chip into an output
waveguide comprising a transmission line;

two or more of the input antennas or input E-probes divide the input signal equally among the multiplying structures within
the chip;

two or more of the output antennas or output E-probes combine the output signals at the output waveguide; and
an improvement in power-handling capabilities and output power of a factor equal to a number of the multiplying structures
included in the chip is achieved.

US Pat. No. 9,090,936

USING A FIELD EFFECT DEVICE FOR IDENTIFYING TRANSLOCATING CHARGE-TAGGED MOLECULES IN A NANOPORE SEQUENCING DEVICE

CALIFORNIA INSTITUTE OF T...

1. A detector apparatus comprising:
a membrane containing a nanopore; and
first and second wrap-around carbon nanotube field-effect transistors configured to undergo a change in amplitude of a source-to-drain
current when at least a portion of a charge-tagged molecule translocates through the nanopore,

wherein:
the nanopore has a nanopore longitudinal axis parallel to a direction of propagation of the at least a portion of the charge-tagged
molecule translocating through the nanopore,

the first wrap-around carbon nanotube field-effect transistor has a first transistor longitudinal axis parallel to the nanopore
longitudinal axis,

the second wrap-around carbon nanotube field-effect transistor has a second transistor longitudinal axis parallel to the nanopore
longitudinal axis, and

the first and second wrap-around carbon nanotube field effect transistors are arranged on diametrically opposing edges of
the nanopore for substantially concurrently detecting the at least a portion of the charge-tagged molecule translocating through
the nanopore.

US Pat. No. 9,057,070

GENERATION OF BACTERIODES FRAGILIS CAPSULAR POLYSACCHARIDE A-ONLY PRODUCING MUTANT STRAIN

California Institute of T...

1. A recombinant Bacteroides fragilis (B. fragilis) bacterial cell expressing a native capsular polysaccharide A (PSA), and lacking expression of native capsular polysaccharide
B (PSB), capsular polysaccharide C (PSC), capsular polysaccharide D (PSD), capsular polysaccharide E (PSE), capsular polysaccharide
F (PSF), capsular polysaccharide G (PSG), and capsular polysaccharide H (PSH), wherein biosynthetic genes for native capsular
polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH are deleted from the cell's genome, and wherein a native multiple promoter
invertase (mpi) gene that controls expression of native biosynthetic genes of native capsular polysaccharides PSA, PSB, PSD,
PSE, PSF, PSG and PSH has not been mutated or deleted.

US Pat. No. 9,349,543

NANO TRI-CARBON COMPOSITE SYSTEMS AND MANUFACTURE

CALIFORNIA INSTITUTE OF T...

1. A method of tri-nano-carbon composite product manufacture, the method comprising:
depositing a catalyst for graphene and a catalyst for carbon nanotubes (CNTs) on a substrate;
growing graphene and CNTs;
attaching fullerenes to the CNTs; and
etching the substrate.
US Pat. No. 9,309,269

TRANSITION-METAL-FREE SILYLATION OF AROMATIC COMPOUNDS

California Institute of T...

1. A chemical system for silylating aromatic substrates comprising an aromatic moiety, said system comprising a mixture of
(a) at least one organosilane and (b) at least one strong hydride or alkoxide base, said system being capable of silylating
the organic substrate; wherein the system is substantially free of transition-metal compounds.

US Pat. No. 9,291,600

PIEZORESISTIVE NEMS ARRAY NETWORK

CALIFORNIA INSTITUTE OF T...

1. An article comprising:
at least one array comprising a plurality of resonators,
wherein the resonators are arranged in a plurality of rows and a plurality of columns,
and wherein the resonators are adapted to vibrate at about the same resonance frequency and about the same phase, wherein
the article is configured to detect at least one analyte based on contact of the analyte with the surface of the resonators.

US Pat. No. 9,217,151

VERSATILE NUCLEIC ACID HAIRPIN MOTIF FOR PROGRAMMING BIOMOLECULAR SELF-ASSEMBLY PATHWAYS

California Institute of T...

1. A system for performing a dynamic function comprising:
a first hairpin monomer comprising:
a first domain comprising a first toehold and a first propagation region, wherein the first toehold is exposed such that it
is available to hybridize to a portion of a first nucleic acid sequence complementary to the first domain, and wherein the
first toehold is located at an end of the monomer; and

a second domain comprising a second toehold and a second propagation region, wherein the second toehold is hybridized to a
portion of the first propagation region;

an initiator molecule, wherein said first nucleic acid sequence complementary to the first domain comprises a portion of the
initiator molecule; and

a second hairpin monomer comprising:
a first domain comprising a first toehold and a first propagation region, wherein the first toehold comprises a nucleic acid
sequence complementary to the second toehold of the first monomer, wherein the first toehold is located at an end of the monomer
and is exposed such that it is available to hybridize to the second toehold of the first hairpin monomer, and wherein the
first propagation region is complementary to the second propagation region of the first hairpin monomer; and

a second domain comprising a second toehold and a second propagation region, the second toehold of the second hairpin monomer
comprising a nucleic acid sequence complementary to the first toehold of the first hairpin monomer,

wherein the second toehold of the second hairpin monomer is hybridized to a portion of the first propagation region of the
second hairpin monomer,

wherein the second propagation region of the second hairpin monomer comprises a sequence complementary to the first propagation
region of the first hairpin monomer, and

wherein the second domain of the second hairpin monomer comprises the sequence of the portion of the initiator that is complementary
to the first domain of the first hairpin monomer so that upon hybridization of the second domain of the second hairpin monomer
to the first domain of the first hairpin monomer, any initiator hybridized to the first domain of the first hairpin monomer
is displaced.

US Pat. No. 9,465,110

THREE-DIMENSIONAL TOMOGRAPHIC IMAGING CAMERA BASED ON COMPRESSIVE SENSING

TELARIS INC., Santa Moni...

1. An apparatus for detecting the range of one or more targets comprising:
a swept frequency laser source for generating an output launched laser beam whose frequency varies as a function of time over
a predetermined optical bandwidth;

an interferometer for receiving said launched laser beam and dividing said laser beam into a target beam and a reference beam,
said interferometer including a first, target arm for directing said target beam to one or more targets whose range is to
be determined, receiving a one or more reflected target beams from said one or more targets; a second, reference arm for transmitting
said reference beam; and a combiner for combining said reference beam in said reference arm with said one or more reflected
target beams in said target arm and forming a combined output beam;

a modulator for modulating at least one of said target beam and said reference beam;
a waveform generator for applying one of a plurality of non-sinusoidal waveforms to said modulator such that said combined
output beam contains at least range information for each of said one or more targets;

a photodetector for receiving said combined output beam and generating an output measurement in response thereto; and
a processor for controlling operation of said swept frequency laser source and said waveform generator so that a sequence
of said non-sinusoidal waveforms is applied to said modulator by said waveform generator and said photodetector generates
a sequence of output measurements, each of which corresponds to one of said non-sinusoidal waveforms applied to said modulator;
and wherein said processor receives said sequence of output measurements from said photodetector and is programmed to determine
the range of said one or more targets by using compressive sensing techniques with said sequence of output measurements.

US Pat. No. 9,395,428

PARTIAL/FRACTIONAL POLARIZATION TRANSFER FOR SINGLE-SCAN MAGNETIC RESONANCE SPECTROSCOPY AND IMAGING

California Institute of T...

1. A method of measuring precessing magnetization with a magnetic resonance system in a single magnetic resonance scan sequence,
the method comprising:
(a) providing, on a first site, a first nucleus having a first spin order;
(b) providing, on a second site, a second nucleus;
(c) exposing a sample including the first site and the second site to a magnetic field provided by the magnetic resonance
system, wherein timing and phase parameters of the magnetic field are determined by a processor in order to achieve a desired
transfer efficiency;

(d) transferring, as a result of exposing the sample to the magnetic field, a fractional portion of the first spin order of
the first nucleus from the first site into a second spin order at the second nucleus on the second site, the transferring
occurring at the desired transfer efficiency, and the second spin order being orthogonal to the first spin order;

(e) measuring a precessing magnetization of the first site or the second site using a magnetic detector, the measured precessing
magnetization indicating either a retained portion of the first spin order or the transferred fractional portion of the first
spin order;

(f) repeating (c)-(e) a predetermined number of times, with the desired transfer efficiency of each repetition being variable,
in order to transfer additional fractional portions of the first spin order from the first site to the second site within
the course of the single magnetic resonance scan sequence.

US Pat. No. 9,347,815

SINGLE-PROTEIN NANOMECHANICAL MASS SPECTROMETRY IN REAL TIME

CALIFORNIA INSTITUTE OF T...

1. A method comprising:
measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced
frequency shifts in at least two modes of a resonator resonance frequency, wherein during the resolving of the frequency shifts
in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte
mass-position pair is one-to-one.

US Pat. No. 9,279,977

COMPACT LASER PROJECTION SYSTEMS AND METHODS

CALIFORNIA INSTITUTE OF T...

1. A compact laser projection system comprising:
a housing;
a mounting platform located inside the housing;
a cantilever lens mount having a proximal end attached to the mounting platform and a free-standing distal end projecting
beyond an edge of the mounting platform;

an output lens mounted at the distal end of the cantilever lens mount;
a laser source mounted at a first location on the mounting platform, the laser source configured for projecting a beam along
a first axis;

a movable beam steering mirror mounted at a second location on the mounting platform for intercepting the beam projected by
the laser source and reflecting the beam along a second axis that is substantially orthogonal to the first axis;

a positive lens mounted at a third location on the mounting platform, the third location selected to a) place the positive
lens in the second axis for intercepting the beam reflected by the movable beam steering mirror, and b) to create an image
of the output lens at the second location wherein the movable beam steering mirror is mounted; and

a fold mirror mounted at a fourth location on the mounting platform for intercepting the beam projected through the positive
lens and to further reflect the beam along a third axis that is substantially orthogonal to the second axis, the third axis
aligned with a longitudinal axis of the cantilever lens mount whereby the further reflected beam is incident upon the output
lens for projecting out of the laser projection system.

US Pat. No. 9,252,731

PASSIVE PHASE NOISE CANCELLATION ELEMENT

CALIFORNIA INSTITUTE OF T...

1. A method for reducing phase noise in an oscillator comprising:
providing a noise reduction device comprising two coupled nonlinear resonators having linear mode frequencies of ?1 and ?2 respectively;

providing an oscillator which produces an output signal having a frequency around ?1+?2 and having a phase noise;

parametrically driving the coupled nonlinear resonators with the oscillator signal to induce a non-degenerate response with
an output signal at a frequency ?1??2;

wherein the phase noise of the oscillator output signal is reduced or eliminated in the output signal of the non-degenerate
response.

US Pat. No. 9,250,148

MULTI-DIRECTIONAL ENVIRONMENTAL SENSORS

California Institute of T...

1. A multi-directional environmental sensor comprising:
an inner conductive element that is contiguous and substantially symmetrical about each of three orthogonal planes;
an outer conductive element that is contiguous and substantially symmetrical about each of three orthogonal planes; and
a device that measures the electrical characteristics of the multi-directional environmental sensor, the device having a first
terminal and a second terminal;

wherein the outer surface of the outer conductive element defines a volume, and the inner conductive element is positioned
entirely within the volume;

wherein the inner conductive element is electrically coupled to the first terminal of the device; and
wherein the outer conductive element is electrically coupled to the second terminal of the device.

US Pat. No. 9,219,486

QUADRATURE-BASED INJECTION LOCKING OF RING OSCILLATORS

CALIFORNIA INSTITUTE OF T...

1. A method to injection-lock a ring oscillator having a plurality of inverters and a natural frequency, the method comprising:
injecting an external signal with an injection frequency into the plurality of inverters;
detecting a first phase signal, formed from a coupling of the natural frequency and the injection frequency, from a first
inverter in the plurality of inverters;

detecting a second phase signal, formed from the coupling of the natural frequency and the injection frequency, from a second
inverter in the plurality of inverters;

determining a mean quadrature error (MQE) from at least the first phase signal and the second phase signal;
generating a control signal from the determined MQE; and
adjusting the natural frequency of the ring oscillator based on the control signal.
US Pat. No. 9,115,355

EXONUCLEASE RESISTANT POLYNUCLEOTIDE AND RELATED DUPLEX POLYNUCLEOTIDES, CONSTRUCTS, COMPOSITIONS, METHODS AND SYSTEMS

CALIFORNIA INSTITUTE OF T...

1. An exonuclease resistant duplex polynucleotide comprising a duplex RNA having a length of about 19 to about 30 bp and comprising
a guide strand complementary bound to a passenger strand, each of the guide strand and passenger strand having a 5? end and
a 3? end, the duplex RNA being in a configuration allowing processing of the guide strand by dicer and/or an argonaute enzyme,
the passenger strand comprising an exonuclease resistant polynucleotide having a 5? end and a 3? end and comprising a blocker
domain having a non-nucleic acid polymer segment and a phosphorothioate segment, wherein

the non-nucleic acid polymer segment comprises a non-nucleic acid linear polymer having a first end and a second end, the
non-nucleic acid linear polymer having two to six residues linked one to another by a residue-to-residue bond, with an end-to-end
distance for the non-nucleic acid linear polymer in a fully extended conformation of up to about 1 nm, the non-nucleic acid
linear polymer having a persistence length up to about 0.5 nm;

the phosphorothioate segment comprises one to five nucleotides linked by phosphorothioate linkages to form a phosphorothioate
sequence having a 5? and a 3? end;

the phosphorothioate segment attaches the first end of the non-nucleic acid polymer segment at the 5? end of phosphorothioate
sequence through a phosphodiester linkage; and

the second end of the non-nucleic acid polymer segment is presented at the 5? end of the exonuclease resistant polynucleotide,
the exonuclease resistant polynucleotide in a configuration in which the second end of the non-nucleic acid polymer is presented
at the 5? end of the passenger strand.

US Pat. No. 9,103,786

APPARATUS FOR DETECTING TARGET MOLECULES AND RELATED METHODS

CALIFORNIA INSTITUTE OF T...

1. A method for pressurizing a microfluidic chip comprising sealed fluidic circuits, comprising:
providing a first chamber in a control circuit in the microfluidic chip;
introducing a liquid in the control circuit;
sealing the control circuit;
providing a sealed controllable microfluidic circuit sealed from the control circuit in the microfluidic chip; and
actuating the sealed controllable microfluidic circuit by a transfer of pressure from the control circuit to the controllable
circuit without transfer of liquid from the control circuit to the controllable circuit, wherein the transfer of pressure
comprises:

pressurizing a chamber of the microfluidic circuit by one or more of:
pressurizing a chamber of the microfluidic circuit; or
switching an open/shut or on/off state of a valve controlling a flow in a micro-channel of the microfluidic circuit.

US Pat. No. 9,100,641

SINGLE-LENS, SINGLE-SENSOR 3-D IMAGING DEVICE WITH A CENTRAL APERTURE FOR OBTAINING CAMERA POSITION

CALIFORNIA INSTITUTE OF T...

1. A device for three-dimensional (3-D) imaging comprising:
a lens;
a mask;
at least two defocusing apertures located off of the optical axis to pass at least two defocused images of the target object,
wherein the at least two defocusing apertures are located in the mask;

a single sensor operable to capture electromagnetic radiation transmitted from the target object through the lens and the
at least two defocusing apertures in the form of at least two defocused images of the target object, the sensor further operable
to output the at least two defocused images as sensor information; and

a processor communicatively connected with the sensor that processes the sensor information, determines depth information
by measuring a distance between the at least two defocused images, and produces a 3-D image of the object.

US Pat. No. 9,435,803

OPTICAL RESONATOR DIAGNOSTIC DEVICE AND METHODS OF USE

CALIFORNIA INSTITUTE OF T...

1. A diagnostic device fabricated in silicon, the diagnostic device comprising:
a first optical nanobeam resonator, made of silicon, the first optical nanobeam resonator comprising a first capture agent
located at a first binding site;

an optical waveguide, made of silicon, the optical waveguide configured for propagating a laser beam and for coupling a first
portion of the propagated laser beam into the first optical nanobeam resonator; and

a first detector configured for detecting a) a first resonant wavelength generated by the first optical nanobeam resonator
when no binding reaction is present at the first binding site, and b) a second resonant wavelength generated by the first
optical nanobeam resonator upon undergoing a change in refractive index when a binding reaction is present at the first binding
site,

wherein the first optical nanobeam resonator is comprised of one or more substantially circular holes on a surface of the
optical waveguide.

US Pat. No. 9,404,891

APPARATUS FOR AND METHOD OF MONITORING CONDENSED WATER IN STEAM PIPES AT HIGH TEMPERATURE

CALIFORNIA INSTITUTE OF T...

1. A monitoring system for determining the status of a steam pipe, comprising:
a programmable computer which when operating under control of a set of instructions recorded on a machine readable memory
performs the steps of:

controlling the emission of a probe ultrasonic signal having a frequency in the range of 2.25 Mega Hertz and above from an
ultrasonic signal generator into a steam pipe;

receiving from an ultrasonic signal receiver an electrical signal representative of an ultrasonic response signal which is
generated in said steam pipe in response to said probe ultrasonic signal;

processing said electrical signal by application of one or more of a filter, a moving average, a window, a transformation,
a Shannon Energy Envelope and an autocorrelation method to produce a result representing a status of said steam pipe; and

performing at least one of recording said result, displaying said result, and transmitting said result to another system.

US Pat. No. 9,382,387

RAPID SELF-ASSEMBLY OF BLOCK COPOLYMERS TO PHOTONIC CRYSTALS

CALIFORNIA INSTITUTE OF T...

1. A structure comprising a supramolecular assembly of a plurality of block copolymers; wherein each of said block copolymers
independently comprises:
a first polymer block comprising first repeating units; wherein each of said first repeating units of said first polymer block
comprises a first polymer backbone group covalently linked to a first polymer side chain group or a first wedge group characterized
by at least three branch points each terminating in an independent branch moiety comprising at least 10 atoms; said first
wedge group having a molecular weight greater than or equal to 50 Da; and

a second polymer block comprising second repeating units; wherein each of said second repeating units of said second polymer
block comprises a second polymer backbone group covalently linked to a second wedge group or a second polymer side chain group
that is different than said first wedge group or said first polymer side chain group; said second wedge group characterized
by at least three branch points each terminating in an independent branch moiety comprising at least 10 atoms; and said second
wedge group having a molecular weight greater than or equal to 50 Da;

wherein said first and second repeating units are directly or indirectly covalently linked along a backbone of said block
copolymer;

wherein a domain length (DL) of the structure increases substantially linearly with molecular weight (MW) of said copolymer
pursuant to the expression (E4) wherein 0.85
DL?MWx  (E4);

wherein said structure is characterized by at least one domain having a DL greater than 160 nm;
wherein said structure absorbs, scatters or reflects electromagnetic radiation having
wavelengths greater than or equal to 600 nm;
wherein each of said block copolymers has a molecular weight selected from the range of 2,000,000 Da to 30,000,000 Da; and
wherein each of said copolymers has the formula (FX1a):
wherein:
Z1 is said first polymer backbone group and Z2 is said second polymer backbone group;

Q1 is a first backbone terminating group and Q2 is a second backbone terminating group;

L1 is a first linking group, and L2 is a second linking group;

A is independently a polymer side chain group or a wedge group, wherein A is said first wedge group or said first polymer
side chain group;

wherein B is said second polymer side chain group or said second wedge group; and
each of n and m is independently an integer selected from the range of 10 to 2000.

US Pat. No. 9,385,825

SENSOR WEB

CALIFORNIA INSTITUTE OF T...

1. A method, comprising:
deploying a plurality of sensor pods having a specified hardware characteristic and forming a sensor web;
establishing wireless communications between sensor pods of the plurality of sensor pods that are within a communication range
of other sensor pods of the plurality of sensor pods;

activating the sensor pods of said plurality to carry out a specified operation at each of a plurality of spaced locations;
evolving the sensor web by adding more sophisticated sensor pods which have an additional hardware characteristic than said
specified hardware characteristic; and

carrying out indirect measurements with at least one sensor pod by processing nonlocal information received from other sensor
pods of the plurality of sensor pods.

US Pat. No. 9,297,058

INJECTION MOLDING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE

California Institute of T...

1. A rapid capacitor discharge injection molding apparatus comprising:
a source of electrical energy comprising a capacitor;
at least two electrodes configured to interconnect said source of electrical energy to a sample of metallic glass formed from
a metallic glass forming alloy when placed in contact with said electrodes, said sample having a substantially uniform cross-section;

at least one plunger being movable in relation to said sample;
an injection force generator disposed in relation to the at least one movable plunger such that an injection force may be
applied to the sample though said movable plunger;

an injection molding die formed in two cooperative halves, such that when the cooperative halves are brought together they
combine to comprise:

an electrically insulated feedstock channel configured to accept the sample and place said sample in electrical connection
with said at least two electrodes such that substantially intimate connections are formed between said electrodes and said
sample, and in mechanical connection with said at least one plunger such that said injection force is transmitted to said
sample,

a thermally conductive mold configured to cool and form said sample into a metallic glass article, and
at least one thermally conductive runner channel forming a fluid interconnection between said feedstock channel and said mold;
wherein said source of electrical energy is capable of producing and discharging a quantum of electrical energy sufficient
to substantially uniformly heat the sample to a processing temperature between the glass transition temperature of the metallic
glass and the equilibrium melting point of the metallic glass forming alloy;

wherein said injection force generator is capable of applying an injection force through said at least one movable plunger
sufficient to urge said heated sample through said runner channel into said mold to form a net shape article therein.

US Pat. No. 9,265,829

TARGETED NANOPARTICLES

California Institute of T...

1. A targeted nanoparticle comprising a mucic acid-containing polymer, a therapeutic agent, a polymer containing a nitrophenylboronic
acid, said nitrophenylboronic acid being coupled to the mucic acid polymer with a reversible covalent linkage, said targeted
nanoparticle being configured to present the polymer containing the nitrophenylboronic acid to an environment external to
the nanoparticle, wherein the polymer containing the nitrophenylboronic acid is conjugated to a targeting ligand at its terminal
end opposite the nanoparticle, wherein said targeted nanoparticle has a nanoparticle to targeting ligand molecule ratio of
1 to 1.

US Pat. No. 9,177,933

THREE-DIMENSIONAL HIGH SURFACE AREA ELECTRODES

CALIFORNIA INSTITUTE OF T...

1. A three dimensional high surface electrode comprising at least one pillar between 1 micron and 50 nm tall with a core of
silicon or silicon alloy, a complete and uniform layer of insulator between 50 nm and 250 nm, and a complete and uniform layer
of conductive metal between 50 nm and 250 nm.
US Pat. No. 9,421,164

STIMULI RESPONSIVE ADHESIVE GEL FOR REMOVAL OF FOREIGN PARTICLES FROM SOFT TISSUE

California Institute of T...

1. An aqueous composition comprising:
(a) a copolymer comprising co-polymerized monomers of:
(i) N-methacryloyl-3,4-dihydroxyl phenylalanine;
(ii) N-isopropylacrylamide, N,N-dimethylacrylamide, N,N-diethylacrylamide, 2-aminoethyl methacrylate, 2-(dimethylamino)ethyl
(meth)acrylate, 2-(dimethylamino)ethyl(meth)acrylamide, N-(3-aminopropyl)-(meth)acrylate, or a combination thereof; and

(iii) optionally (meth)acrylic acid; or
(b) a polymer or copolymer comprising co-polymerized monomers of N-isopropylacrylamide, N,N-dimethylacrylamide, N,N-diethylacrylamide
or a combination thereof, the polymer or copolymer being end capped by at least one 4-(2-amino-ethyl)-benzene-1,2-diol group,
each group linked to the polymer or copolymer by a 3-mercaptopropionic acid ester linkage; or

(c) a PEO-PPO-PEO copolymer, PEO-PPO copolymer, PPO-PEO-PPO copolymer, or a mixture thereof, end capped by at least one 4-(2-amino-ethyl)-benzene-1,
2-diol, each group linked to the copolymer by a carbamate or an ethylene 1,2-dicarboxyester linkage;

wherein the N-methacryloyl-3,4-dihydroxyl phenylalanine or 4-(2-amino-ethylbenzene-1,2-diol is present in a range of about
0.1 mol % to about 10 mol %, based on the total monomer content of the copolymer;

the copolymer has a number average, Mn, molecular weight in a range of from about 50,000 to about 500,000 g/mol and is present
in the composition in a range of about 10 mg/mL to about 500 mg/mL of the composition;

said composition having a lower critical solubility temperature (LCST) in a range of from about 15° C. to about 35° C.
US Pat. No. 9,228,240

METHODS FOR DETECTING AND QUANTIFYING VIABLE BACTERIAL ENDO-SPORES

CALIFORNIA INSTITUTE OF T...

1. A method to detect a viable bacteria cell and/or endospore in a sample, the method comprising:
contacting the sample with an agent to produce a first signal, upon the labeling of a nucleic acid from the non-viable bacterial
cell and/or endospore;

after contacting the sample with the agent to produce the first signal, detecting the first signal from the sample;
treating the sample to render accessible nucleic acids from the viable bacterial cell and/or endospore;
after the treating, contacting the sample with the agent to produce a second signal, the second signal produced upon labeling
of the nucleic acids rendered accessible from the viable bacterial cell and/or endospore;

after contacting the sample with the agent to produce the second signal, detecting the second signal from the sample; and
subtracting the first signal from the second signal to detect the viable bacteria cells and/or endospore in the sample.

US Pat. No. 9,196,426

ELECTRODES INCORPORATING NANOSTRUCTURED POLYMER FILMS FOR ELECTROCHEMICAL ION STORAGE

California Institute of T...

1. An ion storage electrode comprising: a substrate having a nanofibrillar film with a thickness of at least one monolayer
disposed thereon, the film being formed from a plurality of doped amphoteric conjugate polymer nanofibers, wherein the polymer
nanofibers have a diameter of from 1 to 100 nm and a length of from 2 to 30 ?m, wherein the film of nanofibers is substantially
free from polymer aggregates, and wherein the film of nanofibers is disposed on the substrate such that the polymer nanofibers
are oriented substantially parallel to the substrate surface.

US Pat. No. 9,176,137

APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING

California Institute of T...

1. A method of conducting cellular analysis, comprising
(a) providing a suspension of cells,
(b) labeling at least a portion of the cells with a labeled ligand,
(c) introducing the cells into a channel configured and arranged to deliver a plurality of individual cells from the suspension
into a mass spectrometer,

(d) measuring the label from the plurality of individual cells by mass spectrometry to determine a property of the individual
cells.

US Pat. No. 9,057,780

REAL-TIME AND POST-PROCESSED ORBIT DETERMINATION AND POSITIONING

CALIFORNIA INSTITUTE OF T...

1. A method comprising:
receiving, by a computer, measurements from at least one global navigation satellite system (GNSS) receiver;
analyzing, by the computer, the measurements, thereby detecting and flagging anomalous measurements and phase breaks;
calculating, by the computer, high-fidelity satellite and signal models that approximate the measurements, wherein the models
comprise a plurality of model parameters having a priori values;

estimating, by the computer, values for the plurality of model parameters affecting orbital and clock states of a GNSS satellite
or affecting reception of said measurements by the at least one GNSS receiver, wherein the estimating is based on the measurements,
thereby obtaining a plurality of estimated model parameters;

calculating, by the computer, improved orbital and clock states based on the plurality of estimated model parameters and the
measurements;

calculating, by the computer, refined model parameters, additionally to the improved orbital and clock states, based on the
plurality of estimated model parameters and the measurements; and

transmitting, by the computer, the improved orbital and clock states and the refined model parameters to the at least one
GNSS receiver,

wherein the calculating, by the computer, improved orbital and clock states comprises:
calculating, by the computer and at a first data rate, improved orbital states based on the plurality of physical parameters;
and

calculating, by the computer and at a second data rate, improved clock states based on the improved orbital states, wherein
the first data rate is slower than the second data rate.

US Pat. No. 9,482,796

CONTROLLABLE PLANAR OPTICAL FOCUSING SYSTEM

CALIFORNIA INSTITUTE OF T...

1. An optical device, comprising:
a substrate;
a first metasurface disposed over the substrate, the first metasurface comprising a first high-contrast pattern operable for
modifying, over a first phase profile, a phase front of a collimated narrow-band light beam incident to the first metasurface;

a second metasurface disposed over a plane parallel to the first metasurface, the second metasurface comprising a second high-contrast
pattern operable for shaping, over a second phase profile, the phase front of the modified phase front of the incident light
beam into a converging spherical phase front; and

a spacer layer in which the modified phase front of the incident light beam diffracts, the spacer layer disposed in a controllable
separation between the first metasurface and the second surface, the separation relating to a position of a focus point of
the converging spherical phase front beyond the second metasurface, in relation to the first metasurface in a direction of
propagation of the incident light beam, wherein controllably changing the separation between the first metasurface and the
second metasurface by a first distance correspondingly changes the position of the focus point of the converging spherical
phase front by a second distance, wherein the second distance exceeds the first distance to a significant degree.

US Pat. No. 9,456,588

TRANSGENIC MOUSE HAVING A GENOME COMPRISING A HOMOZYGOUS DISRUPTION OF THE ENDOGENOUS MFN2 GENE EXPRESSION IN THE DOPAMINERGIC NEURONS

CALIFORNIA INSTITUTE OF T...

1. A transgenic mouse having a genome comprising a homozygous disruption of the endogenous Mfn2 gene expression in the dopaminergic
neurons, wherein the transgenic mouse exhibits locomotive defects compared to a mouse having a wildtype Mfn2 genotype.

US Pat. No. 9,291,536

BROADBAND ELECTROMECHANICAL SPECTROSCOPY

California Institute of T...

1. An apparatus, comprising:
an electronic circuit for applying one or more secondary tuning electromagnetic fields to a specimen comprising a material,
wherein one or more properties of the material are altered by the one or more secondary tuning electromagnetic fields;

one or more electromagnetic coils for generating one or more primary driving electromagnetic fields that produce one or more
mechanical responses of the specimen comprised of the material during application of the one or more secondary tuning electromagnetic
fields, or a selected temperature, or the selected temperature and the one or more secondary tuning electromagnetic fields;

a specimen grip for physically holding the specimen inside the apparatus, wherein the specimen grip electrically isolates
the specimen from the apparatus while applying the one or more secondary tuning electromagnetic fields;

a clamp for attaching a permanent magnet to the specimen, wherein;
the permanent magnet converts the applied one or more primary driving electromagnetic fields to one or more mechanical forces
on the specimen,

the one or more mechanical forces cause the one or more mechanical responses of the material in the specimen, and
the clamp is electrically isolated from the specimen;
a detector positioned to receive a laser beam reflected from a mirror attached to the specimen to detect one or more specimen
motions,

a laser positioned to focus the laser beam on the mirror; and
a vacuum chamber enclosing at least the material to enable measurement of the one or more mechanical responses under ambient
pressures from atmospheric pressure (1000 mbar) down to a vacuum pressure; and

wherein the one or more specimen motions result from the one or more mechanical responses and are used to measure the one
or more properties of the material during application of the one or more secondary tuning electromagnetic fields, or the selected
temperature, or the one or more secondary tuning electromagnetic fields and the selected temperature.

US Pat. No. 9,269,731

INTEGRATED TERAHERTZ IMAGING SYSTEMS

California Institute of T...

1. An integrated circuit comprising a plurality of pixels, each of the plurality of pixels comprising:
an antenna adapted to receive an incoming electromagnetic wave;
circuitry adapted to downconvert a frequency of the received electromagnetic wave and generate an electrical signal in response;
and

a plurality of output terminals adapted to supply the electrical signals.

US Pat. No. 9,249,016

GRAPHENE-BASED MULTI-JUNCTIONS FLEXIBLE SOLAR CELL

CALIFORNIA INSTITUTE OF T...

14. A multijunction solar cell, comprising:
a first sub-cell comprising:
a first monoatomic graphene layer;
a second monoatomic graphene layer in contact with the first monoatomic graphene layer;
a first n-type dopant distributed with the entire first monoatomic graphene layer; and
a first p-type dopant distributed with the entire second monoatomic graphene layer, wherein both the first and the second
monoatomic graphene layers have the same first band gap;

a first transparent or translucent layer in contact with either the first monoatomic graphene layer or the second monoatomic
graphene layer; and

a second sub-cell beneath the first transparent or translucent layer, the second sub-cell comprising:
a third monoatomic graphene layer;
a fourth monoatomic graphene layer in contact with the third monoatomic graphene layer,
a second n-type dopant distributed with the entire third monoatomic graphene layer; and
a second p-type dopant distributed with the entire fourth monoatomic graphene layer, wherein both the third and the fourth
monoatomic graphene layers have the same second band gap, the second band gap being smaller than the first band gap.

US Pat. No. 9,238,833

THERMALLY CONTROLLED CHAMBER WITH OPTICAL ACCESS FOR HIGH-PERFORMANCE PCR

CALIFORNIA INSTITUTE OF T...

1. A device comprising:
a bottom heater layer, wherein the bottom heater layer comprises a bottom substrate layer, a first adhesive layer, heater
elements, a top substrate layer, and fluidics channels;

a central reacting layer, wherein the central reacting layer comprises a fluidics chamber connected to the fluidics channels;
and

a top heater layer, the top heater layer comprising a transparent insulating layer, a transparent conducting layer, a digitated
conducting layer, and a top protective layer, wherein the transparent insulating layer is connected to the central reacting
layer;

wherein the bottom heater layer is bonded to the central reacting layer with a second adhesive layer, and the central reacting
layer is bonded to the top heater layer with a third adhesive layer.

US Pat. No. 9,190,724

PHASED ANTENNA ARRAY FOR GLOBAL NAVIGATION SATELLITE SYSTEM SIGNALS

CALIFORNIA INSTITUTE OF T...

1. A phased array antenna comprising:
a three-dimensionally printed support structure, wherein the support structure comprises a base structure lying on a ground
plane, and an array of support elements protruding away from the ground plane;

an array of active elements, comprising a first conducting wire wound around the array of support elements, wherein a phase
of a radio wave emitted by the active elements of the array of active elements is adjustable; and

a combiner network, comprising a second conducting wire connecting to the first conducting wire, configured so that a beam
pattern of the radio wave can be steered in a desired direction by way of phase adjustment.

US Pat. No. 9,064,667

SYSTEMS AND METHODS FOR IMPLEMENTING ROBUST CARBON NANOTUBE-BASED FIELD EMITTERS

California Institute of T...

1. A method of fabricating a carbon nanotube-based field emitter, comprising:
patterning a substrate with a catalyst;
wherein the substrate has thereon disposed a diffusion barrier layer;
growing a plurality of carbon nanotubes on at least a portion of the patterned catalyst; and
heating the substrate, in the absence of any growth gases, to an extent where it begins to soften such that at least a portion
of at least one carbon nanotube becomes enveloped by the softened substrate.

US Pat. No. 9,057,568

TEMPERATURE CONTROL DEVICES AND METHODS

CALIFORNIA INSTITUTE OF T...

1. A temperature control method comprising:
providing an object of interest at a first temperature, the object of interest coupled to a first non-fluidic thermal path;
providing a thermal mass at a second temperature, the thermal mass coupled to a second non-fluidic thermal path;
using a thermoelectric heater/cooler for setting the thermal mass at the second temperature;
providing a thermal contact having a first position and a second position, the first position selected to accommodate a thermal
transfer between the object of interest and the thermal mass through the first and second non-fluidic thermal paths;

setting the thermal contact to the first position;
establishing a desired temperature between the first temperature and the second temperature; and
setting the thermal contact to the second position when the object of interest reaches the desired temperature;
wherein the thermal contact comprises a liquid metal filled syringe, wherein the setting the thermal contact to the first
position is set by pushing a syringe plunger, and the setting the thermal contact to the second position is set by pulling
the syringe plunger.

US Pat. No. 10,075,151

HIGH POWER W-BAND/F-BAND SCHOTTKY DIODE BASED FREQUENCY MULTIPLIERS

California Institute of T...

1. A Schottky diode based all-solid-state frequency multiplier, comprising:a substrate; and
a single chip mounted on the substrate, the single chip configured for outputting an output power of at least 100 milliwatts (mW) at a frequency of at least 70 GHz in response to input power having an input frequency, including components for handling the input power of at least 200 mW and a plurality of on-chip power combined multiplying structures, each multiplying structure comprising:
an input antenna or input E-probe,
a plurality of Schottky diodes,
an output antenna or output E-probe,
a first impedance matching structure connected to the Schottky diodes and the output antenna or the output E-probe, and
a second impedance matching structure connected to the Schottky diodes and the input antenna or the input E-probe, and
wherein:
the input power received from a transmission line is distributed to each of the multiplying structures using the input antennas or the input E-probes located on the chip, each of the input antennas or the input E-probes connected to a different one of the multiplying structures, and
the Schottky diodes each have their anode size and epi-structure configured to generate a higher frequency output through frequency-multiplication of the input frequency so that each of the higher frequency outputs can be combined to form the output power of at least 100 mW using the multiple output E-probes or output antennas of the different multiplying structures.

US Pat. No. 9,458,497

MULTIPLEX Q-PCR ARRAYS

CALIFORNIA INSTITUTE OF T...

1. A method comprising:
(a) providing an array comprising a solid surface with a plurality of nucleic acid probes at independently addressable locations,
which plurality of nucleic acid probes comprises 5 or more different nucleotide sequences;

(b) using the array to measure an amount of 5 or more amplicons corresponding to the 5 or more different nucleotide sequences
in a single fluid volume during or after multiple amplification cycles to determine amplicon amount-amplification cycle values;
and

(c) using the amplicon amount-amplification cycle values to determine a presence or amount of the 5 or more nucleotide sequences
in a sample,

wherein the amount of the 5 or more amplicons is measured by measuring kinetics of binding of the 5 or more amplicons to nucleic
acid probes.

US Pat. No. 9,447,461

ANALYSIS DEVICES, KITS, AND RELATED METHODS FOR DIGITAL QUANTIFICATION OF NUCLEIC ACIDS AND OTHER ANALYTES

CALIFORNIA INSTITUTE OF T...

1. A method, comprising:
dispersing a first sample that comprises at least one molecule of interest among a plurality of first areas in both a first
substrate and a second substrate, at least one of the plurality of first areas containing one and only one molecule of interest,
wherein dispersing said first sample comprises exerting the sample through a first conduit in fluidic communication with the
plurality of first areas via a first continuous fluidic path within said first and second substrates:

dispersing a reactant material into a plurality of second areas in both said first substrate and said second substrate; and
effecting pairwise placement of at least some of the plurality of first areas into direct fluidic communication with at least
some of the plurality of second areas so as to form closed reaction chambers and contact reactant material with the first
sample, wherein the pairwise placement comprises relative motion between the first and second substrates which isolates the
plurality of first areas disposed in the first substrate from the plurality of first areas disposed in the second substrate.

US Pat. No. 9,339,945

SYSTEMS AND METHODS FOR GRAVITY-INDEPENDENT GRIPPING AND DRILLING

CALIFORNIA INSTITUTE OF T...

1. A gripping device comprising:
a center housing;
an array of hooks circumferentially distributed around the center housing, the array of hooks adapted to grip a surface on
which the array of hooks rest;

one or more actuators connected with the center housing and the array of hooks, the one or more actuators operative to cause
the array of hooks to grip or release the surface; and

an array of microspine assemblies, each microspine assembly comprising a plurality of microspine toes layered adjacent to
each other within a same microspine assembly, one or more hooks of the array of hooks being embedded in each microspine toe.

US Pat. No. 9,292,789

CONTINUOUS-WEIGHT NEURAL NETWORKS

CALIFORNIA INSTITUTE OF T...

1. A computer-based multi-layer artificial network named continuous-weight neural network (CWNN) configured to receive an
input feature set wherein the input feature set comprises a variable number of features wherein each feature of the variable
number of features is represented by an input pair comprising an input value and an input point provided to the CWNN, the
input value being a real number input value and the input point being a real vector input point, the CWNN further comprising:
a main network and a control network,
wherein the control network is a multilayer perceptron which comprises: i) an input layer comprising CI nodes, and wherein
CI equals to a dimension of the real vector input point and ii) an output layer comprising CO nodes, and

wherein the main network comprises: i) a hidden layer comprising CO nodes and ii) a plurality of input nodes equal to the
variable number of features, wherein the input value of the variable number of features is fed to the input nodes;

CO connections between the CO nodes of the hidden layer and an input node of the main network; and
CO weights associated to each of the CO connections, wherein the CO weights are in correspondence of an output of the control
network;

wherein the output of the control network is in correspondence of an input point vector associated to an input value fed to
the input node of the main network, and a set comprising the CO weights is equal to the output of the control network, the
output of the control network being based on the input point fed to an input layer of the control network.

US Pat. No. 9,243,015

METALLOCORROLES

California Institute of T...

1. A metallocorrole according to Formula II:
wherein:
M is a third row transition metal;
each of R1 through R6 is independently selected from the group consisting of substituted aryl, unsubstituted aryl, and unsubstituted heteroaryl;

each of Xi through X14 is independently selected from the group consisting of H, halo, formyl, carboxyl, cyanoacetyl, sulfonyl, SO3H, SO2NR7R8, COCl, CONR7R8, or NO2, wherein R7 and R8 are the same or different, and each is selected from the group consisting of H, alkyl, aryl, and heteroaryl; and

each of L1 through L4 is independently selected from the group consisting of bidentate ligands.

US Pat. No. 9,054,871

PHYSICAL KEY-PROTECTED ONE TIME PAD

California Institute of T...

1. A device, comprising one or more Communication Physical Unclonable Function (CPUF) devices, the CPUF devices capable of
key storage and the CPUF devices each comprising:
a coherent Electromagnetic (EM) radiation source;
a spatial light modulator (SLM) connected to the coherent EM radiation source, wherein:
the SLM comprises pixels and is positioned to receive, on the pixels, coherent Electromagnetic (EM) radiation from the coherent
EM radiation source; and

upon receipt of the coherent EM radiation, the pixels shape or modify a phase and/or an amplitude of the coherent EM radiation
according to one or more patterns or a sequence of patterns, to form and transmit patterned EM radiation having a patterned
phase and a patterned amplitude;

a volumetric scattering medium connected to the SLM, wherein:
the volumetric scattering medium is positioned to receive and scatter the patterned EM radiation into keyed EM radiation;
and

upon receipt of the patterned EM radiation, the volumetric scattering medium shapes or modifies the patterned phase and the
patterned amplitude of the patterned EM radiation into a keyed phase and a keyed amplitude of keyed EM radiation;

a detector connected to the volumetric scattering medium, the detector positioned to detect an output speckle of the keyed
EM radiation and comprising a circuit that produces a digital signal in response to the keyed EM radiation; and

one or more processors or one or more circuits connected to the detector and one or more processors or one or more circuits
connected to the SLM, wherein one or more of the processors or one or more of the circuits randomize the digital signal to
transform the output speckle into a digital key used to encrypt a message.

US Pat. No. 9,053,903

CHARACTERIZATION OF NANOSCALE STRUCTURES USING AN ULTRAFAST ELECTRON MICROSCOPE

California Institute of T...

1. A system for imaging a sample, the system comprising:
a stage assembly disposed in a chamber and adapted to receive a sample to be imaged;
a first laser source capable of emitting a first optical pulse;
a second laser source capable of emitting a second optical pulse;
a cathode operable to emit an electron pulse in response to at least one of the first optical pulse or the second optical
pulse;

a lens assembly operable to direct the electron pulse to impinge on the sample disposed on the stage assembly; and
a detector operable to capture the electron pulse passing through the sample.

US Pat. No. 9,044,800

HIGH ASPECT RATIO PARTS OF BULK METALLIC GLASS AND METHODS OF MANUFACTURING THEREOF

California Institute of T...

1. A method of manufacturing an amorphous metal article comprising:
providing a blank from a bulk metallic glass;
heating the blank from the glass state to a processing temperature above the crystallization temperature, Tx, but below the melting temperature, Tm, of the bulk metallic glass, wherein the bulk metallic glass is heated substantially uniformly throughout the blank at a
heating rate of at least 100° C./s to a the processing temperature wherein the viscosity of the bulk metallic glass is between
1and 105 Pa-s;

applying a shaping pressure to the blank in a shaping tool to form an amorphous metallic article having a high aspect ratio
of at least 100and dimensions in all axes of at least 0.5 mm; and

quenching the article at a cooling rate sufficient to ensure that the article retains an amorphous phase.

US Pat. No. 9,493,799

IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES

CALIFORNIA INSTITUTE OF T...

1. A reaction mixture for producing a cyclopropanation product, the reaction mixture comprising an olefinic substrate, a carbene
precursor, and a heme enzyme, wherein the cyclopropanation product is a compound according to Formula I:

wherein:
R1 is independently selected from the group consisting of H, optionally substituted C1-18 alkyl, optionally substituted C6-10 aryl, optionally substituted 5- to 10-membered heteroaryl, C(O)OR1a, and C(O)R8;

R2 is independently selected from the group consisting of H, optionally substituted C1-18 alkyl, optionally substituted C6-10 aryl, optionally substituted 5- to 10-membered heteroaryl, C(O)OR2a, and C(O)R8; and

R3, R4, R5, and R6 are independently selected from the group consisting of H, C1-18 alkyl, optionally substituted C6-10 aryl, optionally substituted C1-C6 alkoxy, NR7C(O)R8, C(O)R8, C(O)OR8, and N(R9)2;

wherein:
R1a and R2a are independently selected from the group consisting of H and optionally substituted C1-18 alkyl;

each R7 and R8 is independently selected from the group consisting of H, optionally substituted C1-12 alkyl, and optionally substituted C6-10 aryl; and

two R9 moieties, together with the nitrogen atom to which they are attached, form an optionally substituted 5- to 10-membered heterocyclyl.

US Pat. No. 9,463,498

SHEET FORMING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE

California Institute of T...

1. A rapid capacitor discharge apparatus for rapidly heating an amorphous metal and forming the amorphous metal into a sheet
comprising:
a sample of an amorphous metal, said sample having a substantially uniform cross-section;
a source of electrical energy;
at least two electrodes interconnecting said source of electrical energy to said sample of amorphous metal, said electrodes
being attached to said sample;

a sheet forming tool comprising an enclosure having at least one opening and a plunger, and at least one pair of rollers arranged
parallel to each other and disposed external to the enclosure and adjacent to the opening;

wherein said source of electrical energy is capable of discharging a quantum of electrical energy sufficient to heat the entirety
of said sample to a processing temperature between the glass transition temperature of the amorphous metal and the equilibrium
melting point of the alloy, and wherein said sheet forming tool is capable of applying a compressive force sufficient to eject
said heated sample through said opening and between the at least one pair of rollers, and the roller pair being configured
to apply a deformational force to form a sheet.

US Pat. No. 9,322,001

CYTOCHROME P450 OXYGENASES

California Institute of T...

1. An isolated polypeptide comprising:
(i) a higher capability than a wild-type cytochrome P450 to oxidize at least one substrate selected from an alkane comprising
a carbon-chain of no more than 8 carbons and an alkene comprising a carbon-chain no more than 8 carbons; and

(ii) a higher organic solvent resistance than the corresponding wild-type cytochrome P450, and
wherein the polypeptide comprises an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 2, and comprises
amino acid substitutions at:

(a) two residues of SEQ ID NO: 2 selected from the group consisting of V78, H138, T175, A184, H236, E252, R255, A290, A295,
and L353; and

(b) two residues of SEQ ID NO: 2 selected from the group consisting of F87, T235, R471, E494, and S1024.
US Pat. No. 9,206,419

TARGETING DOMAIN AND RELATED SIGNAL ACTIVATED MOLECULAR DELIVERY

CALIFORNIA INSTITUTE OF T...

1. A molecular complex for enzyme-assisted molecular delivery, the molecular complex comprising:
a targeting domain comprising
a targeting domain duplex RNA having a length of about 19 to about 30 bp, the targeting domain duplex RNA comprising a guide
strand complementary bound to a passenger strand,

wherein
the passenger strand is nicked in two passenger strand segments each about 2 to about 17 bp long and allowing the targeting
domain duplex RNA to adopt a folded conformation and an unfolded conformation,

in the folded conformation, opposite ends of the targeting domain duplex RNA are in a configuration that minimizes processing
of the guide strand by dicer and/or an argonaute enzyme, and

in the unfolded conformation, the opposite ends of the targeting domain duplex RNA are in a configuration allowing processing
of the guide strand by dicer and/or an argonaute enzyme,

a locking sensor, the locking sensor domain comprising
an activation segment;
a displacement segment complementary to the activation segment, the displacement segment complementarily binding the activation
segment; and

a toehold segment complementary to a signal polynucleotide
wherein the targeting domain is bound to the locking sensor in the folded conformation through covalent attachment of the
opposite ends of the targeting domain to a first strand presented on the displacement segment and a second strand presented
on the activation segment,

wherein the displacement segment, and the activation segment are configured so that the molecular complex is configured to
release the targeting domain in an unfolded conformation upon binding of a signal molecule to the toehold segment and consequent
displacement of the displacement segment from the activation segment.

US Pat. No. 9,166,249

FLUORIDE ION BATTERY COMPOSITIONS

California Institute of T...

1. A fluoride ion battery comprising:
an anode
a cathode,
an electrolyte comprising an ionic liquid solvent, and a dissolved fluoride salt, the electrolyte being liquid at a temperature
less than 200 degrees Celsius and the fluoride salt comprising a fluoride anion and a cation comprising an organic group or
comprising a metal-organic species, a substituted metal-organic species or a metal-coordination complex species.

US Pat. No. 9,122,956

AUTOMATED FEATURE ANALYSIS, COMPARISON, AND ANOMALY DETECTION

CALIFORNIA INSTITUTE OF T...

1. A computer implemented method comprising:
providing a sensing and analyzing device, the sensing and analyzing device comprising a plurality of sensors configured to
detect a plurality of physical features describing a plurality of physical objects;

generating, by the sensing and analyzing device, a plurality of feature vectors representing the plurality of objects, based
on the plurality of physical features, wherein the plurality of feature vectors comprises a plurality of components describing
the plurality of physical features, wherein each component of the plurality of components has a numerical range, wherein each
physical feature of the plurality of physical features is represented by at least one component within each feature vector;

converting, by the sensing and analyzing device, the numerical range of each component to a range between 0 and 1, wherein
the converting is carried out by formula


where F1ij is a normalized value of ith object and jth feature component, OrigFij is an original jth feature component value of ith object, MinFj and MaxFj are a minimum value and a maximum value of jth feature component, thereby obtaining a first plurality of normalized feature vectors comprising a first plurality of normalized
components and further comprising a total number of components for each physical feature of each first normalized feature
vector of the first plurality of normalized feature vectors;

for each first normalized feature vector of the first plurality of feature vectors, dividing, by the sensing and analyzing
device, the plurality of normalized components for each physical feature of each first normalized feature vector by the total
number of components for each physical feature of the first normalized feature vector, thereby obtaining a second plurality
of normalized feature vectors;

normalizing, by the sensing and analyzing device, the second plurality of normalized feature vectors by formula

where F2ij is a component of a feature vector of the second plurality of normalized feature vectors, and F3ij is a resultant component for each feature vector of a third plurality of normalized feature vectors;

clustering, by the sensing and analyzing device, the third plurality of normalized feature vectors, thereby obtaining a plurality
of clustered normalized feature vectors;

applying, by the sensing and analyzing device, principal component analysis to the plurality of clustered normalized feature
vectors, thereby obtaining a distance flag value and a first evaluated plurality of normalized feature vectors;

calculating, by the sensing and analyzing device, a number flag value by counting each feature vector of the plurality of
clustered normalized feature vectors, based on a threshold value, thereby obtaining a second evaluated plurality of normalized
feature vectors;

analyzing, by the sensing and analyzing device, the plurality of physical objects, based on the first or second evaluated
plurality of normalized feature vectors.

US Pat. No. 9,101,979

METHODS FOR FABRICATING GRADIENT ALLOY ARTICLES WITH MULTI-FUNCTIONAL PROPERTIES

California Institute of T...

1. A method of fabricating a multi-functional multilayer article comprising:
determining a shape for the article and defining at least two spatially separated regions on said article, said two regions
to be formed of at least two distinct materials being joined by at least one compositional gradient transition region;

mapping a compositional gradient pathway onto said article between said at least two regions such that the at least one compositional
gradient transition region substantially excludes any undesirable compositional phases; and

forming the article, wherein at least the at least one compositional gradient transition region comprises a plurality of distinct
gradient layers formed by incrementally adjusting the compositional ratio between the at least two distinct materials.

US Pat. No. 9,476,129

SOLAR FUELS GENERATOR

California Institute of T...

1. A solar fuels generator, comprising:
an ionically conductive separator between a first phase and a second phase;
a photoanode that uses one or more components of the first phase to generate cations during operation of the solar fuels generator;
and

a solid cation conduit positioned such that the cations that travel along a pathway from the photoanode to the separator are
conducted through the solid cation conduit.

US Pat. No. 9,357,202

HIGH RESOLUTION IMAGING DEVICES WITH WIDE FIELD AND EXTENDED FOCUS

California Institute of T...

1. A high resolution imaging device with wide field and extended focus, comprising:
a body comprising a light detector layer outside a transparent surface element;
a beam generator having a beam generator surface, the beam generator configured to generate a plurality of nondiffracting
beams, each nondiffracting beam having a substantially constant spot size and a beam length, wherein each nondiffracting beam
is configured to propagate imaging illumination along the beam length;

a scanning mechanism for moving the plurality of nondiffracting beams through an object being imaged between the beam generator
surface and the transparent surface element or moving the object through the plurality of nondiffracting beams in order to
propagate the imaging illumination m lengths of the nondiffracting beams through a volume of the object;

a light detector in the light detector layer, the light detector configured to receive light incident across the light detector
layer and measure light data associated with the plurality of nondiffracting beams illuminating the volume of the object;
and

a processor configured to generate an image of the object based on the light data measured by the light detector, wherein
the image is at a focal plane within the extended depth of focus defined by the beam lengths of the nondiffracting beams.

US Pat. No. 9,096,519

PROCESS FOR THE SYNTHESIS OF KETONES FROM INTERNAL ALKENES

California Institute of T...

1. A method comprising contacting an organic substrate, having an initial internal olefin, with a mixture of
(a) a biscationic palladium salt; and
(b) an oxidizing agent;dissolved or dispersed in a solvent system to form a reaction mixture, said solvent system comprising at least one C2-6 carbon nitrile and optionally at least one secondary alkyl amide, said method conducted under conditions sufficient to convert
at least 50 mol % of the initial internal olefin to a ketone, said ketone positioned on a carbon of the initial internal olefin.
US Pat. No. 9,231,180

NANOSTRUCTURED SILICIDE COMPOSITES FOR THERMOELECTRIC APPLICATIONS

California Institute of T...

1. A method of preparing a nanocomposite thermoelectric material comprising:
heating a reaction mixture comprising a semiconductor material and a metal complex to a temperature greater than the decomposition
temperature of the metal complex, wherein the semiconductor material comprises Si, wherein the metal complex comprises a transition
metal, wherein the heating initiates a reaction between the transition metal and the semiconductor material that forms metallic
inclusions having a size less than about 100 nm that are substantially evenly distributed throughout the semiconductor material,
and wherein the metallic inclusions comprise a silicide of the formula

Mx-1Six
wherein
M is the transition metal, and
subscript x is greater than 1,
thereby preparing the nanocomposite thermoelectric material.