US Pat. No. 9,649,064

CONTROLLED SYMPATHECTOMY AND MICRO-ABLATION SYSTEMS AND METHODS

AUTONOMIX MEDICAL, INC., ...

1. A system, comprising:
a tool comprising:
a delivery catheter;
one or more microfingers having substantially elongate structures;
a plurality of sensing tips electrically and mechanically coupled to the one or more microfingers, the plurality of sensing
tips configured to interface with a wall of a lumen coupled to an organ of a subject on deployment of the one or more microfingers
from the delivery catheter; and

a local control circuit embedded in the substantially elongate structure of at least one of the one or more microfingers;
and

a feedback system coupled to the tool;
wherein the tool is configured:
to apply a procedure to a first region in a vicinity of the lumen via delivery of at least one of energy and a chemical to
at least one of the plurality of sensing tips under control of the local control circuit; and

to apply a follow on procedure to a second region in the vicinity of the lumen via delivery of at least one of energy and
a chemical to at least one of the plurality of sensing tips under control of the local control circuit, the second region
being located equidistant or closer to the organ than the first region;

to monitor one or more physiologic parameters of the subject utilizing at least one of the plurality of sensing tips after
application of the follow on procedure;

to condition one or more signals representing the monitored physiologic parameters utilizing the local control circuit; and
to convey the conditioned one or more signals representing the monitored physiologic parameters to the feedback system;
wherein the feedback system is configured:
to receive the conditioned one or more signals representing the monitored physiologic parameters;
to analyze the received signals to determine one or more changes in the physiologic parameters; and
to convey an outcome of the procedure to an operator based upon the determined changes in the physiologic parameters.

US Pat. No. 9,968,790

ENDOSCOPIC SYMPATHECTOMY SYSTEMS AND METHODS

AUTONOMIX MEDICAL, INC., ...

1. A microsurgical tool, comprising:an endoscopically deliverable elongate structure configured so as to extend from an entry site within a body to a vicinity of an organ; and
at least one sensing tip electrically and mechanically coupled to the elongate structure, the at least one sensing tip being configured:
to interface with tissues in the vicinity of the organ;
to measure local neural activity associated with the tissues in the vicinity of the organ; and
to convey one or more electrophysiological signals associated with an electrophysiological activity;
wherein the at least one sensing tip comprises a clamp structure having an inner surface configured to contact the tissues in the vicinity of the organ and an outer surface opposite the inner surface; and
wherein the at least one sensing tip comprises:
a plurality of electrodes arranged on the inner surface of the clamp, the plurality of electrodes comprising one or more sensing electrodes configured to measure the local neural activity associated with the tissues in the vicinity of the organ; and
one or more additional electrodes arranged on the outer surface of the clamp, the one or more additional electrodes arranged on the outer surface of the clamp being configured to determine a reference signal used by the at least one sensing tip to cancel out ambient environmental action potentials and noise from measurements of the local neural activity by the one or more sensing electrodes on the inner surface of the clamp; and
wherein the clamp structure comprises a self-wrapping tool.

US Pat. No. 9,730,639

ELONGATED CONDUCTORS AND METHODS OF MAKING AND USING THE SAME

Autonomix Medical, Inc., ...

1. An elongated conductor comprising:
an elongated structure having a proximal region and a distal region and comprising two or more insulated conducting members
that are in fixed relative position along at least a portion of the elongated structure and extend from the proximal region
to the distal region; and

a pattern of insulation openings among the insulated conducting members at one or both of the proximal and distal regions;
wherein the insulated conducting members assume a wound configuration along at least a portion of the elongated structure.

US Pat. No. 9,956,034

SYSTEMS, METHODS, AND DEVICES FOR MONITORING AND TREATMENT OF TISSUES WITHIN AND/OR THROUGH A LUMEN WELL

AUTONOMIX MEDICAL, INC., ...

1. A tool, comprising:an elongate member with a distal tip and a control end, the distal tip thereof shaped and dimensioned so as to fit within a lumen, the elongate member shaped and dimensioned so as to extend from an entry site on a body into the lumen; and
one or more probes each configured with a probe tip, the probes deploy-ably coupled with the distal tip of the elongate member and at least one of electrically, mechanically, and fluidly coupled to the control end of the elongate member, the probe tips shaped so as to at least one of penetrate into and penetrate through a wall of the lumen upon deployment from the elongate member, one or more of the probes comprising one or more electrodes electrically coupled to the probes, one or more of the electrodes configured to at least one of convey a signal associated with an electrophysiological activity and to alter the electrophysiological activity upon deployment;
wherein the tool is configured for at least one of monitoring and altering electrophysiological activity within the vicinity of the lumen within the body; and
a controller configured:
to record one or more electrophysiological signals from monitored electrophysiological activity within the vicinity of one or more of the electrodes coupled to the probes;
to cancel one or more movement artifacts from the recorded electrophysiological signals utilizing a corrective signal, the corrective signal being generated from monitoring one or more physiological parameters of the subject at a location remote from the vicinity of the one or more electrodes coupled to the probes.

US Pat. No. 10,004,458

SYSTEMS AND METHODS FOR NEUROLOGICAL TRAFFIC AND/OR RECEPTOR FUNCTIONAL EVALUATION AND/OR MODIFICATION

AUTONOMIX MEDICAL, INC., ...

22. A system for neuromodulating an anatomical site in a vicinity of a lumen, comprising:a subsystem configured to perform a surgical procedure on the anatomical site;
a guidewire configured to monitor electrophysiological activity within a parenchyma of an organ coupled to the lumen and to generate one or more signals therefrom; and
a control unit configured to accept signals from the guidewire, and to at least one of: adjust the surgical procedure dependent upon the signals; display the signals; evaluate the surgical procedure dependent upon the signals; plan a surgical path dependent upon the signals; and determine the extent of the procedure dependent upon the signals;
wherein the guidewire comprises:
an elongate body dimensioned for insertion into a lumen within a body; and
a sensing tip electrically and mechanically coupled to the elongate body, configured to interface with the wall of the lumen, the sensing tip configured to convey one or more electrophysiological signals associated with an electrophysiological activity in the vicinity of an anatomical site of interest within the vicinity of the lumen;
wherein the sensing tip comprises:
a flexible substrate dimensioned to form a base and two or more tines extending from the base;
a plurality of electrodes formed on the two or more tines of the flexible substrate;
one or more microcircuits formed on the base of the flexible substrate;
one or more conducting traces formed on the flexible substrate providing electrical interconnection between the one or more microcircuits and the plurality of electrodes; and
one or more interconnects for coupling at least one of the one or more microcircuits formed on the base of the flexible substrate with one or more power and signal lead wires; and
wherein the flexible substrate is rolled to form the sensing tip.

US Pat. No. 10,022,085

CONTROLLED SYMPATHECTOMY AND MICRO-ABLATION SYSTEMS AND METHODS

AUTONOMIX MEDICAL, INC., ...

1. A method, comprising the steps of:applying a procedure to a first region in a vicinity of a lumen coupled to an organ in a subject via delivery of at least one of energy and a chemical to at least one of a plurality of sensing tips of a tool under control of a local control circuit, the tool comprising a delivery catheter, one or more microfingers having substantially elongate structures, the plurality of sensing tips electrically and mechanically coupled to the one or more microfingers, and the local control circuit embedded in the substantially elongate structure of at least one of the one or more microfingers, wherein the plurality of sensing tips are configured to interface with a wall of the lumen coupled to the organ on deployment of the one or more microfingers from the delivery catheter;
subsequently applying a follow on procedure to a second region in the vicinity of the lumen via delivery of at least one of energy and a chemical to at least one of the plurality of sensing tips under control of the local control circuit, the second region being equidistant or closer to the organ than the first region;
monitoring one or more physiologic parameters of the subject utilizing at least one of the plurality of sensing tips after application of the follow on procedure;
conditioning one or more signals representing the monitored physiologic parameters utilizing the local control circuit;
conveying the conditioned one or more signals representing the monitored physiologic parameters to a feedback system coupled to the tool;
analyzing the conditioned one or more signals utilizing the feedback system to determine one or more changes in the physiologic parameters; and
determining an outcome of the procedure based upon the determined changes in the physiologic parameters.

US Pat. No. 10,238,340

ELONGATED CONDUCTORS AND METHODS OF MAKING AND USING THE SAME

Autonomix Medical, Inc., ...

1. A method comprising:contacting an effector of a device comprising:
(a) an elongated conductor comprising:
(i) an elongated structure having a proximal region and a distal region and comprising two or more insulated conducting members that are in fixed relative position along at least a portion of the elongated structure and extend from the proximal region to the distal region; and
(ii) a pattern of insulation openings among the insulated conducting members at one or both of the proximal and distal regions;
(b) a connector positioned at the proximal end of the elongated conductor; and
(c) the effector positioned at the distal end of the elongated conductor;
with a tissue location of a living subject.

US Pat. No. 10,092,241

ELONGATED CONDUCTORS AND METHODS OF MAKING AND USING THE SAME

Autonomix Medical, Inc., ...

1. An elongated conductor comprising:an elongated structure having a proximal region and a distal region and comprising two or more insulated conducting members that are in fixed relative position along at least a portion of the elongated structure and extend from the proximal region to the distal region, wherein the insulated conducting members are not present in a wound configuration along at least a portion of the elongated structure; and
a pattern of insulation openings among the insulated conducting members at one or both of the proximal and distal regions.

US Pat. No. 10,143,419

SYSTEMS AND METHODS FOR TREATING CANCER AND/OR AUGMENTING ORGAN FUNCTION

AUTONOMIX MEDICAL, INC., ...

1. A system, comprising:one of a catheter and a guidewire dimensioned for insertion into a lumen comprising a wall, the lumen being in fluid communication with at least one of a target organ and a tumor;
one of the catheter and the guidewire comprising a distal tip configured to interface with the wall of the lumen, the distal tip configured to deliver at least one of an energy and a substance to at least one of: one or more nerves coupled to the target organ; and the wall of the lumen;
one or more sensing elements coupled with the distal tip; and
a controller coupled to one of the catheter and the guidewire, the controller being configured:
to utilize at least one of the one or more sensing elements coupled with the distal tip to acquire positional information related to placement of the distal tip relative to the target organ;
to apply a stimulus to the target organ while monitoring neural traffic along the wall of the lumen utilizing at least one of the one or more sensing elements;
to adjust placement of the distal tip relative to the target organ based on the monitored neural traffic along the wall of the lumen; and
to control delivery of at least one of the energy and the substance to the target organ to alter one or more neural structures coupled to the tumor;
wherein the controller is configured to adjust the placement of the distal tip relative to the target organ based on the monitored neural traffic along the wall of the lumen to a desired location relative to the target organ by monitoring the neural traffic along the wall of the lumen in response to the applied stimulus until the monitored neural traffic registers a desired response to the applied stimulus.

US Pat. No. 10,206,616

DEVICES, SYSTEMS, AND METHODS FOR DIAGNOSIS AND TREATMENT OF OVERACTIVE BLADDER

AUTONOMIX MEDICAL, INC., ...

1. An apparatus, comprising:an elongate delivery member configured to be inserted into a bladder through a urethra;
a therapy delivery element coupled with the elongate delivery member, the therapy delivery element being configured to interface with a tissue in a target region of a bladder wall to provide therapy to the target region;
one or more sensing tips electrically and mechanically coupled with the elongate delivery member, the sensing tips being configured to interface with one or more tissue surfaces of at least one of the bladder wall and the urethra, the sensing tips configured to convey one or more electrophysiological signals associated with the tissue surfaces at least one of before, during, and after the therapy;
wherein the apparatus is configured to neuromodulate bladder function;
wherein a given one of the sensing tips comprises:
one or more electrodes on a tissue-interfacing surface thereof; and
a degradable support structure configured to dissolve in the presence of a liquid;
wherein the degradable support structure is arranged relative to the tissue-interfacing surface of the given sensing tip such that the degradable support structure when placed beside the bladder wall and wetted dissolves to cause one or more of the electrodes on the tissue-interfacing surface of the given sensing tip to contact the bladder wall; and
a housing configured for implantation inside the bladder, the housing comprising one or more microcircuits, an antenna and at least one of the sensing tips, the one or more microcircuits configured:
to monitor electrophysiological signals at said at least one sensing tip;
to perform signal conditioning of the monitored electrophysiological signals; and
to convey the conditioned electrophysiological signals to an external reader outside the bladder utilizing the antenna;
wherein the housing comprises a coating, the coating comprising a neuromodulating substance in a biodegradable retaining medium, the biodegradable retaining medium configured to provide controlled release of the neuromodulating substance into the tissue in the target region of the bladder wall.

US Pat. No. 10,136,944

SYSTEMS AND METHODS FOR TREATING CANCER AND/OR AUGMENTING ORGAN FUNCTION

AUTONOMIX MEDICAL, INC., ...

1. A composition, for use in blocking at least one of one or more nerves and one or more lymphatic ducts, comprising:a neurolytic agent;
a sympathetic nerve selective neurotoxin for ablating a region surrounding a nutrient artery of a bone; and
an inflammatory agent;
wherein the neurolytic agent comprises ethanol;
wherein the inflammatory agent comprises one or more of poly(lactic-co-glycolic acid) (PLGA), polysaccharides, collagen, silica particles, carbon micro or nanoparticles, and microbeads; and
wherein the sympathetic nerve selective neurotoxin comprises at least one of 6-hydroxydopamine, ?-conotoxin, and bungarotoxin.

US Pat. No. 10,226,633

ENDOSCOPIC SYMPATHECTOMY SYSTEMS AND METHODS

AUTONOMIX MEDICAL, INC., ...

1. A microsurgical tool comprising:an endoscopically deliverable elongate structure configured so as to extend from an entry site within a body to a vicinity of an organ;
at least one sensing tip electrically and mechanically coupled to the endoscopically deliverable elongate structure, the at least one sensing tip comprising a plurality of electrodes arranged on at least one surface thereof, the at least one sensing tip being configured:
to interface with tissues in the vicinity of the organ;
to measure local neural activity associated with the tissues in the vicinity of the organ utilizing one or more of the plurality of electrodes; and
to convey one or more electrophysiological signals associated with an electrophysiological activity;
wherein the at least one surface of the at least one sensing tip comprises a self-wrapping tool; and
wherein the at least one surface of the at least one sensing tip comprises one or more microchannels, the one or more microchannels being configured to provide a vacuum to provide movement of the self-wrapping tool.

US Pat. No. 10,363,359

SYSTEMS AND METHODS FOR REGULATING ORGAN AND/OR TUMOR GROWTH RATES, FUNCTION, AND/OR DEVELOPMENT

AUTONOMIX MEDICAL, INC., ...

1. An apparatus comprising:an elongate member comprising a distal tip, the distal tip configured to fit within a lumen of a body of a subject, the elongate member configured to extend from outside the body, through an entry site on the body, and into the lumen;
wherein the distal tip comprises a plurality of elements, the plurality of elements arranged on the distal tip such that biasing the distal tip engages one or more of the plurality of elements with a wall of the lumen;
wherein the plurality of elements comprises at least one chemical delivery element and at least one sensory circuit, the at least one chemical delivery element comprising one or more probes, at least one of the one or more probes being configured to penetrate through the wall responsive to actuation by a controller;
wherein at least one of the one or more probes is configured, responsive to feedback from the at least one sensory circuit, to deliver a composition of matter to a tissue site beyond the wall of the lumen to apply a block to a target region of the subject; and
wherein the composition of matter comprises at least one of a neurolytic agent and an inflammatory agent for use in blocking at least one of one or more nerves and one or more lymphatic ducts in the target region;
wherein the feedback from the at least one sensory circuit comprises a quantification of nerve activity of the one or more nerves in the target region.

US Pat. No. 10,485,484

ELONGATED CONDUCTORS AND METHODS OF MAKING AND USING THE SAME

Autonomix Medical, Inc., ...

1. A device comprising:(a) an elongated conductor comprising:
(i) an elongated structure having a proximal region and a distal region and comprising two or more insulated conducting members that are in fixed relative position along at least a portion of the elongated structure and extend from the proximal region to the distal region; and
(ii) a pattern of insulation openings among the insulated conducting members at one or both of the proximal and distal regions;
(b) a connector positioned at the proximal end of the elongated conductor; and
(c) an effector positioned at the distal end of the elongated conductor.

US Pat. No. 10,470,684

CONTROLLED SYMPATHECTOMY AND MICRO-ABLATION SYSTEMS AND METHODS

Autonomix Medical, INC., ...

1. A microsurgical tool for monitoring electrophysiological activity within the vicinity of a lumen, the microsurgical tool comprising:a microfinger having a substantially elongate structure configured so as to bias a region thereof against a wall of the lumen upon deployment within the lumen;
a plurality of sensing tips electrically and mechanically coupled to the microfinger in the vicinity of the region, configured to interface with the wall of the lumen, a given one of the sensing tips configured:
to measure electrophysiological activity within the vicinity of the lumen; and
to convey, to an extracorporeal system, one or more electrophysiological signals associated with the measured physiological activity within the vicinity of the lumen; and
a microcircuit electrically coupled to the given sensing tip and attached to the microfinger proximate to the given sensing tip such that, upon deployment of the microfinger within the lumen, the microcircuit is positioned in the lumen;
wherein the microcircuit is configured to condition the electrophysiological signals sensed by the given sensing tip within the lumen prior to conveying the electrophysiological signals outside the lumen to the extracorporeal system;
wherein conditioning the electrophysiological signals sensed by the given sensing tip comprises at least one of: converting the electrophysiological signals into digital form; and amplifying the electrophysiological signals;
wherein the given sensing tip comprises a first core flexure and at least a second core flexure;
wherein the first core flexure and the second core flexure each comprise at least one region covered with an insulating layer and at least one exposed region;
wherein the first core flexure comprises a first exposed region providing a first electrode at a tip region of the given sensing tip;
wherein the second core flexure comprises a second exposed region providing at least a second electrode at a shank region of the given sensing tip;
wherein a portion of the insulating layer extends between the first and second exposed regions; and
wherein the microcircuit is configured to utilize electrophysiological signals measured by the first electrode and the second electrode to monitor neural activity differences between the tip region and the shank region of the given sensing tip.