US Pat. No. 9,462,943

APPARATUS, SYSTEM AND METHOD FOR PRECISION DEPTH MEASUREMENT

AMO Development, LLC, Sa...

1. A method of locating tissue layers within a cornea, the cornea having an anterior surface, a posterior surface, and a photodisruption
threshold, the method comprising the steps of:
generating a pulsed laser beam from a femtosecond laser, the laser beam having a wavelength between 400 nm to 3000 nm and
a pulse width from 100 femtoseconds to 10 nanoseconds;

focusing the laser beam to a laser spot having an energy level such that the irradiance of the laser spot is below the photodisruption
threshold of the cornea;

varying a position of the laser spot between the anterior surface of the cornea and the posterior surface of the cornea and
across at least one transition of the tissue layers, a harmonic signal being produced as the laser spot propagates in the
cornea wherein the harmonic signal has an intensity correlated with a density of the cornea; and

determining the transition of the tissue layers based on a change in the harmonic signal, the change comprising a change in
the intensity of the harmonic signal.

US Pat. No. 9,138,351

METHOD FOR SCANNING A PULSED LASER BEAM

AMO Development, LLC, Sa...

1. A method of photoaltering a sub-surface region of a patient's cornea using a pulsed laser beam to create a corneal flap,
the sub-surface region having an outer periphery, a first portion defined within and circumscribed by the periphery, and a
second portion smaller than and located within the first portion, the method comprising the steps of:
transmitting the pulsed laser beam with a scanner to the first portion of the region in accordance with only a first laser
scan pattern based on a continuous scan of the pulsed laser beam, the first laser scan pattern requiring a first maximum scanner
movement acceleration associated with the second portion;

transmitting the pulsed laser beam with a scanner to the second portion of the region in accordance with only a second laser
scan pattern based on a continuous scan of the pulsed laser beam and that is different than the first laser scan pattern,
the second laser scan pattern requiring a second maximum scanner movement acceleration associated with the second portion
that is less than the first maximum scanner movement acceleration; and

separating a corneal flap of the material at the region.

US Pat. No. 9,158,084

SCANNING LENS SYSTEMS AND METHODS OF REDUCING REACTION FORCES THEREIN

AMO Development, LLC, Sa...

16. A scanning lens system comprising:
a primary axis stage including a first central opening for receiving an incident beam of light, the primary axis stage movable
along a primary axis in a first direction and in an opposite second direction;

a transverse axis stage disposed adjacent to the primary axis stage and including a second central opening for receiving the
incident beam of light, the transverse axis stage movable along a transverse axis in a third direction and in an opposite
fourth direction, and the transverse axis being substantially orthogonal to the primary axis;

a lens coupled to the transverse axis stage;
a primary axis voice coil motor coupled to the primary axis stage and including a first coil movable with the primary axis
stage and a first magnet configured to move along the primary axis in the second direction, if the primary axis stage moves
a distance along the primary axis in the first direction that exceeds a first predetermined threshold value; and

a transverse axis voice coil motor coupled to the transverse axis stage including a second coil movable with the transverse
axis stage and a second magnet configured to move along the transverse axis in the fourth direction, if the transverse axis
stage moves a distance along the transverse axis in the third direction that exceeds a second predetermined threshold value.

US Pat. No. 9,402,714

METHOD OF TRANSPLANTING A CORNEA

AMO Development, LLC, Sa...

10. A method of transplanting a cornea from a donor to a recipient in preparation for performing a Laser Assisted In-Situ
Keratomileusis (“LASIK”) procedure, the method comprising:
excising a corneal section from a donor cornea, wherein the donor cornea has an anterior surface;
photoaltering stromal tissue within the corneal section to form an undercut within the stromal tissue, wherein the undercut
is formed posterior to the anterior surface of the donor cornea so that underlying stromal tissue of the donor cornea is disposed
posterior to the undercut;

photoaltering the corneal section to form a sidecut, the sidecut extending only partially circumferentially about a central
portion of the donor cornea, wherein the combination of the undercut and the sidecut form a corneal flap; and

grafting the photoaltered corneal section including the corneal flap onto an eye of a recipient wherein after grafting the
donor cornea, the underlying stromal tissue of the donor cornea is located immediately below the undercut and the overlying
stromal tissue of the donor cornea is located immediately above the undercut, and wherein lifting of the corneal flap of the
donor cornea provides access for performing the LASIK procedure on the underlying stromal tissue of the donor cornea.

US Pat. No. 9,295,584

CUSTOMIZED LASER EPITHELIAL ABLATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A system to treat a region of a cornea of an eye, the region comprising an epithelial layer disposed over a stromal layer,
the system comprising:
a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness
over the region;

a device configured to determine a refractive optical property of the eye;
a laser to generate a laser beam of an ablative radiation;
a movable scan component coupled to the laser to scan the laser beam over the region; and
a processor system coupled to the laser and the movable scan component, the processor system comprising a tangible medium
configured to:

(1) arrange epithelial pulses of laser beam to ablate the epithelial layer and expose at least one of the stromal layer or
a Bowman's membrane, the epithelial pulses arranged by the processor system in response to at least (i) the epithelial thickness
map, and (ii) epithelial basis data corresponding to at least one epithelial laser pulse ablation profile for an individual
pulse; and

(2) arrange additional pulses of laser beam to resculpt the stromal layer in response to at least (i) the determined refractive
optical property of the eye, and (ii) stromal basis data corresponding to at least one stromal laser pulse ablation profile
for an individual pulse that is different from the at least one epithelial laser pulse ablation profile,

wherein the at least one stromal laser pulse ablation profile has an inner portion flat curvature and the at least one epithelial
laser pulse ablation profile has an inner portion flat curvature that is sized differently than the inner portion flat curvature
of the at least one stromal laser pulse ablation profile, or

wherein the at least one stromal laser pulse ablation profile has an inner portion convex curvature and the at least one epithelial
laser pulse ablation profile has an inner portion convex curvature that is sized differently than the inner portion convex
curvature of the at least one stromal laser pulse ablation profile.

US Pat. No. 9,662,006

ACCOMMODATION COMPENSATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of determining a vision correction treatment for administration to an eye of a patient, the method comprising:
obtaining an ocular aberration measurement of a lens of the eye, the ocular aberration measurement based on a first induced
metric for the lens that corresponds to a first accommodation state of the eye and a second induced metric for the lens that
corresponds to a second accommodation state of the eye; and

determining a prescription of the vision correction treatment, wherein the prescription is based on the ocular aberration
measurement of the lens.

US Pat. No. 9,398,978

SYSTEMS AND METHODS FOR REMOVING FIXATION LIGHT REFLECTION FROM AN OPHTHALMIC IMAGE

AMO Development, LLC, Sa...

1. An ophthalmic treatment system comprising:
one or more visual fixation systems configured to produce one or more fixation lights upon which a patient's eye can be focused;
a digital microscope positioned to capture an image of the patient's eye, wherein the digital microscope capture images in
sequential frames with an inter-frame time period between the frames during which the digital microscope does not capture
image data;

a display device operably coupled to the digital microscope to display the image of the patient's eye captured by the digital
microscope; and

a switch operably coupled to the digital microscope and the one or more visual fixation systems and configured to cause any
of the one or more visual fixation systems to produce the visual fixation lights only during the inter-frame periods of the
digital microscope, wherein no fixation light enters the patient's eye during time periods when the digital microscope captures
the images in the sequential frames.

US Pat. No. 9,198,572

ACCOMMODATION COMPENSATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. An apparatus for determining an appropriate presbyopia treatment modality for an eye of a patient, the eye having a vision
deficiency, the apparatus comprising:
a first input configured to receive a first induced metric for the eye that corresponds to a first viewing condition;
a second input configured to receive a second induced metric for the eye that corresponds to a second viewing condition;
a first module configured to determine the difference between the first induced metric and the second induced metric;
a second module configured to determine an accommodation characteristic of the eye if the difference between the first induced
metric and second induced metric does not exceed a predetermined threshold;

a third module configured to determine a residual accommodation of the eye based on the accommodation characteristic;
a fourth module configured to receive an ocular aberration measurement of the eye; and
a fifth module configured to determine a presbyopia treatment modality for the eye based on the residual accommodation and
the ocular aberration measurement.

US Pat. No. 9,521,949

OPHTHALMIC RANGE FINDING

AMO Development, LLC, Sa...

1. A system for analyzing a patient's eye comprising:
a laser configured for directing a pulsed laser beam along a path;
an optical beam-splitting device disposed along the path from the laser, the optical beam-splitting device configured to polarize
and rotate the polarity of the laser beam;

an objective component including a focusing lens to focus the laser beam within the eye;
a sensor oriented along the path, wherein the sensor receives a back-reflected laser beam from the eye, and generates a signal
corresponding to that laser beam; and

a computing device communicatively coupled with the sensor and configured to receive the signal, wherein the computing device
determines a position of an anatomical feature of the eye based on the signal.

US Pat. No. 9,421,131

SYSTEM AND METHOD OF IRIS-PUPIL CONTRAST ENHANCEMENT

AMO Development, LLC, Sa...

1. A method of photoaltering a region of an eye using a non-ultraviolet, ultrashort pulsed laser beam, the eye having an iris
and a pupil, the method comprising the steps of:
producing a first digital image of the eye, the first digital image having a first contrast between the iris and the pupil,
wherein the step of producing the first digital image of the eye comprises capturing an image of the eye with a digital camera
having an image sensor, the digital camera having a gamma function setting which converts a brightness of portions of the
image captured by the image sensor to a brightness of each pixel displayed on an imaging interface, wherein the first digital
image having the first contrast is produced based on the gamma function setting of the digital camera which is set to a linear
default gamma function setting; and

displaying the first digital image of the eye on the imaging interface;
manually activating a user-selectable button to increase the first contrast between the iris and the pupil to a second contrast
by modifying the digital camera's gamma function from the linear default setting to a non-linear function that enhances contrast
of the pixels displayed on the imaging interface between the pupil and darker colored irises, wherein the non-linear function
increases the contrast of the pixels displayed on the imaging interface between the pupil and darker colored irises based
on values in a look-up table stored in a data storage device;

displaying a second digital image of the eye on the imaging interface, the second digital image having the second contrast;
centrating the eye based on the second contrast between the iris and the pupil; and
directing the non-ultraviolet, ultrashort pulsed laser beam at the region after the step of centrating to photoalter the region.

US Pat. No. 9,393,156

VARYING A NUMERICAL APERTURE OF A LASER DURING LENS FRAGMENTATION IN CATARACT SURGERY

AMO Development, LLC, Sa...

1. A laser cataract surgery control system comprising:
a laser source configured to emit a laser beam;
a controller comprising one or more physical processors;
a fragmentation module configured to use the one or more physical processors to determine a laser lens fragmentation treatment
plan by determining:

a first region of a lens of a patient's eye to receive a first focus of the laser beam having a first numerical aperture;
and

a second region of the lens of the patient's eye to receive a second focus of the laser beam having a second numerical aperture,
the second numerical aperture being lower than the first numerical aperture, and the second region being radially closer,
on average, to an iris of the patient's eye than the first region;

a laser control module in communication with the laser source and configured to:
control the laser source to deliver the laser beam having the first numerical aperture and a first energy to the first region
of the lens; and

control the laser source to deliver the laser beam having the second numerical aperture and a second energy to the second
region of the lens without delivering the laser beam having the first numerical aperture and the first energy to the second
region of the lens,

wherein the first numerical aperture and the first energy are configured to deliver a first peak laser energy to a retina
of the patient's eye that is less than or equal to a safety threshold.

US Pat. No. 9,763,831

HIGH-ORDER OPTICAL CORRECTION DURING CORNEAL LASER SURGERY

AMO Development, LLC, Sa...

1. A system for imposing a defect-correcting prescription on an eye having a cornea, the system comprising:
a wavefront system that measures optical aberrations of the eye;
an ablative laser that controllably releases laser energy toward the cornea; and
a processor communicatively coupled to the wavefront system and the ablative laser, the processor comprising a tangible medium
comprising instructions that when executed cause the processor to:

process the optical aberrations measured by the wavefront system to generate the defect-correcting prescription for the eye,
determine an ablation profile corresponding to the defect-correcting prescription,
segment the ablation profile into at least a first-segment profile and a second-segment profile, the second-segment profile
corresponding to ablations for imposing at least one high-order optical correction on the cornea,

determine a sequence of laser-energy ablations to impose the ablation profile on the cornea, and
control the ablative laser to direct the sequence of laser energy toward the cornea to impose the ablation profile on the
cornea, wherein the sequence comprises applying ablations corresponding to the first-segment profile prior to applying ablations
corresponding to the second-segment profile.

US Pat. No. 9,592,158

OPERATOR-CONTROLLED SCANNING LASER PROCEDURE DESIGNED FOR LARGE-AREA EPITHELIUM REMOVAL

AMO Development, LLC, Sa...

1. A system to ablate an eye to remove an epithelial layer disposed over a stromal layer in a cornea of the eye, the system
comprising:
a laser to generate a pulsed beam of an ablative radiation;
a movable structure disposed along the laser beam path to adjust a size of the laser beam to at least one smaller size and
at least one larger size;

a movable scan component configured to scan the adjustably sized laser beam over a region of the eye in accordance with a
pulse sequence to ablate the epithelial layer; and

a processor system comprising a tangible medium and a memory, the processor system coupled to the laser, the movable structure
and the movable scan component, the processor system configured to scan the ablative radiation to vary a location of the beam
in accordance with the pulse sequence, wherein the pulse sequence is arranged in response to a plurality of epithelial layer
ring shaped basis profiles, wherein at least some of the plurality of epithelial layer ring shaped basis profiles each comprise
a central portion corresponding to no ablation wherein the pulsed beam of the ablative radiation removes the epithelial layer
to expose at least one of the stromal layer or bowman's membrane and wherein the sequence of pulses of the beam is arranged
to enhance optical feedback based on the tissue fluorescence so that areas of the epithelium larger than the beam can be ablated
and tissue penetration detected.

US Pat. No. 9,345,621

HIGH-ORDER OPTICAL CORRECTION DURING CORNEAL LASER SURGERY

AMO Development, LLC, Sa...

1. A method for sequencing an ablation of a cornea of an eye to impose a defect-correcting prescription on the eye, the method
comprising:
providing the defect-correcting prescription, the prescription comprising a high-order optical correction;
determining an ablation profile to impose the prescription on the cornea, the ablation profile comprising a first-segment
profile and a second-segment profile, the second-segment profile corresponding to at least one high-order optical correction;
and

determining a sequence of laser-energy ablations to impose the ablation profile on the cornea, wherein the sequence comprises
applying ablations corresponding to the first-segment profile prior to applying ablations corresponding to the second segment
profile; providing a wavefront elevation map of optical aberrations of the eye, and determining the defect-correcting prescription
in response to the wavefront elevation map.

US Pat. No. 9,050,030

ZONE EXTENSION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A computer program product for treating a particular patient with a prescription that mitigates or treats a vision condition
of an eye of the patient, the computer program product comprising:
code for accepting a first wavefront map of the eye that corresponds to a first geometrical configuration of the eye in an
evaluation context, the first wavefront map characterized by an original set of coefficients for a basis function that can
be separated into a product of a first set of radial polynomials and a first triangular function;

code for determining a second wavefront map of the eye that corresponds to a second geometrical configuration of the eye in
a treatment context, a difference between the first geometrical configuration of the eye and the second geometrical configuration
of the eye comprising a pupil dilation, the second wavefront map characterized by a transformed set of coefficients for the
basis function that is based on the first geometrical configuration of the eye, the original set of coefficients, and the
second geometrical configuration of the eye, such that each coefficient of the transformed set of coefficients is based on
a corresponding coefficient of the original set of coefficients and a corresponding polynomial;

code for establishing the prescription for the particular patient based on the transformed set of coefficients; and
code for providing instructions to a laser ablation system to modify an optical tissue surface of the eye of the patient according
to the prescription.

US Pat. No. 9,642,518

RANDOM EYE GENERATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of evaluating a vision treatment protocol, the method comprising:
obtaining the vision treatment protocol;
obtaining a random eye generator comprising a first optical parameter, wherein the random eye generator has a Rayleigh distribution
for the first optical parameter; and

evaluating the vision treatment protocol using the random eye generator.

US Pat. No. 9,155,658

SYSTEMS AND METHODS FOR DYNAMIC PATIENT FIXATION SYSTEM

AMO Development, LLC, Sa...

1. An ophthalmic laser-based treatment system comprising:
a laser delivery system for delivering a pulsed laser beam to an eye;
an eye fixation system positioned proximate to the laser delivery system and configured to cause the eye to be fixated at
a desired position, the eye fixation system including one or more light sources generating one or more light beams which are
different from the pulsed laser beam, wherein the laser delivery system delivers the one or more light beams from the eye
fixation system to the eye; and

an eye fixation adjustment system configured to dynamically adjust the eye fixation system to change one or more of: location,
number of beams, pattern, color, brightness, size, and duration, of the one or more light beams in response to an input during
an ophthalmic laser treatment procedure.

US Pat. No. 9,108,270

SYSTEM AND METHOD FOR SCANNING A PULSED LASER BEAM

AMO DEVELOPMENT, LLC, Sa...

1. A system for photoaltering a cornea, the cornea having first and second regions and a surface layer, the second region
being a central region surrounded by the first region, and the first and second regions underlying the surface layer of the
cornea, the system comprising:
a laser configured to produce a pulsed laser beam;
a controller configured to select at least a first laser scan pattern and a second laser scan pattern that is different than
the first laser scan pattern, the laser scan patterns each based on a continuous scan of the pulsed laser beam, the first
laser scan pattern having a first maximum scanner movement acceleration associated with the second region, the second laser
scan pattern having a second maximum scanner movement acceleration associated with the second region, the second maximum scanner
movement acceleration being less than the first maximum scanner movement acceleration; and

a scanner operable in response to the controller to:
transmit the pulsed laser beam to the first region of the material in accordance with only the first laser scan pattern;
transmit the pulsed laser beam to the second region of the material in accordance with only the second laser scan pattern;
and

transmit the pulsed laser beam to the first and second regions of the cornea to at least partially separate the surface layer
from the cornea.

US Pat. No. 9,744,077

METHODS OF LASER MODIFICATION ON INTRAOCULAR LENS

AMO Development, LLC, Sa...

1. A method of modifying a refractive profile of an eye, the eye having an intraocular device implanted therein located at
an initial position within the eye and the eye having an initial refractive profile, the method comprising the steps of:
determining a corrected refractive profile for the eye based on the initial refractive profile;
identifying one or more locations within the intraocular device based on the corrected refractive profile; and
directing a femtosecond pulsed laser beam at the one or more locations to form one or more slip zones within a hinge of a
haptic portion of the intraocular device to increase flexibility of the haptic portion, wherein the one or more slip zones
are configured to reorient the intraocular device to a corrected position within the eye and produce the corrected refractive
profile, the femtosecond pulsed laser having a pulse width between about 300 picoseconds and about 10 femtoseconds.

US Pat. No. 9,370,298

INDUCED HIGH ORDER ABERRATIONS CORRESPONDING TO GEOMETRICAL TRANSFORMATIONS

AMO Development, LLC, Sa...

1. A laser ablation system for correcting or treating presbyopia with a prescription that mitigates or treats a vision condition
of an eye, the laser ablation system comprising:
a computer processor executing a first module comprising a tangible medium embodying machine-readable code that accepts a
first ablation profile that corresponds to a first geometrical configuration of the eye in an evaluation context, the first
ablation profile characterized by an original set of coefficients for a basis function, wherein the basis function is a member
selected from the group consisting of a Zernike series, a Fourier series, and a Taylor series;

the computer processor executing a second module comprising a tangible medium embodying machine-readable code that determines
a second ablation profile that corresponds to a second geometrical configuration of the eye in a treatment context, the second
ablation profile characterized by a transformed set of coefficients for the basis function that is based on the first geometrical
configuration of the eye, the original set of coefficients, and the second geometrical configuration of the eye, such that
each coefficient of the transformed set of coefficients is based on a corresponding coefficient of the original set of coefficients
and a resizing, cyclorotation, or decentration polynomial;

the computer processor executing a third module comprising a tangible medium embodying machine-readable code that establishes
the prescription for the treatment or correction of presbyopia based on the transformed set of coefficients; and

a laser ablation apparatus comprising a laser that performs an ablation according to the established prescription for the
correction or treatment of presbyopia to mitigate or treat the vision condition of the eye.

US Pat. No. 10,028,654

SYSTEM AND METHOD FOR EYE ORIENTATION

AMO Development, LLC, Sa...

1. An eye imaging assembly comprising:an illumination device positioned to illuminate a patient's eye, the illumination device configured to emit one or more light beams from the illumination device;
an imaging device comprising a detector positioned to capture one or more images of the patient's eye;
a processor operatively coupled to the illumination device and the imaging device; and a non-transitory computer readable medium that stores a computer program that, when executed, causes the processor to perform or enable the following steps:
emit the one or more light beams into the patient's eye;
detect one or more eye images with the detector of the imaging device, the one or more eye images comprising a single Purkinje III reflection which is a reflection of the one or more light beams by an anterior surface of a lens of the eye and which forms a part of a circle, and a single Purkinje IV reflection which is a reflection of the one or more light beams by a posterior surface of a lens of the eye and which forms a part of another circle;
determine a Purkinje III diameter and a Purkinje III center location which are respectively a diameter and a center of the circle of the single Purkinje III reflection;
determine a Purkinje IV diameter and a Purkinje IV center location which are respectively a diameter and a center of the circle of the single Purkinje IV reflection;
determine a distance between the Purkinje III center location and the Purkinje IV center location; and
determine a location of a center of the lens of the eye using only the Purkinje III diameter, the Purkinje III center location, the Purkinje IV diameter, the Purkinje IV center location, and the distance between the Purkinje III center location and the Purkinje IV center location which have been determined from the single Purkinje III reflection and the single Purkinje IV reflection.

US Pat. No. 9,501,621

TREATMENT VALIDATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of determining a vision treatment for an eye of a patient, the method comprising:
receiving, at an input, an original target profile for the eye of the patient;
obtaining a deconvolved target profile based on the original target profile and a low pass filter;
obtaining a scale factor, wherein the scale factor is based on a low order refraction measure of a test eye population and
a low order refraction measure of a convolved test eye population profile, and wherein the convolved test eye population profile
is based on a convolution of the test eye population profile;

determining a scaled target profile based on the deconvolved target profile and the scale factor; and
determining the vision treatment based on the scaled target profile.

US Pat. No. 9,655,513

WAVEFRONT MEASUREMENT PRE-SMOOTHING SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of generating a vision treatment target for an eye of a patient, comprising:
receiving, at a processor, a wavefront measurement for the eye of the patient;
executing, on the processor, computer executable code stored on a non-transitory computer readable medium, the computer executable
code comprising instructions that when executed on the processor cause the processor to process the wavefront measurement,
using a low pass filter, to obtain an ocular wavefront; and

generating the vision treatment target based on the ocular wavefront.

US Pat. No. 9,200,957

ULTRAVIOLET RADIATION SENSOR AND SENSOR MOUNT

AMO Development, LLC, Sa...

1. A sensor for measuring ultraviolet (UV) radiation, the sensor comprising:
a converter plate having an anterior side for receiving UV radiation, a posterior side opposite the anterior side, a perimeter,
and an edge about the perimeter extending between the anterior side and the posterior side, the converter plate configured
to fluoresce in response to the UV radiation incident on the converter plate;

a retainer comprising a conical mirror and a frame, the conical mirror configured to couple with the converter plate about
the perimeter, the frame comprising a blocker configured to absorb UV radiation propagating through the posterior side of
the converter plate; and

a detector coupled to the frame and positioned posteriorly from the blocker, the conical mirror further configured to direct
a portion of the fluorescent light emitted from the edge of the converter plate around the blocker in the posterior direction
to the detector, the detector configured to detect the fluorescent light from the converter plate and produce an electrical
signal proportional to the magnitude of fluorescent light.

US Pat. No. 9,668,649

SYSTEM AND METHODS FOR MITIGATING CHANGES IN PUPIL SIZE DURING LASER REFRACTIVE SURGERY TO MAINTAIN ABLATION CENTRATION

AMO Development, LLC, Sa...

1. A method for mitigating a change in pupil size of an eye of a patient while an ophthalmological procedure is performed
on the eye of the patient, the method comprising:
obtaining a first image of the eye with an imaging device at a first lighting condition at the eye;
obtaining a second image of the eye with the imaging device at the first lighting condition at the eye;
determining the change in pupil size by using the first and second images;
determining, with a processor, a desired optical light output corresponding to a second lighting condition at the eye different
from the first lighting condition, in response to the change in pupil size, the desired optical light output configured to
induce a desired pupillary response mitigating the change in pupil size; and

directing the desired optical light output from a variable illumination source to the eye while the ophthalmological procedure
is performed on the eye of the patient, thereby providing the second lighting condition at the eye that mitigates the change
in pupil size during performance of the ophthalmological procedure,

wherein the ophthalmological procedure comprises a wavefront measurement of the eye, a laser ablation treatment of the eye,
or a wavefront measurement and a laser ablation treatment of the eye.

US Pat. No. 9,427,357

PREFORMED LENS SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A system for altering refraction of a cornea of an eye of a patient, the system comprising:
a photoalteration laser for transmitting a laser beam along an optical path;
a corneal deformation mechanism configured to provide a first applanation shape configuration, and a second applanation shape
configuration different from the first applanation shape configuration, the corneal deformation mechanism comprising:

an applanation plate having a flat proximal portion and a distal portion; wherein the proximal portion is configured to receive
the laser beam from the photoalteration laser and the distal portion is configured to engage an anterior corneal surface of
the eye so as to induce a first intended biomechanical conformation of reshaping the cornea in the eye in a first profile;
and

a removable body removably attached to the applanation plate;
wherein the removable body is detached from the applanation plate when the plate is positioned against the cornea in the first
profile and attached to the applanation plate when the removable body is positioned against the cornea in a second profile,
the removable body having a proximal portion configured to engage the distal portion of the applanation plate and couple the
removable body to the applanation plate, and a distal portion configured to engage the anterior corneal surface of the eye
so as to induce a second intended biomechanical conformation of reshaping the cornea in the eye in the second profile by altering
a depth of focus of the photoalteration laser relative to the anterior corneal surface by deforming the cornea without refracting
the photoalteration laser;

a support for positioning the corneal deformation mechanism along the optical path;
a processor for determining a first laser target surface based on the first applanation shape configuration and a second laser
target surface based on the second applanation shape configuration; wherein the first and second laser target surfaces define
a volumetric lenticule that is based on measured refractive properties of the eye and correspond to a desired refractive correction
intended for the eye; and

beam scanning optics coupled to the processor for scanning the laser beam along the first laser target surface when the eye
assumes the first intended biomechanical conformation responsive to engagement with the first applanation shape configuration,
and along the second laser target surface when the eye assumes the second intended biomechanical conformation responsive to
engagement with the second applanation shape configuration.

US Pat. No. 9,402,366

CUSTOMIZED LASER EPITHELIAL ABLATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method for treating an eye of a patient using a laser, the eye having an epithelial layer and a stromal layer, the method
comprising:
receiving, at a processor system, a refractive optical property of the eye;
receiving, at the processor system, an epithelial thickness map of the eye;
receiving, at the processor system, an epithelial basis data corresponding to an epithelial laser pulse ablation profile for
a first individual laser beam pulse;

receiving, at the processor system, a stromal basis data corresponding to a stromal laser pulse ablation profile for a second
individual laser beam pulse; and

executing, using the processor system, computer executable code stored on a non-transitory computer readable medium, the computer
executable code comprising instructions for the laser to ablate the epithelial layer with an epithelial arrangement of laser
beam pulses, the epithelial arrangement comprising the first individual laser pulse corresponding to the epithelial basis
data and to ablate the stromal layer with a stromal arrangement of laser beam pulses, the stromal arrangement comprising the
second individual laser pulse corresponding to the stromal basis data, the instructions based on the refractive optical property
of the eye and the epithelial thickness map of the eye, thereby treating the eye of the patient using the laser,

wherein the stromal laser pulse ablation profile has an inner portion flat curvature and the epithelial laser pulse ablation
profile has an inner portion flat curvature that is sized differently than the inner portion flat curvature of the stromal
laser pulse ablation profile, or

wherein the stromal laser pulse ablation profile has an inner portion convex curvature and the epithelial laser pulse ablation
profile has an inner portion convex curvature that is sized differently than the inner portion convex curvature of the stromal
laser pulse ablation profile.

US Pat. No. 9,125,599

SYSTEMS AND METHODS FOR BALANCING INFRARED ILLUMINATION IN EYE IMAGING

AMO DEVELOPMENT, LLC, Sa...

1. An eye imaging assembly comprising:
an imaging device positioned to capture an image of a patient's eye;
an illumination device positioned to illuminate the patient's eye;
a processor operatively coupled to the imaging device; and
a computer readable medium that stores a computer program that, when executed, causes the processor to perform or enable the
following steps:

capturing an eye image of the patient's eye with the imaging device;
detecting an outer iris boundary within the captured eye image;
selecting a first region of interest in a nasal sclera area and a second region of interest in a temporal sclera area within
the captured eye image;

calculating a ratio of illumination imbalance between illumination of the first region of interest and illumination of the
second region of interest within the captured eye image;

adjusting the illumination device; and
repeating the adjusting, capturing, detecting, selecting, and calculating steps until the ratio of illumination imbalance
reaches a predetermined tolerance level.

US Pat. No. 10,070,783

INDUCED HIGH ORDER ABERRATIONS CORRESPONDING TO GEOMETRICAL TRANSFORMATIONS

AMO Development, LLC, Sa...

1. A system for developing a lens that mitigates a vision condition of an eye of a patient, the system comprising:a wavefront sensor that captures an image of the eye of the patient; and
a processor communicatively coupled to the wavefront sensor, wherein the processor:
receives, from the sensor, the image of the eye,
calculates, based on the image of the eye, a first wavefront map of the eye that corresponds to a first geometrical configuration of the eye in an evaluation context,
selects, based on the first wavefront map, a basis function that can be separated into a product of a first set of radial polynomials and a first triangular function,
calculates for the first wavefront map an original set of coefficients of the basis function;
determines a second wavefront map of the eye that corresponds to a second geometrical configuration of the eye in a treatment context,
calculates a transformed set of coefficients for the basis function based on the original set of coefficients, the second geometrical configuration of the eye, the first set of radial polynomials and the first triangular function wherein each coefficient of the transformed set of coefficients is based on a corresponding coefficient of the original set of coefficients and a corresponding polynomial, and
calculates a prescription for a lens based on the transformed set of coefficients, wherein the prescription mitigates the vision condition of the eye of the patient; and
a fabrication system that produces the lens according to the prescription.

US Pat. No. 9,795,509

HYBRID OPHTHALMIC INTERFACE APPARATUS

AMO Development, LLC, Sa...

1. An interface for coupling a patient's eye to an ophthalmic surgical laser system, the interface comprising:
a fluid-filled bladder, made entirely of a flexible material, attached to a lower end of a lens cone, the lens cone being
adapted to couple to an ophthalmic laser delivery system, the lens cone including a lower ring and a lens disposed inside
the lower ring, the bladder having a lower dome-shaped contact portion and an upper tubular collar which forms an opening
of the bladder allowing loading of a fluid into the bladder, the upper tubular collar surrounding and being attached to an
outside surface of the lower ring of the lens cone, the bladder containing a fixed volume of the fluid and having sufficient
flexibility to deform upon contact with the patient's eye so as to conform to a cornea of the eye, the bladder and the lens
cone cooperating with each other to form a sealed volume containing the fluid, the lens being in direct contact with the fluid
and being free from direct attachment to the bladder, wherein the bladder is capable of deforming upon contact with the patient's
eye such that a working diameter defined by a surface area of the bladder in contact with the patient's eye extends radially
outward past the cornea to the limbus or further.

US Pat. No. 9,439,561

ACCOMMODATION COMPENSATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of determining a treatment for an eye of a patient, the method comprising:
obtaining a corneal aberration measurement corresponding to a corneal plane of the eye of the patient;
obtaining an ocular aberration measurement corresponding to an exit pupil plane of the eye of the patient;
determining the aberration of a lens based on a difference between the corneal aberration measurement and the ocular aberration
measurement represented at a lens plane of the eye of the patient;

determining a contact lens treatment for the eye based on the aberration of the lens; and
providing a contact lens prescription based on the determined treatment for the eye.

US Pat. No. 9,226,853

METHOD FOR SCANNING A PULSED LASER BEAM

AMO Development, LLC, Sa...

1. A method of photoaltering a sub-surface area of a patient's cornea using a pulsed laser beam, the sub-surface area having
a first region and a second region which is a central region surrounded by the first region, the method comprising the steps
of:
transmitting the pulsed laser beam with a scanner to the first region of the sub-surface area of the cornea in accordance
with only a first laser scan pattern based on a continuous scan of the pulsed laser beam, the first laser scan pattern continuing
until an acceleration associated with scanning the first laser scan pattern reaches a pre-determined maximum limit; and

after the first laser scan pattern reaches the pre-determined maximum limit of the acceleration associated therewith, transmitting
the pulsed laser beam with a scanner to the second region of the sub-surface area of the cornea in accordance with only a
second laser scan pattern based on a continuous scan of the pulsed laser beam that is different than the first laser scan
pattern, the second laser scan pattern having an associated acceleration that is less than the pre-determined maximum limit,
and wherein the first region and the second region combine to span the entire sub-surface area of the cornea.

US Pat. No. 10,028,862

COMPENSATION SYSTEMS AND METHODS FOR FLAP INDUCED ABERRATIONS

AMO Development, LLC, Sa...

1. A method of generating a vision treatment protocol for a patient, the method executed by a computer system, the method comprising:statistically deriving, from a set of clinical study data, a flap induced aberration parameter, the statistically deriving including:
obtaining, from the set of clinical study data, a set of data that includes data points linking induced spherical aberration values that correspond to post-operative aberration to pre-operative spherical equivalent values that correspond to ablation magnitude, and
deriving, from the set of data, a spherical-aberration-zero value that quantifies change in spherical aberration when no volumetric sculpting is performed, the spherical-aberration-zero value comprising the flap induced aberration parameter, the spherical-aberration-zero value comprising the change in spherical aberration when no volumetric sculpting is performed but a flap is created;
generating the vision treatment protocol with the computer system, wherein the computer system comprises a processor and a tangible non-transitory computer readable medium, and wherein the computer readable medium is programmed with a computer application that, when executed by the processor, causes the processor to generate the vision treatment protocol based on the flap induced aberration parameter by generating the vision treatment protocol based on a treatment target that is adjusted based on the spherical-aberration-zero value, the treatment target comprising a desired effect to be delivered to the cornea;
creating a corneal flap in an eye of the patient; and
delivering the vision treatment protocol to the eye of the patient, wherein the vision treatment protocol comprises a laser treatment.

US Pat. No. 9,814,621

OPERATOR-CONTROLLED SCANNING LASER PROCEDURE DESIGNED FOR LARGE-AREA EPITHELIUM REMOVAL

AMO Development, LLC, Sa...

1. A system to ablate an eye to remove an epithelial layer of the eye, the system comprising:
a laser to generate a beam or an ablative radiation:
a movable scan component configured to scan the laser beam over a region of the eye to ablate the epithelial layer;
a sensor to measure fluorescent light and generate a signal when the beam of ablative radiation irradiates the eye;
a processor system comprising a tangible medium and a memory, the processor system coupled to the laser, the movable scan
component and the sensor, the processor system configured to scan the beam of ablative radiation in response to the signal
and within the region in accordance with a pulse sequence, and wherein the processor system is configured to sort the pulse
sequence to enhance the signal based on a tissue fluorescence of the epithelial layer in response to the ablative radiation.

US Pat. No. 9,724,238

OPHTHALMIC INTERFACE APPARATUS, METHOD OF INTERFACING A SURGICAL LASER WITH AN EYE, AND SUPPORT RING FOR USE WITH A SUCTION RING

AMO Development, LLC, Sa...

1. A support ring for use with a suction ring of an ocular stability device, the support ring comprising:
a first end surface;
a second end surface opposite the first end surface having a width that is greater than a width of the first end surface,
the second end surface extending toward a central opening in the support ring to define a concave curvature configured to
substantially match a curvature of a patient's eye; and

an outer surface extending between the first end surface and the second end surface, the outer surface including an annular
groove formed adjacent the first end surface and a plurality of exterior vacuum channels spaced around the annular groove
and extending axially from the annular groove to the second end surface,

wherein the first end surface includes a plurality of notches each radially aligned with a corresponding one of the plurality
of exterior vacuum channels.

US Pat. No. 9,510,747

SYSTEM AND METHOD FOR OPHTHALMIC SURFACE MEASUREMENTS BASED ON OBJECTIVE QUALITY ESTIMATION

AMO Development, LLC, Sa...

1. A method of evaluating a topography of a corneal surface of an eye of a patient, the method comprising:
measuring a topography elevation field for the patient eye corneal surface;
determining a measured Zernike amplitude profile for the patient eye based on the topography elevation field;
combining the measured Zernike amplitude profile with a priori corneal surface information to provide an estimated Zernike
amplitude profile and an estimated Zernike amplitude covariance matrix for the patient eye, the a priori corneal surface information
comprising mean and covariance Zernike amplitude profiles associated with multiple corneal surfaces of a general population;

constructing a corneal topography map for the patient based on the estimated Zernike amplitude profile;
constructing a corneal topography uncertainty map for the patient based on the estimated Zernike covariance matrix; and
evaluating the patient corneal surface topography based on the corneal topography map and the corneal uncertainty map.

US Pat. No. 9,498,117

SYSTEMS AND METHODS FOR TREATMENT DECONVOLUTION USING DUAL SCALE KERNELS

AMO Development, LLC, Al...

1. A method of determining a laser-ablation vision treatment plan for an eye of a patient, the method executed by a computer-based
treatment-planning system, the method comprising:
receiving, at an input of the treatment-planning system, an original target profile for the eye of the patient, the original
target profile based on a desired cornea shape of the eye after the laser-ablation vision treatment;

obtaining a low-pass spatial domain kernel filter that simulates post-operative corneal epithelial remodeling of the eye occurring
after the laser-ablation vision treatment;

convolving the original target profile with the low-pass spatial domain kernel filter to obtain a convolved target profile;
and

determining the laser-ablation vision treatment plan based on the convolved target profile.

US Pat. No. 9,844,463

OPHTHALMIC LASER APPARATUS, SYSTEM, AND METHOD WITH HIGH RESOLUTION IMAGING

AMO Development, LLC, Sa...

1. A system for photoaltering a region of an eye, the system comprising:
a laser assembly that outputs a non-ultraviolet, ultrashort pulsed laser beam;
a controller coupled to the laser assembly programmed to perform operations of directing the laser assembly to output the
pulsed laser beam to the region of the eye;

an imaging system to which the controller is coupled, comprising:
an image sensor capturing a high resolution first real-time digital image of the eye having a first resolution and a frame
rate of at least about 20 frames per second; and

an imaging system monitor displaying a second real-time digital image of the eye based on the high resolution first real-time
digital image of the eye, the second real-time digital image having a second resolution that is less than the first resolution,
wherein the controller produces the second real-time digital image of the eye via a compression of the first real-time digital
image of the eye and outputs the second real-time digital image of the eye to the imaging system monitor to be continuously
displayed; and

a user interface to which the controller is coupled, the user interface having a touch-sensitive monitor for displaying digital
video received from the controller, and a plurality of laser operating parameters and controls, wherein the touch-sensitive
monitor of the user interface and the imaging system monitor are separate monitors for displaying respective images,

wherein the controller is further programmed to produce a third real-time digital image of the eye selected from either the
first real-time digital image of the eye or the second real-time digital image of the eye and output the third real-time digital
image of the eye to and display it on the touch-sensitive monitor of the user interface, and respond to operator input of
the laser operating controls after display of the third real-time digital image of the eye.

US Pat. No. 9,603,519

OPHTHALMIC RANGE FINDING

AMO DEVELOPMENT, LLC, Sa...

1. A system for treating an eye of a patient, the eye including a fluid and a tissue posterior to a cornea, the system comprising:
a femtosecond laser configured for directing femtosecond energy pulses along an optical path;
an optical system disposed along the optical path from the laser, the optical system including a focusing lens and a scanner
so as to scan a non-plasma-generating focus of the femtosecond energy along a scan path within the patient's eye, the scan
path extending posterior to the patient's cornea within the fluid and the tissue so that the scan path includes a first location
disposed within the tissue of the eye and a second location disposed within the cornea;

a sensor, comprising an image acquisition device, oriented and disposed along a part of the optical path outside of the patient's
eye so as to sense a first signal to form a first reflectance image associated with a first focus location within the eye,
and to sense a second signal to form a second reflectance image associated with a second focus location within the eye, the
first and second signals being reflectance signals of the femtosecond pulses of the laser which have a wavelength equal to
that of the femtosecond pulses, which are reflected respectively by the eye at the first and second focus locations; and

a computing device communicatively coupled with the sensor, wherein the computing device determines a location of an interface
between the fluid and the tissue of the eye based on a comparison between a size of a focal spot in the first reflectance
image formed by the first signal and a size of a focal spot in the second reflectance image formed by the second signal.

US Pat. No. 9,916,423

RANDOM EYE GENERATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of evaluating a vision treatment, the method comprising:
using a random eye generator to generate a plurality of random eye models, the plurality of random eye models having a model
value distribution for an optical parameter, wherein the model value distribution for the optical parameter matches a general
population distribution for the optical parameter;

generating an expected ablation outcome for each of the random eye models, each of the expected ablation outcomes having an
optical shape;

generating a simulated ablation outcome for each of the random eye models based on the vision treatment, each of the simulated
ablation outcomes having an optical shape;

evaluating the vision treatment by comparing, for each of the random eye models, the respective optical shape of the expected
ablation outcome with the respective optical shape of the simulated ablation outcome.

US Pat. No. 9,861,527

ROBUST LASER CUTTING METHODS FOR OPHTHALMIC SURGERY

AMO Development, LLC, Sa...

1. An apparatus for performing an ocular laser surgical procedure, comprising:
a laser configured to emit a beam;
optical elements configured to focus the beam emitted by the laser at a desired focus position on an eye of a patient; and
a controller configured to control the laser and the optical elements, wherein the controller is configured to use a cutting
pattern to control the laser and the optical elements to scan the focus position in an oscillating manner along an axial direction
of the eye and to simultaneously move the focus position around a periphery of a capsule of the eye, the cutting pattern comprising
a plurality of photodisruption points forming a generally circular cut with a sine wave shape in a side view around the periphery
of the capsule of the eye;

wherein each photodisruption point in the cutting pattern comprises a laser target point.

US Pat. No. 10,191,299

ZONE EXTENSION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of performing a prescriptive treatment on an optical system of a patient, through use of a computer, the method comprising:inputting an original normalized Zernike expansion coefficient for the optical system, the original normalized Zernike expansion coefficient associated with a first pupil dimension;
calculating a modified normalized Zernike expansion coefficient for the optical system, the modified normalized Zernike expansion coefficient associated with a second pupil dimension, the second pupil dimension greater than the first pupil dimension;
determining a treatment for the optical system of the patient based on the modified normalized Zernike expansion coefficient, wherein the modified normalized Zernike expansion coefficient is calculated based on the original normalized Zernike expansion coefficient scaled by a scaling factor, the scaling factor comprising a ratio of the second pupil dimension to the first pupil dimension, the ratio raised to the power of a factor comprising a radial degree of the coefficient; and
performing the prescriptive treatment according to the treatment determined, wherein the prescriptive treatment comprises a member selected from the group consisting of an intraocular lens treatment, a contact lens treatment, and a refractive laser treatment.

US Pat. No. 9,658,468

ZONE EXTENSION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of calculating effective powers of an optical system of a patient, through the use of a computer processor, the
method comprising:
calculating a first effective power using a first Zernike expansion coefficient for the optical system, the first Zernike
expansion coefficient associated with a first aperture dimension; and

calculating a second effective power using a second Zernike expansion coefficient for the optical system, the second Zernike
expansion coefficient associated with a second aperture dimension, the second aperture dimension greater than the first aperture
dimension, the second Zernike expansion coefficient scaled relative to the first Zernike expansion coefficient using a scaling
factor comprising a ratio of the second aperture dimension to the first aperture dimension raised to a power of a factor comprising
a radial degree of the coefficient; and

determining a treatment for the optical system of the patient based on the calculated first effective power and the calculated
second effective power,

wherein the optical system comprises an optical tissue of the patient, the first aperture dimension comprises a first pupil
dimension, and the second aperture dimension comprises a second pupil dimension, and

wherein the treatment comprises a member selected from the group consisting of an intraocular lens treatment, a contact lens
treatment, and a refractive laser treatment.

US Pat. No. 10,098,785

TREATMENT VALIDATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A system for determining a vision treatment for an eye of a patient, the system comprising:an input that receives an original target profile for the eye of the patient;
a processor; and
computer executable code stored on a non-transitory computer readable medium, the computer executable code comprising instructions that when executed by the processor cause the processor to determine a deconvolved target profile based on the original target profile and a low pass filter, to determine a scaled target profile based on the deconvolved target profile and a scale factor, and to determine the vision treatment based on the scaled target profile,
wherein the scale factor is based on a low order refraction measure of a test eye population and a low order refraction measure of a convolved test eye population profile, and
wherein the convolved test eye population profile is based on a convolution of the test eye population profile.

US Pat. No. 9,659,151

SYSTEMS AND METHODS FOR TREATMENT TARGET DECONVOLUTION

AMO Development, LLC, Sa...

1. A method of determining a vision treatment for an eye of a patient, the method comprising:
receiving, at an input, an original target profile for the eye of the patient;
obtaining a spatial domain kernel filter, wherein the spatial domain kernel filter is based on an inverse Fourier transform
of a Fourier domain noise filter;

convolving, using a convolution module, the original target profile with the spatial domain kernel filter, wherein the convolving
module comprises a processor and a tangible non-transitory computer readable medium, and the computer readable medium is programmed
with a computer application that, when executed by the processor, causes the processor to determine a convolved profile based
on the original target profile and the spatial domain kernel filter; and

determining the vision treatment based on the convolved profile.

US Pat. No. 9,814,620

SYSTEMS AND METHODS FOR TREATMENT DECONVOLUTION USING MULTI-SCALE KERNELS

AMO Development, LLC, Sa...

1. A method of determining a laser-ablation vision treatment plan for an eye of a patient, the method executed by a computer-based
treatment-planning system, the method comprising:
receiving, at an input of the treatment-planning system, an original target profile for the eye of the patient, the original
target profile based on a desired cornea shape of the eye after the laser-ablation vision treatment;

obtaining a spatial domain kernel filter that simulates post-operative corneal epithelial remodeling of the eye occurring
after the laser-ablation vision treatment, wherein the spatial domain kernel filter is an inverse of a power expansion;

convolving the original target profile with the spatial domain kernel filter to obtain a convolved target profile; and
determining the laser-ablation vision treatment plan based on the convolved target profile.

US Pat. No. 10,568,765

OPHTHALMIC DOCKING SYSTEM WITH 3-DIMENSIONAL AUTOMATIC POSITIONING USING MAGNETIC SENSING ARRAY

AMO DEVELOPMENT, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery head, including optics which define an optical axis for delivering a laser beam to an eye of a patient; and
an magnetic field sensing system, which includes a first, a second, a third and a fourth magnetic field sensors and a control device electrically coupled to the first through fourth sensors,
wherein the first through fourth sensors are affixed on the laser delivery head and located in a plane perpendicular to the optical axis, wherein the first and second sensors have identical structures and are located at equal distances from the optical axis along a first line that passes through the optical axis, wherein the third and fourth sensors have identical structures and are located at equal distances from the optical axis along a second line that passes through the optical axis, and
wherein the control device is configured to control each of the first through fourth sensors to measure a magnetic field, and based on the measured magnetic field signals by the first through fourth sensors, to determine whether or not an external magnet that has generated the magnetic field is located within a predetermined distance from the optical axis.

US Pat. No. 10,098,783

TILT COMPENSATION, MEASUREMENT, AND ASSOCIATED ADJUSTMENT OF REFRACTIVE PRESCRIPTIONS DURING SURGICAL AND OTHER TREATMENTS OF THE EYE

AMO Development, LLC, Sa...

1. A method for treating an eye of a patient by ablation, the method comprising:obtaining a plurality of measurements of the eye;
calculating an ellipsoid shape corresponding to an anterior corneal surface of the eye based on the plurality of measurements of the eye, the ellipsoid shape having an anterior portion, a major axis, and an apex, wherein the major axis intersects the anterior portion at the apex;
determining a tilted orientation of the eye when the patient fixates on a target during a laser ablation procedure, wherein the tilted orientation includes a first tilt in a first direction and a second tilt in a second direction orthogonal to the first direction;
determining an ablation treatment based on the ellipsoid shape and the tilted orientation; and
controlling a pattern of laser pulses of a laser eye surgery system according to the ablation treatment determined.

US Pat. No. 10,758,416

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

AMO Development, LLC, Sa...

1. A system for ophthalmic surgery of an eye of a patient, comprising:a laser source, configured to alternatively deliver an ultraviolet treatment laser beam and an ultraviolet probe laser beam, each laser beam comprising a plurality of ultraviolet laser pulses, wherein a pulse energy of the ultraviolet probe laser beam is lower than a pulse energy of the ultraviolet treatment laser beam;
an optical system operatively coupled to the laser source and configured to direct the laser beams;
an imaging system operatively coupled to the laser source and optical system and configured to detect a back reflected light from the eye; and
a controller coupled to the laser source, the optical system and the imaging system, and programmed to operate the laser source, the optical system and the imaging system to:
focus the ultraviolet probe laser beam to a focal spot and direct the focal spot of the ultraviolet probe laser beam in a imaging scan pattern into at least one intraocular target of the eye and to confocally detect back reflected light of the probe laser beam from the at least one intraocular target, thereby obtaining image data corresponding to the at least one intraocular target;
automatically generate a treatment scan pattern based at least in part on the image data; and
focus the ultraviolet treatment laser beam to a focal spot and direct the focal spot of the ultraviolet treatment laser beam in the treatment scan pattern into the at least one intraocular target, wherein the ultraviolet treatment laser in the treatment scan pattern alters the at least one intraocular target; and
wherein a spacing between at least two adjacent focal spots in the imaging scan is greater than a spot spacing between at least two adjacent focal spots in the treatment scan of the same intraocular target.

US Pat. No. 10,299,960

CUSTOMIZED LASER EPITHELIAL ABLATION SYSTEMS AND METHODS

AMO DEVELOPMENT, LLC, Sa...

1. A method for treating a region of a cornea of an eye, the region comprising an epithelial layer disposed over a stromal layer, the method comprising:mapping a thickness of the epithelial layer in the region of the cornea to obtain a map profile of the epithelial layer;
obtaining a wavefront map profile from measurements of refractive optical properties of the eye;
calculating an optical path length for the map profile of the epithelial layer;
deriving a remainder portion by subtracting the optical path length from the wavefront map profile;
deriving a stromal ablation profile from the wavefront map profile, the stromal ablation profile including a remainder portion profile that corrects a wavefront error of the remainder portion;
ablating the epithelial layer of the region of the cornea to expose the stromal layer according to the map profile of the epithelial layer; and
ablating the stromal layer of the region of the cornea according to the stromal ablation profile.

US Pat. No. 10,729,538

METHOD FOR PATTERNED PLASMA-MEDIATED MODIFICATION OF THE CRYSTALLINE LENS

AMO Development, LLC, Sa...

1. A method of treating a cataractous lens of a patient's eye, comprising:a. generating a light beam;
b. deflecting the light beam using a scanner to form a first treatment pattern and a second treatment pattern of the light beam;
c. delivering the light beam to the lens of the patient's eye to create a plurality of cuts in the lens in the form of the first treatment pattern and the second treatment pattern so as to segment the lens tissue into a plurality of patterned pieces, the first treatment pattern comprising a spiral shaped incision as viewed from a posterior to an anterior position along the optical axis and extending along a length between a posterior cutting limit within the lens and an anterior surface of the lens capsule, and the second treatment pattern comprising a plurality of sub-segment incision planes connecting adjacent portions of the spiral shaped incision to create sub-segments of the spiral shaped incision, wherein none of the plurality of sub-segment incision planes intersects with any other sub-segment incision plane; and
d. separating the plurality of patterned pieces.

US Pat. No. 10,709,606

METHODS OF LASER MODIFICATION OF INTRAOCULAR LENS

AMO Development, LLC, Sa...

1. A method of modifying a refractive profile of an eye, the eye having an intraocular device implanted therein located at an initial position within the eye and the eye having an initial refractive profile, the method comprising the steps of:determining a corrected refractive profile for the eye based on the initial refractive profile;
identifying one or more locations within the intraocular device based on the corrected refractive profile, the one or more locations within the intraocular device having a thermal threshold;
selecting properties of a femtosecond pulsed laser beam based on the thermal threshold, the properties including one or more of a pulse energy, a pulse width, a pulse repetition rate, a spot separation, an exposure time, and a scan pattern, the femtosecond laser having a pulse width between about 300 picoseconds and about 10 femtoseconds; and
based on the selected properties, directing the femtosecond pulsed laser beam at the one or more locations to heat the one or more locations above the thermal threshold, wherein the intraocular device is re-oriented by the heating to a corrected position within the eye and produces the corrected refractive profile.

US Pat. No. 10,568,764

SYSTEM AND METHODS FOR DEPTH DETECTION IN LASER-ASSISTED OPHTHALMIC PROCEDURES

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system for a capsulorhexis operation, comprising:a laser delivery system for delivering a pulsed laser beam to a subject's eye to perform capsulorhexis, the pulsed laser beam having ultra-short pulses in a femtoseconds and picoseconds range, the laser delivery system being configured to deliver the pulsed laser beam to the eye according to a vertical side cut pattern which is a cut pattern that forms a circular revolution located at a depth, and to move the vertical side cut pattern in the depth direction from an aqueous humor toward and into a lens capsule and a lens in the lens capsule;
a mirror positioned to transmit at least a portion of collected plasma light from the eye, the plasma light being generated in the eye by the pulsed laser beam when it photoalters tissues of the eye by plasma mediated photoablation which generates a plasma;
a lens positioned to focus the transmitted collected plasma light onto a detector to form spots on the detector;
a Z-position encoder operatively coupled to the detector; and
a computer comprising a non-volatile memory storing computer-executable code and a processor configured to execute the computer-executable code, wherein the processor is configured to control the Z-position encoder to determine a current location of photoablation in the subject's eye based on data captured by the detector which indicates the spots formed by the collected plasma light focused on the detector, including determining whether the current location of photoablation is within the aqueous humor or has reached the lens capsule based on detecting an increase in intensity of the spots formed by the plasma light, and determining whether the current location of photoablation defined by the vertical side cut pattern is partially or entirely within the lens based on whether the intensity of the spots formed by the plasma light is pulsating or is constant over each side cut revolution of the vertical side cut pattern.

US Pat. No. 10,709,548

METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS

AMO Development, LLC, Sa...

1. A scanning system for treating target tissue in a patient's eye, comprising:a) an ultrafast laser source configured to deliver a laser beam comprising a plurality of laser pulses;
b) an Optical Coherence Tomography (OCT) device configured to generate signals which may be used to create an image of the cornea and limbus of the eye of the patient;
c) a scanner configured to focus and direct the laser beam in a pattern within the cornea or limbus to create incisions therein; and
d) a controller operatively coupled to the laser source and scanner programmed to determine a treatment pattern based upon the signals from the OCT device, the treatment pattern forming a cataract incision in the cornea that provides access for lens removal instrumentation to a crystalline lens of the patient's eye and one or more relaxation incisions in the cornea or limbus, wherein the cataract incision has an arcuate extent of less than 360 degrees in a top view, wherein the cataract incision includes a bevel shape in a cross-sectional view, the bevel shape including a first segment and a second segment which intersect each other at an angle, the cataract incision being entirely located in the cornea and intersecting both an anterior surface and a posterior surface of the cornea, and to control the scanner to scan the position of the laser beam in the treatment pattern.

US Pat. No. 10,631,724

METHOD AND SYSTEM FOR DYNAMICALLY MEASURING TEAR FILM BREAKUP AND IRREGULARITY USING CORNEAL TOPOGRAPHY AND WAVEFRONT ABERROMETRY

AMO Development, LLC, Sa...

1. A system, comprising:a wavefront aberrometer configured to perform a series of wavefront measurements to obtain a plurality of sets of wavefront aberrometry data for an eye, each set of wavefront aberrometry data being obtained at a corresponding different point in time;
a corneal topographer configured to perform a series of corneal topography measurements to obtain a plurality of sets of corneal topography data for the eye, each set of corneal topography data being obtained at a corresponding different point in time; and
a processor configured to process the wavefront aberrometry data and the corneal topography data to produce combined tear film breakup data as a function of time, operative as a metric for evaluating a level of tear film breakup of the eye as a function of time.

US Pat. No. 10,390,995

SHORT PULSE LASER WITH ADJUSTABLE PULSE LENGTH

AMO Development, LLC, Sa...

1. A method for generating a pulse laser beam to be delivered to a patient's eye, comprising:generating a beam of laser pulses by an oscillator, the laser pulses having a first pulse length;
inputting the beam of laser pulses to a compressor;
changing the pulse length of the input laser pulses by the compressor to output a beam of laser pulses having a second pulse length, the compressor comprising a plurality of optical components directing the beam of laser pulses along a beam path, including a moveable optical component mounted on a computer controlled stage, the moveable optical component being at a first position;
focusing the beam of laser pulses having the second pulse length into a first tissue of the patient's eye to perform incisions in the first tissue;
then, receiving a user instruction by a computing device, the user instruction specifying a third pulse length;
in response to the user instruction, controlling the stage by the computing device to reposition the moveable optical component to a second position to output a beam of laser pulses having the third pulse length from the compressor; and
focusing the beam of laser pulses having the third pulse length to a second tissue of the patient's eye to perform incisions in the second tissue, wherein the third pulse length is different from the second pulse length and the second tissue is different from the first tissue.

US Pat. No. 10,376,415

ROBUST LASER CUTTING METHODS FOR OPHTHALMIC SURGERY

AMO DEVELOPMENT, LLC, Sa...

1. A method for performing ophthalmic laser surgery using a device configured to transmit a pulsed laser beam, comprising:establishing an initial cutting pattern comprising a plurality of original photodisruption points;
establishing an enhanced cutting pattern comprising a plurality of enhanced photodisruption points selected to decrease potential adverse effects due to patient movement and having increased density over a fixed area as compared with the plurality of original photodisruption points; and
directing the pulsed laser beam to make a generally circular cut with a sine wave shape in a side view around a periphery of a capsule of an eye of a patient according to the enhanced cutting pattern;
wherein each photodisruption point in the initial cutting pattern and the enhanced cutting pattern comprises a laser targeting point, and wherein the generally circular cut made around the periphery of the capsule provides an increased length scanning pattern length relative to a cut made according to the initial cutting pattern.

US Pat. No. 10,369,054

VARYING A NUMERICAL APERTURE OF A LASER DURING LENS FRAGMENTATION IN CATARACT SURGERY

AMO Development, LLC, Sa...

1. A method for fragmenting a lens of a patient's eye using a surgical laser comprising:measuring features of the patient's eye to find a total laser treatment region; determining:
a safety zone comprising a region of the patient's eye that will not receive focused laser radiation;
a high NA zone, the high numerical aperture (NA) zone comprising a region where a cone angle of a laser beam with a high numerical aperture is not shadowed by an iris of the patient's eye; and
a low NA zone, the low NA zone comprising a region radially closer to the iris than the high NA zone where a cone angle of the laser beam with a low numerical aperture is not shadowed by the iris, the low numerical aperture being lower than the high numerical aperture; and
delivering the laser beam with the high numerical aperture to the high NA zone, and delivering the laser beam with the low numerical aperture to the low NA zone without delivering the laser beam with the high numerical aperture to the low NA zone,
wherein the high NA zone, the low NA zone, and the safety zone occupy, in aggregate, approximately an entirety of the total laser treatment region.

US Pat. No. 10,292,866

METHOD OF TRANSPLANTING A CORNEA

AMO Development, LLC, Sa...

1. A method of transplanting a corneal section from a donor to a recipient in preparation for performing a Laser Assisted In-Situ Keratomileusis (“LASIK”) procedure, the method comprising:incising an undercut within stromal tissue of a donor cornea of a donor, wherein the donor cornea has an anterior surface, and wherein the undercut is incised posterior to the anterior surface of the donor cornea so that underlying stromal tissue of the donor cornea is disposed posterior to the undercut and overlying stromal tissue of the donor cornea is disposed anterior to the undercut;
incising a sidecut in the donor cornea such that the combination of the sidecut and the undercut create a corneal flap having a hinge portion, the underlying stromal tissue connected with the overlying stromal tissue via the hinge portion on one side of the corneal flap, the underlying stromal tissue unconnected with the overlying stromal tissue on a second side of the corneal flap opposing the first side;
after forming the corneal flap in the donor cornea, excising a corneal section containing the corneal flap from the donor cornea; and
grafting the incised corneal section onto an eye of a recipient;
wherein, after the donor corneal section is grafted onto the eye of the recipient, the underlying stromal tissue of the donor corneal section is located immediately below the undercut and the overlying stromal tissue of the donor corneal section is located immediately above the undercut, and lifting of the corneal flap of the donor corneal section provides access for performing the LASIK procedure on the underlying stromal tissue of the donor corneal section that has been grafted onto the eye of the recipient.

US Pat. No. 10,624,786

MONITORING LASER PULSE ENERGY IN A LASER EYE SURGERY SYSTEM

AMO Development, LLC, Sa...

1. An apparatus to treat a material with pulsed light energy, the apparatus comprising:a pulsed laser to generate light energy comprising a plurality of pulses to treat the material;
a detector responsive to the light energy;
a plurality of integrators comprising a first integrator and a second integrator coupled to the detector; and
switching circuitry coupled to the pulsed laser, the detector and the plurality of integrators to couple the detector to the first integrator for a first pulse of the light energy and the second integrator for a second pulse of the light energy.

US Pat. No. 10,709,611

SYSTEMS AND METHODS FOR LENTICULAR LASER INCISION

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye;
an XY-scan device to deflect the pulsed laser beam;
a Z-scan device to modify a depth of a focus of the pulsed laser beam; and
a controller configured to control the XY-scan device and the Z-scan device to form a top lenticular incision and a bottom lenticular incision of a lens in a cornea of the subject's eye, wherein the top lenticular incision has a top convex spherical portion at a center and a top edge transition portion that surrounds the top spherical portion, the top spherical portion being a part of a first sphere, the top edge transition portion being not a part of the first sphere and being located within a volume defined by the first sphere, the top lenticular incision being a smooth surface, wherein the bottom lenticular incision has a bottom convex spherical portion at a center and a bottom edge transition portion that surrounds the bottom spherical portion, the bottom spherical portion being a part of a second sphere, the bottom edge transition portion being not a part of the second sphere and being located within a volume defined by the second sphere, the bottom lenticular incision being a smooth surface, wherein the top and bottom edge transition portions are mirror symmetrical to each other with respect to a transverse center plane perpendicular to an optical axis of the eye, and wherein the top and bottom edge transition portions intersect each other at an intersection location and both extend beyond the intersection location such that the overall lenticule is sufficiently thick to be extracted as a whole piece and the lenticule edge is sufficiently thick to reduce the likelihood of it being torn during extraction.

US Pat. No. 10,690,486

WATER-IMMERSED HIGH PRECISION LASER FOCUS SPOT SIZE MEASUREMENT APPARATUS

AMO Development, LLC, Sa...

1. A measurement apparatus for measuring a laser focus spot size, comprising:a two-dimensional image detector having a detecting surface;
an imaging system including at least an objective lens, the imaging system being disposed in front of the image detector and configured to form a magnified image of an object located on an object plane onto the detecting surface of the image detector; and
a sealed liquid container containing a liquid, the container including a flexible body with a transparent window and an opening, wherein the objective lens is partially disposed through the opening and joined to the body in a liquid-tight seal, and wherein a front optical surface of the objective lens is exposed to the liquid inside the container and is separated from the transparent window in an axial direction by the liquid inside the container, wherein the flexible body is deformable in the axial direction and an axial distance between the transparent window and the front optical surface of the objective lens is adjustable by deformation of the flexible body.

US Pat. No. 10,702,209

GRAPHICAL USER INTERFACE FOR LASER EYE SURGERY SYSTEM

AMO Development, LLC, Sa...

1. A system for planning and performing a laser surgery procedure on an eye having a cornea, a pupil, and a lens, the cornea having an anterior surface and a posterior surface, the lens being disposed within a lens capsule having an anterior portion and a posterior portion, the system comprising:a treatment lase delivery system including a laser source configured to produce a treatment beam that includes a plurality of laser pulses;
an integrated optical system that includes an imaging assembly containing at least one optical lens and operatively coupled to the treatment laser delivery system for the treatment beam such that the imaging assembly and the treatment laser delivery system share at least one common optical element, the integrated optical system being configured to locate at least a portion of the corneal anterior surface and at least a portion of the corneal posterior surface;
a patient interface configured to couple the eye with the integrated optical system so as to constrain the position of the eye relative to the integrated optical system;
a display device; and
a controller operatively coupled with the display device, the laser source, and the integrated optical system; the controller being configured to:
generate, relative to the integrated optical system, a spatial disposition of the corneal anterior surface and a spatial disposition of the corneal posterior surface by using the integrated optical system to locate at least portions of the corneal anterior and posterior surfaces;
generate a spatial disposition of an incision to be formed in the cornea using the spatial dispositions of the corneal anterior and posterior surfaces and at least one corneal incision parameter, the at least one corneal incision parameter including a first numerical parameter that defines an amount of an uncut anterior region of the cornea and/or a second numerical parameter that defines an amount of an uncut posterior region of the cornea, the incision being a two-dimensional surface, wherein the corneal incision extends partially through the cornea so as to leave the uncut anterior or posterior region of the cornea aligned with one or more cut portions of the corneal incision, the corneal incision and the uncut anterior or posterior region of the cornea defining an access path for a cataract surgery instrument;
display a composite image on the display device, the composite image including an image representative of the spatial dispositions of the corneal anterior and posterior surfaces and an image representing the corneal incision, and display the first and/or the second numerical parameter on the display device; and
operate the a treatment lase delivery system to deliver the treatment beam into the eye to form the incision in the cornea.

US Pat. No. 10,610,411

ADJUSTABLE LASER SURGERY SYSTEM

AMO Development, LLC, Sa...

9. A laser surgery system, comprising:a laser source to produce a laser beam containing a plurality of laser beam pulses;
a measurement system for measuring a cornea of an eye;
an optical delivery system coupled to the laser source and the measurement system to output the laser beam at a predetermined adjustable incident angle, the optical delivery system comprising:
a first rotator assembly containing a first mirror and receiving the beam from the laser source along a first beam axis, wherein the first rotator assembly rotates around the first beam axis and the first mirror of the first rotator assembly reflects the beam along a second beam axis different from the first beam axis;
a second rotator assembly containing a second mirror and receiving the beam from the first rotator assembly along the second beam axis, wherein the second rotator assembly rotates around the second beam axis and the second mirror of the second assembly reflects the beam along a third beam axis different from the second beam axis, wherein the second rotator assembly follows the rotation of the first rotator assembly and the rotation of the first rotator assembly is independent of the rotation of the second rotator assembly;
a processor coupled to the laser source, measurement system and optical delivery system, the processor comprising a tangible non-volatile computer readable medium comprising instructions to:
determine an angular orientation of an optical axis of the cornea by the measurement system;
determine a rotation of the first rotator assembly and the second rotator assembly to align the incident angle of the output beam with the angular orientation of the optical axis of the cornea; and
rotate the first rotator assembly and the second rotator assembly by the determined rotation.

US Pat. No. 10,327,952

ULTRAVIOLET RADIATION SENSOR SYSTEMS AND METHODS FOR LASER PULSE ENERGY CONTROL IN EYE SURGERY

AMO Development, LLC, Sa...

1. A system comprising:an ultraviolet radiation source that produces an initial ultraviolet radiation pulse;
a fluorescent plate that receives the initial ultraviolet radiation and generates a visible light pulse in response to the initial ultraviolet radiation pulse;
a photon detector that receives the visible light pulse and generates an electrical signal in response to the visible light pulse received;
a memory; and
a processor communicatively coupled to the ultraviolet radiation source; the photon detector and the memory, wherein the processor;
retrieves calibration data from the memory, and
determines an energy of the initial ultraviolet radiation pulse by applying the calibration data to an amplitude and a decay time of the electrical signal,
wherein the processor stores the calibration data in the memory by:
setting the fluorescent plate to a reference temperature;
outputting, using the ultraviolet radiation source, a reference ultraviolet radiation pulse having a known energy, the reference ultraviolet radiation pulse being incident on the fluorescent plate;
receiving a reference electrical signal generated by the photon detector in response to receiving visible light emitted by the fluorescent plate in response to the reference ultraviolet radiation pulse,
deriving a reference decay constant and a reference amplitude based on the reference electrical signal, and
determining first calibration data based on a correlation between the reference temperature, the reference decay constant and a reference temperature adjustment coefficient,
for each of a plurality of calibration temperatures:
setting the fluorescent plate to a respective calibration temperature from the plurality of calibration temperatures;
outputting, using the ultraviolet radiation source, a calibration ultraviolet radiation pulse having a known energy for each respective calibration temperature, the calibration ultraviolet radiation pulse being incident on the fluorescent plate;
receiving a calibration reference signal generated by the photon detector in response to receiving visible light emitted by the fluorescent plate in response to the calibration ultraviolet radiation pulse;
deriving a calibration decay constant and a calibration amplitude based on the calibration reference signal;
calculating a calibration temperature adjustment coefficient based on the calibration amplitude and the reference amplitude; and
determining second calibration data based a correlation between the respective calibration temperature, the calibration decay constant, and the calibration temperature adjustment coefficient, and
storing, using the memory, the first calibration data and the second as the calibration data.

US Pat. No. 10,327,954

VARYING A NUMERICAL APERTURE OF A LASER DURING LENS FRAGMENTATION IN CATARACT SURGERY

AMO DEVELOPMENT, LLC, Sa...

1. A method of treating a lens in a patient's eye with an ultra-short pulsed laser comprising: determining, using at least one physical processor, a first region of the lens in the patient's eye to receive a laser beam having a first numerical aperture; determining, using the at least one physical processor, a second region of the lens of in the patient's eye to receive a laser beam having a second numerical aperture, the second numerical aperture being lower than the first numerical aperture, and the second region being radially closer, on average, to an iris of the patient's eye than the first region; controlling a laser source to deliver the laser beam having the first numerical aperture and a first energy to the first region of the lens; and controlling the laser source to deliver the laser beam having the second numerical aperture and a second energy to the second region of the lens without delivering the laser beam having the first numerical aperture and the first energy to the second region of the lens, wherein the first numerical aperture and the first energy are configured to deliver a peak laser energy to a retina of the patient's eye that is less than a safety threshold, and the safety threshold is determined based on a safety standard that conforms to ANSI Z136.1-2000 Standard.

US Pat. No. 10,682,056

OPTICAL MEASUREMENT SYSTEMS AND PROCESSES WITH WAVEFRONT ABERROMETER HAVING VARIABLE FOCAL LENGTH LENS

AMO Development, LLC, Sa...

1. A system, comprising:a variable focal length lens;
a processor configured to adjust a focal length of the variable focal length lens;
a switchable calibration light source disposed at a known distance from the variable focal length lens and configured to provide a calibration light beam to the variable focal length lens;
a wavefront sensor configured to receive the calibration light beam from the variable focal length lens when the switchable calibration light source is on, and in response thereto to output image data; and
at least one flip-in auxiliary lens disposed near the switchable calibration light source and configured to collimate the calibration light beam received by the wavefront sensor when the calibration light beam is otherwise uncollimated by the adjusted focal length of the variable focal length lens having too great or too small of a value,
wherein the processor is configured to receive the image data, and
wherein the processor is further configured to control the switchable calibration light source to be on and to adjust the focal length of the variable focal length lens to have an adjusted focal length, and to ascertain the adjusted focal length of the variable focal length lens from the image data output from the wavefront sensor in response to the calibration light beam received by the wavefront sensor from switchable calibration light source.

US Pat. No. 10,667,949

LASER BEAM CALIBRATION AND BEAM QUALITY MEASUREMENT IN LASER SURGERY SYSTEMS

AMO Development, LLC, Sa...

1. A method for determining the diameter of a focused laser beam in a laser eye surgery system, comprising:by a target holder, supporting a target at a first fixed position relative to an objective lens of the eye surgery system;
by a scanning mirror, scanning the focused laser beam over a first line at a first position on the target which is being supported at the first fixed position;
by a sensor, sensing laser light reflected or scattered by the first line as the focused laser beam crosses onto the first line;
by the sensor, providing a first sensed light signal based on the laser light sensed as the focused laser beam crosses onto the first line;
by a computer, calculating a first diameter of the focused laser beam at the first position on the target which is being supported at the first fixed position based on the first sensed light signal and a scanning velocity of the focused laser beam at the first position;
by the scanning mirror, scanning the focused laser beam over a second line at a second position on the target which is being supported at the first fixed position;
by the sensor, sensing laser light reflected or scattered by the second line as the focused laser beam crosses onto the second line;
by the sensor, providing a second sensed light signal based on the laser light sensed as the focused laser beam crosses onto the second line;
by the computer, calculating a second diameter of the focused laser beam at the second position on the target which is being supported at the first fixed position based on the second sensed light signal and a scanning velocity of the focused laser beam at the second position;
by the target holder, supporting the target at a second fixed position relative to the objective lens of the eye surgery system, wherein the second fixed position is different from the first fixed position along a propagation direction of the laser beam;
by the scanning mirror, scanning the focused laser beam over a third line at a third position on the target which is being supported at the second fixed position;
by the sensor, sensing laser light reflected or scattered by the third line as the focused laser beam crosses onto the third line;
by the sensor, providing a third sensed light signal based on the laser light sensed as the focused laser beam crosses onto the third line;
by the computer, calculating a third diameter of the focused laser beam at the third position on the target which is being supported at the second fixed position based on the third sensed light signal and a scanning velocity of the focused laser beam at the third position;
by a display, displaying a beam quality indicator based on the first, second and third diameters; and
by the computer, comparing the first or second diameter with the third diameter to identify a focal plane position along the propagation direction of the laser beam where the laser beam is best focused.

US Pat. No. 10,610,410

LASER CAPSULOVITREOTOMY

AMO Development, LLC, Sa...

1. A method for performing laser-assisted surgery on an eye having a lens capsule, an anterior hyaloid surface, and a Berger's space between a posterior portion of the lens capsule and the anterior hyaloid surface, the method comprising:forming, by a laser, a plurality of bubbles in a layer pattern which is located within the Berger's space, the layer pattern occupying a central area of the Berger's space including an optical axis of the eye and extending laterally in directions transverse to the optical axis without extending across the anterior hyaloid surface, to increase separation between the posterior portion of the lens capsule and the anterior hyaloid surface; and
after forming the plurality of bubbles, incising the posterior portion of the lens capsule.

US Pat. No. 10,575,988

OPHTHALMIC DOCKING SYSTEM WITH 3-DIMENSIONAL AUTOMATIC POSITIONING USING DIFFERENTIAL RF COUPLING

AMO DEVELOPMENT, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery head, including optics which define an optical axis for delivering a laser beam to an eye of a patient; and
an RF (radio frequency) detector system, which includes a first, a second, a third and a fourth RF antenna and a control device electrically coupled to the first through fourth antennas,
wherein the first through fourth antennas are affixed on the laser delivery head and located in a plane perpendicular to the optical axis, wherein the first and second antennas have identical structures and are located at equal distances from the optical axis along a first line that passes through the optical axis, wherein the third and fourth antennas have identical structures and are located at equal distances from the optical axis along a second line that passes through the optical axis, and
wherein the control device is configured to control each of the first through fourth antennas to measure an RF signal, and based on the measured RF signals by the first through fourth antennas, to determine whether or not an external RF antenna that has generated the RF signal is located within a predetermined distance from the optical axis.

US Pat. No. 10,792,188

SYSTEMS AND METHODS FOR HIGH SPEED MODULATION OF A RESONANT SCANNER IN OPHTHALMIC LASER APPLICATIONS

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, the pulsed laser beam having a pulse energy and pulse repetition rate;
a high frequency scanner configured to produce a scan line formed by the pulsed laser beam;
an XY-scan device to deflect the scan line;
a Z-scan device to modify a depth of a focus of the scan line; and
a controller configured to:
control the high frequency scanner to produce the scan line, the scan line having a scan width;
control the XY-scan device and the Z-scan device to carry out of first sweep of the scan line in a first sweep direction;
control the XY-scan device and the Z-scan device to carry out a second sweep of the scan line in a second sweep direction that is not parallel to the first sweep direction, thereby defining an overlap region, wherein at least one of the pulse energy, repetition rate, XY-scan speed, and the scan width are varied during at least one of the first sweep and second sweep so as to reduce an exposure of an ophthalmic tissue in the overlap region to multiple exposures of laser pulses configured to modify ophthalmic tissue.

US Pat. No. 10,687,980

SYSTEM AND METHOD OF IRIS-PUPIL CONTRAST ENHANCEMENT

AMO Development, LLC, Sa...

1. A system comprising:a processor;
a user input device; and
a memory storing computer readable instructions that when executed by the processor cause the system to perform a method of photoaltering a region of an eye having an iris and a pupil, comprising:
producing a first digital image of the eye, the first digital image having a first contrast between the iris and the pupil;
in response to a first user input received via the user input device, displaying the first digital image of the eye;
in response to a second user input received via the user input device, the second user input being different from the first user input, selectively increasing the first contrast between the iris and the pupil to a second contrast which is greater than the first contrast between the iris and the pupil;
displaying a second digital image of the eye, the second digital image having the second contrast between the iris and the pupil;
centrating the eye to align the eye with a pulsed laser beam based on the second contrast between the iris and the pupil; and
after centrating the eye, directing the pulsed laser beam to the region of the eye to photoalter the region of the eye.

US Pat. No. 10,646,116

IN SITU DETERMINATION OF REFRACTIVE INDEX OF MATERIALS

AMO Development, LLC, Sa...

1. A method of determining an index of refraction of a material, the method comprising:focusing light from a light source along a beam path to a focal point having a location within the material, wherein the material comprises a surface adjacent a second material having a second index of refraction, the index of refraction of the material being different from the second index of refraction, and wherein the beam path extends a distance from the surface to the focal point; and
determining the index of refraction of the material in response to the distance from the surface to the location of the focal point within the material.

US Pat. No. 10,390,996

OPHTHALMIC RANGE FINDING

AMO Development, LLC, Sa...

1. A non-transitory machine-readable medium having machine-executable instructions configured to perform a method for analyzing an ophthalmic anatomy of a patient posterior to a cornea, the method comprising:scanning a focus of a femtosecond laser beam of a femtosecond laser along a path within the patient's eye, wherein at least a portion of the path is disposed posterior to the patient's cornea, and wherein the path includes a first location and a second location;
acquiring a first reflectance image associated with the focus disposed at the first location;
acquiring a second reflectance image associated with the focus disposed at the second location; and
determining the presence or absence of an ophthalmic anatomical feature of the eye based on a comparison between the first reflectance image and the second reflectance image by comparing a color, shape, or intensity of a focus spot in the first reflectance image respectively with a color, shape, or intensity of a focus spot in the second reflectance image.

US Pat. No. 10,363,174

EYE TISSUE MEASUREMENTS

AMO DEVELOPMENT, LLC, Sa...

1. A method for the precise incision of tissue in a cornea, comprising:docking a femtosecond laser patient interface to a cornea of a patient;
attenuating the femtosecond laser power to a level for measuring,
wherein the attenuated femtosecond laser has a power at the focus point of less than 40 milliwatts;
focusing the femtosecond laser to a beam at a focal point in the interior side of the cornea of the patient in x lateral axis, y lateral axis and a z depth axis;
moving the femtosecond laser focal point in the z axis from the interior side of the cornea through the cornea and toward an exterior side of the cornea;
capturing a backscatter of the femtosecond laser focal point as it moves in the z axis from the interior side of the cornea to the exterior side of the cornea; and
recording a time the femtosecond laser focal point moves in the z depth axis from the interior side of the cornea to the exterior side of the cornea;
calculating a power of the captured backscatter as the laser focal point moves in the z depth axis from the interior side of the cornea to the exterior side of the cornea;
determining a cutting distance, based on the recorded time the laser focal point moves and the calculated power of the captured backscatter;
powering up the femtosecond laser from the measuring power to an incision power; and
incising the cornea at the determined cutting distance in the cornea to remove a portion of the cornea.

US Pat. No. 10,702,146

ANGULAR MULTIPLEXED OPTICAL COHERENCE TOMOGRAPHY SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. An optical coherence tomography system, comprising:a detector comprising an array of pixels;
a light source configured to supply a sample light beam to an eye and to further supply a reference light beam;
an optical element configured to direct the reference light beam to the array of pixels; and
an optical splitter configured to divide light returning from the eye into a plurality of individual signal beams each having a corresponding different path length from an output of the optical splitter to the optical element and each corresponding to a respective different anatomical location of the eye,
wherein each of the individual signal beams impinges on the optical element at a corresponding different angle with respect to the reference light beam, and
wherein the optical element is configured to direct the plurality of individual signal beams simultaneously to the array of pixels.

US Pat. No. 10,660,794

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

AMO Development, LLC, Sa...

1. A laser ophthalmic surgical system comprising:a laser system configured to produce a treatment beam;
an imaging device;
a scanning assembly configured to deflect a focal point of the treatment beam;
a patient interface assembly comprising a patient interface housing and one or more registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative to the patient interface housing, the patient interface housing comprising a distal end for coupling to one or more surfaces of the eye of the patient, and a proximal end opposite the distal end, the patient interface housing arranged such that a field of view of the imaging device passes through a passage of the patient interface housing defined by the proximal and distal ends; and
control electronics operatively coupled to the laser system, the imaging device, and the scanning assembly, the control electronics programmed to:
successively image the one or more registration fiducials and predetermined geometric markers on the eye of the patient using the imaging device; and
process successive imaging data generated via the imaging device so as to determine a successive position in X, Y, and Z, together with a successive pitch, yaw, and roll of the patient interface housing.

US Pat. No. 10,369,052

SYSTEMS AND METHODS FOR LENTICULAR LASER INCISION

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system for delivering a focus of a pulsed laser beam to a target in a subject's eye;
a high frequency scanner to scan the focus of the pulsed laser beam back and forth parallel to an XY plane at a predefined frequency;
an XY-scanner to deflect the focus of the pulsed laser beam parallel to the XY plane, the XY-scanner being different from the high frequency scanner;
a Z-scanner to modify a depth of the focus of the pulsed laser beam, the depth being in a Z direction perpendicular to the XY plane; and
a controller configured to control the high frequency scanner, the XY-scanner and the Z-scanner to successively form a plurality of sweeps which collectively form at least one lenticular incision of a lens in the subject's eye, the lens having a curved surface that defines an apex and a Z axis passing through the apex, wherein each sweep is formed by: controlling the high frequency scanner to deflect the pulsed laser beam back and forth to form a scan line, the scan line being a straight line having a predefined length and being parallel to the XY plane and tangential to a parallel of latitude of the lens, the parallel of latitude being a circle on the surface of the lens that is perpendicular to the Z axis and has a defined distance to the apex, while controlling the XY-scanner and the Z-scanner to move the scan line along a meridian of longitude of the lens, the meridian of longitude being a curve that passes through the apex and has a defined angular position around the Z axis, wherein the plurality of sweeps are successively formed one after another along the respective meridians of longitude which are different from one another.

US Pat. No. 11,110,007

OPHTHALMIC LASER SURGICAL METHOD AND SYSTEM FOR FORMING CORNEAL LENTICULE WITH SIDE TAB FOR EASY EXTRACTION

AMO Development, LLC, Sa...


1. A method for extracting a lenticule from a cornea of a patient's eye, comprising: to correct a vision of the patient's eyeoperating an ophthalmic surgical laser system to form a top lenticule surface incision in the cornea; and
operating the ophthalmic surgical laser system to form a bottom lenticule surface incision in the cornea,
wherein the top and bottom lenticule surface incisions intersect each other to form an isolated volume of corneal tissue between them, the isolated volume of corneal tissue being isolated from remaining portions of the cornea, and
wherein the isolated volume of corneal tissue includes a lenticular portion having a circular or oval shape in a top view, and a side tab portion connected to the lenticular portion and protrudes from a peripheral location of the lenticular portion, wherein the side tab portion has a defined thickness profile in a side cross-sectional view; and extracting the isolated volume of corneal tissue from the patient's eye, whereby the vision of the patient's eye is corrected.

US Pat. No. 11,026,841

CLOSED-LOOP LASER EYE SURGERY TREATMENT

AMO Development, LLC, Sa...

1. A laser eye surgery system, comprising:a laser system to generate a laser beam and direct the laser beam to an eye of a patient;
a topography measurement system for measuring topography of a cornea of the eye;
a processor coupled to the laser system and the topography measurement system, the processor comprising a tangible non-volatile computer recordable medium embodying instructions to:
measure a first corneal topography of the eye using the topography measurement system;
determine a first curvature of the cornea based on the first corneal topography, and determine a target curvature of the cornea that provides a desired treatment of the eye;
determine a first set of incisions in the cornea to achieve the target curvature of the corneal;
determine a first set of first partial incisions in the cornea, wherein the first partial incisions are smaller than the incisions of the first set of incisions;
perform the first set of first partial incisions on the cornea using the laser system;
measure a second corneal topography using the topography measurement system after performing the first set of first partial incisions;
determine a second curvature of the cornea based on the second corneal topography;
determine whether the second curvature differs from the target curvature by more than a predetermined threshold;
when it is determined that the second curvature and the target curvature do not differ by more than the predetermined threshold, then end treatment of the eye; and
when it is determined that the second curvature and the target curvature differ by more than the predetermined threshold, then:
determine a second set of incisions in the cornea different from the first set of incisions to achieve the target curvature in the cornea; and
determine a second set of second partial incisions in the cornea; wherein the second partial incisions of the second set of partial incisions are smaller than the incisions of the second set of incisions; and
perform the second set of second partial incisions on the cornea using the laser system.

US Pat. No. 10,736,780

LASER EYE SURGERY SYSTEM

AMO Development, LLC, Sa...

1. A method for laser eye surgery while accommodating patient movement, the method comprising:generating a first electromagnetic radiation beam by a beam source;
propagating the first electromagnetic radiation beam from the beam source to an xy-scanning mirror along a variable optical path;
changing an optical path length of the variable optical path between the beam source and a pivot point of the xy-scanning mirror by freely floating the pivot point of the xy-scanning mirror in tandem with movement of the eye in a z-dimension;
focusing the first electromagnetic radiation beam to a first focal point at a location within the eye;
scanning the first focal point to different locations within the eye in at least one dimension transverse to a propagation direction of the first electromagnetic radiation beam by the xy-scanning mirror;
wherein the changing the optical path length accommodates the movement of the eye and corresponding movement of the pivot point of the xy-scanning mirror relative to the beam source while maintaining alignment between the eye and the scanned electromagnetic radiation beam;
propagating a portion of the first electromagnetic radiation beam reflected from the focal point location back along a portion of the variable optical path to a sensor;
generating an intensity signal by the sensor, the intensity signal being indicative of the intensity of the portion of the first electromagnetic radiation beam reflected from the first focal point location and propagated to the sensor;
generating a second electromagnetic radiation beam configured to modify eye tissue;
propagating the second electromagnetic beam to the xy-scanning mirror along the variable optical path;
focusing the second electromagnetic radiation beam to a second focal point; and
scanning the second focal point within the eye by the xy-scanning mirror to create a corneal incision in the eye.

US Pat. No. 10,722,398

EYE DOCKING FOR LASER EYE SURGERY

AMO Development, LLC, Sa...

1. A system, comprising:a structural frame;
a gantry attached to the structural frame and movable relative to the structural frame;
a docking receptacle configured to be removably attached to an eye docking assembly which is attached to an eye;
a plurality of connectors configured to resiliently attach the docking receptacle to the gantry, the plurality of connectors including one or more springs and one or more voice coils which cooperate to generate a docking force between the docking receptacle and the gantry, wherein the docking force includes a first force component generated by the one or more springs and a second force component generated by the one or more voice coils, wherein the first force component is proportional to a difference between a Z-direction distance between a surface of gantry and a surface of docking receptacle and an initial Z-direction distance, the initial Z-direction distance being a distance between the surface of gantry and the surface of docking receptacle at which a load on the one or more springs and a weight of the docking receptacle produce a balance;
an adjustable table attached to the gantry and movable in the Z direction relative to the gantry, the adjustable table including a Z stage configured to move in the Z direction relative to the gantry;
a lens assembly attached to the adjustable table, wherein the adjustable table is configured to move the lens assembly in the Z direction relative to the eye;
at least one sensor configured to sense at least one of (1) the distance between the surface of the gantry and the surface of the docking receptacle which is attached resiliently to the gantry by the one or more connectors, and (2) a change in the distance between the surface of the gantry and the surface of the docking receptacle, and in response thereto to output at least one sensing signal; and
a controller configured to control movement of the adjustable table in response to the at least one sensing signal to maintain a target distance between the lens assembly and a reference area of the eye docking assembly,
wherein the controller is further configured to control, in response to the at least one sensing signal, an amount of current which passes through at least one of the one or more voice coils to minimize the docking force between the docking receptacle and the gantry.

US Pat. No. 10,675,147

ADDITIVE MANUFACTURING INSIDE THE HUMAN EYE

AMO Development, LLC, Sa...

1. A method for forming an artificial intra-ocular lens (IOL) inside a patient's eye, comprising:using a pulse laser beam from a laser system to form an opening in a cornea and an opening in a lens capsule of the patient's eye;
using the pulse laser beam from the laser system to break up a crystalline lens of the eye from the lens capsule;
removing the broken up crystalline lens through the openings in the cornea and the lens capsule;
injecting a liquefied photopolymer resin into the lens capsule through the openings in the cornea and the lens capsule, wherein the injected liquefied photopolymer resin forms a volume of the liquefied photopolymer resin inside the lens capsule; and
forming said artificial IOL directly inside the lens capsule by scanning a focal spot of the pulse laser beam from the laser system inside the lens capsule in a defined scanning pattern to transform the liquefied photopolymer resin in a vicinity of the focal spot of the pulse laser beam;
wherein the liquefied photopolymer resin is photosolidified in the vicinity of the focal spot of the pulse laser beam;
wherein the forming step includes:
adjusting a depth of the focal spot of the pulse laser beam within the volume of the liquefied photopolymer resin;
scanning the focal spot of the pulse laser beam in a lateral plane at the adjusted depth across a defined area; and
repeating the adjusting step and the scanning step such that the liquefied photopolymer resin is transformed in a layer by layer manner to form the IOL; and
wherein the scanning pattern of the focal spot of the pulse laser beam for each layer is determined based on the properties of the photopolymer resin and the desired shape of the IOL to be formed.

US Pat. No. 10,292,864

WAVEFRONT MEASUREMENT PRE-SMOOTHING SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of performing a vision treatment on an eye of a patient, comprising:receiving, by a processor, multiple wavefront measurements for the eye of the patient from a wavefront sensor;
determining, by the processor, an ocular wavefront based on the multiple wavefront measurements, wherein the ocular wavefront represents an averaged version of the multiple wavefront measurements, such that high spatial frequency features present in the multiple wavefront measurements are not present in the ocular wavefront;
calculating, by the processor, a vision treatment target based on the ocular wavefront; and
controlling, by the processor, an eye surgery system to perform the vision treatment according to the vision treatment target.

US Pat. No. 10,758,417

METHODS AND SYSTEMS FOR LASER SCAN LOCATION VERIFICATION AND LASER SURGICAL SYSTEMS WITH LASER SCAN LOCATION VERIFICATION

AMO Development, LLC, Sa...

1. A method of verifying the calibration of a laser eye surgical system, comprising:imaging at least a portion of a calibration apparatus, the calibration apparatus including a container having a viscous substance or a solid substance, and either an iris structure or a lens structure having a luminescence emissive surface, the resulting image comprising a predetermined location for a laser scan;
identifying the predetermined location in the image, thereby establishing an expected scan location of the laser scan in the image;
performing the laser scan of the calibration apparatus by scanning a focal point of the laser beam in a scanned area, the laser beam having a wavelength;
detecting a luminescence from the scanned area without receiving or detecting a reflected light from the eye tissue having a same wavelength as the wavelength of the laser beam, and identifying an actual scanned location within the image based on the detected luminescence; and
determining whether the laser surgical system is calibrated based on a difference between the actual scanned location and expected scan location.

US Pat. No. 10,736,779

LASER EYE SURGERY SYSTEM

AMO Development, LLC, Sa...

1. A method of imaging an eye while accommodating patient movement, the method comprising:generating an electromagnetic radiation beam by a beam source;
propagating the electromagnetic radiation beam from the beam source to an xy-scanning mirror along a variable optical path;
changing an optical path length of the variable optical path between the beam source and a pivot point of the xy-scanning mirror by freely floating the pivot point of the xy-scanning mirror in tandem with movement of the eye in a z-dimension;
focusing the electromagnetic radiation beam to a focal point at a location within the eye;
scanning the focal point to different locations within the eye in at least one dimension transverse to a propagation direction of the electromagnetic radiation beam, by the xy-scanning mirror;
wherein the changing the optical path length accommodates the movement of the eye and corresponding movement of the pivot point of the xy-scanning mirror relative to the beam source while maintaining alignment between the eye and the scanned electromagnetic radiation beam;
propagating a portion of the electromagnetic radiation beam reflected from the focal point location back along a portion of the variable optical path to a sensor; and
generating an intensity signal by the sensor, the intensity signal being indicative of the intensity of the portion of the electromagnetic radiation beam reflected from the focal point location and propagated to the sensor; and
controlling a power level of the electromagnetic radiation beam between a first level of power configured to modify the eye and a second level of power configured not to modify the eye.

US Pat. No. 11,033,431

SYSTEMS AND METHODS FOR SYNCHRONIZED THREE-DIMENSIONAL LASER INCISIONS

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye;
an XY-scan device to deflect the pulsed laser beam;
a Z-scan device to modify a depth of a focus of the pulsed laser beam along an optical axis; and
a controller configured to synchronize an oscillation of the XY-scan device and an oscillation of the Z-scan device to form an angled three-dimensional laser tissue dissection, including to control the XY-scan device to move the focus of the laser beam in a plane perpendicular to the optical axis in an angular direction, which is a direction around the optical axis, from a first angular position to a second angular position once within a time interval while oscillating a radius of the focus, which is a distance from the optical axis, a first plurality of times within the same time interval, each time between a minimum radius and a maximum radius, the minimum radius being the same for the first plurality of times and the maximum radius being the same for the first plurality of times, and to simultaneously control the Z-scan device to oscillate the depth of the focus a second plurality of times within the same time interval, wherein the first plurality of times is equal to the second plurality of times or twice the second plurality of times.

US Pat. No. 10,743,758

MULTIPLE DEPTH OPTICAL COHERENCE TOMOGRAPHY SYSTEM AND METHOD AND LASER EYE SURGERY SYSTEM INCORPORATING THE SAME

AMO Development, LLC, Sa...

1. A multiple depth optical coherence tomography (OCT) system for imaging positions at multiple depth positions in an object, the OCT system comprising:a light source for providing a beam of light;
a beam splitter disposed to receive the beam of light from the light source and split the beam of light into a sample light and a reference light;
a beam combiner;
an OCT detector;
a sample arm configured to propagate the sample light from the beam splitter to the object and to direct an object return light from the object to the beam combiner, the object return light comprising a first return light beam reflected from a first position in the object and a second return light beam reflected from a second position in the object, the first position and the second position being at different depths in the object located along a common axis, the first return light beam and the second return light beams being superimposed on each other, the second return light having a second dispersion level that is larger than a first dispersion level of the first return light beam by a dispersion difference amount;
a first reference arm configured to propagate a first portion of the reference light from the beam splitter to the beam combiner with a third dispersion level that is substantially the same as the first dispersion level; and
a second reference arm configured to propagate a second portion of the reference light from the beam splitter to the beam combiner with a fourth dispersion level that is substantially the same as the second dispersion level;
wherein the beam combiner is configured to combine the object return light including the first return light beam and the second return light beam, the first portion of the reference light, and the second portion of the reference light to superimpose them into one combined beam, and to direct the combined beam along a single common optical path to the OCT detector; and
wherein the OCT detector is configured to receive the combined beam, to measure an interferogram based on the combined beam, and to obtain imaging information for both the first position and the second position from the interferogram based on the dispersion difference amount.

US Pat. No. 10,695,223

SYSTEM AND METHOD OF IRIS-PUPIL CONTRAST ENHANCEMENT

AMO Development, LLC, Sa...

1. A system for photoaltering a region of an eye, the eye having a pupil and an iris, the system comprising:a laser assembly configured to output a pulsed laser beam;
a user interface including a user-selectable light/dark eye control, wherein the system is configured such that, in response to the user-selectable light/dark eye control not being selected by a user, the system displays via the user interface a first digital image of the eye having a first contrast between the pupil and the iris, and wherein the system is further configured such that, in response to the user-selectable light/dark eye control being selected by the user, the system displays via the user interface a second digital image of the eye having a second contrast between the pupil and the iris which is different than the first contrast; and
a controller coupled to the laser assembly and the user interface, the controller configured to:
selectively change the first contrast between the pupil and the iris to the second contrast between the pupil and the iris in response to the user-selectable light/dark eye control being selected by the user to generate the second digital image for display by the user interface; and
direct the pulsed laser beam to the region of the eye based on the first digital image in response to the user-selectable light/dark eye control not being selected by the user, and based on the second digital image in response to the user-selectable light/dark eye control being selected by the user.

US Pat. No. 10,639,140

METHOD FOR PATTERNED PLASMA-MEDIATED MODIFICATION OF THE CRYSTALLINE LENS

AMO DEVELOPMENT, LLC, Sa...

1. A method of treating a cataractous lens of a patient's eye, comprising:a. generating a light beam;
b. deflecting the light beam using a scanner to form a treatment pattern of the light beam;
c. delivering the treatment pattern to the lens of the patient's eye to create a plurality of cuts in the lens in the form two or more different incision patterns within the lens to segment the lens tissue into a plurality of patterned pieces, the incision patterns comprising:
a first incision pattern comprising a plurality of laser incision planes each extending along a first length between a posterior and an anterior surface of the lens capsule, wherein the plurality of the laser incision planes of the first incision pattern comprise two or more crossing cut incision planes, wherein at least one of the crossing cut incision planes is inclined in a side cross-sectional view that passes through an optical axis of the eye; and
d. mechanically breaking the lens into a plurality of pieces along the two or more crossing cut incision planes.

US Pat. No. 11,026,575

METHODS AND SYSTEMS OF OPTICAL COHERENCE TOMOGRAPHY WITH FIDUCIAL SIGNAL FOR CORRECTING SCANNING LASER NONLINEARITY

AMO Development, LLC, Sa...

1. A system, comprising:a swept laser light source configured to generate laser light having a frequency swept across a frequency bandwidth as a function of time;
a sample path configured to direct a first portion of the laser light to an eye as a probe beam and to receive a returned portion of the probe beam from the eye, returned by at least one of reflection and scattering, wherein the sample path includes a fiducial generator configured to introduce a fiducial signal into the returned portion of the probe beam from the eye, the fiducial generator including:
an optical path length;
a reflective surface disposed at a first end of the optical path length; and
a beam splitter configured to couple part of the first portion of the laser light to a second end of the optical path length, and to combine reflected light from the reflective surface with the returned portion of the probe beam from the eye, wherein the reflected light from the reflective surface constitutes the fiducial signal;
a reference path for passing therethrough a second portion of the laser light, the reference path having a defined optical path length;
a detector configured to receive the returned portion of the probe beam from the eye and the second portion of the laser light from the swept laser light source which passed through the reference path, and in response thereto to output an optical coherence tomography (OCT) output signal having a fiducial peak corresponding to the fiducial signal and having OCT peaks whose relative timing represents depths of surfaces of structures of the eye; and
a signal processor configured to process the OCT output signal and to produce data indicating the depths of surfaces of structures of the eye.

US Pat. No. 10,952,606

OPTICAL MEASUREMENT SYSTEM AND METHOD INCLUDING BLINK RATE MONITOR AND/OR TEAR FILM BREAKUP DETECTOR

AMO Development, LLC, Sa...

1. A method for measuring a characteristic of a subject's eye, the method comprising:an optical measurement instrument receiving from an operator, via a user interface of the optical measurement instrument, a begin measurement instruction indicating the start of a measurement period for objectively measuring at least one characteristic of the subject's eye;
subsequent to receiving the begin measurement instruction, determining whether the subject's eye exhibits excessive tearing; and
in response to determining that the subject's eye exhibits excessive tearing, taking one or more corrective actions to measure the characteristic of the subject's eye under a condition wherein the subject's eye does not exhibit excessive tearing.

US Pat. No. 10,864,114

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

AMO Development, LLC, Sa...

1. A system for ophthalmic surgery, the system comprising:a laser system comprising an optical system and a laser source configured to deliver a laser beam, the laser beam comprising a plurality of laser pulses having a pulse energy between 0.01 microJoules and 500 microJoules, a pulse duration between 400 picoseconds and 700 picoseconds, and a wavelength between 320 nanometers and 370 nanometers, the optical system being operatively coupled to the laser source and configured to focus the laser beam to a focal spot and scan the focal spot; and
control electronics operatively coupled to the laser system and configured to operate the laser system to scan the focal spot in a pattern in a lens capsule of a patient's eye, wherein the pattern defines one or more capsulotomies in the lens capsule, and wherein the pulse energy, the pulse duration, and the focal spot are configured such that the laser beam irradiance at the focal spot is sufficiently high to physically modify the lens capsule by photodecomposition but not exceeding a threshold of formation of a plasma and associated cavitation event.

US Pat. No. 10,863,899

SYSTEM AND METHOD FOR EYE ORIENTATION

AMO Development, LLC, Sa...

1. A method for locating the center of a lens in an eye center location system, comprising:emitting, by an illumination device, one or more light beams to illuminate a patient's eye;
capturing, by an imaging device, one or more eye images of the patient's eye, the one or more eye images including a single Purkinje III reflection which is a reflection of the one or more light beams by an anterior surface of a lens of the eye and which forms a part of a circle, and a single Purkinje IV reflection which is a reflection of the one or more light beams by a posterior surface of a lens of the eye and which forms a part of another circle;
by a processor:
determining a Purkinje III diameter and a Purkinje III center location which are respectively a diameter and a center of the circle of the single Purkinje III reflection;
determining a Purkinje IV diameter and a Purkinje IV center location which are respectively a diameter and a center of the circle of the single Purkinje IV reflection;
determining a distance between the Purkinje III center location and the Purkinje IV center location; and
determining a location of a center of the lens of the eye using only the Purkinje III diameter, the Purkinje III center location, the Purkinje IV diameter, the Purkinje IV center location, and the distance between the Purkinje III center location and the Purkinje IV center location which have been determined from the single Purkinje III reflection and the single Purkinje IV reflection.

US Pat. No. 10,786,389

OPHTHALMIC LASER DELIVERY APPARATUS USING MEMS MICROMIRROR ARRAYS FOR SCANNING AND FOCUSING LASER BEAM

AMO Development, LLC, Sa...

1. An ophthalmic laser delivery system for delivering a pulsed laser beam generated by a laser to a patient's eye, comprising:a laser beam scanner for reflecting an input laser beam to generate one or more output laser beams and scanning the output laser beams in two orthogonal directions, the laser beam scanner including a single micromirror array, the micromirror array including a plurality of micromirrors forming a two-dimensional array, wherein each micromirror in the micromirror array rotates around two orthogonal rotation axes, the respective one of the two rotation axes of all micromirrors in the micromirror array being parallel to each other, the plurality of micromirrors capable of being individually controlled to rotate to different angles;
optics for directing the pulsed laser beam from the laser to the laser beam scanner as the input laser beam and directing the output laser beams from the laser beam scanner to the patient's eye; and
a controller coupled to the laser beam scanner for controlling a rotation of each of the plurality of micromirrors of the single micromirror array,
wherein the laser beam scanner, as controlled by the controller, cooperates with the optics to focus the pulsed laser beam to one or more focal spots in the patient's eye and to scan the one or more focal spots according to a predefined scan pattern.

US Pat. No. 10,736,733

INTRAOCULAR LENS

AMO Development, LLC, Sa...

1. An intraocular lens for replacing a natural lens in a lens capsule of a patient's eye, the intraocular lens comprising:a lens portion configured to focus light passing therethrough; and
a peripheral member disposed around the lens portion and mechanically coupled to the lens portion, the peripheral member having a circumferential groove with a radially inner end located radially inward of a peripheral edge of the peripheral member, the groove configured to position and retain the peripheral member within a capsulorhexis incision in the lens capsule of the patient's eye at a rotational orientation with respect to a central optical axis of the lens portion, wherein the radially inner end of the groove forms a closed and continuous asymmetric shape in a plane perpendicular to the optical axis of the lens portion, wherein the closed and continuous asymmetric shape is one which, when rotated around the optical axis of the lens portion, coincides with itself only after a 360 degree rotation,
wherein the lens portion is configured to rotate within the peripheral member.

US Pat. No. 10,706,560

METHODS AND SYSTEMS FOR CORNEAL TOPOGRAPHY, BLINK DETECTION AND LASER EYE SURGERY

AMO Development, LLC, Sa...

1. A method, comprising:providing to an eye of a patient a light pattern produced by one or more geometric markers of a corneal topography measurement structure;
for each of a plurality of time periods:
detecting light returned from the eye of the subject while providing the light pattern to the eye,
converting the light returned from the eye into corresponding image data,
analyzing the image data to determine whether the light pattern is present in the detected light,
when it is determined that the light pattern is present in the detected light, using at least a portion of the image data corresponding to the light pattern to make a corneal topography measurement of a cornea of the eye of the subject, and
when it is determined that the light pattern is not present in the detected light, determining that the subject blinked and excluding the image data from the corneal topography measurement of the eye of the subject.

US Pat. No. 10,456,297

SYSTEMS AND METHODS FOR SYNCHRONIZED THREE-DIMENSIONAL LASER INCISIONS

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye;
an XY-scan device to deflect the pulsed laser beam;
a Z-scan device to modify a depth of a focus of the pulsed laser beam along an optical axis; and
a controller configured to synchronize an oscillation of the XY-scan device and an oscillation of the Z-scan device to form a three-dimensional laser tissue dissection, including to control the XY-scan device to move the focus of the laser beam in a plane perpendicular to the optical axis in an angular direction, which is a direction around the optical axis, from a first angular position to a second angular position once within a time interval while oscillating a radius of the focus, which is a distance from the optical axis, a first plurality of times within the same time interval, and to simultaneously control the Z-scan device to oscillate the depth of the focus a second plurality of times within the same time interval, wherein the first plurality of times is equal to the second plurality of times multiplied by two, three or four.

US Pat. No. 10,314,745

AUTOMATIC CENTRATION OF A SURGICAL PATTERN ON THE APEX OF A CURVED PATIENT INTERFACE

AMO Development, LLC, Sa...

1. An apparatus to treat an eye having a cornea, the apparatus comprising:a laser source to generate a laser beam to treat the eye;
an optically transmissive interface to couple to the cornea of the patient, the optically transmissive interface having a curved surface to contact an anterior surface of the cornea;
an optical delivery system to deliver the laser beam to the eye;
a measurement module coupled to the optical delivery system to measure the curved surface; and
a processor coupled to the optical delivery system and the laser source to treat the cornea with a treatment profile, the processor comprising a computer readable non-transitory medium having embedded therein computer readable program instructions to measure a plurality of vertical distances of the curved surface at a plurality of measurement locations which have known spatial relationships to a central measurement axis and to align the central measurement axis with a defined position of the curved surface based on the plurality of vertical distances.

US Pat. No. 11,058,583

METHOD AND SYSTEM FOR MODIFYING EYE TISSUE AND INTRAOCULAR LENSES

AMO Development, LLC, Sa...


1. A system for ophthalmic surgery, the system comprising:a laser system comprising an optical system and a laser source configured to deliver a laser beam to intraocular targets and for physically modifying at least one of the intraocular targets, the laser beam comprising a plurality of laser pulses having pulse energies, a pulse duration between 400 and 700 picoseconds, and a wavelength between 320 nanometers and 400 nanometers, the optical system being operatively coupled to the laser source and configured to focus the laser beam to a focal spot and scan the focal spot within the intraocular targets;
a confocal imaging subsystem configured to detect light from the intraocular targets and form images based on the detected light; and
a controller operably coupled to the laser system and the confocal imaging subsystem, wherein the controller is configured to operate the laser system and confocal imaging subsystem to:control the laser system to deliver interleaved higher energy treatment laser pulses and lower energy probe laser pulses to the intraocular targets, the treatment laser pulses having pulse energies configured to physically modify the intraocular targets, wherein the pulse energy, the pulse duration, and the focal spot of the treatment laser pulses are configured such that a laser beam irradiance of the treatment laser pulses at the focal spot is sufficiently high to physically modify the at least one of the intraocular targets by photodecomposition but not exceeding a threshold of formation of a plasma and associated cavitation event, the probe laser pulses having pulse energies lower than the pulse energies of the treatment laser pulses;
control the confocal imaging subsystem to detect back-reflected light or auto fluorescence light generated by the intraocular targets in response to the probe pulses, and based on the detected back-reflected light or auto fluorescence light in response to the probe pulses, to determine whether cavitation bubbles have been formed by the treatment laser pulses previously delivered into the intraocular targets; and
adjust the pulse energies of the treatment laser pulses based on a determination that cavitation bubbles have been formed by the treatment laser pulses.


US Pat. No. 11,039,959

OPHTHALMIC LASER SURGICAL SYSTEM AND METHOD FOR CORNEAL LENTICULAR INCISIONS WITH UNAMBIGUOUS ENTRY CUTS

AMO Development, LLC, Sa...


1. A method for extracting a lenticule from a cornea of a patient's eye, comprising:operating an ophthalmic surgical laser system to form a top lenticule surface incision and a bottom lenticule surface incision in the cornea, the top and bottom lenticule surface incisions intersecting each other at a closed line defining a lenticule edge, the top and bottom lenticule incisions forming a lenticule of corneal tissue between them; and
operating the ophthalmic surgical laser system to form a top entry cut in the cornea, the top entry cut having a shape that starts from a top surface of the cornea, extends downwardly and inwardly, intersects the top lenticule surface incision at an intersection location, and ends at an end location inside the lenticule, wherein the end location is at a distance between 3 to 40 microns from the intersection location, and wherein at the intersection location, an angle between a portion of the top entry cut above the intersection location and a portion of the top lenticule surface incision inside of the intersection location is an acute angle.

US Pat. No. 11,033,380

NON-INVASIVE REFRACTIVE TREATMENT USING NANOPARTICLES

AMO Development, LLC, Sa...

1. A system for optical treatment of an eye, the system comprising:a delivery device; and
dopant operably coupled with the delivery device so as to be deliverable from the delivery device into the eye in a dopant pattern, wherein the dopant comprises a plurality of nanoparticles, wherein each nanoparticle is either a metallic nanoparticle producing surface plasmon effects, or a nanoparticle formed of an inorganic polymer with an inorganic transparent material embedded in the inorganic polymer;
wherein the delivery device is configurable to deliver the dopant into the eye so that the dopant pattern locally changes a refractive index of the eye so as to impose a desired correction to the eye to mitigate an optical aberration of the eye.

US Pat. No. 11,020,272

LASER SCANNER

AMO Development, LLC, Sa...

1. A laser scanner comprising:a laser source;
a first optical element adapted to move along an optical axis of light from the laser source;
a focusing element receiving laser light from the first optical element, wherein the focusing element is adapted to move orthogonally to the optical axis; and
a second optical element, which is a block of refractive material having a refractive index greater than one, the second optical element receiving laser light from the focusing element on a first flat surface at a first side of the second optical element and transmitting the laser light out of a second flat surface at a second side of the second optical element which is different from the first side, wherein the second optical element is adapted to effectively increase a focal length of the focusing element without increasing the f number of the focusing element.

US Pat. No. 11,020,273

AUTOMATED CALIBRATION OF LASER SYSTEM AND TOMOGRAPHY SYSTEM WITH FLUORESCENT IMAGING OF SCAN PATTERN

AMO Development, LLC, Sa...

1. A laser system, comprising:an electromagnetic radiation beam source configured to output a beam along a beam path toward a treatment space;
a scanning system, including an xy-scan device, disposed along the beam path, the scanning system configured to direct the outputted beam to a plurality of locations in the treatment space;
a camera configured to capture images of the treatment space, wherein the camera comprises a sensor having an array of pixels, each pixel having a pixel location; and
a processor coupled with the scanning system and the camera, the processor configured to calibrate the scanning system by:
mapping camera pixel locations to the treatment space;
controlling the xy-scan device based on a series of control parameters of the xy-scan device to scan the electromagnetic radiation beam of the laser system orthogonally to a propagation direction of the electromagnetic radiation beam to a series of corresponding scanning locations of a fluorescent material disposed in the treatment space, the series of scanning locations of the fluorescent material corresponding to the series of control parameters of the xy-scan device;
capturing, using the camera, an emitted light from the series of locations of the fluorescent material in response to the scanned electromagnetic radiation beam to obtain a corresponding series of measured positions, represented by camera pixel locations, of the series of locations of the fluorescent material; and
calibrating the scanning system with the treatment space per the camera captured series of locations and the mapping of the camera pixel locations to the treatment space, including mapping the series of control parameters of the xy-scan device to the corresponding series of measured positions obtained by the camera.

US Pat. No. 11,020,274

SUB-NANOSECOND LASER CATARACT SURGERY SYSTEM

AMO Development, LLC, Sa...

1. A laser cataract surgery system, comprising:a sub-nanosecond laser source generating a treatment beam that includes a plurality of laser beam pulses;
an optical delivery system coupled to the sub-nanosecond laser source to receive and direct the treatment beam; and
a processor coupled to the sub-nanosecond laser source and the optical delivery system, the processor comprising a tangible non-volatile computer readable medium comprising instructions to:
determine a lens cut pattern inside a lens of an eye for lens fragmentation, the lens cut pattern including a plurality of trajectory positions each having a depth defined from an anterior surface of the lens;
determine a plurality of pulse energies of the treatment beam to be delivered to the corresponding plurality of trajectory positions based on a linear function between the pulse energy of the treatment beam and the depth of the trajectory position; and
control the sub-nanosecond laser source and the optical delivery system to deliver a plurality of focal points of laser pulses inside the lens of the eye to generate bubbles inside the lens at the focal points, wherein each laser pulse focal point is delivered to one of the plurality of trajectory positions at a corresponding depth inside the lens as defined by the cut pattern and has a corresponding one of the pulse energies, wherein the bubbles generated by the plurality of laser pulse focal points form cuts inside the lens.

US Pat. No. 10,973,683

METHODS AND SYSTEMS FOR LASER OPHTHALMIC SURGERY THAT PROVIDE FOR IRIS EXPOSURES BELOW A PREDETERMINED EXPOSURE LIMIT

AMO Development, LLC, Sa...

1. A system for cataract surgery on an eye of a patient, comprising:a laser assembly for generating a pulsed laser treatment beam;
an imaging system configured for imaging an ocular tissue of the patient, the ocular tissue comprising corneal tissue;
an optical scanning system configured for positioning a focal zone of the treatment beam to targeted locations of the ocular tissue, the targeted locations including a location in the corneal tissue; and
a computer control system operatively coupled to the laser assembly, the imaging system, and the optical scanning system, and programmed to:
a) generate a simulated initial treatment scan pattern of the laser treatment beam for incising the corneal tissue and calculate an initial exposure level, which is an amount of laser energy per unit area of the laser treatment beam on an iris tissue of the eye caused by the initial treatment scan pattern;
b) determine whether the initial exposure level satisfies a predetermined safe exposure condition which is below an exposure that causes a minimal visible lesion in the iris tissue;
c) generate a simulated revised treatment scan pattern of the laser treatment beam for incising the corneal tissue which is different from the initial treatment scan pattern and which comprises one or more treatment scan modifying elements when the initial exposure level fails to satisfy the predetermined safe exposure condition, wherein the one or more treatment scan modifying elements cause a calculated revised exposure level, which is an amount of laser energy per unit area of the laser treatment beam on the iris tissue caused by the revised treatment scan pattern, to satisfy the predetermined safe exposure condition;
wherein the one or more treatment modifying elements comprises: (1) an extension of a scan path of the scan pattern so that a portion of each turnaround of the scan path occurs beyond an incision boundary, the extension of the scan path being greater than 50% of a turnaround distance of the scan path, or (2) an extension of the scan path of the scan pattern so that a portion of each turnaround of the scan path is gated and extends beyond the incision boundary, the extension of the scan path being greater than 50% of a turnaround distance of the scan path, or (3) a reoriented scan axis, wherein the reoriented axis is reoriented along an axis corresponding to a largest distance between opposing incision boundaries, or (4) an insertion of gated rows with respective active rows in a fixed proportion, the fixed proportion being greater than or equal to one, and less than or equal to 10; and
d) operate the optical scanning system and laser assembly to direct a treatment beam in a pattern corresponding to the revised treatment scan pattern so as to create a corneal incision.

US Pat. No. 10,973,685

SYSTEMS AND METHODS FOR REDUCING SPHERICAL ABERRATION USING PERIPHERY MODIFICATION

AMO Development, LLC, Sa...

1. A computer implemented method of controlling ablation applied to an eye of a patient, the method comprising:receiving a first treatment target corresponding to a first target shape of a surface of the eye;
obtaining a periphery modification function (PMF);
determining a second treatment target corresponding to a second target shape of the surface of the eye by multiplying, for each of a plurality of points on the surface of the eye, the PMF by the first treatment target;
scaling the second treatment target using a scaling factor such that values of the second treatment target are scaled to be lower at a mid-periphery of the eye and scaled to be smaller at a far-periphery of the eye; and
controlling an ablation treatment parameter of the ablation applied, by an ablation device, to the surface of the eye by the scaled second treatment target.

US Pat. No. 10,973,688

EYE SUCTION LOSS AND CORNEAL APPLANATION DETECTION IN OPHTHALMIC DOCKING SYSTEM USING OPTICAL SIGNAL

AMO Development, LLC, Sa...

1. An ophthalmic laser surgical method for treating an eye of a patient, comprising:coupling the eye to a patient interface device, including forming a direct contact of an output surface of the patient interface device with an eye tissue of the eye;
a laser system generating a laser beam and focusing it to a laser beam focus;
scanning devices of the laser system, controlled by a controller, scanning the laser beam focus within the eye according to one or more scan patterns;
while the laser beam focus is being scanned within the eye, a confocal assembly of the laser system continuously detecting a confocal signal, the confocal signal representing an intensity of a portion of the laser beam that has been reflected by the eye, focused by one or more lenses onto a pinhole, passed through the pinhole, and detected by a photodetector behind the pinhole;
based on the confocal signal, the controller detecting, in real time, a loss of the direct contact between the output surface of the patient interface device and the eye tissue; and
in response to detecting the loss of the direct contact, the controller performing a predefined corrective action.

US Pat. No. 10,966,864

PATIENT INTERFACE DEVICE FOR OPHTHALMIC SURGICAL LASER SYSTEM

AMO Development, LLC, Sa...

1. A patient interface device for coupling an eye of a patient to an ophthalmic surgical laser system, comprising:a hollow shell formed of a rigid material and defining an interior space, the shell having an upper rim and a lower portion;
a transparent applanation lens disposed inside of and fixedly mounted to the lower portion of the hollow shell; and
a flexible skirt having a circular shape, the flexible skirt being affixed to and extending downwardly from a lower end of the lower portion of the shell, wherein a lower rim of the flexible skirt is located below the applanation lens,
wherein the lower portion of the shell defines one or more through channels in a region between the applanation lens and a side wall of the lower portion, wherein each of the one or more through channels is open to and in air communication with both the interior space of the shell above the applanation lens and a space which is located below the applanation lens and encircled by the flexible skirt wherein each of the one or more through channels is configured to communicate a vacuum to secure the patient interface device to the ophthalmic surgical laser system and to the eye.

US Pat. No. 10,925,720

METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS

AMO Development, LLC, Sa...

1. A method for treating a target tissue in a patient's eye, comprising:generating a treatment light beam;
generating an imaging light beam;
aligning the imaging light beam and the treatment light beam;
deflecting the treatment light beam and the imaging light beam, which have been aligned to each other, with a scanner that is under the control of a controller, the deflected treatment light beam configured to form a treatment pattern;
delivering the treatment light beam and the imaging light beam to the target tissue using a delivery system to form the treatment pattern;
measuring back reflections or scatter of the deflected imaging light beam from structures at or near the target tissue of the patient's eye; and
analyzing the back reflection or scatter of the imaging light beam, based on a pre-established calibration relationship that matches back reflections or scatters of the imaging light to focal positions of the treatment light, to identify a focal position of the treatment light beam,
wherein the target tissue is selected from the group consisting of the lens, lens capsule, cornea, limbus and sclera of the patient's eye.

US Pat. No. 10,898,377

HYBRID OPHTHALMIC INTERFACE APPARATUS

AMO Development, LLC, Sa...

1. A patient interface for coupling a patient's eye to a surgical laser system, the patient interface comprising: an attachment ring, disposed around a central axis, configured to overlay an anterior surface of the eye, the attachment ring having a pair of concentric downwardly projecting flexible rings for contacting the eye and defining a channel therebetween and a suction port in communication with the channel, the pair of flexible rings including an outer skirt and an inner ring, wherein a lower edge of the outer skirt defines a planar surface that is not perpendicular to the central axis.

US Pat. No. 10,898,382

PATIENT INTERFACE DEVICE FOR OPHTHALMIC SURGICAL LASER SYSTEM

AMO Development, LLC, Sa...

1. A patient interface device for coupling an eye of a patient to an ophthalmic surgical laser system, comprising:a hollow shell formed of a rigid material;
a flexible suction ring joined to a lower edge of the shell;
an applanation lens located near the lower edge of the shell, the applanation lens having a spacer attached to its top surface; and
a flexible annular diaphragm, which joins the applanation lens to the shell at a location near the lower edge of the shell, wherein the flexible annular diaphragm allows the applanation lens to move relative to the shell.

US Pat. No. 10,888,459

MICROFEMTOTOMY METHODS AND SYSTEMS

AMO Development, LLC, Sa...

1. A method for performing a laser-assisted treatment of an eye having a lens capsule, the method comprising:forming an anchoring capsulotomy in the lens capsule by using a laser to incise the lens capsule, the anchoring capsulotomy being configured to accommodate a drug eluting plug; and
removably coupling the drug eluting plug to the anchoring capsulotomy, wherein the drug-eluting plug includes at least one cap on a body, wherein a portion of the body of the drug eluting plug is removably fitted through the anchoring capsulotomy to retain the drug eluting plug's position relative to the lens capsule, wherein the portion the body of the drug-eluting plug that passes through the anchoring capsulotomy includes pores configured for dispersion of a drug which is otherwise contained within the drug-eluting plug.

US Pat. No. 10,813,550

OPTICAL MEASUREMENT SYSTEMS AND METHODS WITH CUSTOM CHROMATIC ABERRATION ADJUSTMENTS

AMO DEVELOPMENT, LLC, Sa...

1. A method, comprising:using a probe beam having a first infrared wavelength in the infrared spectrum to measure a refraction of an eye at the first infrared wavelength;
capturing a first Purkinje image from a first surface of a lens of the eye at a first visible wavelength;
capturing a second Purkinje image from the first surface of the lens at a second infrared wavelength;
capturing a third Purkinje image from the first surface of the lens at a third infrared wavelength different from the second infrared wavelength;
determining from the first, second, and third Purkinje images a value for a radius of curvature of the first surface of the lens;
using the value for the radius of curvature of the first surface of the lens to determine a customized chromatic adjustment factor for the eye; and
adjusting the measured refraction of the eye at the first infrared wavelength with the customized chromatic adjustment factor to determine a refraction of the eye at a second visible wavelength in the visible spectrum.

US Pat. No. 10,799,394

PATIENT INTERFACE DEVICE FOR LASER EYE SURGERY HAVING LIGHT GUIDING STRUCTURE FOR ILLUMINATING EYE

AMO Development, LLC, Sa...

10. A system, comprising:a laser surgery apparatus, comprising: a laser source,
a lens assembly configured to direct laser light from the laser source to a target area of a patient's eye for laser surgery,
a docking receptacle, and
an illuminating light source; and
a patient interface device, comprising:
a shell, defining a chamber within the shell,
a first interface port configured to be interfaced with the patient's eye, the first interface port being disposed at a first side of the shell and including an applanating lens for application to the patient's eye during a laser surgery procedure and a flexible or semi-flexible membrane on which the applanating lens is provided, the membrane having through channels extending through the membrane from the chamber above the applanating lens to a space below the applanating lens,
a second interface port disposed at a second side of the shell which is opposite the first side of the shell and which is configured to be interfaced with the docking receptacle, and
a light guiding structure having at a first end thereof a light receiving interface, configured to receive light from the illuminating light source, and having at a second end thereof a light-diffusing, light-emitting, interface, wherein the light-diffusing, light-emitting, interface is disposed adjacent the applanating lens and configured to diffusely provide the light in a vicinity of the patient's eye when the applanating lens is applied to the patient's eye.

US Pat. No. 10,783,999

BASIS DATA EVALUATION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A method of determining an adjusted basis data that improves an accuracy of a laser ablation vision procedure performed on a patient, the method comprising:inputting an initial basis data, the initial basis data comprising a set of pulse profiles;
determining a first treatment target ablation profile based on the initial basis data and measurements of a previous patient acquired by one or more sensors;
deconvolving the first treatment target ablation profile with a low pass filter to generate a first predicted surgery outcome;
determining an actual surgery outcome for the previous patient after an eye of the previous patient has healed, wherein the previous patient has previously received the laser ablation vision procedure based on the initial basis data;
comparing the first predicted surgery outcome with the actual surgery outcome based on a least mean squares comparison of an optical path difference (OPD) to generate a comparison result;
updating the initial basis data based on the comparison result to form adjusted basis data, wherein the adjusted basis data comprises a second set of pulse profiles that differs from the set of pulse profiles from the initial basis data; and
controlling a laser ablation system to deliver the laser ablation vision procedure to the patient based on the adjusted basis data.

US Pat. No. 10,722,400

HYBRID OPHTHALMIC INTERFACE APPARATUS AND METHOD OF INTERFACING A SURGICAL LASER WITH AN EYE

AMO Development, LLC, Sa...

1. A method for interfacing an eye to a surgical laser, the method comprising:coupling a lens cone to a delivery tip of the surgical laser, the lens cone defining a first plane surface and the delivery tip being positionally referenced to the first plane surface, the lens cone comprising:
an apex ring coupled to the first plane surface, the apex ring comprising a distal end; and
an applanation lens disposed at a distal end of the apex ring and positioned in a second plane surface parallel to the first plane surface such that the delivery tip is positionally referenced to the second plane;
coupling an assembly including an attachment ring and a gripper to an anterior surface of the eye, the attachment ring having an inner surface, the gripper comprising:
a second receptacle configured to receive the attachment ring, the second receptacle having an inner surface; and
a central orifice configured to receive a lens cone,
wherein the anterior surface of the eye, the inner surface of the attachment ring, and an inner surface of the central orifice of the gripper form a first receptacle;
after coupling the assembly to the anterior surface of the eye, receiving a liquid into the first receptacle;
after receiving the liquid into the first receptacle, positioning the distal end of the lens cone in the central orifice, including moving the distal end of the lens cone toward the anterior surface of the eye while displacing a portion of the liquid from the first receptacle, to a position where the applanation lens remains free of contact with the anterior surface of the eye; and
thereafter, stabilizing the relative positions of the lens cone and the attachment ring with the gripper when the lens cone and the attachment ring are received within the gripper, a chamber containing the liquid being formed by the first receptacle and the applanation lens when the lens cone and the attachment ring are received within the gripper.

US Pat. No. 11,076,993

VACUUM LOSS DETECTION DURING LASER EYE SURGERY

AMO Development, LLC, Sa...


1. A method of detecting loss of vacuum in a patient interface of a laser eye surgery system having control electronics, comprising:docking a patient's eye to a suction ring of a patient interface which is aligned with an optical axis of the laser eye surgery system;
supplying a sterile solution to a space within the patient interface between the patient's eye and a posterior surface of a transmissive lens held in the patient interface to form a transmissive chamber through which the laser eye surgery system may operate on the patient's eye;
monitoring a video feed of the laser eye surgery through the patient interface to generate first data;
monitoring a physical force sensor that detects movement of the patient's eye relative to the patient interface to generate second data, wherein the force sensor is disposed in the patient interface between a main body of the patient interface and a coupling adapter of the patient interface; and
monitoring a vacuum sensor connected to a vacuum chamber of the suction ring to generate third data;
aggregating data from all of the steps of monitoring with the control electronics and halting or delaying the laser eye surgery if at least two of the first data, second data and third data are consistent with a threshold likelihood of a significant vacuum leak.

US Pat. No. 11,065,156

LENTICULAR LASER INCISION FOR LOW MYOPIA AND/OR HYPEROPIA PATIENTS

AMO DEVELOPMENT, LLC, Sa...


1. A method for creating lenticular incisions to correct low myopic/hyperopic patients using an ophthalmic surgical laser system, the method comprising:placing a patient interface device in contact with a cornea of a patient's eye to applanate the cornea;
generating a pulsed femtosecond laser beam;
delivering the pulsed femtosecond laser beam into a stroma of the cornea;
deflecting, by an XY-scan device, the pulsed laser beam;
modifying, by a Z-scan device, a depth of a focus of the pulsed laser beam; and
calculating, by a controller, an initial top lenticular shape, an initial bottom lenticular shape, wherein the initial top lenticular shape and the initial bottom lenticular shape define an initial space between them, and a shape of an added space, wherein the initial top lenticular shape and the initial bottom lenticular shape are calculated based on a predetermined correction power, wherein the shape of the added space has a uniform thickness part with a uniform first thickness and a lenticular part with a second thickness at its center, wherein the second thickness is calculated based on a shape difference between the applanated cornea and the cornea in an unapplanated state, and wherein the shape of the added space introduces zero correction power in the cornea in the unapplanated state;
calculating, by the controller, a top lenticular incision shape based on the initial top lenticular shape and the shape of the added space, and a bottom lenticular incision shape based on the initial bottom lenticular shape and the shape of the added space;
controlling, by a controller, the XY-scan device and the Z-scan device to form an incised lenticule in the cornea, by incising, while the cornea is applanated by the patient interface device:a top lenticular incision in the stroma of the cornea, having the calculated top lenticular incision shape and a circumferential periphery;
a bottom lenticular incision in the stroma of the cornea, symmetric to the top lenticular incision, having the calculated bottom lenticular incision shape and a circumferential periphery; and
a transition ring or side cut incision intersecting the circumferential periphery of the top lenticular incision and the circumferential periphery of the bottom lenticular incision; and

removing the patient interface device from the cornea.

US Pat. No. 11,013,407

INTRAOCULAR PRESSURE MEASUREMENT FOR AN EYE DOCKED TO A LASER SYSTEM

AMO Development, LLC, Sa...

9. An ophthalmic surgical laser system, comprising:a laser device configured to generate a laser beam;
a laser beam delivery device configured to deliver the laser beam;
a patient interface assembly, configured to be coupled to the laser beam delivery device at one end and coupled to a patient's eye at another end, the patient interface assembly including at least one force sensor for sensing a force exerted by the patient interface assembly on the eye and generate a real-time external force signal representing the exerted force;
an imaging device configured to image structures of the eye that is coupled to the patient interface assembly and generate a real-time corneal deformation signal representing a deformation of a cornea of the eye; and
a controller coupled to the laser device, the laser beam delivery device, the at least one force sensor and the imaging device, configured to:
continuously receive the real-time external force signal and the corneal deformation signal;
calculate a parameter of a relationship between the real-time external force signal and the real-time corneal deformation signal;
determine an intraocular pressure of the eye that is coupled to the patient interface assembly based on the calculated parameter and a calibration curve between values of intraocular pressure and values of the parameter; and
control the laser device and the laser beam delivery device based in part on the determined intraocular pressure to perform treatment on the eye.

US Pat. No. 10,905,592

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

AMO Development, LLC, Sa...

1. A method for ophthalmic intervention on an eye of a patient having temporary geometric markers thereon indicative of the orientation of axis of the patient's eye, comprising:using an imaging device having a field of view oriented toward the eye of the patient, imaging two or more registration fiducials in reference to the temporary geometric markers on the eye of the patient, the two or more registration fiducials being formed on an inner annulus of a patient interface housing disposed within the field of view of the imaging device, wherein the two or more registration fiducials include at least two registration fiducials either having different shapes or being made of different materials; and
processing image data generated via the imaging device for the two or more registration fiducials and the temporary geometric markers on the eye of the patient, including differentiating the image data for the at least two registration fiducials which either have different shapes or are made of different materials, to determine a position or an angular orientation of the eye relative to the patient interface housing based on locations of the two or more registration fiducials.

US Pat. No. 10,874,553

APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER OPHTHALMIC SURGERY

AMO Development, LLC, Sa...

1. A method of making an incision in eye tissue during a cataract surgical procedure, the method comprising:generating a beam of light, the beam of light being a pulsed laser beam containing laser pulses having pulse durations of less than 10 ps;
operating an imaging system, which is coupled to control electronics, to acquire image data from locations distributed throughout a volume of the eye tissue and construct one or more images of at least a portion of the eye tissue from the image data;
identifying, using the control electronics, a cutting region based on the image data;
passing the beam of light through a multi-focal length optical element, wherein the multi-focal length optical element simultaneously focuses a first portion of the beam of light at a first focal point located at a first depth inside the eye tissue and a second portion of the beam of light at a second focal point located at a second depth inside the eye tissue different than the first depth; and
scanning the first and second focal points in at least a transverse direction inside the eye tissue to form the incision inside the eye tissue, including controlling an optical scanning system using the control electronics based in part on the image data and a scanning pattern, to scan the first focal point and the second focal point within the cutting region.

US Pat. No. 10,801,829

SIGNAL EXTRACTION SYSTEMS AND METHODS

AMO Development, LLC, Sa...

1. A system, comprising:a swept source laser configured to output light having a frequency which is swept over time;
a beamsplitter configured to receive the light and to supply a first portion of the light to a reference path and a second portion of the light to a sample path;
a beam combiner having a first input, a second input, and an output, wherein the first input is configured to receive first portion of the light from the reference path;
optics disposed in the sample path and configured to direct the second portion of the light to a sample and to direct backscattered light from the object to the second input of the beam combiner;
a photo detection device configured to receive from the beam combiner the first portion of the light from the reference path and the backscattered light from the sample and to output an electrical signal produced by interference between a first optical field of the first portion of the light from the reference path and a second optical field of the backscattered light from the sample, wherein the electrical signal comprises a first frequency component at or below a set frequency and a second frequency component above the set frequency; and
a signal processor comprising:
an analog-to-digital conversion subsystem comprising at least a first analog-to-digital converter (ADC);
a frequency down shifter; and
a distribution element configured to receive the electrical signal output by the photo detection device, to send the first frequency component to the analog-to-digital conversion subsystem, and to send the second frequency component to the frequency down shifter,
wherein the frequency down shifter is configured to down shift the second frequency component to a downshifted frequency at or below the set frequency to form a down shifted second frequency component, and to send the down shifted second frequency component to the analog-to-digital conversion subsystem.

US Pat. No. 10,743,765

MINIATURE IMAGING SYSTEM FOR OPHTHALMIC LASER BEAM DELIVERY SYSTEM

AMO Development, LLC, Sa...

1. An optical imaging system for an ophthalmic laser beam delivery system, comprising:a focusing objective including a plurality of lenses;
a folding mirror disposed near an entrance of the focusing objective, wherein the folding mirror has a front surface that faces the entrance of the focusing objective and a back surface that faces away from the entrance of the focusing objective, wherein the folding mirror is configured to reflect a part of a treatment laser beam that is incident on the front surface into the entrance of the focusing objective, wherein the folding mirror is further configured to transmit a part of a collected light, which has exited the entrance of the focusing objective and incident on the front surface, out of the back surface;
a prism disposed adjacent the back surface of the folding mirror, the prism having a first, a second and a third surface, the second surface being disposed adjacent the back surface of the folding mirror and configured to receive the part of the collected light that has exited the entrance of the focusing objective and transmitted through the folding mirror out of the back surface of the folding mirror, the prism being configured to reflect the part of the collected light that has entered the second surface sequentially by the first surface and by the second surface toward the third surface to exit the prism;
a focusing lens module disposed adjacent the third surface of the prism to focus light exiting from the third surface of the prism, the focusing lens module being distinct from the focusing objective; and
an image sensor disposed to receive the light focused by the focusing lens module to form an image.

US Pat. No. 11,123,224

EYE TISSUE MEASUREMENTS

AMO Development, LLC, Sa...


1. A method for incising a cornea of an eye of a patient using a laser system, comprising:docking a patient interface of the laser system to the eye;
generating a first laser beam using the laser system, the first laser beam having a power below a photo disruption threshold for the eye;
focusing the first laser beam to a focal point in an interior side of the cornea;
moving the laser focal point in a depth direction of the eye from the interior side of the cornea through the cornea and to an exterior side of the cornea;
capturing a backscatter of the laser focal point as it moves in the depth direction from the interior side of the cornea to the exterior side of the cornea;
recording a power of the captured backscatter as the laser focal point moves in the depth direction from the interior side of the cornea to the exterior side of the cornea;
identifying peaks of the recorded power of the captured backscatter;
determining a corneal thickness based on the identified peaks of the recorded power, and determining an incision depth based on the corneal thickness;
generating a second laser beam using the laser system, the second laser beam having a power above the photo disruption threshold for the eye; and
incising the cornea at the incision depth using the second laser beam.

US Pat. No. 11,083,625

SUB-NANOSECOND LASER SURGERY SYSTEM UTILIZING MULTIPLE PULSED LASER BEAMS

AMO Development, LLC, Sa...


1. A system for laser ophthalmic surgery on an eye of a patient, comprising:a single laser source, under the operative control of a controller, configured to alternatively deliver a first treatment laser beam and a second treatment laser beam, each treatment laser beam comprising a plurality of laser pulses, the first treatment laser beam having a first wavelength and the second treatment laser beam having a second wavelength which is shorter than the first wavelength, wherein the first treatment laser beam is either a first harmonic which is an infrared wavelength of between 870 nm and 1200 nm, or a second harmonic which is a visible wavelength of between 475 nm and 600 nm, and the second treatment laser beam is a third harmonic which is an ultraviolet wavelength of between 320 nm and 370 nm; and
an optical system operatively coupled to the laser source by the controller and configured to focus the first treatment laser beam to a first focal spot and direct the first focal spot in a first treatment pattern into one or more intraocular targets including a first intraocular target,
the optical system being further configured to focus the second treatment laser beam to a second focal spot and direct the second focal spot in a second treatment pattern into the one or more intraocular targets including a second intraocular target,
wherein the optical system includes a first optical path section, a second optical path section separate from the first optical path section, a beam splitting optical element configured to direct the first treatment laser beam along the first optical path section and direct the second treatment laser beam along the second optical path section, and a beam combining optical element configured to combine the first treatment laser beam on the first optical path section and the second treatment laser beam on the second optical path section into a common optical path section, wherein the first optical path section includes a first confocal imaging assembly which is optimized to detect back reflected light from the eye having the first wavelength, the second optical path section includes a second confocal imaging assembly which is separate from the first confocal imaging assembly and which is optimized to detect back reflected light from the eye having the second wavelength.

US Pat. No. 11,076,990

SYSTEM AND METHOD FOR OPHTHALMIC LASER SURGERY EMPLOYING EYE TRACKING WITHOUT EYE DOCKING

AMO Development, LLC, Sa...


1. A surgical laser system configured to deliver an ultra-short pulsed laser beam to a patient's eye comprising:a lens configured to fit over an anterior surface of the patient's eye and cover a central portion of the cornea, the lens comprising a substantially flat anterior surface and a chamber configured to cooperate with the anterior surface of the patient's eye to maintain fluid in the chamber, the lens further comprising a scleral ring at a base of the lens to support the lens on the eye, wherein the scleral ring is formed of a compliant material, the scleral ring having a first side and a second side opposite to each other, the first side defining a continuous ring-shaped area, the scleral ring configured to have the continuous ring-shaped area of the first side fully contact the anterior surface of the eye, wherein the lens is free of other surfaces that contact the anterior surface of the eye;
wherein the lens is configured to deliver an ultra-short pulsed laser beam to the eye of the patient and facilitate performance of ocular surgery by providing an index of refraction closer to that of ocular tissue than air.

US Pat. No. 11,076,991

LOW VOLTAGE COMMUNICATION BETWEEN SUBSYSTEMS IN A LASER EYE SURGERY SYSTEM

AMO Development, LLC, Sa...


1. A method of communicating between subsystems of a laser eye surgery system, comprising:providing a first subsystem including first subsystem control electronics;
providing a processor;
providing a first subsystem interface connected to the processor and connected to the first subsystem;
providing bidirectional communication between the first subsystem interface and the first subsystem, including:by a first subsystem interface differential transmitter of the first subsystem interface, transmitting a first differential signal to the first subsystem for controlling the first subsystem;
by a first subsystem interface differential receiver of the first subsystem interface, receiving data from the first subsystem via a second differential signal separate from the first differential signal;
by a first subsystem differential receiver of the first subsystem control electronics, wherein the first subsystem differential receiver is separate from the first subsystem interface differential receiver and has a load, receiving from the first subsystem interface differential transmitter the first differential signal for controlling the first subsystem; and
by a first subsystem differential transmitter of the first subsystem control electronics, wherein the first subsystem differential transmitter is separate from the first subsystem interface differential transmitter, transmitting the data to the first subsystem interface differential receiver via the second differential signal.


US Pat. No. 11,051,688

OPTICAL DIAGNOSIS USING MEASUREMENT SEQUENCE

AMO Development, LLC, Sa...


1. An optical diagnostic system for an eye having a pupil, the system comprising:a sensing device for measuring aberrations of the eye for each of a sequence of aberration measurements of the eye; and
a computer coupled with the sensing device, the computer comprising a processor and a computer readable medium comprising instructions executable by the processor to identify an outlier aberration measurement of the sequence of aberration measurements of the eye and exclude the outlier aberration measurement from the sequence of aberration measurements to produce a qualified sequence of aberration measurements.

US Pat. No. 11,051,983

LASER EYE SURGERY SYSTEM CALIBRATION

AMO Development, LLC, Sa...


1. A system to treat an eye with a laser beam, the system comprising:a laser configured to generate the laser beam;
a measurement system configured to measure first and second optically transmissive materials of the eye having differing indices of refraction;
an optical delivery system coupled to the laser to deliver the laser beam to the second material through the first material; and
a processor coupled to the measurement system and the optical delivery system, the processor configured to form a plurality of marks in both the first material and the second material with the laser beam per a plurality of target locations, wherein the marks in the first material and the second material together define a three dimensional calibration volume in the eye that includes both the first material and the second material, to measure a plurality of locations of the marks with the measurement system, to calibrate the system for the calibration volume by comparing the target locations and the measured locations of the marks using the indices of refraction, and to direct the beam toward a treatment target located within the calibration volume within the eye with the calibrated system.

US Pat. No. 11,006,823

METHODS AND SYSTEMS FOR OPTICAL COHERENCE TOMOGRAPHY SCANNING OF CORNEA AND RETINA

AMO Development, LLC, Sa...

1. A method, comprising:aligning an eye measurement instrument to an eye;
directing a sample light beam to the eye via a sample arm of an optical coherence tomographer (OCT) system and via an OCT scanning subsystem which includes a scanning mirror arrangement and an optical system;
controlling the scanning mirror arrangement to scan the light beam simultaneously at a plurality of different angles across a corneal region of the eye and a retinal region of the eye, wherein the corneal region has a diameter of at least approximately 9 millimeters and the retinal region has a diameter of at least approximately 2.5 millimeters;
returning the sample light from the cornea of the eye and the retina of the eye to an OCT interferometer of the OCT system;
determining at least one retinal characteristic of the eye from the returned sample light from the retina of the eye;
determining from the at least one retinal characteristic of the eye whether a retinal health of the eye satisfies one or more retinal health requirements for implanting a premium intraocular lens into the eye;
determining at least one corneal characteristic of the eye from the returned sample light from the cornea of the eye;
selecting an IOL for implantation into the eye based on the at least one corneal characteristic and whether the retinal health of the eye satisfies one or more retinal health requirements; and
planning an IOL implantation surgery, wherein the planning includes using at least the selected IOL.

US Pat. No. 10,857,031

DISPERSION CONTROL USING CHIRPED MIRRORS IN FEMTOSECOND LASER SYSTEM FOR OPHTHALMIC APPLICATION

AMO Development, LLC, Sa...

1. An optical system for directing a pulsed laser beam from a laser to an objective lens, the optical system comprising:a plurality of chirped mirrors disposed along an optical path of the pulsed laser beam; and
one or more optical elements disposed along the optical path, the optical elements including one or more of: half wave plate, beam splitter, beam sampler, XY beam position scanner and Z beam position scanner,
wherein the plurality of chirped mirrors includes a first chirped mirror, a second chirped mirror, a third chirped mirror, and a fourth chirped mirror disposed sequentially in the optical path in an order of from the first to the fourth chirped mirrors, wherein each of the plurality of chirped mirrors is disposed to reflect the pulsed laser beam only once along the optical path, wherein each of the plurality of chirped mirrors provides a negative group delay dispersion (GDD) per bounce to the pulsed laser beam in a defined wavelength range, and wherein the plurality of chirped mirrors provide a combined negative GDD which is approximately identical in absolute value to a combined positive GDD of the one or more optical elements and the objective lens, and
wherein the one or more optical elements are disposed between the third and fourth chirped mirrors or between the first and second chirped mirrors.

US Pat. No. 10,828,149

METHOD FOR PATTERNED PLASMA-MEDIATED MODIFICATION OF THE CRYSTALLINE LENS

AMO Development, LLC, Sa...

1. A system for treating a cataractous lens of a patient's eye, comprising:a. a laser source for generating a light beam;
b. a scanning system for deflecting the light beam to form a treatment pattern of the light beam;
c. a controller operably coupled to the laser source and scanning system and configured to operate the scanner to form the treatment pattern for forming a plurality of cuts in the lens in the form of the treatment pattern so as to segment the lens tissue into a plurality of patterned pieces, the treatment pattern comprising a spiral shaped incision and a plurality of sub-segment incisions as viewed from an anterior to a posterior position along the optical axis and extending along a length between a posterior cutting limit within the lens and an anterior surface of the lens capsule, wherein each of the plurality of sub-segment incision extends between and connects two portions of the spiral shaped incision that are located at different radii, and wherein none of the plurality of sub-segment incisions is radially aligned with another one of the plurality of sub-segment incisions.

US Pat. No. 10,779,988

COMPACT ULTRA-SHORT PULSED LASER EYE SURGERY WORKSTATION

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system configured to deliver a pulsed laser beam at a focal point of a target in a patient's eye, the pulsed laser beam having a pulse repetition rate in the range between 5 MHz and 25 MHz;
a resonant optical scanner, the scanner oscillating at a frequency between 200 Hz and 21000 Hz and configured to scan the pulsed laser beam to form a scan line which extends linearly in a lateral orientation;
a scan-line rotator disposed after the resonant optical scanner and configured to receive the scan line formed by the resonant optical scanner and rotate the lateral orientation of the scan line;
an xy-scan device configured to move the rotated scan line of the pulsed laser beam in two lateral directions;
a z-scan device configured to modify a depth of focus of the pulsed laser beam; and
a controller operably coupled with the laser delivery system, the resonant optical scanner, the scan-line rotator, the xy-scan device and the z-scan device, the controller configured to direct the laser delivery system to output the pulsed laser beam in a desired pattern at the focal point of the target in the eye so as to modify the target.

US Pat. No. 10,751,217

FREE FLOATING PATIENT INTERFACE FOR LASER SURGERY SYSTEM

AMO Development, LLC, Sa...

1. A patient interface assembly for a laser eye surgery system, the patient interface assembly comprising:an eye interface device configured to interface with an eye of a patient;
a scanner configured to be coupled with the eye interface device and operable to scan a laser beam in at least two dimensions;
a beam source that generates the laser beam; and
a free-floating mechanism that supports the scanner and is configured to provide movements of the scanner relative to the beam source, the free-floating mechanism including a first mirror and a second mirror and configured to moveably couple the first mirror to the second mirror to vary a relative position between the first and second mirrors, the first mirror and the second mirror being external to the scanner and located on an optical path between the beam source and the scanner, the second mirror disposed to receive the laser beam from a third direction and reflect it directly to the first mirror along a second direction, and the first mirror disposed to receive the laser beam directly reflected from the second mirror along the second direction and reflect it directly to the scanner along a first direction, the first, second and third directions being non-parallel to one another, wherein the free-floating mechanism is configured to moveably couple the first mirror to the second mirror to support a relative translation movement between the first mirror and the second mirror along the second direction, and wherein the free-floating mechanism is configured to move the scanner and the eye interface device,
wherein the free-floating mechanism includes a first support assembly configured to support the scanner and the first mirror and to provide a relative translation movement between the scanner and the first mirror in the first direction, a second support assembly configured to support the first support assembly and the second mirror and to provide a relative translation movement between the first support assembly and the second mirror in the second direction, and a base assembly configured to support the second support assembly and to provide a relative translation movement between the second support assembly and the base assembly in the third direction.